Scholars@Duke
Sidney Maloch Gospe III

Sidney Maloch Gospe III

Associate Professor of Ophthalmology
Ophthalmology, Neuro-Ophthalmology
sid.gospe@duke.edu
Box 3712 Med Ctr, Durham, NC 27710
2351 Erwin Rd, Durham, NC 27710

Selected Publications

Reduced complex I activity in the retinal pigment epithelium, but not in rod photoreceptors, affects light signaling without impacting cell survival.

Journal Article J Biol Chem · September 2025 Mutations in the mitochondrial respiratory complex I accessory subunit NADH:ubiquinone oxidoreductase subunit S4 (ndufs4) can cause the mitochondrial disease Leigh syndrome, which may be associated with vision loss. We previously demonstrated that mice wit ... Full text Link to item Cite

Correlation between lumbar puncture opening pressure and venous sinus pressure gradient in idiopathic intracranial hypertension (IIH).

Journal Article Interv Neuroradiol · April 24, 2025 BackgroundVenous hypertension has become a recognized condition associated with idiopathic intracranial hypertension (IIH). Thresholds for dural venous sinus stenting (VSS) remain a topic of debate.MethodsIn 50 IIH patients, the lumbar puncture opening pre ... Full text Link to item Cite

Generation of an Armcx1 Conditional Knockout Mouse.

Journal Article Genesis · August 2024 Armadillo repeat-containing X-linked protein-1 (Armcx1) is a poorly characterized transmembrane protein that regulates mitochondrial transport in neurons. Its overexpression has been shown to induce neurite outgrowth in embryonic neurons and to promote ret ... Full text Link to item Cite

A multi-centre case series of patients with coexistent intracranial hypertension and malignant arterial hypertension.

Journal Article Eye (Lond) · February 2024 OBJECTIVE: To describe the clinical characteristics, outcomes, and management of a large cohort of patients with concomitant malignant arterial hypertension and intracranial hypertension. METHODS: Design: Retrospective case series. SUBJECTS: Patients aged ... Full text Link to item Cite

Ophthalmic manifestations of MEPAN syndrome.

Journal Article Ophthalmic Genet · October 2023 BACKGROUND: Mitochondrial enoyl CoA reductase protein-associated neurodegeneration (MEPAN) syndrome is an ultra-rare autosomal recessive disorder caused by loss-of-function mutations in the MECR gene. The syndrome is characterized by dystonia in early chil ... Full text Link to item Cite

Continuous Hypoxia Reduces Retinal Ganglion Cell Degeneration in a Mouse Model of Mitochondrial Optic Neuropathy.

Journal Article Invest Ophthalmol Vis Sci · December 1, 2022 PURPOSE: To test whether continuous hypoxia is neuroprotective to retinal ganglion cells (RGCs) in a mouse model of mitochondrial optic neuropathy. METHODS: RGC degeneration was assessed in genetically modified mice in which the floxed gene for the complex ... Full text Link to item Cite

BILATERAL PARACENTRAL ACUTE MIDDLE MACULOPATHY AFTER CARDIOPULMONARY BYPASS.

Journal Article Retin Cases Brief Rep · May 1, 2022 PURPOSE: To report the first two observations of bilateral paracentral acute middle maculopathy in the early postoperative period after cardiopulmonary bypass procedures. METHODS: Comprehensive ophthalmic examinations were performed, including best-correct ... Full text Link to item Cite

At this junction….

Journal Article Surv Ophthalmol · 2022 An 81-year-old woman developed painful vision loss to hand motions in the right eye over a several-day period. Dilated fundus examination revealed no acute pathology, but automated perimetry showed a superotemporal visual field defect in the asymptomatic l ... Full text Link to item Cite

QUANTITATIVE TOPOGRAPHIC CURVATURE MAPS OF THE POSTERIOR EYE UTILIZING OPTICAL COHERENCE TOMOGRAPHY.

Journal Article Retina · April 1, 2021 PURPOSE: Deformations of the retina such as staphylomas in myopia or scleral flattening in high intracranial pressure can be challenging to quantify with en face imaging. We describe an optical coherence tomography-based method for the generation of quanti ... Full text Open Access Link to item Cite

Magnetic Resonance Imaging Abnormalities of the Optic Nerve Sheath and Intracranial Internal Carotid Artery in Giant Cell Arteritis.

Journal Article J Neuroophthalmol · March 1, 2021 BACKGROUND: Giant cell arteritis (GCA) is an important diagnostic consideration in elderly patients with vision changes. Superficial temporal artery biopsy (TAB) has long been considered the gold standard diagnostic approach for GCA, but MRI has gained int ... Full text Link to item Cite

Neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein associated disorder-optic neuritis: a comprehensive review of diagnosis and treatment.

Journal Article Eye (Lond) · March 2021 Optic neuritis (ON) is the most common cause of acute optic neuropathy in patients younger than 50 years of age and is most frequently idiopathic or associated with multiple sclerosis. However, the discovery of aquaporin-4 immunoglobulin G (IgG) and myelin ... Full text Link to item Cite

Traumatic chiasmopathy following mild trauma in a patient with thyroid orbitopathy.

Journal Article Am J Ophthalmol Case Rep · March 2021 PURPOSE: Traumatic injury to the optic chiasm is rare and most frequently caused by high-velocity head trauma. It classically results in bitemporal hemianopsia and often presents in conjunction with multiple other traumatic injuries, such as skull fracture ... Full text Link to item Cite

Progressive optic atrophy in a retinal ganglion cell-specific mouse model of complex I deficiency.

Journal Article Sci Rep · October 1, 2020 Optic atrophy resulting from retinal ganglion cell (RGC) degeneration is a prominent ocular manifestation of mitochondrial dysfunction. Although transgenic mice lacking the mitochondrial complex I accessory subunit NDUFS4 develop early-onset optic atrophy, ... Full text Link to item Cite

Phosphoinositide Profile of the Mouse Retina.

Journal Article Cells · June 7, 2020 Phosphoinositides are known to play multiple roles in eukaryotic cells. Although dysregulation of phosphoinositide metabolism in the retina has been reported to cause visual dysfunction in animal models and human patients, our understanding of the phosphoi ... Full text Link to item Cite

Photoreceptors in a mouse model of Leigh syndrome are capable of normal light-evoked signaling.

Journal Article J Biol Chem · August 16, 2019 Mitochondrial dysfunction is an important cause of heritable vision loss. Mutations affecting mitochondrial bioenergetics may lead to isolated vision loss or life-threatening systemic disease, depending on a mutation's severity. Primary optic nerve atrophy ... Full text Open Access Link to item Cite

Ectopic Ocular Surface Calcification in Patients With Hypophosphatasia Treated With Asfotase Alfa.

Journal Article Cornea · July 2019 PURPOSE: To assess for ectopic ocular calcification in a series of patients with hypophosphatasia (HPP) treated with asfotase alfa, a recombinant tissue-nonspecific alkaline phosphatase. METHODS: This is a retrospective analysis of subjects enrolled at Duk ... Full text Link to item Cite

Fourth down and five.

Journal Article Surv Ophthalmol · 2019 Binocular diplopia and right hemifacial numbness developed in a 52-year-old woman after resection of a right temporal lobe glioblastoma. Based on the Parks-Bielschowsky 3-step test, she was diagnosed with a right cranial nerve (CN) IV palsy in addition to ... Full text Link to item Cite

Spectral-Domain Optical Coherence Tomography of the Vitreopapillary Interface in Acute Nonarteritic Anterior Ischemic Optic Neuropathy.

Journal Article Am J Ophthalmol · November 2018 PURPOSE: To use spectral-domain optical coherence tomography (SD-OCT) to assess whether epipapillary vitreous traction from evolving posterior vitreous detachment (PVD) is mechanistically involved in the pathogenesis of nonarteritic anterior ischemic optic ... Full text Link to item Cite

Orbital Anatomy.

Journal Article Int Ophthalmol Clin · 2018 Full text Link to item Cite

A sticky situation.

Journal Article Surv Ophthalmol · 2018 An 81-year-old man with bilateral progressively blurry vision and optic disc swelling was referred for evaluation. Examination and ancillary testing confirmed a diagnosis of bilateral vitreopapillary traction accompanied by unilateral tractional retinoschi ... Full text Link to item Cite

A Woman With a Spot in Her Vision.

Journal Article JAMA ophthalmology · September 2017 Full text Cite

Emerging Applications of Optical Coherence Tomography in Pediatric Optic Neuropathies.

Journal Article Semin Pediatr Neurol · May 2017 Limited cooperation and attention span often lead to poorly reliable assessments of visual acuity and visual fields in children, making diagnosis and monitoring of pediatric optic neuropathies challenging. As a noninvasive imaging modality, optical coheren ... Full text Link to item Cite

Anatomic and visual function outcomes in paediatric idiopathic intracranial hypertension.

Journal Article Br J Ophthalmol · April 2016 BACKGROUND: There is a paucity of literature describing risk factors for vision loss in paediatric idiopathic intracranial hypertension (IIH). We investigate the final visual function, spectral domain optical coherence tomography (SD-OCT) and enhanced dept ... Full text Link to item Cite

Keratomalacia in a Patient With Psychogenic Vitamin A Deficiency.

Journal Article Cornea · March 2016 PURPOSE: To report the clinical and histopathological findings of a patient with bilateral keratomalacia arising from severe vitamin A deficiency from panic disorder-related malnutrition. METHODS: Case report. RESULTS: A 47-year-old male with panic disorde ... Full text Link to item Cite

Tug of war.

Journal Article Surv Ophthalmol · 2015 A 74-year-old man had reproducible superior and inferior arcuate visual field defects in the left eye only that were initially believed to be caused by primary open-angle glaucoma. Diagnostic evaluation with the aid of optical coherence tomography revealed ... Full text Link to item Cite

Neuro-ophthalmology

Chapter · January 1, 2015 There are a number of clinical trials that have helped shaped the current practice guidelines in the practice of neuro-ophthalmology. The key neuro-ophthalmology trials are the Optic Neuritis Treatment Trial (ONTT), the Ischemic Optic Neuropathy Decompress ... Cite

A single valine residue plays an essential role in peripherin/rds targeting to photoreceptor outer segments.

Journal Article PLoS One · 2013 Peripherin/retinal degeneration slow (rds) is an integral membrane protein specifically localized to the light-sensing organelle of the photoreceptor cell, the outer segment. Within the outer segment, peripherin is found at the edges of photoreceptor discs ... Full text Link to item Cite

Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptors.

Journal Article J Neurosci · October 12, 2011 The members of the R7 regulator of G-protein signaling (RGS) protein subfamily are versatile regulators of G-protein signaling throughout the nervous system. Recent studies indicate that they are often found in complexes with membrane anchor proteins that ... Full text Link to item Cite

Facilitative glucose transporter Glut1 is actively excluded from rod outer segments.

Journal Article J Cell Sci · November 1, 2010 Photoreceptors are among the most metabolically active cells in the body, relying on both oxidative phosphorylation and glycolysis to satisfy their high energy needs. Local glycolysis is thought to be particularly crucial in supporting the function of the ... Full text Open Access Link to item Cite

The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors.

Journal Article J Cell Biol · November 3, 2008 Photoreceptors are compartmentalized neurons in which all proteins responsible for evoking visual signals are confined to the outer segment. Yet, the mechanisms responsible for establishing and maintaining photoreceptor compartmentalization are poorly unde ... Full text Link to item Cite