Shirish Shenolikar
Professor Emeritus of Psychiatry and Behavioral Sciences
Protein phosphorylation controls a wide range of physiological processes in mammalian tissues. Phosphorylation state of cellular proteins is controlled by the opposing actions of protein kinases and phosphatases that are regulated by hormones, neurotransmitters, growth factors and other environmental cues. Our research attempts to understand the communication between protein kinases and phosphatases that dictates cellular protein phosphorylation and the cell's response to hormones. Over the last decade, our work has provided critical information about the role of protein phosphatase-1 (PP1) in controlling synaptic function, cell stress, gene expression and growth. We have generated a large repertoire of reagents to decipher PP1's role in signaling pathways in mammalian cells and tissues. Emerging evidence suggests that in many cells, PP1 activity is fine tuned by the protein, inhibitor-1 (I-1). A major focus of our research is to elucidate the role of I-1 in kinase-phosphatase cross-talk and impact of the altered I-1 gene expression seen in several human diseases. Our studies showed that recognition of cellular substrates by PP1 is also directed by its association with a variety of targeting subunits that are themselves also subject to physiological control. Thus, the overall focus of our research is to define the physiological mechanisms that regulate PP1 functions relevant to human health and disease.
Current Appointments & Affiliations
- Professor Emeritus of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences 2016
Contact Information
- 3412 East Dobson Place, Ann Arbor, MI 48105
- Box 3813 Med Ctr, Durham, NC 27710
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sheno001@mc.duke.edu
(734) 355-0821
- Background
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Education, Training, & Certifications
- Ph.D., University of Leeds (United Kingdom) 1975
- B.S., University College London (United Kingdom) 1971
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Previous Appointments & Affiliations
- Adjunct Professor in the Department of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2016 - 2017
- Research Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2008 - 2016
- Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2013 - 2016
- Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2008 - 2013
- Adjunct Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2005 - 2008
- Assistant Research Professor in Medicine, Medicine, Cardiology, Medicine 1999 - 2004
- Professor of Pharmacology & Cancer Biology with Tenure, Pharmacology & Cancer Biology, Basic Science Departments 2000 - 2004
- Associate Professor of Pharmacology & Cancer Biology with Tenure, Pharmacology & Cancer Biology, Basic Science Departments 1992 - 2000
- Assistant Research Professor in Medicine, Medicine, Clinical Science Departments 1994 - 1999
- Research
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Selected Grants
- Phosphatase Inhibitor 1, An Amplifier of cAMP Signals awarded by National Institutes of Health 1997 - 2007
- Protein Phosphatase-1 - Targeting the Cytoskeleton awarded by National Institutes of Health 2001 - 2007
- The molecular basis of secretory diarrhea awarded by National Institutes of Health 1999 - 2005
- BIACORE 3000 Biosensor awarded by National Institutes of Health 2002 - 2003
- Phosphatase Inhibitor-1, An Amplifier Of Camp Signals awarded by National Institutes of Health 1997 - 1999
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Sundaram, Jeyapriya Rajameenakshi, Yilong Wu, Irene Chengjie Lee, Simi Elizabeth George, Monalisa Hota, Sujoy Ghosh, Sashi Kesavapany, Mahmood Ahmed, Eng-King Tan, and Shirish Shenolikar. “PromISR-6, a Guanabenz Analogue, Improves Cellular Survival in an Experimental Model of Huntington's Disease.” Acs Chem Neurosci 10, no. 8 (August 21, 2019): 3575–89. https://doi.org/10.1021/acschemneuro.9b00185.Full Text Link to Item
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Wabnitz, Guido H., Henning Kirchgessner, Beate Jahraus, Ludmila Umansky, Shirish Shenolikar, and Yvonne Samstag. “Protein Phosphatase 1α and Cofilin Regulate Nuclear Translocation of NF-κB and Promote Expression of the Anti-Inflammatory Cytokine Interleukin-10 by T Cells.” Mol Cell Biol 38, no. 22 (November 15, 2018). https://doi.org/10.1128/MCB.00041-18.Full Text Open Access Copy Link to Item
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Brautigan, David L., and Shirish Shenolikar. “Protein Serine/Threonine Phosphatases: Keys to Unlocking Regulators and Substrates.” Annu Rev Biochem 87 (June 20, 2018): 921–64. https://doi.org/10.1146/annurev-biochem-062917-012332.Full Text Open Access Copy Link to Item
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Lee, Irene Chengjie, Xue Yan Ho, Simi Elizabeth George, Catherine Wenhui Goh, Jeyapriya Rajameenakshi Sundaram, Karen Ka Lam Pang, Weiwei Luo, Permeen Yusoff, Newman Siu Kwan Sze, and Shirish Shenolikar. “Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function.” Cell Death Differ 25, no. 2 (February 2018): 255–67. https://doi.org/10.1038/cdd.2017.152.Full Text Open Access Copy Link to Item
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Goh, Catherine Wenhui, Irene Chengjie Lee, Jeyapriya Rajameenakshi Sundaram, Simi Elizabeth George, Permeen Yusoff, Matthew Hayden Brush, Newman Siu Kwan Sze, and Shirish Shenolikar. “Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration.” J Biol Chem 293, no. 1 (January 5, 2018): 163–76. https://doi.org/10.1074/jbc.M117.814111.Full Text Open Access Copy Link to Item
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Shenolikar, Shirish. “A SMAP in the face for cancer.” J Clin Invest 127, no. 6 (June 1, 2017): 2048–50. https://doi.org/10.1172/JCI94763.Full Text Open Access Copy Link to Item
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Sundaram, Jeyapriya R., Irene C. J. Lee, and Shirish Shenolikar. “Translating protein phosphatase research into treatments for neurodegenerative diseases.” Biochem Soc Trans 45, no. 1 (February 8, 2017): 101–12. https://doi.org/10.1042/BST20160157.Full Text Link to Item
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Reid, David W., Angeline S. L. Tay, Jeyapriya R. Sundaram, Irene C. J. Lee, Qiang Chen, Simi E. George, Christopher V. Nicchitta, and Shirish Shenolikar. “Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response.” Mol Cell Biol 36, no. 13 (July 1, 2016): 1868–80. https://doi.org/10.1128/MCB.00190-16.Full Text Open Access Copy Link to Item
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Reid, David W., Shirish Shenolikar, and Christopher V. Nicchitta. “Simple and inexpensive ribosome profiling analysis of mRNA translation.” Methods 91 (December 2015): 69–74. https://doi.org/10.1016/j.ymeth.2015.07.003.Full Text Open Access Copy Link to Item
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Choy, Meng S., Permeen Yusoff, Irene C. Lee, Jocelyn C. Newton, Catherine W. Goh, Rebecca Page, Shirish Shenolikar, and Wolfgang Peti. “Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.” Cell Rep 11, no. 12 (June 30, 2015): 1885–91. https://doi.org/10.1016/j.celrep.2015.05.043.Full Text Open Access Copy Link to Item
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Reid, David W., Qiang Chen, Angeline S-L Tay, Shirish Shenolikar, and Christopher V. Nicchitta. “The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum.” Cell 158, no. 6 (September 11, 2014): 1362–74. https://doi.org/10.1016/j.cell.2014.08.012.Full Text Open Access Copy Link to Item
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Shenolikar, Shirish. “Dangerous liaisons: flirtations between oncogenic BRAF and GRP78 in drug-resistant melanomas.” J Clin Invest 124, no. 3 (March 2014): 973–76. https://doi.org/10.1172/JCI74609.Full Text Open Access Copy Link to Item
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Zhou, Wei, Krishna Jeyaraman, Permeen Yusoff, and Shirish Shenolikar. “Phosphorylation at tyrosine 262 promotes GADD34 protein turnover.” J Biol Chem 288, no. 46 (November 15, 2013): 33146–55. https://doi.org/10.1074/jbc.M113.504407.Full Text Open Access Copy Link to Item
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Fullwood, Melissa J., Wei Zhou, and Shirish Shenolikar. “Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease.” Prog Mol Biol Transl Sci 106 (2012): 75–106. https://doi.org/10.1016/B978-0-12-396456-4.00005-5.Full Text Open Access Copy Link to Item
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Weinman, Edward J., Deborah Steplock, Shirish Shenolikar, and Rajatsubhra Biswas. “Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone.” J Biol Chem 286, no. 43 (October 28, 2011): 37216–21. https://doi.org/10.1074/jbc.M111.288357.Full Text Open Access Copy Link to Item
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Zhou, Wei, Matthew H. Brush, Meng S. Choy, and Shirish Shenolikar. “Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein.” J Biol Chem 286, no. 24 (June 17, 2011): 21687–96. https://doi.org/10.1074/jbc.M110.212787.Full Text Open Access Copy Link to Item
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Weinman, Edward J., Rajatsubhra Biswas, Deborah Steplock, Peili Wang, Yuen-Sum Lau, Gary V. Desir, and Shirish Shenolikar. “Increased renal dopamine and acute renal adaptation to a high-phosphate diet.” Am J Physiol Renal Physiol 300, no. 5 (May 2011): F1123–29. https://doi.org/10.1152/ajprenal.00744.2010.Full Text Open Access Copy Link to Item
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Fullwood, Melissa J., Joanne Lee, Lifang Lin, Guoliang Li, Mikael Huss, Patrick Ng, Wing-Kin Sung, and Shirish Shenolikar. “Next-generation sequencing of apoptotic DNA breakpoints reveals association with actively transcribed genes and gene translocations.” Plos One 6, no. 11 (2011): e26054. https://doi.org/10.1371/journal.pone.0026054.Full Text Open Access Copy Link to Item
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Weinman, Edward J., Deborah Steplock, Shirish Shenolikar, and Thomas A. Blanpied. “Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells.” Am J Physiol Renal Physiol 300, no. 1 (January 2011): F231–35. https://doi.org/10.1152/ajprenal.00532.2010.Full Text Open Access Copy Link to Item
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Weinman, Edward J., Deborah Steplock, Yinghua Zhang, Rajatsubhra Biswas, Robert J. Bloch, and Shirish Shenolikar. “Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport.” J Biol Chem 285, no. 33 (August 13, 2010): 25134–38. https://doi.org/10.1074/jbc.M110.132423.Full Text Open Access Copy Link to Item
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Cunningham, Rochelle, Rajatsubhra Biswas, Deborah Steplock, Shirish Shenolikar, and Edward Weinman. “Role of NHERF and scaffolding proteins in proximal tubule transport.” Urol Res 38, no. 4 (August 2010): 257–62. https://doi.org/10.1007/s00240-010-0294-1.Full Text Open Access Copy Link to Item
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Weinman, Edward J., Rajatsubhra Biswas, Deborah Steplock, Tia S. Douglass, Rochelle Cunningham, and Shirish Shenolikar. “Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney.” J Biol Chem 285, no. 18 (April 30, 2010): 13454–60. https://doi.org/10.1074/jbc.M109.094359.Full Text Link to Item
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Weinman, Edward J., Deborah Steplock, Boyoung Cha, Olga Kovbasnjuk, Nicholas A. Frost, Rochelle Cunningham, Shirish Shenolikar, Thomas A. Blanpied, and Mark Donowitz. “PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP.” Am J Physiol Renal Physiol 297, no. 6 (December 2009): F1560–65. https://doi.org/10.1152/ajprenal.90657.2008.Full Text Link to Item
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Virshup, David M., and Shirish Shenolikar. “From promiscuity to precision: protein phosphatases get a makeover.” Mol Cell 33, no. 5 (March 13, 2009): 537–45. https://doi.org/10.1016/j.molcel.2009.02.015.Full Text Link to Item
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Cunningham, Rochelle, Rajatsubhra Biswas, Marc Brazie, Deborah Steplock, Shirish Shenolikar, and Edward J. Weinman. “Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells.” Am J Physiol Renal Physiol 296, no. 2 (February 2009): F355–61. https://doi.org/10.1152/ajprenal.90426.2008.Full Text Link to Item
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Brush, Matthew H., and Shirish Shenolikar. “Control of cellular GADD34 levels by the 26S proteasome.” Mol Cell Biol 28, no. 23 (December 2008): 6989–7000. https://doi.org/10.1128/MCB.00724-08.Full Text Link to Item
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Cunningham, Rochelle, Ali Esmaili, Eric Brown, Rajat S. Biswas, Rakhilya Murtazina, Mark Donowitz, Henry B. Dijkman, et al. “Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice.” Am J Physiol Renal Physiol 294, no. 4 (April 2008): F1001–7. https://doi.org/10.1152/ajprenal.00504.2007.Full Text Link to Item
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Voltz, J. W., M. Brush, S. Sikes, D. Steplock, E. J. Weinman, and S. Shenolikar. “Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets. (Journal of Biological Chemistry (2007) 282 (33879-33887)).” Journal of Biological Chemistry 283, no. 7 (February 15, 2008): 4459.
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Voltz, James W., Matthew Brush, Suzanne Sikes, Deborah Steplock, Edward J. Weinman, and Shirish Shenolikar. “Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets (vol 283, pg 33879, 2007).” Journal of Biological Chemistry 283, no. 7 (February 15, 2008): 4459–4459.Link to Item
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MacIntyre, N. R. “Preface.” Clinics in Chest Medicine 29, no. 2 (January 1, 2008): 13. https://doi.org/10.1016/j.ccm.2008.02.005.Full Text
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Broere, Nellie, Jutta Hillesheim, Biguang Tuo, Huub Jorna, Adriaan B. Houtsmuller, Shirish Shenolikar, Edward J. Weinman, et al. “Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice.” J Biol Chem 282, no. 52 (December 28, 2007): 37575–84. https://doi.org/10.1074/jbc.M704878200.Full Text Link to Item
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Voltz, James W., Matthew Brush, Suzanne Sikes, Deborah Steplock, Edward J. Weinman, and Shirish Shenolikar. “Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets.” J Biol Chem 282, no. 46 (November 16, 2007): 33879–87. https://doi.org/10.1074/jbc.M703481200.Full Text Link to Item
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Weinman, Edward J., Rajat S. Biswas, Guihong Peng, Lily Shen, Christina L. Turner, Xiaofei E, Deborah Steplock, Shirish Shenolikar, and Rochelle Cunningham. “Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1.” J Clin Invest 117, no. 11 (November 2007): 3412–20. https://doi.org/10.1172/JCI32738.Full Text Link to Item
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Gibbons, Jennifer A., Lukasz Kozubowski, Kelly Tatchell, and Shirish Shenolikar. “Expression of human protein phosphatase-1 in Saccharomyces cerevisiae highlights the role of phosphatase isoforms in regulating eukaryotic functions.” J Biol Chem 282, no. 30 (July 27, 2007): 21838–47. https://doi.org/10.1074/jbc.M701272200.Full Text Link to Item
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Cunningham, David, Dennis E. Danley, Kieran F. Geoghegan, Matthew C. Griffor, Julie L. Hawkins, Timothy A. Subashi, Alison H. Varghese, et al. “Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia.” Nat Struct Mol Biol 14, no. 5 (May 2007): 413–19. https://doi.org/10.1038/nsmb1235.Full Text Link to Item
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Cunningham, Rochelle, Marc Brazie, Srilatha Kanumuru, Xiaofei E, Rajat Biswas, Fengying Wang, Deborah Steplock, et al. “Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport.” J Am Soc Nephrol 18, no. 5 (May 2007): 1419–25. https://doi.org/10.1681/ASN.2006090980.Full Text Link to Item
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Capuano, Paola, Desa Bacic, Marcel Roos, Serge M. Gisler, Gerti Stange, Jürg Biber, Brigitte Kaissling, et al. “Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice.” Am J Physiol Cell Physiol 292, no. 2 (February 2007): C927–34. https://doi.org/10.1152/ajpcell.00126.2006.Full Text Link to Item
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Roadcap, David W., Matthew H. Brush, and Shirish Shenolikar. “Identification of cellular protein phosphatase-1 regulators.” Methods Mol Biol 365 (2007): 181–96. https://doi.org/10.1385/1-59745-267-X:181.Full Text Link to Item
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Shenolikar, Shirish. “Analysis of protein phosphatases: toolbox for unraveling cell signaling networks.” Methods Mol Biol 365 (2007): 1–8. https://doi.org/10.1385/1-59745-267-X:1.Full Text Link to Item
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Mansuy, Isabelle M., and Shirish Shenolikar. “Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memory.” Trends Neurosci 29, no. 12 (December 2006): 679–86. https://doi.org/10.1016/j.tins.2006.10.004.Full Text Link to Item
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Margolis, Seth S., Jennifer A. Perry, Craig M. Forester, Leta K. Nutt, Yanxiang Guo, Melanie J. Jardim, Michael J. Thomenius, et al. “Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.” Cell 127, no. 4 (November 17, 2006): 759–73. https://doi.org/10.1016/j.cell.2006.10.035.Full Text Link to Item
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Cunningham, Rochelle, Deborah Steplock, Xiaofei E, Rajat S. Biswas, Fengying Wang, Shirish Shenolikar, and Edward J. Weinman. “Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone.” Am J Physiol Renal Physiol 291, no. 4 (October 2006): F896–901. https://doi.org/10.1152/ajprenal.00036.2006.Full Text Link to Item
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Hu, Xiao Dong, Qing Huang, David W. Roadcap, Shirish S. Shenolikar, and Houhui Xia. “Actin-associated neurabin-protein phosphatase-1 complex regulates hippocampal plasticity.” J Neurochem 98, no. 6 (September 2006): 1841–51. https://doi.org/10.1111/j.1471-4159.2006.04070.x.Full Text Link to Item
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Weinman, Edward J., Viresh Mohanlal, Nicholas Stoycheff, Fengying Wang, Deborah Steplock, Shirish Shenolikar, and Rochelle Cunningham. “Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice.” Am J Physiol Renal Physiol 290, no. 4 (April 2006): F838–43. https://doi.org/10.1152/ajprenal.00374.2005.Full Text Link to Item
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Weinman, Edward J., Randy A. Hall, Peter A. Friedman, Lee-Yuan Liu-Chen, and Shirish Shenolikar. “The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases.” Annu Rev Physiol 68 (2006): 491–505. https://doi.org/10.1146/annurev.physiol.68.040104.131050.Full Text Link to Item
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Weinman, E. J., V. Mohanlal, N. Stoycheff, F. Wang, D. Steplock, S. Shenolikar, and R. Cunningham. “Erratum: Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice (American Journal of Physiology - Renal Physiology (2006) 290, (F838-F843) DOI: 10.1152/ajprenal.00374.2005).” American Journal of Physiology Renal Physiology 291, no. 1 (January 1, 2006). https://doi.org/10.1152/ajprenal.00121.2006.Full Text
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Cunningham, Rochelle, Xiaofei E, Deborah Steplock, Shirish Shenolikar, and Edward J. Weinman. “Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media.” Am J Physiol Renal Physiol 289, no. 4 (October 2005): F933–38. https://doi.org/10.1152/ajprenal.00005.2005.Full Text Link to Item
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Weinman, Edward J., Rochelle Cunningham, James B. Wade, and Shirish Shenolikar. “The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a.” J Physiol 567, no. Pt 1 (August 15, 2005): 27–32. https://doi.org/10.1113/jphysiol.2005.086777.Full Text Link to Item
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Weinman, Edward J., Rochelle Cunningham, and Shirish Shenolikar. “NHERF and regulation of the renal sodium-hydrogen exchanger NHE3.” Pflugers Arch 450, no. 3 (June 2005): 137–44. https://doi.org/10.1007/s00424-005-1384-8.Full Text Link to Item
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Terry-Lorenzo, Ryan T., David W. Roadcap, Takeshi Otsuka, Thomas A. Blanpied, Pedro L. Zamorano, Craig C. Garner, Shirish Shenolikar, and Michael D. Ehlers. “Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation.” Mol Biol Cell 16, no. 5 (May 2005): 2349–62. https://doi.org/10.1091/mbc.e04-12-1054.Full Text Link to Item
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Gibbons, Jennifer A., Douglas C. Weiser, and Shirish Shenolikar. “Importance of a surface hydrophobic pocket on protein phosphatase-1 catalytic subunit in recognizing cellular regulators.” J Biol Chem 280, no. 16 (April 22, 2005): 15903–11. https://doi.org/10.1074/jbc.M500871200.Full Text Link to Item
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Shenolikar, Shirish, James W. Voltz, Rochelle Cunningham, and Edward J. Weinman. “Regulation of ion transport by the NHERF family of PDZ proteins.” Physiology (Bethesda) 19 (December 2004): 362–69. https://doi.org/10.1152/physiol.00020.2004.Full Text Link to Item
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Weiser, Douglas C., Suzanne Sikes, Shi Li, and Shirish Shenolikar. “The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms.” J Biol Chem 279, no. 47 (November 19, 2004): 48904–14. https://doi.org/10.1074/jbc.M404416200.Full Text Link to Item
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Zito, Karen, Graham Knott, Gordon M. G. Shepherd, Shirish Shenolikar, and Karel Svoboda. “Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton.” Neuron 44, no. 2 (October 14, 2004): 321–34. https://doi.org/10.1016/j.neuron.2004.09.022.Full Text Link to Item
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Cunningham, Rochelle, Deborah Steplock, Fengying Wang, Huijun Huang, Xiaofei E, Shirish Shenolikar, and Edward J. Weinman. “Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells.” J Biol Chem 279, no. 36 (September 3, 2004): 37815–21. https://doi.org/10.1074/jbc.M405893200.Full Text Link to Item
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Yeh, Elizabeth, Melissa Cunningham, Hugh Arnold, Dawn Chasse, Teresa Monteith, Giovanni Ivaldi, William C. Hahn, et al. “A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells.” Nat Cell Biol 6, no. 4 (April 2004): 308–18. https://doi.org/10.1038/ncb1110.Full Text Link to Item
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Brush, Matthew H., Amaris Guardiola, John H. Connor, Tso-Pang Yao, and Shirish Shenolikar. “Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases.” J Biol Chem 279, no. 9 (February 27, 2004): 7685–91. https://doi.org/10.1074/jbc.M310997200.Full Text Link to Item
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Wade, James B., Jie Liu, Richard A. Coleman, Rochelle Cunningham, Deborah A. Steplock, Whaseon Lee-Kwon, Thomas L. Pallone, Shirish Shenolikar, and Edward J. Weinman. “Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse.” Am J Physiol Cell Physiol 285, no. 6 (December 2003): C1494–1503. https://doi.org/10.1152/ajpcell.00092.2003.Full Text Link to Item
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Weinman, Edward J., Anuradha Boddeti, Rochelle Cunningham, Michael Akom, Fengying Wang, Yu Wang, Jie Liu, Deborah Steplock, Shirish Shenolikar, and James B. Wade. “NHERF-1 is required for renal adaptation to a low-phosphate diet.” Am J Physiol Renal Physiol 285, no. 6 (December 2003): F1225–32. https://doi.org/10.1152/ajprenal.00215.2003.Full Text Link to Item
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Weinman, Edward J., Yu Wang, Fengying Wang, Charmaine Greer, Deborah Steplock, and Shirish Shenolikar. “A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange.” Biochemistry 42, no. 43 (November 4, 2003): 12662–68. https://doi.org/10.1021/bi035244l.Full Text Link to Item
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Margolis, Seth S., Susan Walsh, Douglas C. Weiser, Minoru Yoshida, Shirish Shenolikar, and Sally Kornbluth. “PP1 control of M phase entry exerted through 14-3-3-regulated Cdc25 dephosphorylation.” Embo J 22, no. 21 (November 3, 2003): 5734–45. https://doi.org/10.1093/emboj/cdg545.Full Text Link to Item
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Leach, Craig, Shirish Shenolikar, and David L. Brautigan. “Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis.” J Biol Chem 278, no. 28 (July 11, 2003): 26015–20. https://doi.org/10.1074/jbc.M300782200.Full Text Link to Item
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Weiser, Douglas C., and Shirish Shenolikar. “Use of protein phosphatase inhibitors.” Curr Protoc Protein Sci Chapter 13 (May 2003): Unit-13.10. https://doi.org/10.1002/0471140864.ps1310s31.Full Text Link to Item
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Weiser, Douglas C., and Shirish Shenolikar. “Use of protein phosphatase inhibitors.” Curr Protoc Mol Biol Chapter 18 (May 2003): Unit-18.10. https://doi.org/10.1002/0471142727.mb1810s62.Full Text Link to Item
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Weinman, Edward J., Deborah Steplock, and Shirish Shenolikar. “NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes.” Febs Lett 536, no. 1–3 (February 11, 2003): 141–44. https://doi.org/10.1016/s0014-5793(03)00043-7.Full Text Link to Item
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Brush, Matthew H., Douglas C. Weiser, and Shirish Shenolikar. “Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.” Mol Cell Biol 23, no. 4 (February 2003): 1292–1303. https://doi.org/10.1128/MCB.23.4.1292-1303.2003.Full Text Link to Item
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Kang-Park, Maeng-Hee, Meredith A. Sarda, Katherine H. Jones, Scott D. Moore, Shirish Shenolikar, Suzanne Clark, and Wilkie A. Wilson. “Protein phosphatases mediate depotentiation induced by high-intensity theta-burst stimulation.” J Neurophysiol 89, no. 2 (February 2003): 684–90. https://doi.org/10.1152/jn.01041.2001.Full Text Link to Item
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Terry-Lorenzo, Ryan T., Elizabeth Elliot, Douglas C. Weiser, Todd D. Prickett, David L. Brautigan, and Shirish Shenolikar. “Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton.” J Biol Chem 277, no. 48 (November 29, 2002): 46535–43. https://doi.org/10.1074/jbc.M206960200.Full Text Link to Item
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Weinman, E. J., J. B. Wade, J. W. Voltz, and S. Shenolikar. “Disruption of the mouse gene encoding NHERF-1, results in renal phosphate wasting.” Journal of the American Society of Nephrology 13 (September 1, 2002): 10A-10A.Link to Item
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Shenolikar, S., J. W. Voltz, C. M. Minkoff, J. B. Wade, and E. J. Weinman. “Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting.” Proc Natl Acad Sci U S A 99, no. 17 (August 20, 2002): 11470–75. https://doi.org/10.1073/pnas.162232699.Full Text Link to Item
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Terry-Lorenzo, Ryan T., Leigh C. Carmody, James W. Voltz, John H. Connor, Shi Li, F Donelson Smith, Sharon L. Milgram, Roger J. Colbran, and Shirish Shenolikar. “The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits.” J Biol Chem 277, no. 31 (August 2, 2002): 27716–24. https://doi.org/10.1074/jbc.M203365200.Full Text Link to Item
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Oliver, Carey J., Ryan T. Terry-Lorenzo, Elizabeth Elliott, Wendy A Christensen Bloomer, Shi Li, David L. Brautigan, Roger J. Colbran, and Shirish Shenolikar. “Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology.” Mol Cell Biol 22, no. 13 (July 2002): 4690–4701. https://doi.org/10.1128/MCB.22.13.4690-4701.2002.Full Text Link to Item
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Morishita, W., J. H. Connor, H. Xia, E. M. Quinlan, S. Shenolikar, and R. C. Malenka. “Regulation of synaptic strength by protein phosphatase 1.” Neuron 32, no. 6 (December 20, 2001): 1133–48. https://doi.org/10.1016/s0896-6273(01)00554-2.Full Text Link to Item
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Weinman, E. J., C. M. Evangelista, D. Steplock, M. Z. Liu, S. Shenolikar, and A. Bernardo. “Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells.” J Biol Chem 276, no. 45 (November 9, 2001): 42339–46. https://doi.org/10.1074/jbc.M106153200.Full Text Link to Item
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Connor, J. H., D. C. Weiser, S. Li, J. M. Hallenbeck, and S. Shenolikar. “Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.” Mol Cell Biol 21, no. 20 (October 2001): 6841–50. https://doi.org/10.1128/MCB.21.20.6841-6850.2001.Full Text Link to Item
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Voltz, J. W., E. J. Weinman, and S. Shenolikar. “Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation.” Oncogene 20, no. 44 (October 1, 2001): 6309–14. https://doi.org/10.1038/sj.onc.1204774.Full Text Link to Item
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Weinman, E. J., D. Steplock, and S. Shenolikar. “Acute regulation of NHE3 by protein kinase A requires a multiprotein signal complex.” Kidney Int 60, no. 2 (August 2001): 450–54. https://doi.org/10.1046/j.1523-1755.2001.060002450.x.Full Text Link to Item
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Weinman, E. J., D. Steplock, J. B. Wade, and S. Shenolikar. “Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells.” Am J Physiol Renal Physiol 281, no. 2 (August 2001): F374–80. https://doi.org/10.1152/ajprenal.2001.281.2.F374.Full Text Link to Item
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Sefton, B. M., and S. Shenolikar. “Overview of protein phosphorylation.” Curr Protoc Mol Biol Chapter 18 (May 2001): Unit-18.1. https://doi.org/10.1002/0471142727.mb1801s33.Full Text Link to Item
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Sefton, B. M., and S. Shenolikar. “Overview of protein phosphorylation.” Curr Protoc Protein Sci Chapter 13 (May 2001): Unit13.1. https://doi.org/10.1002/0471140864.ps1301s00.Full Text Link to Item
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Shenolikar, S. “Detection of phosphorylation by enzymatic techniques.” Curr Protoc Mol Biol Chapter 18 (May 2001): Unit-18.5. https://doi.org/10.1002/0471142727.mb1805s33.Full Text Link to Item
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Shenolikar, S. “Detection of phosphorylation by enzymatic techniques.” Curr Protoc Protein Sci Chapter 13 (May 2001): Unit13.5. https://doi.org/10.1002/0471140864.ps1305s05.Full Text Link to Item
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Schillace, R. V., J. W. Voltz, A. T. Sim, S. Shenolikar, and J. D. Scott. “Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation.” J Biol Chem 276, no. 15 (April 13, 2001): 12128–34. https://doi.org/10.1074/jbc.M010398200.Full Text Link to Item
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Watanabe, T., H. B. Huang, A. Horiuchi, E. F. da Cruze Silva, L. Hsieh-Wilson, P. B. Allen, S. Shenolikar, P. Greengard, and A. C. Nairn. “Protein phosphatase 1 regulation by inhibitors and targeting subunits.” Proc Natl Acad Sci U S A 98, no. 6 (March 13, 2001): 3080–85. https://doi.org/10.1073/pnas.051003898.Full Text Link to Item
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Connor, J. H., S. Li, J. M. Hallenbeck, and S. Shenolikar. “The growth arrest and DNA-damage inducible gene product, GADD-34, recruits protein phosphatase-1 and its regulator, Inhibitor-1, to control protein synthesis.” Faseb Journal 15, no. 4 (March 7, 2001): A1–A1.Link to Item
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Chiang, C. W., G. Harris, C. Ellig, S. C. Masters, R. Subramanian, S. Shenolikar, B. E. Wadzinski, and E. Yang. “Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation.” Blood 97, no. 5 (March 1, 2001): 1289–97. https://doi.org/10.1182/blood.v97.5.1289.Full Text Link to Item
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Shenolikar, S., and E. J. Weinman. “NHERF: targeting and trafficking membrane proteins.” Am J Physiol Renal Physiol 280, no. 3 (March 2001): F389–95. https://doi.org/10.1152/ajprenal.2001.280.3.F389.Full Text Link to Item
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Shenolikar, S., C. M. Minkoff, D. A. Steplock, C. Evangelista, M. Liu, and E. J. Weinman. “N-terminal PDZ domain is required for NHERF dimerization.” Febs Lett 489, no. 2–3 (February 2, 2001): 233–36. https://doi.org/10.1016/s0014-5793(01)02109-3.Full Text Link to Item
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Wade, J. B., P. A. Welling, M. Donowitz, S. Shenolikar, and E. J. Weinman. “Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK.” Am J Physiol Cell Physiol 280, no. 1 (January 2001): C192–98. https://doi.org/10.1152/ajpcell.2001.280.1.C192.Full Text Link to Item
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Shenolikar, S., and D. L. Brautigan. “Meeting report: targeting protein phosphatases-medicines for the new millenium.” Sci Stke 2000, no. 57 (November 7, 2000): pe1. https://doi.org/10.1126/stke.2000.57.pe1.Full Text Link to Item
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Brown, G. P., R. D. Blitzer, J. H. Connor, T. Wong, S. Shenolikar, R. Iyengar, and E. M. Landau. “Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate.” J Neurosci 20, no. 21 (November 1, 2000): 7880–87. https://doi.org/10.1523/JNEUROSCI.20-21-07880.2000.Full Text Link to Item
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Shen, K., M. N. Teruel, J. H. Connor, S. Shenolikar, and T. Meyer. “Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II.” Nat Neurosci 3, no. 9 (September 2000): 881–86. https://doi.org/10.1038/78783.Full Text Link to Item
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Weinman, E. J., C. Minkoff, and S. Shenolikar. “Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA.” Am J Physiol Renal Physiol 279, no. 3 (September 2000): F393–99. https://doi.org/10.1152/ajprenal.2000.279.3.F393.Full Text Link to Item
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Connor, J. H., D. Frederick, H. B. Huang, J. Yang, N. R. Helps, P. T. Cohen, A. C. Nairn, A. DePaoli-Roach, K. Tatchell, and S. Shenolikar. “Cellular mechanisms regulating protein phosphatase-1. A key functional interaction between inhibitor-2 and the type 1 protein phosphatase catalytic subunit.” J Biol Chem 275, no. 25 (June 23, 2000): 18670–75. https://doi.org/10.1074/jbc.M909312199.Full Text Link to Item
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Weinman, E. J., D. Steplock, M. Donowitz, and S. Shenolikar. “NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3.” Biochemistry 39, no. 20 (May 23, 2000): 6123–29. https://doi.org/10.1021/bi000064m.Full Text Link to Item
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Liu, J., J. Wu, C. Oliver, S. Shenolikar, and D. L. Brautigan. “The G(M) targeting subunit of PP1 - Phosphorylation site mutations and glycogen synthase binding.” Faseb Journal 14, no. 8 (May 11, 2000): A1458–A1458.Link to Item
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Katayose, Y., M. Li, S. W. Al-Murrani, S. Shenolikar, and Z. Damuni. “Protein phosphatase 2A inhibitors, I(1)(PP2A) and I(2)(PP2A), associate with and modify the substrate specificity of protein phosphatase 1.” J Biol Chem 275, no. 13 (March 31, 2000): 9209–14. https://doi.org/10.1074/jbc.275.13.9209.Full Text Link to Item
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Liu, J., J. Wu, C. Oliver, S. Shenolikar, and D. L. Brautigan. “Mutations of the serine phosphorylated in the protein phosphatase-1-binding motif in the skeletal muscle glycogen-targeting subunit.” Biochem J 346 Pt 1, no. Pt 1 (February 15, 2000): 77–82.Link to Item
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Terry-Lorenzo, R. T., M. Inoue, J. H. Connor, T. A. Haystead, B. N. Armbruster, R. P. Gupta, C. J. Oliver, and S. Shenolikar. “Neurofilament-L is a protein phosphatase-1-binding protein associated with neuronal plasma membrane and post-synaptic density.” J Biol Chem 275, no. 4 (January 28, 2000): 2439–46. https://doi.org/10.1074/jbc.275.4.2439.Full Text Link to Item
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Weinman, E. J., D. Steplock, X. Zhang, S. Akhter, and S. Shenolikar. “Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor.” Biochim Biophys Acta 1447, no. 1 (October 6, 1999): 71–76. https://doi.org/10.1016/s0167-4781(99)00100-1.Full Text Link to Item
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Minkoff, C., S. Shenolikar, and E. J. Weinman. “Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins.” Curr Opin Nephrol Hypertens 8, no. 5 (September 1999): 603–8. https://doi.org/10.1097/00041552-199909000-00012.Full Text Link to Item
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Zizak, M., G. Lamprecht, D. Steplock, N. Tariq, S. Shenolikar, M. Donowitz, C. H. Yun, and E. J. Weinman. “cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor.” J Biol Chem 274, no. 35 (August 27, 1999): 24753–58. https://doi.org/10.1074/jbc.274.35.24753.Full Text Link to Item
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Connor, J. H., T. Kleeman, S. Barik, R. E. Honkanen, and S. Shenolikar. “Importance of the beta12-beta13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors.” J Biol Chem 274, no. 32 (August 6, 1999): 22366–72. https://doi.org/10.1074/jbc.274.32.22366.Full Text Link to Item
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Beullens, M., A. Van Eynde, V. Vulsteke, J. Connor, S. Shenolikar, W. Stalmans, and M. Bollen. “Molecular determinants of nuclear protein phosphatase-1 regulation by NIPP-1.” J Biol Chem 274, no. 20 (May 14, 1999): 14053–61. https://doi.org/10.1074/jbc.274.20.14053.Full Text Link to Item
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Hansen, L., H. Fjordvang, S. K. Rasmussen, H. Vestergaard, S. M. Echwald, T. Hansen, D. Alessi, et al. “Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients.” Diabetes 48, no. 2 (February 1999): 403–7. https://doi.org/10.2337/diabetes.48.2.403.Full Text Link to Item
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Weinman, E. J., D. Steplock, G. Lamprecht, C. H. Yun, and S. Shenolikar. “Regulation of the Na/H exchanger regulatory factor in OK cells.” Miner Electrolyte Metab 25, no. 3 (1999): 135–42. https://doi.org/10.1159/000057437.Full Text Link to Item
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Wu, J., J. Liu, I. Thompson, C. J. Oliver, S. Shenolikar, and D. L. Brautigan. “A conserved domain for glycogen binding in protein phosphatase-1 targeting subunits.” Febs Lett 439, no. 1–2 (November 13, 1998): 185–91. https://doi.org/10.1016/s0014-5793(98)01371-4.Full Text Link to Item
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Connor, J. H., H. N. Quan, N. T. Ramaswamy, L. Zhang, S. Barik, J. Zheng, J. F. Cannon, E. Y. Lee, and S. Shenolikar. “Inhibitor-1 interaction domain that mediates the inhibition of protein phosphatase-1.” J Biol Chem 273, no. 42 (October 16, 1998): 27716–24. https://doi.org/10.1074/jbc.273.42.27716.Full Text Link to Item
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Oliver, C. J., and S. Shenolikar. “Physiologic importance of protein phosphatase inhibitors.” Front Biosci 3 (September 1, 1998): D961–72. https://doi.org/10.2741/a336.Full Text Link to Item
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Blitzer, R. D., J. H. Connor, G. P. Brown, T. Wong, S. Shenolikar, R. Iyengar, and E. M. Landau. “Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP.” Science 280, no. 5371 (June 19, 1998): 1940–42. https://doi.org/10.1126/science.280.5371.1940.Full Text Link to Item
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Weinman, E. J., D. Steplock, K. Tate, R. A. Hall, R. F. Spurney, and S. Shenolikar. “Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF).” J Clin Invest 101, no. 10 (May 15, 1998): 2199–2206. https://doi.org/10.1172/JCI204.Full Text Link to Item
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Hall, R. A., R. T. Premont, C. W. Chow, J. T. Blitzer, J. A. Pitcher, A. Claing, R. H. Stoffel, et al. “The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.” Nature 392, no. 6676 (April 9, 1998): 626–30. https://doi.org/10.1038/33458.Full Text Link to Item
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Connor, J. H., H. Quan, C. Oliver, and S. Shenolikar. “Inhibitor-1, a regulator of protein phosphatase 1 function.” Methods Mol Biol 93 (1998): 41–58. https://doi.org/10.1385/0-89603-468-2:41.Full Text Link to Item
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Endo, S., J. H. Connor, B. Forney, L. Zhang, T. S. Ingebritsen, E. Y. Lee, and S. Shenolikar. “Conversion of protein phosphatase 1 catalytic subunit to a Mn(2+)-dependent enzyme impairs its regulation by inhibitor 1.” Biochemistry 36, no. 23 (June 10, 1997): 6986–92. https://doi.org/10.1021/bi970418i.Full Text Link to Item
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Shenolikar, S. “Importance of kinase-phosphatase cross-talk in neuronal signaling.” Journal of Neurochemistry 69 (January 1, 1997): S164–S164.Link to Item
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Weinman, E. J., and S. Shenolikar. “The Na-H exchanger regulatory factor.” Exp Nephrol 5, no. 6 (1997): 449–52.Link to Item
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Weinman, E. J., D. Steplock, and S. Shenolikar. “Structure-function of the Na/H exchanger-regulatory factor (NHE-RF).” Journal of the American Society of Nephrology 7, no. 9 (September 1, 1996): A0078–A0078.Link to Item
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Weinman, E. J., D. Steplock, and S. Shenolikar. “Regulation of Na/H exchanger-regulatory factor (NHE-RF) by serum and cAMP.” Journal of the American Society of Nephrology 7, no. 9 (September 1, 1996): A0077–A0077.Link to Item
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Endo, S., X. Zhou, J. Connor, B. Wang, and S. Shenolikar. “Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor.” Biochemistry 35, no. 16 (April 23, 1996): 5220–28. https://doi.org/10.1021/bi952940f.Full Text Link to Item
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Shenolikar, S. “Protein phosphatase regulation by endogenous inhibitors.” Semin Cancer Biol 6, no. 4 (August 1995): 219–27. https://doi.org/10.1006/scbi.1995.0029.Full Text Link to Item
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Weinman, E. J., D. Steplock, Y. Wang, and S. Shenolikar. “Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger.” J Clin Invest 95, no. 5 (May 1995): 2143–49. https://doi.org/10.1172/JCI117903.Full Text Link to Item
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Endo, S., S. D. Critz, J. H. Byrne, and S. Shenolikar. “Protein phosphatase-1 regulates outward K+ currents in sensory neurons of Aplysia californica.” J Neurochem 64, no. 4 (April 1995): 1833–40. https://doi.org/10.1046/j.1471-4159.1995.64041833.x.Full Text Link to Item
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WEINMAN, E. J., D. STEPLOCK, H. CHAMRAS, Y. P. WANG, and S. SHENOLIKAR. “STUDIES ON THE PKA ACTIVATED INHIBITOR (RF) OF BBM NA/H EXCHANGER IN RABBIT KIDNEY AND OK CELLS.” Journal of the American Society of Nephrology 5, no. 3 (September 1, 1994): 265–265.Link to Item
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Alberts, A. S., M. Montminy, S. Shenolikar, and J. R. Feramisco. “Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts.” Mol Cell Biol 14, no. 7 (July 1994): 4398–4407. https://doi.org/10.1128/mcb.14.7.4398-4407.1994.Full Text Link to Item
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Mulkey, R. M., S. Endo, S. Shenolikar, and R. C. Malenka. “Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression.” Nature 369, no. 6480 (June 9, 1994): 486–88. https://doi.org/10.1038/369486a0.Full Text Link to Item
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ENDO, S., D. STEER, X. ZHOU, and S. SHENOLIKAR. “MULTIPLE DOMAINS IN HUMAN INHIBITOR-1 ARE REQUIRED FOR REGULATION OF PROTEIN PHOSPHATASE-1.” Faseb Journal 8, no. 7 (April 19, 1994): A1437–A1437.Link to Item
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HAURA, E., S. ENDO, S. SHENOLIKAR, and S. E. GEORGE. “CALCINEURIN ACTIVATION BY CALMODULIN TROPONIN-C CHIMERAS.” Clinical Research 42, no. 2 (April 1, 1994): A113–A113.Link to Item
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WEINMAN, E. J., S. SHENOLIKAR, and D. STEPLOCK. “CLONING OF CDNAS ENCODING PROTEINS RELATED TO A CAMP-DEPENDENT PROTEIN-KINASE (PKA) REGULATOR OF THE RENAL BBM NA/H EXCHANGER.” Clinical Research 42, no. 2 (April 1, 1994): A316–A316.Link to Item
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Shenolikar, S. “Protein serine/threonine phosphatases--new avenues for cell regulation.” Annu Rev Cell Biol 10 (1994): 55–86. https://doi.org/10.1146/annurev.cb.10.110194.000415.Full Text Link to Item
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Weinman, E. J., D. Steplock, and S. Shenolikar. “CAMP-mediated inhibition of the renal brush border membrane Na+-H+ exchanger requires a dissociable phosphoprotein cofactor.” J Clin Invest 92, no. 4 (October 1993): 1781–86. https://doi.org/10.1172/JCI116767.Full Text Link to Item
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Lutz, M. P., D. I. Pinon, L. K. Gates, S. Shenolikar, and L. J. Miller. “Control of cholecystokinin receptor dephosphorylation in pancreatic acinar cells.” J Biol Chem 268, no. 16 (June 5, 1993): 12136–42.Link to Item
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Weinman, E. J., D. Steplock, D. Corry, and S. Shenolikar. “Identification of the human NHE-1 form of Na(+)-H+ exchanger in rabbit renal brush border membranes.” J Clin Invest 91, no. 5 (May 1993): 2097–2102. https://doi.org/10.1172/JCI116433.Full Text Link to Item
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LUTZ, M. P., D. P. PINON, S. SHENOLIKAR, and L. J. MILLER. “CCK STIMULATES A PANCREATIC SER THR PROTEIN PHOSPHATASE-ACTIVITY WHICH DEPHOSPHORYLATES THE CCK RECEPTOR.” Gastroenterology 104, no. 4 (April 1, 1993): A320–A320.Link to Item
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“Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.” Proceedings of the National Academy of Sciences 90, no. 6 (March 15, 1993): 2556–2556. https://doi.org/10.1073/pnas.90.6.2556d.Full Text
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Clark, R. B., J. Friedman, M. W. Kunkel, B. G. January, and S. Shenolikar. “Okadaic acid induces both augmentation and inhibition of beta 2-adrenergic stimulation of cAMP accumulation in S49 lymphoma cells.” J Biol Chem 268, no. 5 (February 15, 1993): 3245–50.Link to Item
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Alberts, A. S., A. M. Thorburn, S. Shenolikar, M. C. Mumby, and J. R. Feramisco. “Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.” Proc Natl Acad Sci U S A 90, no. 2 (January 15, 1993): 388–92. https://doi.org/10.1073/pnas.90.2.388.Full Text Link to Item
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ALBERTS, A. S., A. M. THORBURN, J. FROST, S. SHENOLIKAR, M. C. MUMBY, and J. R. FERAMISCO. “REGULATION OF CELL-CYCLE PROGRESSION AND THE NUCLEAR AFFINITY OF THE RETINOBLASTOMA PROTEIN BY PROTEIN PHOSPHATASES.” Journal of Cellular Biochemistry, January 9, 1993, 290–290.Link to Item
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Alberts, A. S., A. M. Thorburn, S. Shenolikar, M. C. Mumby, and J. R. Feramisco. “Erratum: Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases (Proc. Natl. Acad. Sci. USA (January 15, 1993) 90:2 (388-392)).” Proceedings of the National Academy of Sciences of the United States of America 90, no. 6 (January 1, 1993): 2556.
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Weinman, E. J., D. A. Steplock, and S. Shenolikar. “Trypsin digestion increases Na(+)-H+ exchange rates in native rabbit brush border membrane.” Miner Electrolyte Metab 19, no. 1 (1993): 47–50.Link to Item
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Weinman, E. J., and S. Shenolikar. “Regulation of the renal brush border membrane Na(+)-H+ exchanger.” Annu Rev Physiol 55 (1993): 289–304. https://doi.org/10.1146/annurev.ph.55.030193.001445.Full Text Link to Item
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Weinman, E. J., and S. Shenolikar. “Regulation of the renal brush border membrane Na+-H+ exchanger.” Annual Review of Physiology 55 (1993): 289–304.
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Shenolikar, S. “Opening a window on immunosuppression.” Curr Biol 2, no. 10 (October 1992): 549–51. https://doi.org/10.1016/0960-9822(92)90032-6.Full Text Link to Item
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Hagiwara, M., A. Alberts, P. Brindle, J. Meinkoth, J. Feramisco, T. Deng, M. Karin, S. Shenolikar, and M. Montminy. “Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB.” Cell 70, no. 1 (July 10, 1992): 105–13. https://doi.org/10.1016/0092-8674(92)90537-m.Full Text Link to Item
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Nairn, A. C., and S. Shenolikar. “The role of protein phosphatases in synaptic transmission, plasticity and neuronal development.” Curr Opin Neurobiol 2, no. 3 (June 1992): 296–301. https://doi.org/10.1016/0959-4388(92)90118-5.Full Text Link to Item
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Endo, S., S. Shenolikar, A. Eskin, R. E. Zwartjes, and J. H. Byrne. “Characterization of neuronal protein phosphatases in Aplysia californica.” J Neurochem 58, no. 3 (March 1992): 975–82. https://doi.org/10.1111/j.1471-4159.1992.tb09351.x.Full Text Link to Item
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CLARK, R. B., M. W. KUNKEL, S. SHENOLIKAR, and J. FRIEDMAN. “EFFECTS OF OKADAIC ACID ON ADENYLATE-CYCLASE IN S49 LYMPHOMA-CELLS SUGGEST AN IMPORTANT ROLE FOR PHOSPHATASES IN THE REVERSAL OF PROTEIN-KINASE MODULATION.” Faseb Journal 6, no. 1 (January 1, 1992): A78–A78.Link to Item
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SHENOLIKAR, S., S. ENDO, B. WANG, C. D. RASMUSSEN, A. R. MEANS, and V. P. KNUTSON. “ALTERED INSULIN SIGNALING IN SWISS 3T3-CELLS EXPRESSING PROTEIN PHOSPHATASE INHIBITOR-1.” Faseb Journal 6, no. 1 (January 1, 1992): A261–A261.Link to Item
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Weinman, E., R. Hanley, G. Morell, N. Yuan, D. Steplock, G. Bui, and S. Shenolikar. “Regulation of the renal Na(+)-H+ exchanger by calcium calmodulin-dependent multifunctional protein kinase II.” Miner Electrolyte Metab 18, no. 1 (1992): 35–39.Link to Item
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LA, B. Q., S. L. CAROSI, J. VALENTICH, S. SHENOLIKAR, and S. C. SANSOM. “REGULATION OF EPITHELIAL CHLORIDE CHANNELS BY PROTEIN PHOSPHATASE.” American Journal of Physiology 260, no. 6 (June 1, 1991): C1217–23.Link to Item
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La, B. Q., S. L. Carosi, J. Valentich, S. Shenolikar, and S. C. Sansom. “Regulation of epithelial chloride channels by protein phosphatase.” Am J Physiol 260, no. 6 Pt 1 (June 1991): C1217–23. https://doi.org/10.1152/ajpcell.1991.260.6.C1217.Full Text Link to Item
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PLANASSILVA, M., S. SHENOLIKAR, C. D. RASMUSSEN, and A. R. MEANS. “ALTERED GROWTH-REGULATION IN MOUSE C127 CELL-LINES TRANSFECTED WITH A SYNTHETIC GENE ENCODING THE ACTIVE FRAGMENT OF PROTEIN PHOSPHATASE INHIBITOR-1.” Faseb Journal 5, no. 4 (March 11, 1991): A833–A833.Link to Item
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SHENOLIKAR, S., X. ZHOU, M. BAYNE, and A. R. MEANS. “BACTERIAL EXPRESSION OF PROTEIN PHOSPHATASE INHIBITOR-1 DEFINES STRUCTURAL ELEMENTS ESSENTIAL FOR FUNCTION.” Faseb Journal 5, no. 4 (March 11, 1991): A833–A833.Link to Item
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SHENOLIKAR, S. “Protein phosphatases: recent progress.” Adv Second Messenger Phosphoprotein Res 23 (1991): 1–121.
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Shenolikar, S., and A. C. Nairn. “Protein phosphatases: recent progress.” Adv Second Messenger Phosphoprotein Res 23 (1991): 1–121.Link to Item
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MORELL, G., D. STEPLOCK, S. SHENOLIKAR, and E. J. WEINMAN. “IDENTIFICATION OF A PUTATIVE NA+-H+ EXCHANGER REGULATORY COFACTOR IN RABBIT RENAL BBM.” American Journal of Physiology 259, no. 6 (December 1, 1990): F867–71.Link to Item
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Morell, G., D. Steplock, S. Shenolikar, and E. J. Weinman. “Identification of a putative Na(+)-H+ exchanger regulatory cofactor in rabbit renal BBM.” Am J Physiol 259, no. 6 Pt 2 (December 1990): F867–71. https://doi.org/10.1152/ajprenal.1990.259.6.F867.Full Text Link to Item
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Ichinose, M., S. Endo, S. D. Critz, S. Shenolikar, and J. H. Byrne. “Microcystin-LR, a potent protein phosphatase inhibitor, prolongs the serotonin- and cAMP-induced currents in sensory neurons of Aplysia californica.” Brain Res 533, no. 1 (November 12, 1990): 137–40. https://doi.org/10.1016/0006-8993(90)91806-r.Full Text Link to Item
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Elbrecht, A., J. DiRenzo, R. G. Smith, and S. Shenolikar. “Molecular cloning of protein phosphatase inhibitor-1 and its expression in rat and rabbit tissues.” J Biol Chem 265, no. 23 (August 15, 1990): 13415–18.Link to Item
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Hanley, R. M., S. Shenolikar, J. Pollack, D. Steplock, and E. J. Weinman. “Identification of calcium-calmodulin multifunctional protein kinase II in rabbit kidney.” Kidney Int 38, no. 1 (July 1990): 63–66. https://doi.org/10.1038/ki.1990.167.Full Text Link to Item
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WEINMAN, E. J., D. STEPLOCK, G. BUI, N. YUAN, and S. SHENOLIKAR. “REGULATION OF RENAL NA+-H+ EXCHANGER BY CAMP-DEPENDENT PROTEIN-KINASE.” American Journal of Physiology 258, no. 5 (May 1, 1990): F1254–58.Link to Item
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Weinman, E. J., D. Steplock, G. Bui, N. Yuan, and S. Shenolikar. “Regulation of renal Na(+)-H+ exchanger by cAMP-dependent protein kinase.” Am J Physiol 258, no. 5 Pt 2 (May 1990): F1254–58. https://doi.org/10.1152/ajprenal.1990.258.5.F1254.Full Text Link to Item
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WEINMAN, E. J., R. M. HANLEY, G. MORELL, and S. SHENOLIKAR. “CALCIUM-CALMODULIN DEPENDENT MULTIFUNCTIONAL PROTEIN KINASE-II (CAM-KII) INHIBITION OF THE RABBIT RENAL BRUSH-BORDER MEMBRANE (BBM) NA+-H+ EXCHANGER.” Clinical Research 38, no. 2 (April 1, 1990): A469–A469.Link to Item
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Dayani, N., R. W. McNaught, S. Shenolikar, and R. G. Smith. “Receptor interconversion model of hormone action. 2. Requirement of both kinase and phosphatase activities for conferring estrogen binding activity to the estrogen receptor.” Biochemistry 29, no. 11 (March 20, 1990): 2691–98. https://doi.org/10.1021/bi00463a011.Full Text Link to Item
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Smith, R. G., A. Nag, N. Dayani, R. W. McNaught, and S. Shenolikar. “Estrogen receptor interconversion, factors regulating conformation and functions.” Prog Clin Biol Res 322 (1990): 83–95.Link to Item
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WEINMAN, E. J., and S. SHENOLIKAR. “FRACTIONATION OF SOLUBILIZED RABBIT RENAL BRUSH-BORDER MEMBRANES (BBM) BY ANION-EXCHANGE CHROMATOGRAPHY DISSOCIATES THE ACTIVITY OF THE RECONSTITUTED NA+-H+ EXCHANGER FROM ITS REGULATION BY CAMP DEPENDENT PROTEIN-KINASE (PKA).” Kidney International 37, no. 1 (January 1, 1990): 234–234.Link to Item
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Weinman, E. J., W. Dubinsky, and S. Shenolikar. “Regulation of the renal Na+-H+ exchanger by protein phosphorylation.” Kidney Int 36, no. 4 (October 1989): 519–25. https://doi.org/10.1038/ki.1989.226.Full Text Link to Item
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Weinman, E. J., W. P. Dubinsky, Q. Dinh, D. Steplock, and S. Shenolikar. “Effect of limited trypsin digestion on the renal Na+-H+ exchanger and its regulation by cAMP-dependent protein kinase.” J Membr Biol 109, no. 3 (August 1989): 233–41. https://doi.org/10.1007/BF01870280.Full Text Link to Item
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Kunkel, M. W., J. Friedman, S. Shenolikar, and R. B. Clark. “Cell-free heterologous desensitization of adenylyl cyclase in S49 lymphoma cell membranes mediated by cAMP-dependent protein kinase.” Faseb J 3, no. 9 (July 1989): 2067–74. https://doi.org/10.1096/fasebj.3.9.2545497.Full Text Link to Item
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HANLEY, R. M., S. SHENOLIKAR, and E. J. WEINMAN. “CALCIUM-CALMODULIN MULTIFUNCTIONAL DEPENDENT PROTEIN-KINASE (CAM K-II) IN RABBIT PROXIMAL CONVOLUTED TUBULE.” Clinical Research 37, no. 2 (April 1, 1989): A491–A491.Link to Item
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Weinman, E. J., W. P. Dubinsky, and S. Shenolikar. “Regulation of the renal Na+-H+ exchanger.” Hosp Pract (Off Ed) 24, no. 3 (March 15, 1989): 157-passim. https://doi.org/10.1080/21548331.1989.11703683.Full Text Link to Item
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WEINMAN, E. J., S. SHENOLIKAR, and W. DUBINSKY. “CO-RECONSTITUTION OF TRYPSINIZED SOLUBILIZED BRUSH-BORDER MEMBRANE-PROTEINS WITH SMALL MOLECULAR-WEIGHT PEPTIDES RESTORES THE INHIBITORY EFFECT OF PKA ON THE NA+-H+ EXCHANGER.” Kidney International 35, no. 1 (January 1, 1989): 166–166.Link to Item
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Weinman, E. J., W. Dubinsky, and S. Shenolikar. “Regulation of the renal Na+-H+ exchanger by protein phosphorylation.” Kidney International 36, no. 4 (1989): 519–25.
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Weinman, E. J., W. P. D. Jr, and S. Shenolikar. “Regulation of the renal Na+-H+ exchanger.” Hospital Practice 24, no. 3 (1989): 157–74.
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Lickteig, R., S. Shenolikar, L. Denner, and P. T. Kelly. “Regulation of Ca2+/calmodulin-dependent protein kinase II by Ca2+/calmodulin-independent autophosphorylation.” J Biol Chem 263, no. 35 (December 15, 1988): 19232–39.Link to Item
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Shenolikar, S. “Protein phosphorylation: hormones, drugs, and bioregulation.” Faseb J 2, no. 12 (September 1988): 2753–64. https://doi.org/10.1096/fasebj.2.12.2842213.Full Text Link to Item
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Weinman, E. J., W. P. Dubinsky, K. Fisher, D. Steplock, Q. Dinh, L. Chang, and S. Shenolikar. “Regulation of reconstituted renal Na+/H+ exchanger by calcium-dependent protein kinases.” J Membr Biol 103, no. 3 (August 1988): 237–44. https://doi.org/10.1007/BF01993983.Full Text Link to Item
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Hanley, R. M., A. R. Means, B. E. Kemp, and S. Shenolikar. “Mapping of calmodulin-binding domain of Ca2+/calmodulin-dependent protein kinase II from rat brain.” Biochem Biophys Res Commun 152, no. 1 (April 15, 1988): 122–28. https://doi.org/10.1016/s0006-291x(88)80688-0.Full Text Link to Item
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HANLEY, R. M., A. R. MEANS, B. E. KEMP, and S. SHENOLIKAR. “MAPPING OF THE CALMODULIN BINDING DOMAIN OF CA-2+/CALMODULIN-DEPENDENT PROTEIN KINASE-II.” Clinical Research 36, no. 3 (April 1, 1988): A622–A622.Link to Item
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Shenolikar, S., J. Langston, C. M. Schworer, and P. T. Kelly. “Substrate specificity of Ca2+/CaM-dependent multifunctional protein kinases: comparison of isoenzymes from brain, liver and skeletal muscle.” Biochem Biophys Res Commun 151, no. 3 (March 30, 1988): 1332–38. https://doi.org/10.1016/s0006-291x(88)80508-4.Full Text Link to Item
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SHAPIRO, L. M., P. BROWN, M. ZIMNIAK, P. SHAW, and S. SHENOLIKAR. “MONOCLONAL AND POLYCLONAL ANTIBODIES TO PROTEIN PHOSPHATASE INHIBITOR-1.” Faseb Journal 2, no. 4 (March 15, 1988): A550–A550.Link to Item
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Maddox, A. M., A. L. Steiner, and S. Shenolikar. “Species specificity of antibodies to regulatory subunits of cyclic AMP-dependent protein kinases.” Second Messengers Phosphoproteins 12, no. 2–3 (1988): 83–94.Link to Item
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Shenolikar, S., K. Fischer, L. Chang, and E. J. Weinman. “Type II cAMP-dependent protein kinase is associated with the rabbit kidney brush border membranes.” Second Messengers Phosphoproteins 12, no. 2–3 (1988): 95–104.Link to Item
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WEINMAN, E. J., W. DUBINSKY, and S. SHENOLIKAR. “TRYPSIN STIMULATION OF RENAL NA+-H+ EXCHANGER.” Kidney International 33, no. 1 (January 1, 1988): 408–408.Link to Item
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Weinman, E. J., S. Shenolikar, E. J. Cragoe, and W. P. Dubinsky. “Solubilization and reconstitution of renal brush border Na+-H+ exchanger.” J Membr Biol 101, no. 1 (1988): 1–9. https://doi.org/10.1007/BF01872814.Full Text Link to Item
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Weinman, E. J., W. P. Dubinsky, and S. Shenolikar. “Reconstitution of cAMP-dependent protein kinase regulated renal Na+-H+ exchanger.” J Membr Biol 101, no. 1 (1988): 11–18. https://doi.org/10.1007/BF01872815.Full Text Link to Item
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Lavis, V. R., D. P. Lee, and S. Shenolikar. “Evidence that forskolin binds to the glucose transporter of human erythrocytes.” J Biol Chem 262, no. 30 (October 25, 1987): 14571–75.Link to Item
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WEINMAN, E. J., W. DUBINSKY, and S. SHENOLIKAR. “CALCIUM-CALMODULIN DEPENDENT PROTEIN-KINASE (CA+/-(-)CM PK) REGULATION OF THE RECONSTITUTED RENAL NA+/H+ EXCHANGER.” Clinical Research 35, no. 3 (April 1, 1987): A560–A560.Link to Item
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HANLEY, R. M., J. R. DEDMAN, and S. SHENOLIKAR. “IDENTIFICATION OF HIGH-AFFINITY CALMODULIN-BINDING PROTEINS IN RAT-LIVER.” American Journal of Physiology 252, no. 3 (March 1, 1987): C277–84.Link to Item
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SHENOLIKAR, S., and J. LANGSTON. “ISOLATION OF A NOVEL PROTEIN PHOSPHATASE-1 INHIBITOR FROM RABBIT SKELETAL-MUSCLE.” Federation Proceedings 46, no. 3 (March 1, 1987): 811–811.Link to Item
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Hanley, R. M., J. R. Dedman, and S. Shenolikar. “Identification of high-affinity calmodulin-binding proteins in rat liver.” Am J Physiol 252, no. 3 Pt 1 (March 1987): C277–84. https://doi.org/10.1152/ajpcell.1987.252.3.C277.Full Text Link to Item
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Hanley, R. M., S. J. Strada, A. L. Steiner, W. J. Thompson, and S. Shenolikar. “Increase in liver protein phosphatase-1 in spontaneously diabetic Chinese hamsters.” Mol Cell Endocrinol 50, no. 1–2 (March 1987): 115–22. https://doi.org/10.1016/0303-7207(87)90083-9.Full Text Link to Item
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SHENOLIKAR, S., L. CHANG, and E. WEINMAN. “ASSOCIATION OF THE REGULATORY SUBUNIT OF CYCLIC-AMP DEPENDENT PROTEIN-KINASE WITH THE RABBIT APICAL MEMBRANES.” Kidney International 31, no. 1 (January 1, 1987): 181–181.Link to Item
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WEINMAN, E. J., S. SHENOLIKAR, and A. M. KAHN. “CAMP-ASSOCIATED INHIBITION OF NA+-H+ EXCHANGER IN RABBIT KIDNEY BRUSH-BORDER MEMBRANES.” American Journal of Physiology 252, no. 1 (January 1, 1987): F19–25.Link to Item
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WEINMAN, E. J., S. SHENOLIKAR, and W. P. DUBINSKY. “RECONSTITUTION OF CAMP PROTEIN-KINASE REGULATED RENAL NA+-H+ EXCHANGER.” Kidney International 31, no. 1 (January 1, 1987): 186–186.Link to Item
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Kelly, P. T., and S. Shenolikar. “Role of autophosphorylation in regulating calmodulin-dependent protein kinases.” Methods Enzymol 139 (1987): 690–714. https://doi.org/10.1016/0076-6879(87)39121-9.Full Text Link to Item
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Lavis, V. R., D. P. Lee, and S. Shenolikar. “Evidence that forskolin binds to the glucose transporter of human erythrocytes.” Journal of Biological Chemistry 262, no. 30 (January 1, 1987): 13571–575.
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Weinman, E. J., S. Shenolikar, and A. M. Kahn. “cAMP-associated inhibition of Na+-H+ exchanger in rabbit kidney brush-border membranes.” Am J Physiol 252, no. 1 Pt 2 (January 1987): F19–25. https://doi.org/10.1152/ajprenal.1987.252.1.F19.Full Text Link to Item
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Shenolikar, S., R. Lickteig, D. G. Hardie, T. R. Soderling, R. M. Hanley, and P. T. Kelly. “Calmodulin-dependent multifunctional protein kinase. Evidence for isoenzyme forms in mammalian tissues.” Eur J Biochem 161, no. 3 (December 15, 1986): 739–47. https://doi.org/10.1111/j.1432-1033.1986.tb10502.x.Full Text Link to Item
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Karbon, E. W., S. Shenolikar, and S. J. Enna. “Phorbol esters enhance neurotransmitter-stimulated cyclic AMP production in rat brain slices.” J Neurochem 47, no. 5 (November 1986): 1566–75. https://doi.org/10.1111/j.1471-4159.1986.tb00796.x.Full Text Link to Item
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Shenolikar, S., E. W. Karbon, and S. J. Enna. “Phorbol esters down-regulate protein kinase C in rat brain cerebral cortical slices.” Biochem Biophys Res Commun 139, no. 1 (August 29, 1986): 251–58. https://doi.org/10.1016/s0006-291x(86)80106-1.Full Text Link to Item
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SHENOLIKAR, S., and T. CORNWELL. “POLYAMINE STIMULATION OF PROTEIN PHOSPHATASE-2A FROM RAT-LIVER.” Federation Proceedings 45, no. 6 (May 1, 1986): 1802–1802.Link to Item
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HANLEY, R., S. SHENOLIKAR, A. L. STEINER, and J. DEDMAN. “CHARACTERIZATION OF A MAJOR HEPATIC CALMODULIN ACCEPTOR PROTEIN(CAP-60).” Clinical Research 34, no. 2 (April 1, 1986): A725–A725.Link to Item
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WEINMAN, E. J., M. K. HISE, S. SHENOLIKAR, and W. P. DUBINSKY. “RECONSTITUTION OF RENAL-CORTEX BRUSH-BORDER NA+/H+ EXCHANGER.” Clinical Research 34, no. 2 (April 1, 1986): A612–A612.Link to Item
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Cornwell, T., P. Mehta, and S. Shenolikar. “Polyamine stimulation of protein phosphatase-2A from rat liver using a non-protein phosphoester substrate.” J Cyclic Nucleotide Protein Phosphor Res 11, no. 5 (1986): 373–82.Link to Item
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Hanley, R. M., J. R. Dedman, A. L. Steiner, and S. Shenolikar. “Characterization of a major hepatic calmodulin acceptor protein (CAP-60).” Trans Assoc Am Physicians 99 (1986): 78–85.Link to Item
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Shenolikar, S. “Control of cell function by reversible protein phosphorylation.” J Cyclic Nucleotide Protein Phosphor Res 11, no. 7 (1986): 531–41.Link to Item
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Weinman, E. J., and S. Shenolikar. “Protein kinase C activates the renal apical membrane Na+/H+ exchanger.” J Membr Biol 93, no. 2 (1986): 133–39. https://doi.org/10.1007/BF01870805.Full Text Link to Item
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Shenolikar, S., W. J. Thompson, and S. J. Strada. “Characterization of a Ca2+-calmodulin-stimulated cyclic GMP phosphodiesterase from bovine brain.” Biochemistry 24, no. 3 (January 29, 1985): 672–78. https://doi.org/10.1021/bi00324a020.Full Text Link to Item
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Alemany, S., H. Y. Tung, S. Shenolikar, S. J. Pilkis, and P. Cohen. “The protein phosphatases involved in cellular regulation. Antibody to protein phosphatase-2A as a probe of phosphatase structure and function.” Eur J Biochem 145, no. 1 (November 15, 1984): 51–56. https://doi.org/10.1111/j.1432-1033.1984.tb08520.x.Full Text Link to Item
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Tung, H. Y., T. J. Resink, B. A. Hemmings, S. Shenolikar, and P. Cohen. “The catalytic subunits of protein phosphatase-1 and protein phosphatase 2A are distinct gene products.” Eur J Biochem 138, no. 3 (February 1, 1984): 635–41. https://doi.org/10.1111/j.1432-1033.1984.tb07962.x.Full Text Link to Item
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Shenolikar, S., L. Chang, and R. Hanley. “Characteristics of high affinity cyclic AMP phosphodiesterase in a genetically diabetic hypoinsulinemic hamster model.” Federation Proceedings 43, no. 6 (January 1, 1984).
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Shenolikar, S., and A. L. Steiner. “Immunological approach to the study of hormone action: regulation of the phosphorylation state of protein phosphatase inhibitor-1 by hormones.” Adv Cyclic Nucleotide Protein Phosphorylation Res 17 (1984): 405–15.Link to Item
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Shenolikar, S., and T. S. Ingebritsen. “Protein (serine and threonine) phosphate phosphatases.” Methods Enzymol 107 (1984): 102–29. https://doi.org/10.1016/0076-6879(84)07007-5.Full Text Link to Item
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SHENOLIKAR, S., S. J. STRADA, H. HUANG, and A. L. STEINER. “CAMP MEDIATED PROTEIN-PHOSPHORYLATION - HORMONALLY DIRECTED REGULATION OF PROTEIN PHOSPHATASE INHIBITOR-I.” Clinical Research 31, no. 2 (January 1, 1983): A529–A529.Link to Item
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SHENOLIKAR, S., S. J. STRADA, and A. L. STEINER. “REGULATION OF THE PHOSPHORYLATION STATE OF PROTEIN PHOSPHATASE INHIBITOR-1 OF RAT-LIVER BY GLUCAGON AND INSULIN.” Federation Proceedings 42, no. 7 (January 1, 1983): 1801–1801.Link to Item
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THOMPSON, W. J., L. K. CHANG, S. SHENOLIKAR, M. L. PRATT, and S. J. STRADA. “PURIFICATION OF RABBIT SKELETAL-MUSCLE HIGH-AFFINITY CAMP PHOSPHODIESTERASE - ANALYSIS BY WESTERN BLOT IMMUNOREACTIVITY.” Federation Proceedings 42, no. 7 (January 1, 1983): 1847–1847.Link to Item
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Picton, C., S. Shenolikar, R. Grand, and P. Cohen. “Calmodulin as an integral subunit of phosphorylase kinase from rabbit skeletal muscle.” Methods Enzymol 102 (1983): 219–27. https://doi.org/10.1016/s0076-6879(83)02023-6.Full Text Link to Item
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Shenolikar, S., and K. J. Stevenson. “Purification and partial characterization of a thiol proteinase from the thermophilic fungus Humicola lanuginosa.” Biochem J 205, no. 1 (July 1, 1982): 147–52. https://doi.org/10.1042/bj2050147.Full Text Link to Item
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Grand, R. J., S. Shenolikar, and P. Cohen. “The amino acid sequence of the delta subunit (calmodulin) of rabbit skeletal muscle phosphorylase kinase.” Eur J Biochem 113, no. 2 (January 1981): 359–67. https://doi.org/10.1111/j.1432-1033.1981.tb05074.x.Full Text Link to Item
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Cohen, P., C. B. Klee, C. Picton, and S. Shenolikar. “Calcium control of muscle phosphorylase kinase through the combined action of calmodulin and troponin.” Ann N Y Acad Sci 356 (1980): 151–61. https://doi.org/10.1111/j.1749-6632.1980.tb29608.x.Full Text Link to Item
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Shenolikar, S., P. T. Cohen, P. Cohen, A. C. Nairn, and S. V. Perry. “The role of calmodulin in the structure and regulation of phosphorylase kinase from rabbit skeletal muscle.” Eur J Biochem 100, no. 2 (October 15, 1979): 329–37. https://doi.org/10.1111/j.1432-1033.1979.tb04175.x.Full Text Link to Item
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Shenolikar, S., and P. Cohen. “The substrate specificity of cyclic AMP-dependent protein kinase: amino acid sequences at the phosphorylation sites of herring protamine (clupeine).” Febs Lett 86, no. 1 (February 1, 1978): 92–98. https://doi.org/10.1016/0014-5793(78)80106-9.Full Text Link to Item
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Shenolikar, S., J. G. Foulkes, and P. Cohen. “Isolation of an active fragment of protein phosphatase inhibitor-I from rabbit skeletal muscle.” Biochem Soc Trans 6, no. 5 (1978): 935–37. https://doi.org/10.1042/bst0060935.Full Text Link to Item
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Chattaway, F. W., S. Shenolikar, J. O’Reilly, and A. J. Barlow. “Changes in the cell surface of the dimorphic forms of Candida albicans by treatment with hydrolytic enzymes.” J Gen Microbiol 96, no. 2 (August 1976): 335–47. https://doi.org/10.1099/00221287-95-2-335.Full Text Link to Item
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Chattaway, F. W., S. Shenolikar, and A. J. Barlow. “The release of acid phosphatase and polysaccharide- and protein-containing components from the surface of the dimorphic forms of Candida albicans by treatment with dithiothreitol.” J Gen Microbiol 83, no. 2 (August 1974): 423–25. https://doi.org/10.1099/00221287-83-2-423.Full Text Link to Item
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Book Sections
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Shenolikar, S. “Serine/Threonine Phosphatase Inhibitor Proteins.” In Handbook of Cell Signaling: Volume 1-3, 1–3:627–29, 2003. https://doi.org/10.1016/B978-012124546-7/50466-6.Full Text
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Conference Papers
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Shenolikar, Shirish. “New Frontiers: Science and Science Education in "Emerging" Countries.” In Faseb Journal, Vol. 26. FEDERATION AMER SOC EXP BIOL, 2012.Link to Item
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Roadcap, D. W., R. Terry-Lorenzo, M. D. Ehlers, and S. Shenolikar. “Modulation of the actin cytoskeleton, filopodia initiation and dendritic soine maturayion by the protein phosphatase-1 binding protein neurabin-I.” In Molecular Biology of the Cell, 15:50A-50A. AMER SOC CELL BIOLOGY, 2004.Link to Item
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Cunningham, R. M., E. J. Weinman’, A. Boddeti, M. Akom, F. Y. Wang, Y. Wang, J. Liu, D. Steplock, S. Shenolikar, and J. B. Wade. “NHERF-1 is required for renal adaptation to a low phosphate diet.” In Journal of the American Society of Nephrology, 14:547A-547A. LIPPINCOTT WILLIAMS & WILKINS, 2003.Link to Item
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Voltz, J. W., Y. Cao, E. J. Weinman, and S. Shenolikar. “Role of protein phosphorylation in regulating NHERF-1 function.” In Molecular Biology of the Cell, 13:425A-426A. AMER SOC CELL BIOLOGY, 2002.Link to Item
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