Skip to main content

Shiao-Wen David Hsu

Professor of Medicine
Medicine, Medical Oncology
Duke Box 3233, Durham, NC 27710
Dept of Medicine, Box 3233, Durham, NC 27710

Selected Grants


Role of the NLRP3-NLRC5 Signaling Pathway in Melanoma Immune Evasion and Dormancy

ResearchCollaborator · Awarded by Department of Defense · 2024 - 2027

Precision Medicine Trial Using MicroOrganoSpheres to Guide Care in Colorectal Cancer

Clinical TrialPrincipal Investigator · Awarded by Mario Family Foundation · 2022 - 2025

Targeting convergent oncogenic signaling during AR inhibition to overcome metastasis and immune evasion in prostate cancer

ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2025

Dissecting the evolutionary landscape of treatment resistance in rectal cancer using patient-derived models.

ResearchCollaborator · Awarded by American Gastroenterological Association · 2022 - 2025

(R21) Microfluidic Droplet Organoids to Decipher the Tumor Heterogeneity in CRC of African Ancestry

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2025

Synthetic lethality by targeting the core senescent mechanism in lung cancer.

ResearchCollaborator · Awarded by National Institutes of Health · 2020 - 2025

The role of ferroptosis in the metastatic ovarian cancer

ResearchCo Investigator · Awarded by Ovarian Cancer Research Alliance · 2022 - 2024

Epigenomic Reprogramming in Patient Derived Models of Colorectal Cancer

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2024

Targeting KRAS (G12C) Mutant in Colorectal Cancer

ResearchPrincipal Investigator · Awarded by Amgen, Inc. · 2018 - 2024

Therapeutic targeting of MESH1 in renal cell carcinoma

ResearchCo Investigator · Awarded by Department of Defense · 2020 - 2023

Global Measurements of Protein Folding Stability for Characterization of Aging and Disease

ResearchCollaborating Investigator · Awarded by National Institutes of Health · 2019 - 2023

Inhibition of CaMKK2 sensitizes rectal cancers to radiation therapy

ResearchCollaborator · Awarded by National Institutes of Health · 2021 - 2022

Therapeutic targeting of cystine addiction of renal cell carcinoma

ResearchCo Investigator · Awarded by Department of Defense · 2019 - 2022

Targeting the p38/Snail/PD-L1 axis in hormone-therapy resistance and metastasis

ResearchCo Investigator · Awarded by Department of Defense · 2018 - 2022

Targeting tumor-specific apoptosis regulation in advanced ER+ breast cancer

ResearchCollaborator · Awarded by Department of Defense · 2019 - 2022

Selectively targeting apoptosis in PIK3CA mutant colorectal cancers

ResearchCollaborator · Awarded by National Institutes of Health · 2016 - 2022

Anonymous Donation

ResearchProject Leader · Awarded by Anonymous Trust · 2020 - 2022

Medical Scientist Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022

Understanding methionine metabolism and its therapeutic potential in cancer

ResearchAdvisor · Awarded by National Institutes of Health · 2019 - 2021

Determining the Efficacy of Liposomal Gemcitabine in Patient Derived Xenografts (PDXs)

ResearchPrincipal Investigator · Awarded by FUJIFILM Pharmaceuticals U.S.A. · 2017 - 2019

Identifying gene-environment interactions that confer metabolic vulnerabilities in cancer

FellowshipCollaborator · Awarded by National Institutes of Health · 2018 - 2019

Targeting differential apoptosis regulation in triple negative breast cancer

ResearchCollaborator · Awarded by Department of Defense · 2016 - 2019

Targeting the TK1 receptor in colorectal and lung PDX using CarT cell and Motorcar cell

ResearchPrincipal Investigator · Awarded by Thunder Biotech · 2017 - 2019

Role of the Stroma in Fibrolamellar Hepatocellular Carcinoma

ResearchInvestigator · Awarded by Fibrolamellar Cancer Foundation · 2016 - 2019

Using bacterial CRISPR/Cas endonucleases to selectively eliminate HPV-transformed cells in vivo

ResearchCo Investigator · Awarded by National Institutes of Health · 2015 - 2017

Targeting Calreticulin in Colorectal Cancer Liver Metastasis

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2017

Development and Validation of Novel Therapeutic Targets in Anal Cancer

ResearchPrincipal Investigator · Awarded by The Farrah Fawcett Foundation · 2015 - 2016

Aptamer Targeted Drug and Toxin Delivery to Prostate Cancer

FellowshipCollaborator · Awarded by Department of Defense · 2014 - 2016

A Platform for Real-time Drug Profiling of Patient-Derived Melanomas

FellowshipCollaborator · Awarded by National Institutes of Health · 2014 - 2016

In Vivo Selection of Tumor-Specific RNA Binding Motifs

ResearchCollaborator · Awarded by National Institutes of Health · 2011 - 2015

Administrative Supplement for Recruitment of New Faculty

ResearchProject PI · Awarded by National Cancer Institute · 2009 - 2011

External Relationships


  • AccuBeing LLC
  • Xilis, Inc

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.