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Archeological Echocardiography: Digitization and Speckle Tracking Analysis of Archival Echocardiograms in the HyperGEN Study.

Publication ,  Journal Article
Aguilar, FG; Selvaraj, S; Martinez, EE; Katz, DH; Beussink, L; Kim, K-YA; Ping, J; Rasmussen-Torvik, L; Goyal, A; Sha, J; Irvin, MR; Shah, SJ ...
Published in: Echocardiography
March 2016

BACKGROUND: Several large epidemiologic studies and clinical trials have included echocardiography, but images were stored in analog format and these studies predated tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE). We hypothesized that digitization of analog echocardiograms, with subsequent quantification of cardiac mechanics using STE, is feasible, reproducible, accurate, and produces clinically valid results. METHODS: In the NHLBI HyperGEN study (N = 2234), archived analog echocardiograms were digitized and subsequently analyzed using STE to obtain tissue velocities/strain. Echocardiograms were assigned quality scores and inter-/intra-observer agreement was calculated. Accuracy was evaluated in: (1) a separate second study (N = 50) comparing prospective digital strain versus post hoc analog-to-digital strain, and (2) in a third study (N = 95) comparing prospectively obtained TDI e' velocities with post hoc STE e' velocities. Finally, we replicated previously known associations between tissue velocities/strain, conventional echocardiographic measurements, and clinical data. RESULTS: Of the 2234 HyperGEN echocardiograms, 2150 (96.2%) underwent successful digitization and STE analysis. Inter/intra-observer agreement was high for all STE parameters, especially longitudinal strain (LS). In accuracy studies, LS performed best when comparing post hoc STE to prospective digital STE for strain analysis. STE-derived e' velocities correlated with, but systematically underestimated, TDI e' velocity. Several known associations between clinical variables and cardiac mechanics were replicated in HyperGEN. We also found a novel independent inverse association between fasting glucose and LS (adjusted β = -2.4 [95% CI -3.6, -1.2]% per 1-SD increase in fasting glucose; P < 0.001). CONCLUSIONS: Archeological echocardiography, the digitization and speckle tracking analysis of archival echocardiograms, is feasible and generates indices of cardiac mechanics similar to contemporary studies.

Duke Scholars

Published In

Echocardiography

DOI

EISSN

1540-8175

Publication Date

March 2016

Volume

33

Issue

3

Start / End Page

386 / 397

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Signal Processing, Computer-Assisted
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiology Information Systems
  • Image Interpretation, Computer-Assisted
  • Humans
  • Elasticity Imaging Techniques
  • Echocardiography
  • Data Mining
 

Citation

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Aguilar, F. G., Selvaraj, S., Martinez, E. E., Katz, D. H., Beussink, L., Kim, K.-Y., … Shah, S. J. (2016). Archeological Echocardiography: Digitization and Speckle Tracking Analysis of Archival Echocardiograms in the HyperGEN Study. Echocardiography, 33(3), 386–397. https://doi.org/10.1111/echo.13095
Aguilar, Frank G., Senthil Selvaraj, Eva E. Martinez, Daniel H. Katz, Lauren Beussink, Kwang-Youn A. Kim, Jie Ping, et al. “Archeological Echocardiography: Digitization and Speckle Tracking Analysis of Archival Echocardiograms in the HyperGEN Study.Echocardiography 33, no. 3 (March 2016): 386–97. https://doi.org/10.1111/echo.13095.
Aguilar FG, Selvaraj S, Martinez EE, Katz DH, Beussink L, Kim K-YA, et al. Archeological Echocardiography: Digitization and Speckle Tracking Analysis of Archival Echocardiograms in the HyperGEN Study. Echocardiography. 2016 Mar;33(3):386–97.
Aguilar, Frank G., et al. “Archeological Echocardiography: Digitization and Speckle Tracking Analysis of Archival Echocardiograms in the HyperGEN Study.Echocardiography, vol. 33, no. 3, Mar. 2016, pp. 386–97. Pubmed, doi:10.1111/echo.13095.
Aguilar FG, Selvaraj S, Martinez EE, Katz DH, Beussink L, Kim K-YA, Ping J, Rasmussen-Torvik L, Goyal A, Sha J, Irvin MR, Arnett DK, Shah SJ. Archeological Echocardiography: Digitization and Speckle Tracking Analysis of Archival Echocardiograms in the HyperGEN Study. Echocardiography. 2016 Mar;33(3):386–397.

Published In

Echocardiography

DOI

EISSN

1540-8175

Publication Date

March 2016

Volume

33

Issue

3

Start / End Page

386 / 397

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Signal Processing, Computer-Assisted
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiology Information Systems
  • Image Interpretation, Computer-Assisted
  • Humans
  • Elasticity Imaging Techniques
  • Echocardiography
  • Data Mining