Scholars@Duke
Sean Michael O'Brien

Sean Michael O'Brien

Associate Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
sean.m.obrien@duke.edu
Duke Box 3850, Durham, NC 27710
200 Morris Street, 7816 200 Morris, Durham, NC 27701

Selected Grants

2/2 IMPRroving Outcomes in Vascular DisEase - Aortic Dissection (IMPROVE-AD)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2030

Integrated Biostatistical Training for CVD Research

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by North Carolina State University · 2022 - 2027

ISCHEMIA-Extend_Resubmission

ResearchPrincipal Investigator · Awarded by New York University · 2022 - 2026

The North Carolina Congenital Heart Disease Surveillance Network

Public ServiceStatistical Investigator · Awarded by Centers for Disease Control and Prevention · 2019 - 2025

Postdoctoral Training in Cardiovascular Clinical Research

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2003 - 2025

RECOVER Infrastructure Modification 11 (Yr 3)

ResearchCo-Principal Investigator · Awarded by Research Triangle Institute International · 2022 - 2025

Duke CTSA (TL1) Year 5

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2018 - 2024

Unified Program for Therapeutics in Children

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2019 - 2024

ACTIV-1

Clinical TrialCo Investigator · Awarded by Technical Resources International · 2020 - 2023

ISCHEMIA-CKD SDCC

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2022

The ISCHEMIA Trial - SDCC

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2022

Leveraging registry resources for efficient and cost effective clinical trials

Clinical TrialStatistical Investigator · Awarded by National Institutes of Health · 2016 - 2022

Administrative Claims-based Efficiencies for the Advancement of Regulatory Sciences

ResearchSenior Statistician · Awarded by Burroughs Wellcome Fund · 2014 - 2021

Understanding Quality and Costs in Congenital Heart Surgery

ResearchPrincipal Investigator · Awarded by Society of Thoracic Surgeons · 2014 - 2021

North Carolina Congenital Heart Defects Surveillance Network

ResearchStatistical Investigator · Awarded by Centers for Disease Control and Prevention · 2015 - 2020

Optimizing Health Outcomes in Patients with Symptomatic Aortic Valve Disease

ResearchStatistical Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2014 - 2020

CIAO-ISCHEMIA

Clinical TrialPrincipal Investigator · Awarded by New York University · 2017 - 2019

Methodology for Linking Clinical and Administrative Databases

ResearchPrincipal Investigator · Awarded by Patient-Centered Outcomes Research Institute · 2014 - 2019

The ISCHEMIA Trial - SDCC- Subcontract with NYU

Clinical TrialPrincipal Investigator · Awarded by New York University · 2017 - 2019

The ISCHEMIA Trial - SDCC

Clinical TrialCo-Principal Investigator · Awarded by National Institutes of Health · 2011 - 2019

Statistical Methods for Complex Data in Cardiovascular Disease

ResearchPrincipal Investigator · Awarded by North Carolina State University · 2013 - 2018

Duke CTSA (UL1): Statistical methods for complex data in CV disease research

ResearchMentor · Awarded by National Institutes of Health · 2013 - 2018

Efficiencies for Outcome Ascertainment throughout the Total Product Life Cycle

ResearchCo Investigator · Awarded by Food and Drug Administration · 2012 - 2017

Anatomic and Physiologic Determinants of Vessel-Specific Ischemia by Coronary CT

ResearchPrincipal Investigator · Awarded by Weill Medical College of Cornell University · 2014 - 2016

Centers for Cardiovascular Outcomes Research

ResearchCo Investigator · Awarded by National Institutes of Health · 2010 - 2016

Career Development in Outcomes Assessment in Congenital Heart Surgery

ResearchStatistician · Awarded by National Institutes of Health · 2010 - 2014

TO # 1 - Coordinating Center for Cardiovascular Disease - OPTION YEAR 2

ResearchInvestigator · Awarded by Agency for Healthcare Research and Quality · 2011 - 2013

Comparative Effectiveness of Medications Used in Congenital Heart Surgery

ResearchStatistical Investigator · Awarded by National Institutes of Health · 2009 - 2012

Duke Cardiovascular CERTs

ResearchCo Investigator · Awarded by Agency for Healthcare Research and Quality · 2007 - 2012

TO # 1 - Coordinating Center for Cardiovascular Disease

ResearchInvestigator · Awarded by Agency for Healthcare Research and Quality · 2010 - 2011

DEcIDE AVR

ResearchStatistician · Awarded by Agency for Healthcare Research and Quality · 2009 - 2011