Seh Hoon Oh

Journal Article Hepatology · October 2022 BACKGROUND AND AIMS: Within the next decade, NAFLD is predicted to become the most prevalent cause of childhood liver failure in developed countries. Predisposition to juvenile NAFLD can be programmed during early life in response to maternal metabolic syn ... Full text Link to item Cite

Dysregulated activation of fetal liver programme in acute liver failure.

Journal Article Gut · June 2019 OBJECTIVE: Uncertainty about acute liver failure (ALF) pathogenesis limits therapy. We postulate that ALF results from excessive reactivation of a fetal liver programme that is induced in hepatocytes when acutely injured livers regenerate. To evaluate this ... Full text Link to item Cite

Senescence-Associated Reprogramming Promotes Hepatocarcinogenesis in Nonalcoholic Steatohepatitis

Conference HEPATOLOGY · October 1, 2018 Link to item Cite

Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes.

Journal Article J Hepatol · August 2018 BACKGROUND & AIMS: Chronic failure of mechanisms that promote effective regeneration of dead hepatocytes causes replacement of functional hepatic parenchyma with fibrous scar tissue, ultimately resulting in cirrhosis. Therefore, defining and optimizing mec ... Full text Open Access Link to item Cite

RNA Binding Proteins Control Transdifferentiation of Hepatic Stellate Cells into Myofibroblasts.

Journal Article Cell Physiol Biochem · 2018 BACKGROUND/AIMS: Myofibroblasts (MF) derived from quiescent nonfibrogenic hepatic stellate cells (HSC) are the major sources of fibrous matrix in cirrhosis. Because many factors interact to regulate expansion and regression of MF-HSC populations, efforts t ... Full text Link to item Cite