Overview
Current Appointments & Affiliations
Professor Emeritus of Psychiatry and Behavioral Sciences
·
2016 - Present
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences,
Psychiatry & Behavioral Sciences
Recent Publications
Integrated stress response plasticity governs normal cell adaptation to chronic stress via the PP2A-TFE3-ATF4 pathway.
Journal Article Cell Death Differ · December 2024 The integrated stress response (ISR) regulates cell fate during conditions of stress by leveraging the cell's capacity to endure sustainable and efficient adaptive stress responses. Protein phosphatase 2A (PP2A) activity modulation has been shown to be suc ... Full text Link to item CitePromISR-6, a Guanabenz Analogue, Improves Cellular Survival in an Experimental Model of Huntington's Disease.
Journal Article ACS Chem Neurosci · August 21, 2019 Guanabenz (GBZ), an α2-adrenergic agonist, demonstrated off-target effects that restored protein homeostasis and ameliorated pathobiology in experimental models of neurodegenerative disease. However, GBZ did not directly activate the integrated stress resp ... Full text Link to item CiteProtein Phosphatase 1α and Cofilin Regulate Nuclear Translocation of NF-κB and Promote Expression of the Anti-Inflammatory Cytokine Interleukin-10 by T Cells.
Journal Article Mol Cell Biol · November 15, 2018 While several protein serine/threonine kinases control cytokine production by T cells, the roles of serine/threonine phosphatases are largely unexplored. Here, we analyzed the involvement of protein phosphatase 1α (PP1α) in cytokine synthesis following cos ... Full text Open Access Link to item CiteRecent Grants
Phosphatase Inhibitor 1, An Amplifier of cAMP Signals
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1997 - 2007Protein Phosphatase-1 - Targeting the Cytoskeleton
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2001 - 2007The molecular basis of secretory diarrhea
ResearchConsultant · Awarded by National Institutes of Health · 1999 - 2005View All Grants
Education, Training & Certifications
University of Leeds (United Kingdom) ·
1975
Ph.D.
University College London (United Kingdom) ·
1971
B.S.