Scholars@Duke
Senthil Selvaraj

Senthil Selvaraj

Assistant Professor of Medicine
Medicine, Cardiology
senthil.selvaraj@duke.edu
300 N. Duke Street, Carmichael, Office 50-101, Durham, NC 27701

Selected Publications

Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction.

Journal Article JACC Heart Fail · December 2025 BACKGROUND: The etiology of exercise intolerance in heart failure with preserved ejection fraction (HFpEF) is multifactorial. Several contributing pathways may be improved by ketone ester (KE). OBJECTIVES: This study aims to determine whether KE improves e ... Full text Link to item Cite

Clinical Outcomes and Health Care Costs in Patients Hospitalized With Heart Failure and Transthyretin Amyloid Cardiomyopathy: Findings From GWTG-HF.

Journal Article J Card Fail · November 8, 2025 BACKGROUND: The real-world clinical and economic burden of transthyretin amyloid cardiomyopathy (ATTR-CM) is not well characterized. Prior studies have often been limited by uncertain generalizability or reliance on administrative claims data, which can la ... Full text Link to item Cite

Abstract 4365864: Post-Discharge Outcomes and Healthcare Costs for Patients Hospitalized for Heart Failure with Transthyretin Amyloid Cardiomyopathy: Findings From GWTG–HF

Conference Circulation · November 4, 2025 Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is associated with high risk for heart failure (HF) hospitalization. However, little is known regarding post-discharge outcom ... Full text Cite

Dapagliflozin's Association With Cardiorenal Outcomes and Apolipoprotein M Levels in HFrEF Patients: Insights From DEFINE-HF.

Journal Article JACC Adv · June 2025 BACKGROUND: Apolipoprotein M (ApoM) is associated with lower mortality in heart failure (HF) patients and protects against cardiac and kidney injury in mice. OBJECTIVES: The authors investigated dapagliflozin's cardiorenal effects by studying its associati ... Full text Link to item Cite

Integrating Ketone Bodies in Multi-Marker Risk Prediction of Incident Heart Failure in the Multi-Ethnic Study of Atherosclerosis (MESA).

Journal Article Eur J Prev Cardiol · March 21, 2025 AIMS: Circulating ketone bodies (KB) have emerged as a potential adjunctive biomarker for incident heart failure (HF) risk and might provide incremental information beyond established biomarkers. A multi-marker risk score may improve risk stratification of ... Full text Link to item Cite

Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF.

Journal Article JACC Basic Transl Sci · March 2025 Growing evidence supports therapeutic ketosis in heart failure with reduced ejection fraction, though uncertainty exists regarding use with SGLT2i and dose-dependent effects. In a phase I trial of 2 ketone ester (KE) doses in 20 heart failure with reduced ... Full text Link to item Cite

Should We Systematically Screen for the Amyloidogenic V142I Variant?

Journal Article J Card Fail · January 2025 Is it time to employ systematic genetic screening for V142I transthyretin cardiac amyloidosis? Strategic research programs are needed to fill evidence gaps before meaningful and equitable implementation can begin to reduce health disparities and improve mo ... Full text Link to item Cite

Cardiac mechanics and the risk of atrial fibrillation in a community-based cohort of older adults.

Journal Article Eur Heart J Cardiovasc Imaging · November 27, 2024 AIMS: Assessment of cardiac structure and function improves risk prediction of new-onset atrial fibrillation (AF) in different populations. We aimed to comprehensively compare standard and newer measures of cardiac structure and function in improving predi ... Full text Link to item Cite

Abstract 4116177: Metabolic and Pharmacokinetic Profiling of Ketone Ester by Background SGLT2 Inhibitor Therapy in Heart Failure with Reduced Ejection: A Phase I Clinical Trial

Conference Circulation · November 12, 2024 Background: Growing evidence supports a therapeutic role for ketones in HFrEF. However, no pharmacokinetic (PK) studies are available to guide further investigation, and uncertainty exists regarding u ... Full text Cite

Metabolic Effects of the SGLT2 Inhibitor Dapagliflozin in Heart Failure Across the Spectrum of Ejection Fraction.

Journal Article Circ Heart Fail · November 2024 BACKGROUND: Mechanisms of benefit with SGLT2is (sodium-glucose cotransporter-2 inhibitors) in heart failure (HF) remain incompletely characterized. Dapagliflozin alters ketone and fatty acid metabolism in HF with reduced ejection fraction though similar ef ... Full text Link to item Cite

Towards Metabolomic-Based Precision Approaches for Classifying and Treating Heart Failure.

Journal Article JACC Basic Transl Sci · September 2024 Both heart failure and cardiometabolic disease are on the rise, and abnormal cardiac and peripheral metabolism are central to the syndrome of heart failure. Advances in metabolomic profiling have improved our understanding of the heart's metabolic flexibil ... Full text Link to item Cite

Relationship of Ketosis With Myocardial Glucose Uptake Among Patients Undergoing FDG PET/CT for Evaluation of Cardiac Sarcoidosis.

Journal Article Circ Cardiovasc Imaging · August 2024 BACKGROUND: Fluorine-18 fluorodeoxyglucose (FDG) with positron emission tomography (PET) is the standard for detecting myocardial inflammation in cardiac sarcoidosis, requiring preparation with the ketogenic diet (KD) to achieve myocardial glucose suppress ... Full text Link to item Cite

Cardiovascular Burden of the V142I Transthyretin Variant.

Journal Article JAMA · June 4, 2024 IMPORTANCE: Individual cohort studies concur that the amyloidogenic V142I variant of the transthyretin (TTR) gene, present in 3% to 4% of US Black individuals, increases heart failure (HF) and mortality risk. Precisely defining carrier risk across relevant ... Full text Link to item Cite

Targeted Metabolomic Profiling of Dapagliflozin in Heart Failure With Preserved Ejection Fraction: The PRESERVED-HF Trial.

Journal Article JACC Heart Fail · June 2024 BACKGROUND: Although sodium glucose co-transporter 2 inhibitors (SGLT2is) improve heart failure (HF)-related symptoms and outcomes in HF with preserved ejection fraction (HFpEF), underlying mechanisms remain unclear. In HF with reduced EF, dapagliflozin al ... Full text Link to item Cite

METABOLIC EFFECTS OF DAPAGLIFLOZIN IN HEART FAILURE ACROSS THE SPECTRUM OF EJECTION FRACTION

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · 2024 Cite

METABOLIC EFFECTS OF DAPAGLIFLOZIN IN HEART FAILURE ACROSS THE SPECTRUM OF EJECTION FRACTION

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · 2024 Cite

Dapagliflozin and Apparent Treatment-Resistant Hypertension in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: The DELIVER Trial.

Journal Article Circulation · December 12, 2023 BACKGROUND: Apparent treatment-resistant hypertension (aTRH) is prevalent and associated with adverse outcomes in heart failure with mildly reduced or preserved ejection fraction. Less is known about the potential role of sodium-glucose co-transporter 2 in ... Full text Link to item Cite

Age Dependency of Cardiovascular Outcomes With the Amyloidogenic pV142I Transthyretin Variant Among Black Individuals in the US.

Journal Article JAMA Cardiol · August 1, 2023 IMPORTANCE: Hereditary transthyretin cardiac amyloidosis is an increasingly recognized cause of heart failure (HF) with distinct treatment. The amyloidogenic pV142I (V122I) variant is present in 3% to 4% of Black individuals in the US and increases the ris ... Full text Link to item Cite

Assessing Heuristic Bias During Care for Patients Hospitalized for Heart Failure: Get With The Guidelines-Heart Failure.

Journal Article Circ Heart Fail · February 2023 BACKGROUND: Heuristic biases are increasingly recognized, and potentially modifiable, contributors to patient care and outcomes. Left digit bias is a cognitive bias where continuous variables are categorized by their left-most digit. The impact of this heu ... Full text Link to item Cite

Blood Pressure and Dapagliflozin in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: DELIVER.

Journal Article JACC Heart Fail · January 2023 BACKGROUND: Optimizing systolic blood pressure (SBP) in heart failure (HF) with preserved ejection fraction carries a Class I recommendation but with limited evidence. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have antihypertensive effects across c ... Full text Link to item Cite

Comprehensive nutrient consumption estimation and metabolic profiling during ketogenic diet and relationship with myocardial glucose uptake on FDG-PET.

Journal Article Eur Heart J Cardiovasc Imaging · November 17, 2022 AIMS: The ketogenic diet (KD) is standard-of-care to achieve myocardial glucose suppression (MGS) for assessing inflammation using fluorine-18 fluorodeoxyglucose-positron emission tomography (FDG-PET). As KD protocols remain highly variable between centres ... Full text Link to item Cite

Effect of Immunosuppressive Therapy and Biopsy Status in Monitoring Therapy Response in Suspected Cardiac Sarcoidosis.

Journal Article JACC Cardiovasc Imaging · November 2022 BACKGROUND: Patients with suspected cardiac sarcoidosis frequently undergo fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) imaging to assess disease activity at baseline and after treatment initiation. OBJECTIVES: This ... Full text Link to item Cite

Metabolomic Profiling of the Effects of Dapagliflozin in Heart Failure With Reduced Ejection Fraction: DEFINE-HF.

Journal Article Circulation · September 13, 2022 BACKGROUND: Sodium-glucose cotransporter-2 inhibitors are foundational therapy in patients with heart failure with reduced ejection fraction (HFrEF), but underlying mechanisms of benefit are not well defined. We sought to investigate the relationships betw ... Full text Link to item Cite

Apolipoprotein E Polymorphism, Cardiac Remodeling, and Heart Failure in the ARIC Study.

Journal Article J Card Fail · July 2022 BACKGROUND: β-Amyloid has recently been discovered in the myocardium of patients with Alzheimer's disease (AD). Whether genetic variation in apolipoprotein E (APOE) ɛ4, a common variant associated with Alzheimer's disease, is associated with incident heart ... Full text Link to item Cite

Comparison of Exogenous Ketone Administration Versus Dietary Carbohydrate Restriction on Myocardial Glucose Suppression: A Crossover Clinical Trial.

Journal Article J Nucl Med · May 2022 The ketogenic diet (KD) is the standard of care to achieve myocardial glucose suppression (MGS) for assessing inflammation using 18F-FDG PET. However, failure to suppress physiologic glucose uptake remains a significant diagnostic barrier. Although extendi ... Full text Link to item Cite

Association of Left Atrial Structure and Function With Heart Failure in Older Adults.

Journal Article J Am Coll Cardiol · April 26, 2022 BACKGROUND: Limited data exist to characterize novel measures of left atrial (LA) structure and function in older adults without prevalent heart failure (HF). OBJECTIVES: The aim was to assess reference range of LA measures, their associations with N-termi ... Full text Link to item Cite

Impact of Icosapent Ethyl on Cardiovascular Risk Reduction in Patients With Heart Failure in REDUCE-IT.

Journal Article J Am Heart Assoc · April 5, 2022 Background Patients with heart failure (HF) are at high risk for atherosclerotic cardiovascular disease. Studies of atherothrombotic treatments in this population have been disappointing to date. Icosapent ethyl reduced the risk of atherosclerotic cardiova ... Full text Link to item Cite

Acute Echocardiographic Effects of Exogenous Ketone Administration in Healthy Participants.

Journal Article J Am Soc Echocardiogr · March 2022 BACKGROUND: Interest in therapeutic applications of exogenous ketones has grown significantly, spanning patients with heart failure to endurance athletes. Exogenous ketones engender significant effects on cardiac function in heart failure and provide an er ... Full text Link to item Cite

Effects of Sacubitril/Valsartan on Serum Lipids in Heart Failure With Preserved Ejection Fraction.

Journal Article J Am Heart Assoc · September 7, 2021 Background Dyslipidemia is common in heart failure with preserved ejection fraction. Sacubitril/valsartan improves glycemic control and augments natriuretic peptide signaling, providing mechanisms by which sacubitril/valsartan may affect serum lipids. Howe ... Full text Link to item Cite

Management of hypertension in heart failure with preserved ejection fraction: is there a blood pressure goal?

Journal Article Curr Opin Cardiol · July 1, 2021 PURPOSE OF REVIEW: Hypertension remains a leading risk factor for heart failure with preserved ejection fraction (HFpEF), and elevated blood pressure (BP) portends an adverse prognosis in patients with established HFpEF. We summarize current evidence for m ... Full text Link to item Cite

Diagnostic accuracy of SPECT and PET myocardial perfusion imaging in patients with left bundle branch block or ventricular-paced rhythm.

Journal Article J Nucl Cardiol · June 2021 BACKGROUND: The difference in diagnostic accuracy of coronary artery disease (CAD) between vasodilator SPECT and PET myocardial perfusion imaging (MPI) in patients with left bundle branch block (LBBB) or ventricular-paced rhythm (VPR) is unknown. METHODS: ... Full text Link to item Cite

Incremental prognostic value of visually estimated coronary artery calcium in patients undergoing positron emission tomography imaging.

Journal Article Open Heart · May 2021 OBJECTIVE: Visually estimated coronary artery calcium (VECAC) from chest CT or attenuation correction (AC)/CT obtained during positron emission tomography (PET)-myocardial perfusion imaging (MPI) is feasible. Our aim was to determine the prognostic value o ... Full text Link to item Cite

Body Composition, Natriuretic Peptides, and Adverse Outcomes in Heart Failure With Preserved and Reduced Ejection Fraction.

Journal Article JACC Cardiovasc Imaging · January 2021 OBJECTIVES: The purpose of this study was to determine the relationship between body composition, N-terminal B-type natriuretic peptide (NT-proBNP) levels, and heart failure (HF) phenotypes and outcomes. BACKGROUND: Abnormalities in body composition can in ... Full text Link to item Cite

Potential Cardiovascular Applications of Total-body PET Imaging.

Journal Article PET Clin · January 2021 Cardiovascular conditions can exist as part of a systemic disorder (eg, sarcoidosis, amyloidosis, or vasculitis) or have systemic consequences as a result of the cardiovascular insult (eg, myocardial infarction). In other circumstances, multisystem evaluat ... Full text Link to item Cite

Serum uric acid, influence of sacubitril-valsartan, and cardiovascular outcomes in heart failure with preserved ejection fraction: PARAGON-HF.

Journal Article Eur J Heart Fail · November 2020 AIMS: This study aimed to determine the prognostic value of serum uric acid (SUA) on outcomes in heart failure (HF) with preserved ejection fraction (HFpEF), and whether sacubitril-valsartan reduces SUA and use of SUA-related therapies. METHODS AND RESULTS ... Full text Link to item Cite

Application of Diagnostic Algorithms for Heart Failure With Preserved Ejection Fraction to the Community.

Journal Article JACC Heart Fail · August 2020 OBJECTIVES: This study sought to describe characteristics and risk of adverse outcomes associated with the H2FPEF and HFA-PEFF scores among participants in the community with unexplained dyspnea. BACKGROUND: Diagnosing heart failure with preserved ejection ... Full text Link to item Cite

Implications of Altered Ketone Metabolism and Therapeutic Ketosis in Heart Failure.

Journal Article Circulation · June 2, 2020 Despite existing therapy, patients with heart failure (HF) experience substantial morbidity and mortality, highlighting the urgent need to identify novel pathophysiological mechanisms and therapies, as well. Traditional models for pharmacological intervent ... Full text Link to item Cite

Systolic Blood Pressure in Heart Failure With Preserved Ejection Fraction Treated With Sacubitril/Valsartan.

Journal Article J Am Coll Cardiol · April 14, 2020 BACKGROUND: Guidelines recommend targeting systolic blood pressure (SBP) <130 mm Hg in heart failure with preserved ejection fraction (HFpEF) with limited data. OBJECTIVES: This study sought to determine the optimal achieved SBP and whether the treatment e ... Full text Link to item Cite

Prognostic Implications of Congestion on Physical Examination Among Contemporary Patients With Heart Failure and Reduced Ejection Fraction: PARADIGM-HF.

Journal Article Circulation · October 22, 2019 BACKGROUND: The contemporary prognostic value of the physical examination- beyond traditional risk factors including natriuretic peptides, risk scores, and symptoms-in heart failure (HF) with reduced ejection fraction is unknown. We aimed to determine the ... Full text Link to item Cite

Walking pace is inversely associated with risk of death and cardiovascular disease: The Physicians' Health Study.

Journal Article Atherosclerosis · October 2019 BACKGROUND: Walking pace is increasingly being used to assess functional status in ambulatory settings. METHODS: We conducted a prospective analysis within the Physicians' Health Study to examine whether walking pace is associated with mortality and incide ... Full text Link to item Cite

Utility of the Cardiovascular Physical Examination and Impact of Spironolactone in Heart Failure With Preserved Ejection Fraction.

Journal Article Circ Heart Fail · July 2019 BACKGROUND: The prognostic value of physical examination, its relation to quality of life, and influence of therapy in heart failure with preserved ejection fraction is not well known. METHODS AND RESULTS: We studied participants from the Americas with ava ... Full text Link to item Cite

Axial Muscle Size as a Strong Predictor of Death in Subjects With and Without Heart Failure.

Journal Article J Am Heart Assoc · February 19, 2019 Background The impact of skeletal muscle size, quantified using simple noninvasive images routinely obtained during cardiac magnetic resonance imaging studies on mortality in the heart failure ( HF ) population is currently unknown. Methods and Results We ... Full text Link to item Cite

HFE H63D Polymorphism and the Risk for Systemic Hypertension, Myocardial Remodeling, and Adverse Cardiovascular Events in the ARIC Study.

Journal Article Hypertension · January 2019 H63D has been identified as a novel locus associated with the development of hypertension. The quantitative risks for hypertension, cardiac remodeling, and adverse events are not well studied. We analyzed white participants from the ARIC study (Atheroscler ... Full text Link to item Cite

Clinical correlates and heritability of cardiac mechanics: The HyperGEN study.

Journal Article Int J Cardiol · January 1, 2019 BACKGROUND: Indices of cardiac mechanics are sensitive markers of subclinical myocardial dysfunction. Improved understanding of the clinical correlates and heritability of cardiac mechanics could result in novel insight into the acquired and genetic risk f ... Full text Link to item Cite

Prognostic Value of Albuminuria and Influence of Spironolactone in Heart Failure With Preserved Ejection Fraction.

Journal Article Circ Heart Fail · November 2018 BACKGROUND: Albuminuria predicts adverse events in heart failure with preserved ejection fraction. No therapies to date have reduced albuminuria in heart failure with preserved ejection fraction. METHODS AND RESULTS: We analyzed 1175 participants from the ... Full text Link to item Cite

Lack of Association Between Anemia and Intrinsic Left Ventricular Diastolic Function or Cardiac Mechanics in Heart Failure With Preserved Ejection Fraction.

Journal Article Am J Cardiol · October 15, 2018 Anemia is associated with a poor prognosis in heart failure with preserved ejection fraction (HFpEF), but the reasons underlying this association are unclear. Previous studies have reported an association between anemia and diastolic dysfunction. However, ... Full text Link to item Cite

Lack of Association Between Heart Failure and Incident Cancer.

Journal Article J Am Coll Cardiol · April 10, 2018 BACKGROUND: Several recent studies have suggested an increased cancer risk among patients with heart failure (HF). However, these studies are constrained by limited size and follow-up, lack of comprehensive data on other health attributes, and adjudicated ... Full text Link to item Cite

Association of Electronic Health Record Use With Quality of Care and Outcomes in Heart Failure: An Analysis of Get With The Guidelines-Heart Failure.

Journal Article J Am Heart Assoc · March 30, 2018 BACKGROUND: Adoption of electronic health record (EHR) systems has increased significantly across the nation. Whether EHR use has translated into improved quality of care and outcomes in heart failure (HF) is not well studied. METHODS AND RESULTS: We exami ... Full text Link to item Cite

Systolic blood pressure and cardiovascular outcomes in heart failure with preserved ejection fraction: an analysis of the TOPCAT trial.

Journal Article Eur J Heart Fail · March 2018 AIMS: Recent guidelines have advocated for stricter systolic blood pressure (SBP) control in heart failure with preserved ejection fraction (HFpEF), though data regarding the optimal SBP in HFpEF are sparse. METHODS AND RESULTS: We analysed participants fr ... Full text Link to item Cite

Association of Estimated Sodium Intake With Adverse Cardiac Structure and Function: From the HyperGEN Study.

Journal Article J Am Coll Cardiol · August 8, 2017 BACKGROUND: The optimal level of sodium intake remains controversial. OBJECTIVES: This study sought to determine whether examination of left ventricular longitudinal strain (LS), circumferential strain, and e' velocity can provide insight into thresholds f ... Full text Link to item Cite

Pulmonary Hypertension Is Associated With a Higher Risk of Heart Failure Hospitalization and Mortality in Patients With Chronic Kidney Disease: The Jackson Heart Study.

Journal Article Circ Heart Fail · June 2017 BACKGROUND: African Americans develop chronic kidney disease and pulmonary hypertension (PH) at disproportionately high rates. Little is known whether PH heightens the risk of heart failure (HF) admission or mortality among chronic kidney disease patients, ... Full text Link to item Cite

Phenomapping for the Identification of Hypertensive Patients with the Myocardial Substrate for Heart Failure with Preserved Ejection Fraction.

Journal Article J Cardiovasc Transl Res · June 2017 We sought to evaluate whether unbiased machine learning of dense phenotypic data ("phenomapping") could identify distinct hypertension subgroups that are associated with the myocardial substrate (i.e., abnormal cardiac mechanics) for heart failure with pre ... Full text Link to item Cite

Reply: Pulse Pressure and Cardiovascular Death.

Journal Article J Am Coll Cardiol · July 5, 2016 Full text Link to item Cite

Association of Central Adiposity With Adverse Cardiac Mechanics: Findings From the Hypertension Genetic Epidemiology Network Study.

Journal Article Circ Cardiovasc Imaging · June 2016 BACKGROUND: Central obesity, defined by increased waist circumference or waist:hip ratio (WHR), is associated with increased cardiovascular events, including heart failure. However, the pathophysiological link between central obesity and adverse cardiovasc ... Full text Link to item Cite

Archeological Echocardiography: Digitization and Speckle Tracking Analysis of Archival Echocardiograms in the HyperGEN Study.

Journal Article Echocardiography · March 2016 BACKGROUND: Several large epidemiologic studies and clinical trials have included echocardiography, but images were stored in analog format and these studies predated tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE). We hypothesized ... Full text Link to item Cite

Pulse Pressure and Risk for Cardiovascular Events in Patients With Atherothrombosis: From the REACH Registry.

Journal Article J Am Coll Cardiol · February 2, 2016 BACKGROUND: Pulse pressure (PP) provides valuable prognostic information in specific populations, but few studies have assessed its value on cardiovascular outcomes in a broad, worldwide population. OBJECTIVES: The aim of this study was to determine whethe ... Full text Link to item Cite

A non-invasive assessment of cardiopulmonary hemodynamics with MRI in pulmonary hypertension.

Journal Article Magn Reson Imaging · December 2015 PURPOSE: We propose a method for non-invasive quantification of hemodynamic changes in the pulmonary arteries resulting from pulmonary hypertension (PH). METHODS: Using a two-element Windkessel model, and input parameters derived from standard MRI evaluati ... Full text Link to item Cite

Effects of ranolazine on exercise capacity, right ventricular indices, and hemodynamic characteristics in pulmonary arterial hypertension: a pilot study.

Journal Article Pulm Circ · September 2015 Ranolazine, a late inward sodium current and fatty acid oxidation inhibitor, may improve right ventricular (RV) function in pulmonary arterial hypertension (PAH); however, the safety and efficacy of ranolazine in humans with PAH is unknown. Therefore, we s ... Full text Link to item Cite

Phenomapping for novel classification of heart failure with preserved ejection fraction.

Journal Article Circulation · January 20, 2015 BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous clinical syndrome in need of improved phenotypic classification. We sought to evaluate whether unbiased clustering analysis using dense phenotypic data (phenomapping) cou ... Full text Link to item Cite

Diastolic wall strain: a simple marker of abnormal cardiac mechanics.

Journal Article Cardiovasc Ultrasound · October 3, 2014 BACKGROUND: Diastolic wall strain (DWS), defined using posterior wall thickness (PWT) measurements from standard echocardiographic images (DWS = [PWT(systole)-PWT(diastole)]/PWT(systole)), has been proposed as a marker of left ventricular (LV) diastolic st ... Full text Link to item Cite

Association of comorbidity burden with abnormal cardiac mechanics: findings from the HyperGEN study.

Journal Article J Am Heart Assoc · April 29, 2014 BACKGROUND: Comorbidities are common in heart failure (HF), and the number of comorbidities has been associated with poor outcomes in HF patients. However, little is known about the effect of multiple comorbidities on cardiac mechanics, which could impact ... Full text Link to item Cite

Prognostic importance of pathophysiologic markers in patients with heart failure and preserved ejection fraction.

Journal Article Circ Heart Fail · March 1, 2014 BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome associated with multiple pathophysiologic abnormalities, including left ventricular (LV) diastolic dysfunction, longitudinal LV systolic dysfunction, abnormal ve ... Full text Link to item Cite

Association of low-grade albuminuria with adverse cardiac mechanics: findings from the hypertension genetic epidemiology network (HyperGEN) study.

Journal Article Circulation · January 7, 2014 BACKGROUND: Albuminuria is a marker of endothelial dysfunction and has been associated with adverse cardiovascular outcomes. The reasons for this association are unclear but may be attributable to the relationship between endothelial dysfunction and intrin ... Full text Link to item Cite

Media coverage of medical journals: do the best articles make the news?

Journal Article PLoS One · 2014 BACKGROUND: News coverage of medical research is followed closely by many Americans and affects the practice of medicine and influence of scientific research. Prior work has examined the quality of media coverage, but no investigation has characterized the ... Full text Link to item Cite

Can a resident's publication record predict fellowship publications?

Journal Article PLoS One · 2014 BACKGROUND: Internal medicine fellowship programs have an incentive to select fellows who will ultimately publish. Whether an applicant's publication record predicts long term publishing remains unknown. METHODS: Using records of fellowship bound internal ... Full text Link to item Cite

Association of the frontal QRS-T angle with adverse cardiac remodeling, impaired left and right ventricular function, and worse outcomes in heart failure with preserved ejection fraction.

Journal Article J Am Soc Echocardiogr · January 2014 BACKGROUND: No prior studies have investigated the association of QRS-T angle with cardiac structure and function and outcomes in heart failure with preserved ejection fraction (HFpEF). The aim of this study was to test the hypothesis that increased fronta ... Full text Link to item Cite

Role of pretransplant echocardiographic evaluation in predicting outcomes following liver transplantation.

Journal Article Am J Transplant · September 2013 Maintenance of cardiac function is critical to the survival of patients with end-stage liver disease after liver transplantation (LT). We sought to determine whether pre-LT echocardiographic indices of right heart structure and function were independently ... Full text Link to item Cite

A decade of reversal: an analysis of 146 contradicted medical practices.

Journal Article Mayo Clin Proc · August 2013 OBJECTIVE: To identify medical practices that offer no net benefits. METHODS: We reviewed all original articles published in 10 years (2001-2010) in one high-impact journal. Articles were classified on the basis of whether they addressed a medical practice ... Full text Link to item Cite

Association of serum triiodothyronine with B-type natriuretic peptide and severe left ventricular diastolic dysfunction in heart failure with preserved ejection fraction.

Journal Article Am J Cardiol · July 15, 2012 There are well-documented changes in thyroid hormone metabolism that accompany heart failure (HF). However, the frequency of thyroid hormone abnormalities in HF with preserved ejection fraction (HFpEF) is unknown, and no studies have investigated the assoc ... Full text Link to item Cite

In vivo determination of mouse olfactory mucus cation concentrations in normal and inflammatory states.

Journal Article PLoS One · 2012 OBJECTIVE: Olfaction is impaired in chronic rhinosinusitis (CRS). The study has two aims: (1) to determine whether changes in cation concentration occur in the olfactory mucus of mice with CRS, which may affect chemo-electrical transduction, (2) and to exa ... Full text Link to item Cite