Scholars@Duke
Sergio Pina-Oviedo

Sergio Pina-Oviedo

Associate Professor of Pathology
Pathology
sergio.pinaoviedo@duke.edu
40 Duke Medicine Circle, Durham, NC 27710

Selected Publications

Marginal zone lymphoma of extranodal sites: A review with an emphasis on diagnostic pitfalls and differential diagnosis with reactive conditions.

Journal Article Hum Pathol · February 2025 Marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) represents 8% of all B-cell lymphomas and it is the most common small B-cell lymphoma arising at extranodal sites. The gold-standard test to establish a diagnosis of MALT lymph ... Full text Link to item Cite

Recent trends in the causation of peritoneal mesothelioma: fiber burden analysis of ten cases.

Journal Article Ultrastruct Pathol · 2025 Mesothelioma in the past has been strongly associated with a history of asbestos exposure. Studies have shown that, on average, a higher dose of asbestos exposure is required for the development of peritoneal mesothelioma, and a smaller percentage of cases ... Full text Link to item Cite

The over diagnosis of diffuse mesothelioma: An analysis of 311 cases with recommendations for the avoidance of pitfalls.

Journal Article Ann Diagn Pathol · February 2024 BACKGROUND: The diagnosis of mesothelioma may be challenging. We investigated a large database of cases in order to determine the frequency with which a diagnosis of mesothelioma was made incorrectly and the most frequent causes of error. DESIGN: A databas ... Full text Link to item Cite

Flow cytometry quantification of tumor-infiltrating lymphocytes to predict the survival of patients with diffuse large B-cell lymphoma.

Journal Article Front Immunol · 2024 INTRODUCTION: Our previous studies have demonstrated that tumor-infiltrating lymphocytes (TILs), including normal B cells, T cells, and natural killer (NK) cells, in diffuse large B-cell lymphoma (DLBCL) have a significantly favorable impact on the clinica ... Full text Open Access Link to item Cite

Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22-modified FK520 analog against C. neoformans.

Journal Article mBio · October 31, 2023 Fungal infections cause significant morbidity and mortality globally. The therapeutic armamentarium against these infections is limited, and the development of antifungal drugs has been hindered by the evolutionary conservation between fungi and the human ... Full text Link to item Cite

Diagnostic Approach to Pulmonary B-Cell Lymphomas in Small Biopsies, with Practical Recommendations to Avoid Misinterpretation.

Journal Article Diagnostics (Basel) · October 26, 2023 Pulmonary lymphomas are rare. With the current less invasive approaches used to obtain material for diagnosis, the diagnosis of pulmonary lymphoma is now frequently established in a small biopsy rather than in a resection. Therefore, the diagnosis has beco ... Full text Link to item Cite

Primary Cutaneous Anaplastic Large Cell Lymphoma-A Review of Clinical, Morphological, Immunohistochemical, and Molecular Features.

Journal Article Cancers (Basel) · August 14, 2023 Primary cutaneous anaplastic large cell lymphoma (ALCL) is the second most common cutaneous T-cell lymphoma after mycosis fungoides and belongs to the spectrum of cutaneous CD30+ T-cell lymphoproliferative disorders. Although primary cutaneous ALCL usually ... Full text Link to item Cite

Liver Metastasis of Thymoma: Case Report and Review of the Literature.

Journal Article Int J Surg Pathol · August 2023 The 2021 "World Health Organization (WHO) Classification of Thoracic Tumours" classifies epithelial tumors of the thymus (thymomas) based on cytomorphology. Thymomas with benign cytomorphology are classified as type A, AB, B1, B2, and B3, while those with ... Full text Link to item Cite

Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22 modified FK520 analog against C. neoformans.

Journal Article bioRxiv · July 11, 2023 UNLABELLED: Fungal infections are of mounting global concern, and the current limited treatment arsenal poses challenges when treating such infections. In particular, infections by Cryptococcus neoformans are associated with high mortality, emphasizing the ... Full text Link to item Cite

Mediastinal Lymphoproliferative Disorders

Chapter · January 1, 2023 This chapter discusses the clinical, radiologic, histopathologic, and relevant cytogenetic and molecular alterations of reactive and malignant mediastinal lymphoproliferative disorders. All these entities comprise a significant proportion of cases seen by ... Full text Cite

Pulmonary Lymphoproliferative Disorders

Chapter · January 1, 2023 This chapter discusses the clinical, radiologic, histopathologic, and relevant cytogenetic and molecular alterations of reactive and malignant pulmonary lymphoproliferative disorders. All of these entities are rare—particularly when confined to the lung—an ... Full text Cite

Diagnostic approach to prevascular (anterior) mediastinal lymphomas: when thoracic pathology meets hematopathology.

Journal Article Mediastinum · 2023 Lymphomas are among the most common malignant tumors occurring in the anterior/prevascular mediastinum. Their diagnoses can be challenging in small biopsies, the current most common method of sampling of an anterior mediastinal mass. Because the initial cl ... Full text Link to item Cite

Rapidly Progressive Bilateral Vitreoretinal Lymphoma.

Journal Article Cureus · November 2022 A 56-year-old male who presented with unilateral localized sub-retinal lesions suspicious for primary vitreoretinal lymphoma (PVRL) developed florid bilateral ocular involvement and was found to have lesions on MRI of the brain in a five-week period despit ... Full text Link to item Cite

Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer.

Journal Article Biomed Pharmacother · September 2022 Glioblastoma (GBM) remains the most frequently diagnosed primary malignant brain cancer in adults. Despite recent progress in understanding the biology of GBM, the clinical outcome for patients remains poor, with a median survival of approximately one year ... Full text Link to item Cite

Monensin and its analogues show anti-glioblastoma activity in an organoid model of cancer

Journal Article FASEB journal : official publication of the Federation of American Societies for Experimental Biology · May 1, 2022 Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Despite numerous clinical trials, the standard of care therapy has remained unchanged for the last decade. One of the main problems contributing to the limited effective treatme ... Full text Cite

Synchronous plasma cell neoplasm and B lymphoblastic leukemia/lymphoma at initial presentation: first report of an unusual association with a good outcome

Journal Article Journal of Hematopathology · March 1, 2022 A synchronous diagnosis of a plasma cell neoplasm (PCN) and a non-plasma cell hematologic malignancy is very rare. We report what we believe is the first instance of a synchronous PCN and B lymphoblastic leukemia/lymphoma (B-ALL) diagnosed at initial prese ... Full text Cite

NUT Carcinoma: Clinicopathologic Features, Molecular Genetics and Epigenetics.

Journal Article Front Oncol · 2022 Nuclear protein in testis (NUT) carcinoma is a rare, highly aggressive, poorly differentiated carcinoma occurring mostly in adolescents and young adults. This tumor usually arises from the midline structures of the thorax, head, and neck, and exhibits vari ... Full text Link to item Cite

Primary histiocytic sarcoma of the clivus with focal extension into central nervous system and neurologic manifestations: First description at an unusual site with an overwhelming and rapid progression.

Journal Article Clin Neuropathol · 2022 Histiocytic sarcoma (HS) is a rare malignant neoplasm of macrophage-dendritic cell lineage that can occur at any site. Primary base of skull involvement is exceedingly rare. We present the case of a previously healthy 56-year-old man who complained of head ... Full text Link to item Cite

Fluorescent Immunohistochemistry.

Chapter · 2022 Immunofluorescence is an important immunochemical technique that utilizes fluorescence-labeled antibodies to detect specific target antigens. It is used widely in both scientific research and clinical laboratories. Immunofluorescence allows for excellent s ... Full text Link to item Cite

Breast implant-associated anaplastic large cell lymphoma: clinical follow-up and analysis of sequential pathologic specimens of untreated patients shows persistent or progressive disease.

Journal Article Mod Pathol · December 2021 Breast implant-associated anaplastic large cell lymphoma (ALCL) is a distinctive type of T-cell lymphoma that arises around textured-surface breast implants. In a subset of patients, this disease can involve surrounding tissues, spread to regional lymph no ... Full text Link to item Cite

P10s-PADRE vaccine combined with neoadjuvant chemotherapy in ER-positive breast cancer patients induces humoral and cellular immune responses.

Journal Article Oncotarget · October 26, 2021 Breast cancer patients diagnosed with HR+/HER2- tumors face a persistent risk of distant recurrence long after completion of their treatment. Strategies to induce anti-tumor immune responses could complement standard-of-care therapies for these patients. T ... Full text Link to item Cite

ALK-Negative Anaplastic Large Cell Lymphoma: Current Concepts and Molecular Pathogenesis of a Heterogeneous Group of Large T-Cell Lymphomas.

Journal Article Cancers (Basel) · September 17, 2021 Anaplastic large cell lymphoma (ALCL) is a subtype of CD30+ large T-cell lymphoma (TCL) that comprises ~2% of all adult non-Hodgkin lymphomas. Based on the presence/absence of the rearrangement and expression of anaplastic lymphoma kinase (ALK), ALCL is di ... Full text Link to item Cite

Mediastinal Lymphoproliferative Disorders.

Journal Article Adv Anat Pathol · September 1, 2021 Lymphoproliferative disorders comprise 50% to 60% of all mediastinal malignancies in both children and adults. Primary mediastinal involvement is rare (∼5%), whereas secondary mediastinal involvement by systemic disease is more common (10% to 25%). Primary ... Full text Link to item Cite

Limitations of an ex vivo breast cancer model for studying the mechanism of action of the anticancer drug paclitaxel.

Journal Article Eur J Pharmacol · January 15, 2021 Paclitaxel is widely used in the treatment of breast, ovarian, lung, and other cancers. Its primary mechanism is to prevent microtubule depolymerization causing loss of dynamic instability crucial for normal microtubule function leading to mitotic arrest. ... Full text Link to item Cite

JCPyV T-Antigen Activation of the Anti-Apoptotic Survivin Promoter-Its Role in the Development of Progressive Multifocal Leukoencephalopathy.

Journal Article Viruses · November 3, 2020 Progressive Multifocal Leukoencephalopathy (PML) is a fatal demyelinating disease of the CNS, resulting from the lytic infection of oligodendrocytes by the human neurotropic polyomavirus JC (JCPyV), typically associated with severe immunocompromised states ... Full text Link to item Cite

Analysis of primary central nervous system large B-cell lymphoma in the era of high-grade B-cell lymphoma: Detection of two cases with MYC and BCL6 rearrangements in a cohort of 12 cases.

Journal Article Ann Diagn Pathol · October 2020 High-grade diffuse large B-cell lymphoma (HG-DLBCL) refers to DLBCL with MYC and BCL2 and/or BCL6 rearrangements (double-hit or triple-hit DLBCL) that exhibits poor prognosis. Double-expressor DLBCL (c-myc+/bcl-2+) has intermediate prognosis when compared ... Full text Link to item Cite

Meningeosis myelomatosis.

Journal Article Blood · September 17, 2020 Full text Link to item Cite

Signet-ring cell large B-cell lymphoma: A potential diagnostic pitfall with signet-ring cell carcinoma.

Journal Article Clin Case Rep · September 2020 This study reveals the importance of recognizing uncommon histologic variants in diffuse large B-cell lymphoma, such as the signet-ring cell variant, which may result in an erroneous or delayed diagnosis with potential impact in patient treatment. ... Full text Link to item Cite

Carbamate derivatives of colchicine show potent activity towards primary acute lymphoblastic leukemia and primary breast cancer cells-in vitro and ex vivo study.

Journal Article J Biochem Mol Toxicol · June 2020 Colchicine (COL) shows strong anticancer activity but due to its toxicity towards normal cells its wider application is limited. To address this issue, a library of 17 novel COL derivatives, namely N-carbamates of N-deacetyl-4-(bromo/chloro/iodo)thiocolchi ... Full text Link to item Cite

Typical and atypical carcinoid tumors of the lung: a clinicopathological correlation of 783 cases with emphasis on histological features.

Journal Article Hum Pathol · April 2020 We present 783 surgical resections of typical and atypical carcinoid tumors of the lung identified in the pathology files of 20 different pathology departments. All cases were critically reviewed for clinical and pathological features and further correlate ... Full text Link to item Cite

A proposal for pathologic processing of breast implant capsules in patients with suspected breast implant anaplastic large cell lymphoma.

Journal Article Mod Pathol · March 2020 Breast implant anaplastic large cell lymphoma is an entity recently recognized by the World Health Organization. The tumor arises around textured-surface breast implants and is usually confined to the surrounding fibrous capsule. Currently, there are no re ... Full text Link to item Cite

Synthesis and Anticancer Activity of Tertiary Amides of Salinomycin and Their C20-oxo Analogues.

Journal Article ChemMedChem · January 17, 2020 The polyether ionophore salinomycin (SAL) has captured much interest because of its potent activity against cancer cells and cancer stem cells. Our previous studies have indicated that C1/C20 double-modification of SAL is a useful strategy to generate dive ... Full text Link to item Cite

Hematopathology

Chapter · January 1, 2020 This chapter covers the most updated classification of neoplastic lymphoid disorders that affect primarily the lymph nodes and also covers the most updated classification of neoplastic disorders that affect primarily the bone marrow and follows the revised ... Full text Cite

Benign Hematopoietic Disorders of the Lung

Chapter · January 1, 2020 The lung is an organ constantly exposed to antigens and pathogens that frequently induce local inflammation. This inflammation produces hyperplasia of the bronchial-associated lymphoid tissue (BALT) that can result in exuberant reactive lymphoid proliferat ... Full text Cite

Malignant Hematopoietic Disorders of the Lung

Chapter · January 1, 2020 Hematopoietic tumors of the lung are uncommon. They comprise cases of non-Hodgkin lymphomas, classic Hodgkin lymphoma, plasmacytoma, and acute myeloid leukemia/myeloid sarcoma (Pina-Oviedo et al. Adv Anat Pathol 22:355-375, 2015). Primary lung involvement ... Full text Cite

Benign Hematopoietic Disorders of the Mediastinum

Chapter · January 1, 2020 Benign or reactive hematopoietic lesions of the mediastinum represent a large part of the routine cases of surgical pathologists and thoracic pathologists. Most of these lesions present as mediastinal lymphadenopathy with or without disease elsewhere, and ... Full text Cite

Pleural Lymphomas

Chapter · January 1, 2020 Pleural lymphomas are very rare as primary disease but a relatively common manifestation in systemic disease (Vega et al., Arch Pathol Lab Med. 130:1497-502, 2006). More than 95% of cases are a manifestation of advanced stage of disease usually as lung inv ... Full text Cite

Malignant Hematopoietic Disorders of the Mediastinum

Chapter · January 1, 2020 Hematopoietic tumors are among the most common neoplasms involving the mediastinum. Lymphomas alone represent ~60% of all mediastinal malignancies (Temes et al. Oncologist 5(3):179-84, 2000; Temes et al. West J Med 170(3):161-6, 1999). Mediastinal lymphoma ... Full text Cite

Primary Mediastinal Nodal and Extranodal Non-Hodgkin Lymphomas: Current Concepts, Historical Evolution, and Useful Diagnostic Approach: Part 2.

Journal Article Advances in anatomic pathology · November 2019 Primary mediastinal non-Hodgkin lymphomas (PM-NHLs) represent ∼5% of all non-Hodgkin lymphomas (NHLs) and comprise lymphomas of B-cell and T-cell origin. PM-NHLs are defined as involvement of mediastinal lymph nodes, thymus, and/or mediastinal organs (hear ... Full text Cite

Primary Mediastinal Nodal and Extranodal Non-Hodgkin Lymphomas: Current Concepts, Historical Evolution, and Useful Diagnostic Approach: Part 1.

Journal Article Adv Anat Pathol · November 2019 Primary mediastinal non-Hodgkin lymphomas (PM-NHLs) represent ~5% of all NHLs and comprise lymphomas of B-cell and T-cell origin. PM-NHLs are defined as involvement of mediastinal lymph nodes, thymus, and/or mediastinal organs (heart, lung, pleura, pericar ... Full text Link to item Cite

Human Polyomavirus JCPyV and Its Role in Progressive Multifocal Leukoencephalopathy and Oncogenesis

Journal Article Frontiers in Oncology · August 8, 2019 The human neurotropic virus JCPyV, a member of the Polyomaviridiae family, is the opportunistic infectious agent of Progressive Multifocal Leukoencephalopathy (PML), a fatal disease seen in severe immunosuppressive conditions and, during the last decade, i ... Full text Cite

Breast implant-associated anaplastic large cell lymphoma: a review.

Journal Article Mod Pathol · February 2019 Breast implant-associated anaplastic large cell lymphoma is a newly recognized provisional entity in the 2017 revision of the World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues. It is an uncommon, slow growing T-cell l ... Full text Link to item Cite

Hematoxylin: Mesoamerica's Gift to Histopathology. Palo de Campeche (Logwood Tree), Pirates' Most Desired Treasure, and Irreplaceable Tissue Stain.

Journal Article International journal of surgical pathology · February 2019 Hematoxylin is a basic dye derived from the heartwood of Palo de Campeche ( Haematoxylum campechianum), the logwood tree native to Mexico and Central America. Haematoxylum means "bloodwood" in reference to its dark-red heartwood and campechianum refers to ... Full text Cite

The response of phyllodes tumor of the breast to anticancer therapy: An in vitro and ex vivo study

Journal Article Oncology Letters · January 1, 2019 Phyllodes tumors of the breast (PTB) are uncommon stromal-epithelial neoplasms, with the main recommended treatment being surgical removal. However, even with adequate resection, the risk of recurrence in the malignant form remains as high as 40%, and ther ... Full text Cite

Focal Rosai-Dorfman disease coexisting with lymphoma in the same anatomic site: a localized histiocytic proliferation associated with MAPK/ERK pathway activation.

Journal Article Mod Pathol · January 2019 Rosai-Dorfman disease is a rare histiocytic disorder shown to have gene mutations that activate the MAPK/ERK pathway in at least one-third of cases. Most patients with Rosai-Dorfman disease present with bulky lymphadenopathy or extranodal disease, but rare ... Full text Link to item Cite

Clinicopathologic Features and Prognostic Impact of Lymph Node Involvement in Patients With Breast Implant-associated Anaplastic Large Cell Lymphoma.

Journal Article Am J Surg Pathol · March 2018 Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a rare T-cell lymphoma that arises around breast implants. Most patients manifest with periprosthetic effusion, whereas a subset of patients develops a tumor mass or lymph node involveme ... Full text Link to item Cite

Cancer Therapy-associated Lymphoproliferative Disorders: An Under-recognized Type of Immunodeficiency-associated Lymphoproliferative Disorder.

Journal Article Am J Surg Pathol · January 2018 We describe the clinicopathologic features of 17 patients who had a hematologic malignancy of various types, were treated, and subsequently developed a lymphoproliferative disorder (LPD). There were 10 men and 7 women with a median age of 59 years (range, ... Full text Link to item Cite

Long-Term Remissions of Patients With Follicular Lymphoma Grade 3 Treated With R-CHOP.

Journal Article Clin Lymphoma Myeloma Leuk · January 2018 BACKGROUND: The optimal management of patients with follicular lymphoma Grade 3 (FLG3) is controversial. PATIENTS AND METHODS: This is a case series of 45 patients with FLG3 treated with first-line R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincrist ... Full text Link to item Cite

Carcinocythemia (carcinoma cell leukemia).

Journal Article Blood · November 23, 2017 Full text Link to item Cite

Follicular lymphoma with hyaline-vascular Castleman-like features: analysis of 6 cases and review of the literature.

Journal Article Hum Pathol · October 2017 Follicular lymphoma (FL) with features reminiscent of hyaline-vascular Castleman disease (CD) is an unusual morphologic variant that may create diagnostic difficulties. To our knowledge, only 5 cases of this variant have been reported. We describe the clin ... Full text Link to item Cite

Mutually exclusive recurrent KRAS and MAP2K1 mutations in Rosai-Dorfman disease.

Journal Article Mod Pathol · October 2017 Rosai-Dorfman disease is a histiocytic disorder with a poorly defined pathogenesis. Recent molecular studies have revealed recurrent mutations involving genes in the MAPK/ERK pathway in Langerhans cell histiocytosis and Erdheim-Chester disease. However, ca ... Full text Link to item Cite

Langerhans cell histiocytosis associated with lymphoma: an incidental finding that is not associated with BRAF or MAP2K1 mutations.

Journal Article Mod Pathol · May 2017 Langerhans cell histiocytosis is characterized by a localized or systemic proliferation of Langerhans cells. BRAF mutations have been reported in 40-70% of cases and MAP2K1 mutations have been found in BRAF-negative cases, supporting that Langerhans cell h ... Full text Link to item Cite

Concomitant Cutaneous Langerhans Cell Hystiocytosis and Leukemia Cutis.

Journal Article Am J Dermatopathol · May 2017 Leukemia cutis develops in <4% of all acute leukemias. Concurrent acute myeloid leukemia (AML) and Langerhans cell histiocytosis (LCH) is rare, with most cases involving lymph nodes or spleen, and no cutaneous involvement. We report the case of a 59-year-o ... Full text Link to item Cite

Human Colors-The Rainbow Garden of Pathology: What Gives Normal and Pathologic Tissues Their Color?

Journal Article Arch Pathol Lab Med · March 2017 CONTEXT: - Colors are important to all living organisms because they are crucial for camouflage and protection, metabolism, sexual behavior, and communication. Human organs obviously have color, but the underlying biologic processes that dictate the specif ... Full text Link to item Cite

Primary Mediastinal Classical Hodgkin Lymphoma.

Journal Article Adv Anat Pathol · September 2016 Primary mediastinal Classical Hodgkin lymphoma (CHL) is rare. Nodular sclerosis CHL (NS-CHL) is the most common subtype involving the anterior mediastinum and/or mediastinal lymph nodes. Primary thymic CHL is exceedingly rare. The disease typically affects ... Full text Link to item Cite

Primary Pulmonary Lymphomas.

Journal Article Adv Anat Pathol · November 2015 Primary lung lymphoma (PLL) is a rare disease that comprises <0.5% of all primary lung tumors. It is defined as lymphoma confined to the lung with or without hilar lymph node involvement at the time of diagnosis or up to 3 months thereafter. Patients with ... Full text Link to item Cite

Diagnostic accuracy of fine-needle aspiration cytology of salivary gland lesions: A 6-year retrospective review

Journal Article Journal of the American Society of Cytopathology · March 1, 2015 Introduction: The aim of this study was to evaluate the diagnostic accuracy of salivary gland fine-needle aspiration (FNA) in comparison to histologic examination and to recognize possible pitfalls in diagnosis. Materials and methods: The diagnoses and dem ... Full text Cite

Chondrosarcoma

Chapter · January 1, 2015 Chondrosarcoma (CHS) represents 20-30 % of all malignant bone neoplasms and is the second most common solid malignant tumor of bone after ostegosarcoma. CHS is classifi ed as primary or secondary if the tumor arises de novo or develops in a preexisting ben ... Full text Cite

Seminal vesicle intraepithelial involvement by prostate cancer: putative mechanism and clinicopathological significance.

Journal Article Hum Pathol · September 2014 We have recently shown seminal vesicle intraepithelial involvement of prostate cancer in cases with seminal vesicle invasion (pT3b). Based on the manner of seminal vesicle invasion, there could be 2 possible mechanisms of seminal vesicle intraepithelial in ... Full text Link to item Cite

Flat pattern of nephrogenic adenoma: previously unrecognized pattern unveiled using PAX2 and PAX8 immunohistochemistry.

Journal Article Mod Pathol · June 2013 Nephrogenic adenoma is a benign lesion of the urinary tract, particularly the urinary bladder. It is a gross and microscopic mimicker of urothelial neoplasm or metastatic carcinoma. Several histological patterns (tubular, tubulocystic, polypoid, papillary, ... Full text Link to item Cite

Interpretation of lung biopsies with parasitic versus pseudoparasitic structures: Artifacts that resemble parasites and parasites that resemble artifacts

Chapter · January 1, 2013 The surgical pathologist occasionally comes across structures that raise a possible diagnosis of a parasitic disease. Parasitic diseases are common in some parts of the world but uncommon in developed countries. Therefore, most pathologists may not have en ... Full text Cite

Follicular adenoma with extensive extracellular mucin deposition: Report on two oases

Journal Article Clinical Medicine Insights: Case Reports · December 10, 2012 We report two cases of follicular adenoma of the thyroid with extensive extracellular mucin deposition. Fine needle aspiration in Case 1 showed singly discohesive polygonal cells in a granular mucinous background. They contained abundant eosinophilic cytop ... Full text Cite

Histopathology of prostate cancer

Chapter · March 14, 2012 Cite

Variants of prostate cancer

Chapter · March 14, 2012 Cite

Synchronous clear cell renal cell carcinoma and tubulocystic carcinoma: genetic evidence of independent ontogenesis and implications of chromosomal imbalances in tumor progression.

Journal Article Diagn Pathol · February 27, 2012 UNLABELLED: Seven percent of renal cell carcinoma (RCC) cases are diagnosed as "unclassified" RCC by morphology. Genetic profiling of RCCs helps define renal tumor subtypes, especially in cases where morphologic diagnosis is inconclusive. This report descr ... Full text Link to item Cite

CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells.

Journal Article FASEB J · July 2010 MicroRNA-mediated regulation of gene expression appears to be involved in a variety of cellular processes, including development, differentiation, proliferation, and apoptosis. Mir-146a is thought to be involved in the regulation of the innate immune respo ... Full text Link to item Cite

Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy.

Journal Article Brain Pathol · March 2010 Although leptin and its receptor (ObR) have emerged as important cancer biomarkers, the role of the leptin system in brain tumor development remains unknown. We screened 87 human brain tumor biopsies using immunohistochemistry and detected leptin and ObR i ... Full text Link to item Cite

Bone marrow-derived mesenchymal stem cells undergo JCV T-antigen mediated transformation and generate tumors with neuroectodermal characteristics.

Journal Article Cancer Biol Ther · February 2010 There is now accumulating evidence showing that some tumors may arise from transformed stem cells. In this study we demonstrate that adult bone marrow- derived mesenchymal stem cells (MSCs) undergo neoplastic transformation induced by the human polyomaviru ... Full text Link to item Cite

Induction of an antiinflammatory effect and prevention of cartilage damage in rat knee osteoarthritis by CF101 treatment.

Journal Article Arthritis Rheum · October 2009 OBJECTIVE: Studies have suggested that rheumatoid arthritis (RA) and osteoarthritis (OA) share common characteristics. The highly selective A(3) adenosine receptor agonist CF101 was recently defined as a potent antiinflammatory agent for the treatment of R ... Full text Link to item Cite

Hypoxia inducible factor-1 alpha activation of the JCV promoter: role in the pathogenesis of progressive multifocal leukoencephalopathy.

Journal Article Acta Neuropathol · August 2009 Activation of viral promoter transcription is a crucial event in the life cycle of several viruses. Hypoxia inducible factor-1 alpha (HIF-1alpha) is an inducible transcription factor whose activity is dependent on environmental conditions, most notably oxy ... Full text Link to item Cite

Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis.

Journal Article J Biol Chem · June 12, 2009 Glomerular visceral epithelial cells (podocytes) play a critical role in the pathogenesis of human immunodeficiency virus (HIV)-associated nephropathy. A key question concerns the mechanism(s) by which the HIV-1 genome alters the phenotype of the highly sp ... Full text Link to item Cite

Immunohistochemical characterization of Renaut bodies in superficial digital nerves: further evidence supporting their perineurial cell origin.

Journal Article J Peripher Nerv Syst · March 2009 Renaut bodies are well-demarcated cylindrical (circular in cross section) hyaline structures attached to the inner layer of the perineurium that can be found in normal and pathological nerves of various animals and humans. They are composed of spidery fibr ... Full text Link to item Cite

Primary adamantinoma of the rib. Unusual presentation for a bone neoplasm of uncertain origin.

Journal Article Pathol Oncol Res · December 2008 Adamantinomas are rare, low-grade malignant intra-osseous tumors composed of epithelial and mesenchymal elements, which show a marked predilection for the tibia and fibula of young adult male patients. Although cases of adamantinoma located to the axial sk ... Full text Link to item Cite

The normal and neoplastic perineurium: a review.

Journal Article Adv Anat Pathol · May 2008 Peripheral nerves consist of 3 layers with differing characteristics: the endoneurium, perineurium, and epineurium. The perineurium represents a continuum with the pia-arachnoid from the central nervous system and extends distally with the sheath of capsul ... Full text Link to item Cite

[Diagnosis of early gastric marginal zone lymphoma (MALT lymphoma) in endoscopic biopsies. Report of a case that demonstrates the utility of immunohistochemistry and the molecular analysis.].

Journal Article Rev Gastroenterol Mex · 2008 MALT lymphomas are a subtype of low grade lymphomas that represent 7-8% of all B-cell lymphomas originated in extranodal sites. Nearly 50% of the cases present as primary gastric lymphomas.They arise from the acquired MALT developed during the course of H. ... Link to item Cite

CD4+/CD56+ hematodermic neoplasm: presentation of 2 cases and review of the concept of an uncommon tumor originated in plasmacytoid dendritic cells expressing CD123 (IL-3 receptor alpha).

Journal Article Appl Immunohistochem Mol Morphol · December 2007 CD4/CD56 hematodermic neoplasm is a rare neoplasm presenting with cutaneous nodules, lymphadenopathy, bone marrow infiltration, and an aggressive clinical course. Recently, the plasmacytoid dendritic cell origin of this neoplasm has been demonstrated. Plas ... Full text Link to item Cite

Effects of JC virus infection on anti-apoptotic protein survivin in progressive multifocal leukoencephalopathy.

Journal Article Am J Pathol · April 2007 Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease of the central nervous system resulting from the productive infection of oligodendrocytes by the opportunistic polyomavirus JC virus (JCV). Apoptosis is a host defense mechan ... Full text Link to item Cite

[Historical development and current concepts on B-cell lymphomas of the marginal extraganglionar site of lymphoid tissue associated with MALT lymphoma. A tribute to Dennis H Wright and Peter G Isaacson].

Journal Article Gac Med Mex · 2007 Significant advances in the understanding of marginal zone lymphoma since the first description in 1983 by Peter Isaacson and Dennis Wright have been noted. MALT lymphomas are a subgroup of low-grade B-cell lymphomas that arise from extranodal sites, compr ... Link to item Cite

Glioblastoma multiforme with small cell neuronal-like component: association with human neurotropic JC virus.

Journal Article Acta Neuropathol · April 2006 The human polyomavirus JCV, the etiological agent of progressive multifocal leukoencephalopathy, has been associated with primitive neuroectodermal tumors and various glial-derived tumors, including glioblastoma multiforme (GBM). Here we describe the uniqu ... Full text Link to item Cite

HIV disorders of the brain: pathology and pathogenesis.

Journal Article Front Biosci · January 1, 2006 Infection with HIV-1 has spread exponentially in recent years to reach alarming proportions. It is estimated than more than 33 million adults and 1.3 million children are infected worldwide. Approximately 16,000 new cases are diagnosed every day and almost ... Full text Link to item Cite