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Facilitative glucose transporter Glut1 is actively excluded from rod outer segments.

Publication ,  Journal Article
Gospe, SM; Baker, SA; Arshavsky, VY
Published in: J Cell Sci
November 1, 2010

Photoreceptors are among the most metabolically active cells in the body, relying on both oxidative phosphorylation and glycolysis to satisfy their high energy needs. Local glycolysis is thought to be particularly crucial in supporting the function of the photoreceptor's light-sensitive outer segment compartment, which is devoid of mitochondria. Accordingly, it has been commonly accepted that the facilitative glucose transporter Glut1 responsible for glucose entry into photoreceptors is localized in part to the outer segment plasma membrane. However, we now demonstrate that Glut1 is entirely absent from the rod outer segment and is actively excluded from this compartment by targeting information present in its cytosolic C-terminal tail. Our data indicate that glucose metabolized in the outer segment must first enter through other parts of the photoreceptor cell. Consequently, the entire energy supply of the outer segment is dependent on diffusion of energy-rich substrates through the thin connecting cilium that links this compartment to the rest of the cell.

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Published In

J Cell Sci

DOI

EISSN

1477-9137

Publication Date

November 1, 2010

Volume

123

Issue

Pt 21

Start / End Page

3639 / 3644

Location

England

Related Subject Headings

  • Xenopus laevis
  • Transgenes
  • Sequence Deletion
  • Rod Cell Outer Segment
  • Retinal Photoreceptor Cell Inner Segment
  • Rats
  • Protein Transport
  • Protein Sorting Signals
  • Protein Engineering
  • Photoreceptor Connecting Cilium
 

Citation

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Gospe, S. M., Baker, S. A., & Arshavsky, V. Y. (2010). Facilitative glucose transporter Glut1 is actively excluded from rod outer segments. J Cell Sci, 123(Pt 21), 3639–3644. https://doi.org/10.1242/jcs.072389
Gospe, Sidney M., Sheila A. Baker, and Vadim Y. Arshavsky. “Facilitative glucose transporter Glut1 is actively excluded from rod outer segments.J Cell Sci 123, no. Pt 21 (November 1, 2010): 3639–44. https://doi.org/10.1242/jcs.072389.
Gospe SM, Baker SA, Arshavsky VY. Facilitative glucose transporter Glut1 is actively excluded from rod outer segments. J Cell Sci. 2010 Nov 1;123(Pt 21):3639–44.
Gospe, Sidney M., et al. “Facilitative glucose transporter Glut1 is actively excluded from rod outer segments.J Cell Sci, vol. 123, no. Pt 21, Nov. 2010, pp. 3639–44. Pubmed, doi:10.1242/jcs.072389.
Gospe SM, Baker SA, Arshavsky VY. Facilitative glucose transporter Glut1 is actively excluded from rod outer segments. J Cell Sci. 2010 Nov 1;123(Pt 21):3639–3644.
Journal cover image

Published In

J Cell Sci

DOI

EISSN

1477-9137

Publication Date

November 1, 2010

Volume

123

Issue

Pt 21

Start / End Page

3639 / 3644

Location

England

Related Subject Headings

  • Xenopus laevis
  • Transgenes
  • Sequence Deletion
  • Rod Cell Outer Segment
  • Retinal Photoreceptor Cell Inner Segment
  • Rats
  • Protein Transport
  • Protein Sorting Signals
  • Protein Engineering
  • Photoreceptor Connecting Cilium