Skip to main content
Journal cover image

Four-year survival with nivolumab in patients with previously treated advanced non-small-cell lung cancer: a pooled analysis.

Publication ,  Journal Article
Antonia, SJ; Borghaei, H; Ramalingam, SS; Horn, L; De Castro Carpeño, J; Pluzanski, A; Burgio, MA; Garassino, M; Chow, LQM; Gettinger, S; Li, A ...
Published in: Lancet Oncol
October 2019

BACKGROUND: Phase 3 clinical data has shown higher proportions of patients with objective response, longer response duration, and longer overall survival with nivolumab versus docetaxel in patients with previously treated advanced non-small-cell lung cancer (NSCLC). We aimed to evaluate the long-term benefit of nivolumab and the effect of response and disease control on subsequent survival. METHODS: We pooled data from four clinical studies of nivolumab in patients with previously treated NSCLC (CheckMate 017, 057, 063, and 003) to evaluate survival outcomes. Trials of nivolumab in the second-line or later setting with at least 4 years follow-up were included. Comparisons of nivolumab versus docetaxel included all randomised patients from the phase 3 CheckMate 017 and 057 studies. We did landmark analyses by response status at 6 months to determine post-landmark survival outcomes. We excluded patients who did not have a radiographic tumour assessment at 6 months. Safety analyses included all patients who received at least one dose of nivolumab. FINDINGS: Across all four studies, 4-year overall survival with nivolumab was 14% (95% CI 11-17) for all patients (n=664), 19% (15-24) for those with at least 1% PD-L1 expression, and 11% (7-16) for those with less than 1% PD-L1 expression. In CheckMate 017 and 057, 4-year overall survival was 14% (95% CI 11-18) in patients treated with nivolumab, compared with 5% (3-7) in patients treated with docetaxel. Survival subsequent to response at 6 months on nivolumab or docetaxel was longer than after progressive disease at 6 months, with hazard ratios for overall survival of 0·18 (95% 0·12-0·27) for nivolumab and 0·43 (0·29-0·65) for docetaxel; for stable disease versus progressive disease, hazard ratios were 0·52 (0·37-0·71) for nivolumab and 0·80 (0·61-1·04) for docetaxel. Long-term data did not show any new safety signals. INTERPRETATION: Patients with advanced NSCLC treated with nivolumab achieved a greater duration of response compared with patients treated with docetaxel, which was associated with a long-term survival advantage. FUNDING: Bristol-Myers Squibb.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Lancet Oncol

DOI

EISSN

1474-5488

Publication Date

October 2019

Volume

20

Issue

10

Start / End Page

1395 / 1408

Location

England

Related Subject Headings

  • Survival Rate
  • Retreatment
  • Randomized Controlled Trials as Topic
  • Progression-Free Survival
  • Oncology & Carcinogenesis
  • Nivolumab
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Antonia, S. J., Borghaei, H., Ramalingam, S. S., Horn, L., De Castro Carpeño, J., Pluzanski, A., … Brahmer, J. (2019). Four-year survival with nivolumab in patients with previously treated advanced non-small-cell lung cancer: a pooled analysis. Lancet Oncol, 20(10), 1395–1408. https://doi.org/10.1016/S1470-2045(19)30407-3
Antonia, Scott J., Hossein Borghaei, Suresh S. Ramalingam, Leora Horn, Javier De Castro Carpeño, Adam Pluzanski, Marco A. Burgio, et al. “Four-year survival with nivolumab in patients with previously treated advanced non-small-cell lung cancer: a pooled analysis.Lancet Oncol 20, no. 10 (October 2019): 1395–1408. https://doi.org/10.1016/S1470-2045(19)30407-3.
Antonia SJ, Borghaei H, Ramalingam SS, Horn L, De Castro Carpeño J, Pluzanski A, et al. Four-year survival with nivolumab in patients with previously treated advanced non-small-cell lung cancer: a pooled analysis. Lancet Oncol. 2019 Oct;20(10):1395–408.
Antonia, Scott J., et al. “Four-year survival with nivolumab in patients with previously treated advanced non-small-cell lung cancer: a pooled analysis.Lancet Oncol, vol. 20, no. 10, Oct. 2019, pp. 1395–408. Pubmed, doi:10.1016/S1470-2045(19)30407-3.
Antonia SJ, Borghaei H, Ramalingam SS, Horn L, De Castro Carpeño J, Pluzanski A, Burgio MA, Garassino M, Chow LQM, Gettinger S, Crinò L, Planchard D, Butts C, Drilon A, Wojcik-Tomaszewska J, Otterson GA, Agrawal S, Li A, Penrod JR, Brahmer J. Four-year survival with nivolumab in patients with previously treated advanced non-small-cell lung cancer: a pooled analysis. Lancet Oncol. 2019 Oct;20(10):1395–1408.
Journal cover image

Published In

Lancet Oncol

DOI

EISSN

1474-5488

Publication Date

October 2019

Volume

20

Issue

10

Start / End Page

1395 / 1408

Location

England

Related Subject Headings

  • Survival Rate
  • Retreatment
  • Randomized Controlled Trials as Topic
  • Progression-Free Survival
  • Oncology & Carcinogenesis
  • Nivolumab
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans