Current Appointments & Affiliations
Professor of Medicine
·
2020 - Present
Medicine, Medical Oncology,
Medicine
Member of the Duke Cancer Institute
·
2019 - Present
Duke Cancer Institute,
Institutes and Centers
Member of the Duke Human Vaccine Institute
·
2023 - Present
Duke Human Vaccine Institute,
Institutes and Centers
Recent Publications
Phase I study of peposertib and avelumab with or without palliative radiotherapy in patients with advanced solid tumors.
Journal Article ESMO Open · February 2024 INTRODUCTION: We report results from a phase I, three-part, dose-escalation study of peposertib, a DNA-dependent protein kinase inhibitor, in combination with avelumab, an immune checkpoint inhibitor, with or without radiotherapy in patients with advanced ... Full text Link to item CiteFirst-line nivolumab plus ipilimumab versus chemotherapy for the treatment of unresectable malignant pleural mesothelioma: patient-reported outcomes in CheckMate 743.
Journal Article Lung Cancer · May 2022 OBJECTIVE: In CheckMate 743 (NCT02899299), nivolumab + ipilimumab significantly prolonged overall survival in patients with unresectable malignant pleural mesothelioma (MPM). We present patient-reported outcomes (PROs). MATERIALS AND METHODS: Patients (N = ... Full text Link to item CiteFour-year survival with nivolumab in patients with previously treated advanced non-small-cell lung cancer: a pooled analysis.
Journal Article Lancet Oncol · October 2019 BACKGROUND: Phase 3 clinical data has shown higher proportions of patients with objective response, longer response duration, and longer overall survival with nivolumab versus docetaxel in patients with previously treated advanced non-small-cell lung cance ... Full text Link to item CiteRecent Grants
Epigenetic Programming of T Cells for Enhanced Cellular Immunotherapy
ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2029Role of mregDC-PCSK9-mediated Inhibition of DC Antigen Cross-Presentation in Tumor Immunotherapy Resistance
ResearchCollaborator · Awarded by V Foundation for Cancer Research · 2024 - 2027Novel roles of PCSK9 in regulating the tumor immune microenvironment during radiotherapy
ResearchCo-Principal Investigator · Awarded by National Cancer Institute · 2022 - 2027View All Grants
Education, Training & Certifications
University of Connecticut, School of Medicine ·
1989
M.D.
University of Connecticut, School of Medicine ·
1987
Ph.D.