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Sean Michael O'Brien
Associate Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
sean.m.obrien@duke.edu
Duke Box 3850, Durham, NC 27710
200 Morris Street, 7816 200 Morris, Durham, NC 27701
Research
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Credentials
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Research
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Selected Grants
iPediHeart: Interdisciplinary Research Training Program for Pediatric Heart Disease
Inst. Training Prgm or CME
Mentor ·
Awarded by National Institutes of Health ·
2025 - 2030
2/2 IMPRroving Outcomes in Vascular DisEase - Aortic Dissection (IMPROVE-AD)
Research
Principal Investigator ·
Awarded by National Institutes of Health ·
2023 - 2030
Integrated Biostatistical Training for CVD Research
Inst. Training Prgm or CME
Principal Investigator ·
Awarded by North Carolina State University ·
2022 - 2027
RECOVER Infrastructure Modification 11 (Yr 3)
Research
Co-Principal Investigator ·
Awarded by Research Triangle Institute International ·
2022 - 2026
The North Carolina Congenital Heart Disease Surveillance Network
Public Service
Statistical Investigator ·
Awarded by Centers for Disease Control and Prevention ·
2019 - 2025
Postdoctoral Training in Cardiovascular Clinical Research
Inst. Training Prgm or CME
Mentor ·
Awarded by National Institutes of Health ·
2003 - 2025
Duke CTSA (TL1) Year 5
Inst. Training Prgm or CME
Mentor ·
Awarded by National Institutes of Health ·
2018 - 2024
ACTIV-1
Clinical Trial
Co Investigator ·
Awarded by Technical Resources International ·
2020 - 2023
ISCHEMIA-CKD SDCC
Clinical Trial
Principal Investigator ·
Awarded by National Institutes of Health ·
2013 - 2022
The ISCHEMIA Trial - SDCC
Clinical Trial
Principal Investigator ·
Awarded by National Institutes of Health ·
2011 - 2022
Leveraging registry resources for efficient and cost effective clinical trials
Clinical Trial
Statistical Investigator ·
Awarded by National Institutes of Health ·
2016 - 2022
Administrative Claims-based Efficiencies for the Advancement of Regulatory Sciences
Research
Senior Statistician ·
Awarded by Burroughs Wellcome Fund ·
2014 - 2021
Understanding Quality and Costs in Congenital Heart Surgery
Research
Principal Investigator ·
Awarded by Society of Thoracic Surgeons ·
2014 - 2021
North Carolina Congenital Heart Defects Surveillance Network
Research
Statistical Investigator ·
Awarded by Centers for Disease Control and Prevention ·
2015 - 2020
Optimizing Health Outcomes in Patients with Symptomatic Aortic Valve Disease
Research
Statistical Investigator ·
Awarded by Patient-Centered Outcomes Research Institute ·
2014 - 2020
CIAO-ISCHEMIA
Clinical Trial
Principal Investigator ·
Awarded by New York University ·
2017 - 2019
Methodology for Linking Clinical and Administrative Databases
Research
Principal Investigator ·
Awarded by Patient-Centered Outcomes Research Institute ·
2014 - 2019
The ISCHEMIA Trial - SDCC- Subcontract with NYU
Clinical Trial
Principal Investigator ·
Awarded by New York University ·
2017 - 2019
The ISCHEMIA Trial - SDCC
Clinical Trial
Co-Principal Investigator ·
Awarded by National Institutes of Health ·
2011 - 2019
Statistical Methods for Complex Data in Cardiovascular Disease
Research
Principal Investigator ·
Awarded by North Carolina State University ·
2013 - 2018
Duke CTSA (UL1): Statistical methods for complex data in CV disease research
Research
Mentor ·
Awarded by National Institutes of Health ·
2013 - 2018
Efficiencies for Outcome Ascertainment throughout the Total Product Life Cycle
Research
Co Investigator ·
Awarded by Food and Drug Administration ·
2012 - 2017
Anatomic and Physiologic Determinants of Vessel-Specific Ischemia by Coronary CT
Research
Principal Investigator ·
Awarded by Weill Medical College of Cornell University ·
2014 - 2016
Centers for Cardiovascular Outcomes Research
Research
Co Investigator ·
Awarded by National Institutes of Health ·
2010 - 2016
Career Development in Outcomes Assessment in Congenital Heart Surgery
Research
Statistician ·
Awarded by National Institutes of Health ·
2010 - 2014
TO # 1 - Coordinating Center for Cardiovascular Disease - OPTION YEAR 2
Research
Investigator ·
Awarded by Agency for Healthcare Research and Quality ·
2011 - 2013
Comparative Effectiveness of Medications Used in Congenital Heart Surgery
Research
Statistical Investigator ·
Awarded by National Institutes of Health ·
2009 - 2012
Duke Cardiovascular CERTs
Research
Co Investigator ·
Awarded by Agency for Healthcare Research and Quality ·
2007 - 2012
TO # 1 - Coordinating Center for Cardiovascular Disease
Research
Investigator ·
Awarded by Agency for Healthcare Research and Quality ·
2010 - 2011
DEcIDE AVR
Research
Statistician ·
Awarded by Agency for Healthcare Research and Quality ·
2009 - 2011
