Current Duke Appointments & Affiliations
Professor of Medicine
·
2020 - Present
Medicine, Medical Oncology,
Medicine
Member of the Duke Cancer Institute
·
2019 - Present
Duke Cancer Institute,
Institutes and Centers
Member of the Duke Human Vaccine Institute
·
2023 - Present
Duke Human Vaccine Institute,
Institutes and Centers
Recent Scholarly Works
Alirocumab plus cemiplimab in immuno-refractory metastatic NSCLC: A single-arm, multi-center, phase 2 study.
Conference Journal of Clinical Oncology · June 1, 2026 2619Background: Immunotherapy resistance remains a significant unmet clinical need for most non-small cell lung cancer (NSCLC) patients. PCSK9 was shown in preclinical models to mediate cancer immunotherapy resistance and may serve as a novel immuno-inhibi ... Full text CiteAlirocumab plus cemiplimab in advanced immuno-refractory metastatic non-small cell lung cancer: an ongoing multi-center phase II study.
Journal article Future Oncol · April 2026 Immunotherapy resistance represents a major unmet clinical need for patients with metastatic non-small cell lung cancer (NSCLC). Preclinical studies have identified PCSK9 as an immunosuppressive regulator of antigen presentation, providing a compelling rat ... Full text Link to item CiteDistinct Tumor-Immune Ecologies in Patients with Lung Cancer Predict Progression and Define a Clinical Biomarker of Therapy Response.
Journal article Cancer Res · March 2, 2026 UNLABELLED: Multiplexed imaging of tissues is an approach that holds promise for improving early detection, diagnosis, and treatment of cancer. In this study, we investigated multiplexed histologic images of paired pretreatment and on-treatment samples fro ... Full text Link to item CiteRecent Grants
Epigenetic Programming of T Cells for Enhanced Cellular Immunotherapy
ResearchCo Investigator · Awarded by National Cancer Institute · 2024 - 2029Utilizing Radiation to Induced Novel Target for CAR-T Cell Therapy
ResearchCollaborator · Awarded by American Society for Radiation Oncology · 2026 - 2028Role of mregDC-PCSK9-mediated Inhibition of DC Antigen Cross-Presentation in Tumor Immunotherapy Resistance
ResearchCollaborator · Awarded by V Foundation for Cancer Research · 2024 - 2027View All Grants
Education
University of Connecticut, School of Medicine ·
1989
M.D.
University of Connecticut, School of Medicine ·
1987
Ph.D.