Scholars@Duke
Semra Ozdemir

Semra Ozdemir

Associate Professor in Population Health Sciences
Population Health Sciences

Selected Publications

How Much Better is Faster? Empirical Tests of QALY Assumptions in Health-Outcome Sequences.

Journal Article Pharmacoeconomics · January 2025 OBJECTIVES: This study was designed to test hypotheses regarding the path dependence of health-outcome values in the form of linear additivity of health-state utilities and diminishing marginal utility of health outcomes. METHODS: We employed a discrete-ch ... Full text Link to item Cite

A Longitudinal Study of the Association of Awareness of Disease Incurability with Patient-Reported Outcomes in Heart Failure.

Journal Article Med Decis Making · January 2025 OBJECTIVES: To examine awareness of disease incurability among patients with heart failure over 24 mo and its associations with patient characteristics and patient-reported outcomes (distress, emotional, and spiritual well-being). METHODS: This study analy ... Full text Link to item Cite

Patient Preferences for Features Associated With Leadless Versus Conventional Transvenous Cardiac Pacemakers.

Journal Article Circ Cardiovasc Qual Outcomes · December 2024 BACKGROUND: Regulatory approval of the first dual-chamber leadless pacemaker system provides patients an alternative to conventional transvenous pacemakers. The study objective was to quantify the preferences of patients for pacemaker features. METHODS: Pa ... Full text Link to item Cite

The Renewing Intimacy and SExuality Intervention for Female Cancer Survivors: A Feasibility Study.

Journal Article Psychooncology · December 2024 PURPOSE: This study examined the feasibility and acceptability of a three-session, psychological-based intervention to improve intimacy and sexuality outcomes among women with breast and gynaecologic cancer in Singapore. METHOD: Patients from outpatient on ... Full text Link to item Cite

Establishing Research Priorities in Geriatric Nephrology: A Delphi Study of Clinicians and Researchers.

Journal Article Am J Kidney Dis · November 26, 2024 RATIONALE & OBJECTIVE: Despite substantial growth of the population of older adults with kidney disease, there remains a lack of evidence to guide clinical care for this group. The Kidney Disease and Aging Research Collaborative conducted a Delphi study to ... Full text Link to item Cite

Opioid Access among Advanced Cancer Patients in Low- and Middle-Income Countries in Asia.

Journal Article J Pain Symptom Manage · October 2024 CONTEXT: Most cancer-associated pain is experienced in low- and middle-income countries (LMICs) due to inequitable access to opioids. OBJECTIVE: To determine opioid access as estimated by both patients and providers and to understand patient and facility-l ... Full text Link to item Cite

Navigating Public Policy Responses to a Pandemic: The Balancing Act Between Physical Health, Mental Health, and Household Income.

Journal Article Value Health · August 2024 OBJECTIVE: During COVID-19, governments imposed restrictions that reduced pandemic-related health risks but likely increased personal and societal mental health risk, partly through reductions in household income. This study aimed to quantify the public's ... Full text Link to item Cite

Discrete choice experiments with eye-tracking: How far we have come and ways forward

Journal Article Journal of Choice Modelling · June 1, 2024 With the increased affordability of eye-tracking technology, its applications in discrete choice experiments (DCEs) are rapidly increasing. It is critical to understand the current state of research, challenges, and potential value of this technology for f ... Full text Cite

Getting it right with discrete choice experiments: Are we hot or cold?

Journal Article Soc Sci Med · May 2024 Discrete Choice Experiments (DCEs) are widely employed survey-based methods to assess preferences for healthcare services and products. While they offer an experimental way to represent health-related decisions, the stylized representation of scenarios in ... Full text Link to item Cite

An Overview of Data Collection in Health Preference Research.

Journal Article Patient · April 25, 2024 This paper focuses on survey administration and data collection methods employed for stated-preference studies in health applications. First, it describes different types of survey administration methods, encompassing web-based surveys, face-to-face (in-pe ... Full text Link to item Cite

Prognostic awareness and prognostic information preferences among advanced cancer patients in Kenya.

Journal Article Afr J Prim Health Care Fam Med · April 11, 2024 BACKGROUND:  Cancer is the third leading cause of death in Kenya. Yet, little is known about prognostic awareness and preferences for prognostic information. AIM:  To assess the prevalence of prognostic awareness and preference for prognostic information a ... Full text Link to item Cite

Goals of Care Among Patients With Advanced Cancer and Their Family Caregivers in the Last Years of Life.

Journal Article JAMA Netw Open · April 1, 2024 IMPORTANCE: Understanding goals of care for terminally ill patients at the end of life is crucial to ensure that patients receive care consistent with their preferences. OBJECTIVES: To investigate the patterns of goals of care among patient-caregiver dyads ... Full text Link to item Cite

The association of prognostic awareness with quality of life, spiritual well-being, psychological distress, and pain severity in patients with advanced cancer: Results from the APPROACH Study in Indonesia.

Journal Article Palliat Support Care · March 7, 2024 BACKGROUND AND OBJECTIVES: Advanced cancer patients' understanding of their illness is key for making informed treatment decisions. Despite the known importance of patients' awareness of their disease prognosis, it is debatable whether this awareness is po ... Full text Link to item Cite

Unravelling complex choices: multi-stakeholder perceptions on dialysis withdrawal and end-of-life care in kidney disease.

Journal Article BMC Nephrol · January 3, 2024 BACKGROUND: For patients on dialysis with poor quality of life and prognosis, dialysis withdrawal and subsequent transition to palliative care is recommended. This study aims to understand multi-stakeholder perspectives regarding dialysis withdrawal and id ... Full text Link to item Cite

Quality of life and its predictors among patients with metastatic cancer in Bangladesh: the APPROACH survey.

Journal Article BMC Palliat Care · January 3, 2024 BACKGROUND: This study aimed to assess the health-related quality of life (HRQOL) (physical, functional, emotional, social, spiritual) and psychological (anxiety and depression) well-being and their associations with patient characteristics among patients ... Full text Link to item Cite

Role Preferences in Medical Decision Making: Relevance and Implications for Health Preference Research.

Conference Patient · January 2024 Health preference research (HPR) is being increasingly conducted to better understand patient preferences for medical decisions. However, patients vary in their desire to play an active role in medical decisions. Until now, few studies have considered pati ... Full text Link to item Cite

Older adult patient preferences for the content and format of prescription medication labels - A best-worst scaling and discrete choice experiment study.

Journal Article Res Social Adm Pharm · November 2023 BACKGROUND: Patient preferences for the content and format of prescription medication labels (PMLs, i.e., sticker labels placed on medication bottles/packets at dispensing) have been extensively studied. However, accommodating all preferences on PMLs is im ... Full text Link to item Cite

Trade-Offs between Vaccine Effectiveness and Vaccine Safety: Personal versus Policy Decisions.

Journal Article Pharmacoecon Open · November 2023 OBJECTIVE: We aimed to investigate whether individuals' trade-offs between vaccine effectiveness and vaccine safety vary if they are asked to consider the perspective of a policymaker making decisions for others compared with the decisions they would make ... Full text Open Access Link to item Cite

Changes in Prognostic Beliefs of Patients With Metastatic Cancer and Their Association With Changing Health Status.

Journal Article J Natl Compr Canc Netw · October 2023 BACKGROUND: Patients' prognostic beliefs are known to influence treatment decisions. However, the evolution of these beliefs over an extended period in patients with metastatic cancer is understudied. We assessed longitudinal changes in prognostic beliefs ... Full text Link to item Cite

Preferences for Enhanced Primary Care Services Among Older Individuals and Primary Care Physicians.

Journal Article Appl Health Econ Health Policy · September 2023 OBJECTIVE: We aimed to identify the factors that are most important for community-dwelling older individuals (i.e., users) and primary care (PC) providers to enhance PC services. METHODS: Discrete choice experiment surveys were administered to 747 individu ... Full text Open Access Link to item Cite

Quality of life and psychological distress of patients with advanced cancer in the Philippines.

Journal Article Qual Life Res · August 2023 PURPOSE: This study aimed to describe the quality of life (QOL) and psychological distress (anxiety and depression) of Filipino patients with advanced solid cancers and identify sociodemographic and clinical-related factors associated with them. METHODS: 1 ... Full text Link to item Cite

The associations between prognostic awareness and health-related quality of life among patients with advanced cancer: A systematic review.

Journal Article Palliat Med · June 2023 BACKGROUND: Prognostic awareness among patients with advanced cancer is important for better palliative and end-of-life care. However, the relationships between prognostic awareness and patient health-related quality of life outcomes remain inconsistent ac ... Full text Open Access Link to item Cite

A prospective cohort study of decision-making role preferences of patients with advanced cancer and their family caregivers.

Journal Article Cancer · May 1, 2023 BACKGROUND: This study aimed to examine (1) the evolution of patients-caregiver dyad decision-making role preferences over 3 years and the predictors of these preferences; and (2) discordance in decision-making role preferences among dyads. METHODS: A tota ... Full text Link to item Cite

A prospective study of psychological distress among patients with advanced cancer and their caregivers.

Journal Article Cancer Med · April 2023 BACKGROUND: Cancer can impact the psychological well-being of both patients and their informal caregivers. We investigated the joint trajectories of psychological distress among Singaporean advanced cancer patients-caregiver dyads. We also examined predict ... Full text Link to item Cite

Stroke survivors' preferences for post-stroke self-management programs: A discrete choice experiment.

Journal Article J Stroke Cerebrovasc Dis · March 2023 BACKGROUND AND PURPOSE: Self-management programs enhance survival in stroke patients. However, they require patient-centered designs to be effective. The aim of this study was therefore to investigate the type of post-stroke self-management programs that a ... Full text Link to item Cite

Caregiver-Reported Roles in Treatment Decision Making in Advanced Cancer and Associated Caregiving Burden and Psychological Distress: A Longitudinal Study.

Journal Article Med Decis Making · February 2023 OBJECTIVE: To longitudinally examine caregiver-reported treatment decision-making roles and to investigate the associations of these roles with caregiver burden, caregiving esteem, caregiver anxiety, and depression. METHODS: 281 caregivers of patients with ... Full text Link to item Cite

Variation in Patient-Reported Decision-Making Roles in the Last Year of Life among Patients with Metastatic Cancer: A Longitudinal Study.

Journal Article Med Decis Making · February 2023 OBJECTIVE: We investigated the variation in patient-reported decision-making roles in the past year of life among patients with metastatic solid cancer and the associations of these roles with patient quality of life and perceived quality of care. METHODS: ... Full text Link to item Cite

Prognostic awareness and its association with health outcomes in the last year of life.

Journal Article Cancer Med · February 2023 BACKGROUND: Little research has examined changes in prognostic awareness (PA) in the last year of life and the extent PA change was associated with anxiety, depression, and spiritual well-being among metastatic cancer patients. METHODS: Two surveys were ad ... Full text Link to item Cite

A Prospective Cohort Study of Medical Decision-Making Roles and Their Associations with Patient Characteristics and Patient-Reported Outcomes among Patients with Heart Failure.

Journal Article Med Decis Making · 2023 OBJECTIVE: Among patients with heart failure (HF), we examined 1) the evolution of patient involvement in decision making over 2 y, 2) the association of patient characteristics with decision-making roles, and 3) the association of decision-making roles wi ... Full text Open Access Link to item Cite

Disparities in end-of-life outcomes among advanced cancer patients in Sri Lanka: Results from the APPROACH study.

Journal Article Palliat Support Care · December 2022 OBJECTIVE: A Universal Health Coverage goal is to provide access to affordable palliative care to reduce disparities in end-of-life (EOL) outcomes. To assess progress toward this goal in Sri Lanka, our primary aim was to systematically assess differences i ... Full text Link to item Cite

Patient Medication Preferences for Managing Dry Eye Disease: The Importance of Medication Side Effects.

Journal Article Patient · November 2022 OBJECTIVES: The side effects of dry eye medications can lead to medication non-adherence and, eventually, to poor outcomes. This study aimed to quantify to what extent the side effects of dry eye disease (DED) medications (burning/stinging sensation and bl ... Full text Link to item Cite

Trajectories of Health-related quality of life in patients with Advanced Cancer during the Last Year of Life: findings from the COMPASS study.

Journal Article BMC Palliat Care · October 14, 2022 BACKGROUND: Patients with advanced cancer prioritise health-related quality of life (HrQoL) in end-of-life care, however an understanding of pre-death HrQoL trajectories is lacking. We aimed to delineate and describe the trajectories of physical, social, e ... Full text Link to item Cite

Awareness and Utilization of Palliative Care Among Advanced Cancer Patients in Asia.

Journal Article J Pain Symptom Manage · October 2022 CONTEXT: To date, little is known about palliative care (PC) awareness and utilization in low- and middle-income countries (LMICs) in Asia. OBJECTIVES: This study aimed to investigate PC awareness and its predictors, utilization of PC services, and perceiv ... Full text Link to item Cite

Preferences for a non-invasive prenatal test as first-line screening for Down Syndrome: A discrete choice experiment.

Journal Article Prenat Diagn · October 2022 OBJECTIVE: To investigate preferences of pregnant women for the characteristics of prenatal testing, and to quantify their willingness-to-pay (WTP) for non-invasive prenatal testing (NIPT) as first-line screening for Down Syndrome. METHOD: A cross-sectiona ... Full text Link to item Cite

Healthcare Cost Trajectories in the Last 2 Years of Life Among Patients With a Solid Metastatic Cancer: A Prospective Cohort Study.

Journal Article J Natl Compr Canc Netw · September 2022 BACKGROUND: Most studies describe the "average healthcare cost trend" among patients with cancer. We aimed to delineate heterogeneous trajectories of healthcare cost during the last 2 years of life of patients with a metastatic cancer and to assess the ass ... Full text Link to item Cite

Patients' Awareness of Advanced Disease Status, Psychological Distress and Quality of Life Among Patients With Advanced Cancer: Results From the APPROACH Study, India.

Journal Article Am J Hosp Palliat Care · July 2022 BACKGROUND: Prognostic disclosure to patients with advanced cancer facilitates treatment decisions and goals of care discussions. However, the perspectives of patients, families and physicians differ in this regard across different cultures. Non-disclosure ... Full text Link to item Cite

Factors associated with women's preferences for labor epidural analgesia in Singapore: a survey approach.

Journal Article Sci Rep · June 29, 2022 Epidural analgesia provides effective pain relief during labor. However, there is limited information on the factors associated with pregnant women's preferences for labor epidural analgesia (LEA) prior to labor onset. We performed a secondary analysis of ... Full text Link to item Cite

Advanced Cancer Patients' Prognostic Awareness and Its Association With Anxiety, Depression and Spiritual Well-Being: A Multi-Country Study in Asia.

Journal Article Clin Oncol (R Coll Radiol) · June 2022 AIMS: The associations between prognostic awareness, acceptance of illness and psychological outcomes (anxiety, depression and spiritual well-being) remain unclear. This study examined the associations between prognostic awareness and various psychological ... Full text Link to item Cite

Perceived stigma and its correlates among Asian patients with advanced cancer: A multi-country APPROACH study.

Journal Article Psychooncology · June 2022 OBJECTIVES: Perceived cancer-related stigma can affect mental health and potentially treatment choices for patients with cancer. Nevertheless, perceived stigma is not very well understood in Asia. This study investigated across six developing Asian countri ... Full text Link to item Cite

A prospective cohort study assessing aggressive interventions at the end-of-life among patients with solid metastatic cancer.

Journal Article BMC Palliat Care · May 16, 2022 BACKGROUND: Many patients with a solid metastatic cancer are treated aggressively during their last month of life. Using data from a large prospective cohort study of patients with an advanced cancer, we aimed to assess the number and predictors of aggress ... Full text Link to item Cite

Adoption of Preventive Behaviour Strategies and Public Perceptions About COVID-19 in Singapore.

Journal Article Int J Health Policy Manag · May 1, 2022 BACKGROUND: The unprecedented severity of coronavirus disease 2019 (COVID-19) constitutes a serious public health concern. However, adoption of COVID-19-related preventive behaviours remain relatively unknown. This study investigated predictors of preventi ... Full text Link to item Cite

Associations Between Prognostic Awareness, Acceptance of Illness, and Psychological and Spiritual Well-being Among Patients With Heart Failure.

Journal Article J Card Fail · May 2022 BACKGROUND: This study aimed to (1) investigate the association of prognostic awareness with psychological (distress level and emotional well-being) and spiritual well-being among patients with heart failure, and (2) assess the main and moderating effects ... Full text Link to item Cite

Trajectories of physical symptom burden and psychological distress during the last year of life in patients with a solid metastatic cancer.

Journal Article Psychooncology · January 2022 OBJECTIVE: To delineate the trajectories of physical symptoms and psychological distress among patients with a solid metastatic cancer during the last year of life. METHODS: We used data of 345 decedents from a prospective cohort of 600 patients with a Sta ... Full text Link to item Cite

Parturients' Stated Preferences for Labor Analgesia: A Discrete Choice Experiment.

Journal Article Patient Prefer Adherence · 2022 OBJECTIVE: The objective was to investigate the extent to which treatment benefits, risks and costs affected parturients' preferences for labor analgesia. METHODS: We recruited 248 healthy parturients prior to labor at an antenatal ward and administered a ... Full text Link to item Cite

Understanding patient preferences in anti-VEGF treatment options for age-related macular degeneration.

Journal Article PLoS One · 2022 PURPOSE: (1) To investigate the relative importance of convenience (consultation frequency and injection frequency) against treatment outcomes (visual and anatomical outcomes) and out-of-pocket medical costs via a discrete choice experiment (DCE), and (2) ... Full text Link to item Cite

Epidemiology of Pain Among Patients with Solid Metastatic Cancer During the Last Year of Life.

Journal Article J Pain Res · 2022 BACKGROUND: Despite medical advancements, pain is a major source of suffering at the end of life for patients with a solid metastatic cancer. We aimed to assess the trajectory of pain prevalence, severity, interference, and inadequacy of analgesia during t ... Full text Link to item Cite

Patient factors determine acceptability of topical immunosuppressives in dry eye

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022 Cite

A Systematic Review of Discrete Choice Experiments and Conjoint Analysis on Genetic Testing.

Journal Article Patient · January 2022 BACKGROUND: Although genetic testing has the potential to offer promising medical benefits, concerns regarding its potential negative impacts may influence its acceptance. Users and providers need to weigh the benefits, costs and potential harms before dec ... Full text Link to item Cite

High anxiety and depression scores and mental health service use among South Asian advanced cancer patients: A multi-country study.

Journal Article J Pain Symptom Manage · November 2021 CONTEXT: Addressing symptoms of anxiety and depression is important in cancer palliative care. However, little information exists on the prevalence of anxiety and depression and mental health service use among advanced cancer patients in South Asia. OBJECT ... Full text Link to item Cite

Patient Decision Aid Development for Older Adults With End-Stage Kidney Disease in Singapore.

Journal Article Kidney Int Rep · November 2021 INTRODUCTION: In managing end-stage kidney disease (ESKD), older adults face a decision regarding whether to undergo dialysis or manage symptoms through kidney supportive care (KSC). This article describes the development of a patient decision aid (PDA) th ... Full text Link to item Cite

Trajectories of Suffering in the Last Year of Life Among Patients With a Solid Metastatic Cancer.

Journal Article J Natl Compr Canc Netw · September 7, 2021 BACKGROUND: Reducing suffering at the end of life is important. Doing so requires a comprehensive understanding of the course of suffering for patients with cancer during their last year of life. This study describes trajectories of psychological, spiritua ... Full text Link to item Cite

Reduced health-care utilization among people with chronic medical conditions during coronavirus disease 2019

Journal Article Proceedings of Singapore Healthcare · September 1, 2021 The coronavirus disease 2019 (COVID-19) outbreak may impact the health-care-seeking behaviour of people with pre-existing chronic medical conditions. We aimed to assess the extent, reasons and correlates of reduced health-care utilization among people with ... Full text Cite

Discordance Between Advanced Cancer Patients' Perceived and Preferred Roles in Decision Making and its Association with Psychological Distress and Perceived Quality of Care.

Journal Article Patient · September 2021 OBJECTIVE: We investigated patient-reported roles of families, physicians, and patients themselves in treatment decision making and whether discordance between perceived and preferred roles is associated with psychological distress and perceived quality of ... Full text Link to item Cite

Who Would Pay Higher Taxes for Better Mental Health? Results of a Large-Sample National Choice Experiment.

Journal Article Milbank Q · September 2021 UNLABELLED: Policy Points  Public funding for mental health programs must compete with other funding priorities in limited state budgets.  Valuing state-funded mental health programs in a policy-relevant context requires consideration of how much benefit f ... Full text Link to item Cite

Experiences with health care practitioners among advanced cancer patients and their family caregivers: A longitudinal dyadic study.

Journal Article Cancer · August 15, 2021 BACKGROUND: Assessing patient and caregiver experiences with care is central to improving care quality. The authors assessed variations in the experiences of advanced cancer patients and their caregivers with physician communication and care coordination b ... Full text Link to item Cite

A Prospective Cohort Study of Stability in Preferred Place of Death Among Patients With Stage IV Cancer in Singapore.

Journal Article J Natl Compr Canc Netw · August 5, 2021 BACKGROUND: Advance care planning (ACP) involves documentation of patients' preferred place of death (PoD). This assumes that patients' preferred PoD will not change over time; yet, evidence for this is inconclusive. We aimed to assess the extent and corre ... Full text Link to item Cite

Development and Validation of a Preference-Based Glaucoma Utility Instrument Using Discrete Choice Experiment.

Journal Article JAMA Ophthalmol · August 1, 2021 IMPORTANCE: A glaucoma-specific instrument for estimating utilities across the spectrum of glaucoma severity is currently lacking, hindering the assessment of the cost-effectiveness of glaucoma treatments. OBJECTIVE: To develop and validate the preference- ... Full text Link to item Cite

The prevalence of perceived stigma and self-blame and their associations with depression, emotional well-being and social well-being among advanced cancer patients: evidence from the APPROACH cross-sectional study in Vietnam.

Journal Article BMC Palliat Care · July 7, 2021 BACKGROUND: There is very limited evidence on the existence of cancer-related perceived stigma and self-blame among patients with advanced cancer in Asia, and how they are associated with psychosocial outcomes. This study aimed to address the gap in the cu ... Full text Link to item Cite

Public Preferences for Government Response Policies on Outbreak Control.

Journal Article Patient · May 2021 OBJECTIVE: The aim of this study was to assess the extent to which public support for outbreak containment policies varies with respect to the severity of an infectious disease outbreak. METHODS: A web-enabled survey was administered to 1017 residents of S ... Full text Link to item Cite

Financial difficulties and patient-reported outcomes among patients with advanced heart failure.

Journal Article Qual Life Res · May 2021 PURPOSE: Management of congestive heart failure (CHF) is associated with high health care costs and financial difficulties for patients. We aimed to comprehensively assess the association between financial difficulties and patients' quality of life (QOL) ( ... Full text Link to item Cite

Perceived quality of care and its associated factors among Chinese patients with advanced cancer: findings from the APPROACH study in Beijing.

Journal Article Support Care Cancer · March 2021 PURPOSE: Patient-perceived quality of care has become an increasingly important index within the healthcare setting. We examined patient-reported overall quality of care and patient experiences in three specific domains of care (physician communication, nu ... Full text Link to item Cite

Role in decision making among congestive heart failure patients and its association with patient outcomes: a baseline analysis of the SCOPAH study.

Journal Article Patient Educ Couns · March 2021 OBJECTIVE: We investigated the predictors of patient-experienced and preferred roles for decision making, and the association between patient-experienced role in decision making and patient outcomes among congestive heart failure (HF) patients in a multi-e ... Full text Link to item Cite

Awareness of and preference for disease prognosis and participation in treatment decisions among advanced cancer patients in Myanmar: Results from the APPROACH study.

Journal Article Asia Pac J Clin Oncol · February 2021 AIM: To investigate prognostic awareness, preference for prognostic information, and perceived and preferred roles in decision making among patients with advanced cancer in Myanmar. METHODS: A cross-sectional survey was administered at the Yangon General H ... Full text Link to item Cite

Patient-Caregiver Treatment Preference Discordance and Its Association With Caregiving Burden and Esteem.

Journal Article Innov Aging · 2021 BACKGROUND AND OBJECTIVES: Many patient-caregiver dyads report conflicting treatment decisions regarding preferences for life extension treatments and symptom management. It is possible that this discordance will lead to negative psychological outcomes inc ... Full text Link to item Cite

Nonurgent Patients' Preferences for Emergency Department Versus General Practitioner and Effects of Incentives: A Discrete Choice Experiment.

Journal Article MDM Policy Pract · 2021 Objective. This study investigates potential of a new financial incentive policy, the GP-referral discount scheme introduced in Singapore, in reducing nonurgent emergency department (ED) visits, and compares it with alternative interventions. Methods. A di ... Full text Link to item Cite

Patient-Reported Roles in Decision-Making Among Asian Patients With Advanced Cancer: A Multicountry Study.

Journal Article MDM Policy Pract · 2021 Purpose. We investigated 1) perceived roles in decision-making among advanced cancer patients in 5 Asian countries 2) associations of patient characteristics with these roles, and 3) the association of perceived roles with quality of life and perceived qua ... Full text Link to item Cite

Family caregivers of advanced cancer patients: self-perceived competency and meaning-making.

Journal Article BMJ Support Palliat Care · December 2020 BACKGROUND: Family caregivers of patients with advanced cancer have been reported to provide long hours of care and be at risk for poor psychological outcomes. Although research has focused on the nature of caregiving burden, little attention has been paid ... Full text Link to item Cite

End of life experiences of patients with advanced cancer in Myanmar: Results from the APPROACH study.

Journal Article Asia Pac J Clin Oncol · December 2020 BACKGROUND: Access to palliative care services is essential for attaining universal health coverage for patients with a terminal cancer. Despite this, many patients with advanced cancer in low-income countries, such as Myanmar, suffer at the end of life (E ... Full text Link to item Cite

The association of self-blame with treatment preferences in a multi-country cohort of advanced cancer patients from the APPROACH study.

Journal Article J Psychosom Res · December 2020 OBJECTIVE: To understand the prevalence of behavioral and characterological self-blame and their associations with stated preferences for life-extension and the use of pain-relief medication in a multi-country cohort of advanced cancer patients. METHODS: T ... Full text Link to item Cite

Socio-economic inequalities in suffering at the end of life among advanced cancer patients: results from the APPROACH study in five Asian countries.

Journal Article Int J Equity Health · September 10, 2020 BACKGROUND: A systematic understanding of socio-economic inequalities in end-of-life (EOL) suffering among advanced cancer patients is required to inform efforts to reduce these inequalities as part of Universal Health Coverage goals. AIMS: To assess inequ ... Full text Link to item Cite

Demand for Cancer Screening Services: Results From Randomized Controlled Discrete Choice Experiments.

Journal Article Value Health · September 2020 OBJECTIVES: Low uptake of cancer screening services is a global concern. Our aim was to understand factors that influence the screening decision, including screening and treatment subsidies and a gain-frame message designed to present screening as a win-wi ... Full text Link to item Cite

Financial difficulties are associated with greater total pain and suffering among patients with advanced cancer: results from the COMPASS study.

Journal Article Support Care Cancer · August 2020 BACKGROUND: The Universal Health Coverage goals call for access to affordable palliative care to reduce inequities in "total pain" and suffering. To achieve this, a patient-centred understanding of these inequities is required. AIM: To assess association o ... Full text Link to item Cite

Patient Preferences for Medications in Managing Type 2 Diabetes Mellitus: A Discrete Choice Experiment.

Journal Article Value Health · July 2020 OBJECTIVES: To quantify patients' maximum acceptable risk (MAR) of urinary and genital tract infections (UGTI) in exchange for benefits associated with treatments for managing type 2 diabetes mellitus (T2DM). METHODS: In a discrete choice experiment, adult ... Full text Link to item Cite

Correction to: Health-related quality of life and its socio-economic and cultural predictors among advanced cancer patients: evidence from the APPROACH cross-sectional survey in Hyderabad-India.

Journal Article BMC Palliat Care · January 23, 2020 Following publication of the original article [1], the corresponding author reported an error on the name of the fourth author. ... Full text Link to item Cite

The Effect of Social Norm-based Intervention with Observable Behaviour on Physical Activity among Adolescents: A Randomized Controlled Trial.

Journal Article BMC Sports Sci Med Rehabil · 2020 BACKGROUND: The rising prevalence of childhood obesity in developing and developed countries poses a major public health challenge to policy makers and an effective strategy to promote physical activity among adolescents is warranted. This study aimed to e ... Full text Link to item Cite

Health-related quality of life and its socio-economic and cultural predictors among advanced cancer patients: evidence from the APPROACH cross-sectional survey in Hyderabad-India.

Journal Article BMC Palliat Care · November 5, 2019 BACKGROUND: Patients with advanced cancer often experience poor health-related quality-of-life (HRQoL) due to cancer and treatment-related side-effects. With India's palliative care landscape in its infancy, there is a concern that advanced cancer patients ... Full text Link to item Cite

Perspectives on decision making amongst older people with end-stage renal disease and caregivers in Singapore: A qualitative study.

Journal Article Health Expect · October 2019 BACKGROUND: End-stage renal disease (ESRD) is increasing both globally and in Asia. Singapore has the fifth highest incidence of ESRD worldwide, a trend that is predicted to rise. Older patients with ESRD are faced with a choice of haemodialysis, peritonea ... Full text Link to item Cite

Biopsychosocial experiences and coping strategies of elderly ESRD patients: a qualitative study to inform the development of more holistic and person-centred health services in Singapore.

Journal Article BMC Public Health · August 14, 2019 BACKGROUND: As the incidence and prevalence rates of end stage renal disease (ESRD) rise globally, a disproportionate increase has been observed in the elderly population. Singapore has the fifth highest incidence of treated ESRD worldwide, with the upward ... Full text Link to item Cite

Palliative Care Awareness Among Advanced Cancer Patients and Their Family Caregivers in Singapore.

Journal Article Ann Acad Med Singap · August 2019 INTRODUCTION: We investigated the awareness of palliative care (PC) services in advanced cancer patients and their family caregivers and whether negative perceptions was a possible barrier to PC utilisation in Singapore. MATERIALS AND METHODS: Patients wit ... Link to item Cite

Family dynamics in a multi-ethnic Asian society: comparison of elderly CKD patients and their family caregivers experience with medical decision making for managing end stage kidney disease.

Journal Article BMC Nephrol · March 1, 2019 BACKGROUND: Elderly end stage kidney patients face a decision concerning whether or not to initiate dialysis. In Asia, this decision is highly influenced by family caregivers. The objective of this paper was to understand patients' experience with and pref ... Full text Link to item Cite

Cognitive Bias: The Downside of Shared Decision Making.

Journal Article JCO Clin Cancer Inform · December 2018 This narrative review presents theoretical and empirical evidence of common cognitive biases that are likely to influence treatment choices of patients with cancer and other illnesses. We present an overview of common cognitive biases that result from how ... Full text Link to item Cite

Bring on the Machines: Could Machine Learning Improve the Quality of Patient Education Materials? A Systematic Search and Rapid Review.

Journal Article JCO Clin Cancer Inform · December 2018 PURPOSE: Clear and trustworthy information is essential for people who are ill. People with cancer, in particular, are targeted with vast quantities of patient education material, but of variable quality. Machine learning technologies are popular across in ... Full text Link to item Cite

Study protocol for a cohort study of patients with advanced heart failure in Singapore.

Journal Article BMJ Open · September 17, 2018 INTRODUCTIO: Understanding the symptom and health expenditure burden among patients with advanced congestive heart failure (CHF) and their family caregivers is essential to reform policy and practice needed to provide quality care to these patients at affo ... Full text Link to item Cite

Understanding factors that influence the demand for dialysis among elderly in a multi-ethnic Asian society.

Journal Article Health Policy · August 2018 BACKGROUND: Despite literature suggesting conservative management (CM) is a viable option for elderly comorbid ESRD patients, the vast majority in Singapore receive dialysis. We hypothesized that the high demand for dialysis is driven by 1) lack of knowled ... Full text Link to item Cite

Cost of Medical Care of Patients with Advanced Serious Illness in Singapore (COMPASS): prospective cohort study protocol.

Journal Article BMC Cancer · April 23, 2018 BACKGROUND: Advanced cancer significantly impacts quality of life of patients and families as they cope with symptom burden, treatment decision-making, uncertainty and costs of treatment. In Singapore, information about the experiences of advanced cancer p ... Full text Link to item Cite

A comparison of attitudes toward length and quality of life between community-dwelling older adults and patients with advanced cancer.

Journal Article Psychooncology · October 2017 OBJECTIVE: Applying prospect theory to end-of-life decision making, we hypothesize that community-dwelling older adults (CDOAs) will be relatively less inclined towards extending length over improving quality of life compared with patients. We also hypothe ... Full text Link to item Cite

Stated Uptake of Physical Activity Rewards Programmes Among Active and Insufficiently Active Full-Time Employees.

Journal Article Appl Health Econ Health Policy · October 2017 BACKGROUND: Employers are increasingly relying on rewards programmes in an effort to promote greater levels of activity among employees; however, if enrolment in these programmes is dominated by active employees, then they are unlikely to be a good use of ... Full text Link to item Cite

Trade-offs between civil liberties and national security: A discrete choice experiment

Journal Article Contemporary Economic Policy · April 1, 2017 We explore differences in perception of national security policies between selfidentified liberals, moderates, and conservatives from a national sample of U.S. adults. Using a discrete choice experiment, we also quantify each group’s willingness to trade o ... Full text Cite

Predicted patient demand for a new delivery system for glaucoma medicine.

Journal Article Medicine (Baltimore) · April 2017 Sustained-release drug delivery systems that replace the need for daily glaucoma medications will improve outcomes for those who are nonadherent and reduce the inconvenience of having to take medications on a recurring basis.The objective is to estimate up ... Full text Link to item Cite

Identifying Factors That Influence Physicians' Recommendations for Dialysis and Conservative Management in Indonesia.

Journal Article Kidney Int Rep · March 2017 INTRODUCTION: For elderly end-stage renal disease (ESRD) patients with multiple comorbidities, dialysis may offer little survival benefit compared to conservative management (CM). Yet, many elderly ESRD patients undergo dialysis, partly due to physicians' ... Full text Link to item Cite

Parents' views on their children's use of eye drops and willingness to accept a new sustained-release subconjunctival injection.

Journal Article Clin Ophthalmol · 2017 AIM: The objectives of this study were to explore parents' views about their children's use of regular eye drops and whether they would consider a sustained-release subconjunctival injection as a replacement for daily drops. METHODS: A survey was conducted ... Full text Link to item Cite

Ideology, public goods and welfare valuation: An experiment on allocating government budgets

Journal Article Journal of Choice Modelling · September 1, 2016 This study demonstrates how experimental survey methods can be used to assess preferences for budget-constrained combinations of public and publicly provided goods and services. The study shows how to calculate welfare changes based on preferences for incr ... Full text Cite

Impact of Treatment Subsidies and Cash Payouts on Treatment Choices at the End of Life.

Journal Article Value Health · 2016 OBJECTIVES: To examine the extent to which financial assistance, in the form of subsidies for life-extending treatments (LETs) or cash payouts, distorts the demand for end-of-life treatments. METHODS: A discrete choice experiment was administered to 290 pa ... Full text Link to item Cite

Measuring High-Risk Patients' Preferences for Pharmacogenetic Testing to Reduce Severe Adverse Drug Reaction: A Discrete Choice Experiment.

Journal Article Value Health · 2016 OBJECTIVES: To investigate patient preferences and willingness to pay (WTP) for a genetic test that can reduce the risk of life-threatening adverse drug reactions (ADRs). We hypothesize that test features (risk of developing the adverse reaction with and w ... Full text Link to item Cite

Improving the Validity of Stated-Preference Data in Health Research: The Potential of the Time-to-Think Approach.

Journal Article Patient · June 2015 The objective of this article was to discuss potential benefits and drawbacks of using a time-to-think (TTT) approach in healthcare research. Implementing a TTT approach in a stated-preference survey study gives respondents the opportunity to reflect on th ... Full text Link to item Cite

Estimating willingness to pay: Do health and environmental researchers have different methodological standards?

Journal Article Applied Economics · June 1, 2013 Health and environmental economists have been employing Stated-Preference (SP) methods such as conjoint analysis or contingent valuation to estimate the monetary value of public health interventions and environmental goods and services. However, the qualit ... Full text Open Access Cite

The long-term dynamics of mortality benefits from improved water and sanitation in less developed countries.

Journal Article PLoS One · 2013 The problem of inadequate access to water, sanitation and hygiene (WASH) in less-developed nations has received much attention over the last several decades (most recently in the Millennium Development Goals), largely because diseases associated with such ... Full text Link to item Cite

Rainwater harvesting practices and attitudes in the mekong delta of Vietnam

Journal Article Journal of Water Sanitation and Hygiene for Development · December 1, 2011 Access to safe drinking water is limited in the Mekong Delta region of Vietnam. Rainwater harvesting (RWH) at household level is among the primary sources of drinking water in the region and is widely practiced throughout Southeast Asia. It has recently be ... Full text Cite

How does cost matter in health-care discrete-choice experiments?

Journal Article Health Econ · March 2011 Willingness-to-pay (WTP) estimates derived from discrete-choice experiments (DCEs) generally assume that the marginal utility of income is constant. This assumption is consistent with theoretical expectations when costs are a small fraction of total income ... Full text Link to item Cite

Quantitative benefit-risk tradeoff preferences for crohn's disease treatments - implications for regulatory decision making and disease management

Chapter · January 1, 2011 In managing Crohn's disease (CD), gastroenterologists increasingly are adopting earlier, more aggressive strategies in the hope of altering the course of the disease. Biologic therapies such as the inhibitors of Tumor Necrosis Factor-alpha (TNF-), inflixim ... Cite

Are gastroenterologists less tolerant of treatment risks than patients? Benefit-risk preferences in Crohn's disease management.

Journal Article J Manag Care Pharm · October 2010 BACKGROUND: Crohn's disease is a serious and debilitating gastrointestinal disorder with a high, unmet need for new treatments. Biologic agents have the potential to alter the natural course of Crohn's disease but present known risks of potential serious a ... Full text Link to item Cite

Patients' benefit-risk preferences for chronic idiopathic thrombocytopenic purpura therapies.

Journal Article Ann Pharmacother · March 2010 BACKGROUND: Idiopathic thrombocytopenic purpura (ITP) primarily is a disorder of adults characterized by autoantibody-induced platelet destruction and reduced platelet production, leading to a low peripheral blood platelet count. The long-term management o ... Full text Link to item Cite

Who pays attention in stated-choice surveys?

Journal Article Health Econ · January 2010 Responses of inattentive or inconsistent subjects in stated-choice (SC) surveys can lead to imprecise or biased estimates. Several SC studies have investigated inconsistency and most of these studies dropped subjects who were inconsistent. However, none of ... Full text Link to item Cite

Quantifying women's stated benefit-risk trade-off preferences for IBS treatment outcomes.

Journal Article Value Health · 2010 BACKGROUND: The Food and Drug Administration, currently, is exploring quantitative benefit-risk methods to support regulatory decision-making. A scientifically valid method for assessing patients' benefit-risk trade-off preferences is needed to compare ris ... Full text Link to item Cite

Effects of simplifying choice tasks on estimates of taste heterogeneity in stated-choice surveys.

Journal Article Soc Sci Med · January 2010 Researchers usually employ orthogonal arrays or D-optimal designs with little or no attribute overlap in stated-choice surveys. The challenge is to balance statistical efficiency and respondent burden to minimize the overall error in the survey responses. ... Full text Link to item Cite

How do physician assessments of patient preferences for colorectal cancer screening tests differ from actual preferences? A comparison in Canada and the United States using a stated-choice survey.

Journal Article Health Econ · December 2009 BACKGROUND: Patient preferences can affect colorectal cancer (CRC) screening test use. We compared utility-based preferences for alternative CRC screening tests from a stated-preference discrete-choice survey of the general population and physicians in Can ... Full text Link to item Cite

Hypothetical bias, cheap talk, and stated willingness to pay for health care.

Journal Article J Health Econ · July 2009 Subjects with rheumatoid arthritis (RA) enrolled in an online panel were asked to evaluate pairs of treatment alternatives with different attributes. Half of the sample saw a cheap-talk text. Preference parameters were estimated using random-parameters log ... Full text Link to item Cite

Multiple sclerosis patients' benefit-risk preferences: serious adverse event risks versus treatment efficacy.

Journal Article J Neurol · April 2009 OBJECTIVE: The aim of this study is to estimate the willingness of multiple sclerosis (MS) patients to accept life-threatening adverse event risks in exchange for improvements in their MS related health outcomes. METHODS: MS patients completed a survey que ... Full text Link to item Cite

Using conjoint analysis to estimate healthy-year equivalents for acute conditions: an application to vasomotor symptoms.

Journal Article Value Health · 2009 OBJECTIVE: Conventional standard gamble and time trade-off methods may be inappropriate for eliciting preferences for some health states because both require subjects to make trade-offs between a morbid health state and death. Thus, the objective of this s ... Full text Link to item Cite

Are adult patients more tolerant of treatment risks than parents of juvenile patients?

Journal Article Risk Anal · January 2009 Understanding patient-specific differences in risk tolerance for new treatments that offer improved efficacy can assist in making difficult regulatory and clinical decisions for new treatments that offer both the potential for greater effectiveness in reli ... Full text Link to item Cite

Convergent validity of attribute-based, choice questions in stated-preference studies

Journal Article Environmental and Resource Economics · January 1, 2009 The application of attribute-based choice questions is well established in the marketing literature, but there are unique aspects of the design that warrant investigation to assess their validity for economic welfare estimation. Three design issues are inv ... Full text Cite

Patients Are Willing to Trade off Efficacy, Safety, and Administration Attributes of Chronic Idiopathic Purpura (ITP) Therapy: Results from a Large North American Discrete Choice Study

Journal Article Blood · November 16, 2008 AbstractOBJECTIVE: To quantify the willingness of patients with chronic idiopathic thrombocytopenic purpura (ITP) to trade off different attributes of ITP treatments, including efficacy, safety, and mode of ... Full text Cite

Women's willingness to accept perceived risks for vasomotor symptom relief.

Journal Article J Womens Health (Larchmt) · September 2007 BACKGROUND: Evidence that long-term hormone therapy (HT) may increase the risk of serious adverse events led to a sharp reduction in all HT use, including short-term use for vasomotor symptom relief. We estimated women's willingness to accept adverse event ... Full text Link to item Cite

Crohn's disease patients' risk-benefit preferences: serious adverse event risks versus treatment efficacy.

Journal Article Gastroenterology · September 2007 BACKGROUND & AIMS: Regulatory assessments of drug risks do not routinely consider patient preferences, despite evidence that some patients are willing to accept increased side-effect risk in exchange for therapeutic benefits. The aim of this study is to es ... Full text Link to item Cite

Factors that affect adherence to bipolar disorder treatments: a stated-preference approach.

Journal Article Med Care · June 2007 BACKGROUND: Medication nonadherence is high among patients with bipolar disorder, and may lead to poor clinical outcomes, decreased quality of life, and increased resource utilization. OBJECTIVE: To investigate the factors associated with nonadherence and ... Full text Link to item Cite

PIH20 CONJOINT-ANALYSIS QALYS FOR ACUTE CONDITIONS

Journal Article Value in Health · November 2006 Full text Cite

Patients willingness to accept risk-benefit trade-offs in treating Crohn's disease

Journal Article PHARMACOEPIDEMIOLOGY AND DRUG SAFETY · August 1, 2006 Link to item Cite