Overview
Senthil Selvaraj, MD, MS, MA, is an Assistant Professor of Medicine in the Duke Molecular Physiology Institute and the Division of Cardiology at Duke University Medical Center. Dr. Selvaraj’s translational research explores the therapeutic relevance of cardiovascular metabolism to patients with heart failure. Through early phase work including several clinical trials, his research employs deep phenotyping to decipher metabolic mechanisms that may be leveraged for cardiovascular benefit. These studies characterize dynamic changes in exercise physiology, biomarker profiles integrating multi-omic platforms, echocardiography, arterial stiffness, metabolic molecular imaging techniques, and several other modalities. More recently, this line of inquiry has explored the potential benefits of endogenous and exogenous ketogenic therapies among patients with heart failure. Dr. Selvaraj’s work is currently or recently funded by the National Institutes of Health, American Heart Association, Doris Duke Charitable Foundation, Mandel Foundation, Heart Center Leadership Council, Institute for Translational Medicine and Therapeutics, American Society for Nuclear Cardiology, and Foundation for Sarcoidosis Research.
Current Appointments & Affiliations
Assistant Professor of Medicine
·
2022 - Present
Medicine, Cardiology,
Medicine
Member of Duke Molecular Physiology Institute
·
2022 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Publications
Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction.
Journal Article JACC Heart Fail · December 2025 BACKGROUND: The etiology of exercise intolerance in heart failure with preserved ejection fraction (HFpEF) is multifactorial. Several contributing pathways may be improved by ketone ester (KE). OBJECTIVES: This study aims to determine whether KE improves e ... Full text Link to item CiteClinical Outcomes and Health Care Costs in Patients Hospitalized With Heart Failure and Transthyretin Amyloid Cardiomyopathy: Findings From GWTG-HF.
Journal Article J Card Fail · November 8, 2025 BACKGROUND: The real-world clinical and economic burden of transthyretin amyloid cardiomyopathy (ATTR-CM) is not well characterized. Prior studies have often been limited by uncertain generalizability or reliance on administrative claims data, which can la ... Full text Link to item CiteAbstract 4365864: Post-Discharge Outcomes and Healthcare Costs for Patients Hospitalized for Heart Failure with Transthyretin Amyloid Cardiomyopathy: Findings From GWTG–HF
Conference Circulation · November 4, 2025 Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is associated with high risk for heart failure (HF) hospitalization. However, little is known regarding post-discharge outcom ... Full text CiteRecent Grants
Diversifying Recruitment to Improve Generalizability of Therapeutic Ketosis Strategies in Heart Failure
ResearchPrincipal Investigator · Awarded by Medical College of Virginia Foundation · 2025 - 2028Probing Regional Metabolism During Exercise through Coronary Sinus Sampling
ResearchPrincipal Investigator · Awarded by National Heart, Lung, and Blood Institute · 2025 - 2027Dissecting the Ketone Metabolic Axis in Heart Failure with Reduced Ejection Fraction
ResearchPrincipal Investigator · Awarded by National Heart, Lung, and Blood Institute · 2022 - 2027View All Grants
Education, Training & Certifications
University of Pennsylvania, School of Medicine ·
2021
M.S.
Northwestern University, Feinberg School of Medicine ·
2013
M.D.
Northwestern University ·
2012
M.A.
Northwestern University ·
2008
B.A.