Seh Hoon Oh

Journal article Hepatology · November 1, 2026 BACKGROUND AND AIMS: Older age increases susceptibility to metabolic dysfunction-associated steatotic liver disease (MASLD), but whether it impacts response to therapies, and how the therapies impact regulators of biological aging, are poorly understood. S ... Full text Link to item Cite

Zinc-dependent RNA-binding protein controls hepatocyte senescence and recovery from alcohol-related liver failure.

Journal article Gut · October 7, 2026 BACKGROUND: Why alcohol-associated liver disease (ALD) resolves after abstinence in most people but progresses to liver failure in others remains poorly understood. Experimental models show that increased exposure to proinflammatory cytokines exacerbates A ... Full text Link to item Cite

Hepatocyte hedgehog signaling controls ferroptosis to alleviate aging-related organ dysfunction.

Journal article JCI Insight · July 22, 2026 Aging drives systemic metabolic dysfunction (SMD) and increases the risk of chronic illnesses such as metabolic dysfunction-associated steatotic liver disease (MASLD) and chronic kidney disease (CKD). However, mechanisms that connect aging to multiorgan de ... Full text Link to item Cite

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Recent Grants

TNF alpha and Recovery from Alcoholic Liver Injury

ResearchResearch Scientist · Awarded by National Institute on Alcohol Abuse & Alcoholism · 2014 - 2030

Heterochronic hepatocyte transplantation to rejuvenate the aged liver

ResearchCo Investigator · Awarded by National Institutes of Health · 2024 - 2026

Phase 1: Development of a Dual Chemokine CCL2/CCL5 Neutralizing Single-domain Antibody for Treating Non-alcoholic Steatoheptitis

ResearchResearch Scientist · Awarded by Oncotrap, Inc. · 2023 - 2025

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Education

Okayama University (Japan) · 1999 Ph.D.