Journal ArticleThromb Res · March 2021
BACKGROUND: Venous thromboembolism (VTE) is a serious complication of orthopedic surgery. Low molecular weight heparin (LMWH) has been the standard of care for thromboprophylaxis in this population. However, direct oral anticoagulants (DOACs) are increasin ...
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Journal ArticleRes Nurs Health · February 2021
Remote triage (RT) allows interprofessional teams (e.g., nurses and physicians) to assess patients and make clinical decisions remotely. RT use has developed widespread interest due to the COVID-19 pandemic, and has future potential to address the needs of ...
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Journal ArticleThromb Res · October 2020
BACKGROUND: Cancer associated venous thromboembolism (VTE) results in significant morbidity and mortality. Low molecular weight heparin (LMWH) has been standard of care for treatment of cancer-associated VTE, however direct oral anticoagulants (DOACs) are ...
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Journal ArticleJ Gen Intern Med · July 2020
BACKGROUND: Technology-based systems can facilitate remote decision-making to triage patients to the appropriate level of care. Despite technologic advances, the effects of implementation of these systems on patient and utilization outcomes are unclear. We ...
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Journal ArticlePalliat Med · February 2019
BACKGROUND:: Despite increasing emphasis on integration of palliative care with disease-directed care for advanced cancer, the nature of this integration and its effects on patient and caregiver outcomes are not well-understood. AIM:: We evaluated the effe ...
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Report · 2019
The US health care system currently faces several challenges including caring for an increasing elderly population, a large numbers of patients with multiple chronic conditions, and an uneven distribution of primary care providers across the country. The f ...
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Journal ArticleJ Altern Complement Med · April 2018
OBJECTIVES: Vasomotor symptoms (VMSs) are the most common symptoms reported during menopause. Although hormone therapy is effective for reducing VMSs, its use is restricted in some women. Many women with VMSs thus seek nonhormonal, nonpharmacologic treatme ...
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Journal ArticleCell Death Dis · January 26, 2018
Aplastic Anemia (AA) is a bone marrow failure (BMF) disorder, resulting in bone marrow hypocellularity and peripheral pancytopenia. Severe aplastic anemia (SAA) is a subset of AA defined by a more severe phenotype. Although the immunological nature of SAA ...
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Journal ArticleBlood Adv · October 24, 2017
Sickle cell disease (SCD) is a chronic, debilitating disorder. Chronically ill patients are at risk for depression, which can affect health-related quality of life (HRQoL), health care utilization, and cost. We performed an analytic epidemiologic prospecti ...
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Journal ArticleComplement Ther Med · October 2017
OBJECTIVES: Vasomotor symptoms (VMS), commonly reported during menopausal transition, negatively affect psychological health and health-related quality of life (HRQoL). While hormone therapy is an effective treatment, its use is limited by concerns about p ...
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Journal ArticleTransfus Apher Sci · June 2017
Ferrous iron can be converted to ferric iron by oxidative stress which results in the formation of methemoglobin. Consequently, the oxygen dissociation curve is shifted to the left, which leads to tissue hypoxia and ultimately may cause death. Acquired met ...
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Journal ArticleClimacteric · April 2017
Postmenopausal women with bothersome vasomotor symptoms (VMS) often seek alternatives to hormone-based treatment due to medication risks or personal preference. We sought to identify the effects of meditation, mindfulness, hypnosis and relaxation on VMS an ...
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Journal ArticleAnn Hematol · January 2017
Sickle cell disease (SCD) is an autosomal recessive inherited hemoglobinopathy, characterized by chronic hemolysis and recurrent vaso-occlusive crisis (VOC). This study investigates changes in leucocyte subsets and the relationship between cell adhesion mo ...
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Journal ArticleHemoglobin · January 2017
Thalassemia is a disorder of hemoglobin (Hb) synthesis characterized by chronic hemolysis. In β-thalassemias major (β-TM), patients require regular transfusion at an early age due to severe anemia. Subsequently, intensive chelation therapy is initiated to ...
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Journal ArticleSyst Rev · April 7, 2016
BACKGROUND: Vasomotor symptoms such as hot flashes and night sweats are a common concern of perimenopausal and postmenopausal women and are associated with a decreased quality of life. These symptoms can be effectively managed with hormone therapy, but saf ...
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Journal ArticleJ Arthroplasty · February 2016
BACKGROUND: Thromboprophylaxis regimens include pharmacologic and mechanical options such as intermittent pneumatic compression devices (IPCDs). There are a wide variety of IPCDs available, but it is uncertain if they vary in effectiveness or ease of use. ...
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Journal ArticleBritish Journal of Haematology · November 2015
SummaryRecent epidemiologic data suggest that sickle cell trait (HbAS; AS) is a risk factor for ven ...
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Journal ArticleThromb Res · March 2021
BACKGROUND: Venous thromboembolism (VTE) is a serious complication of orthopedic surgery. Low molecular weight heparin (LMWH) has been the standard of care for thromboprophylaxis in this population. However, direct oral anticoagulants (DOACs) are increasin ...
Full textLink to itemCite
Journal ArticleRes Nurs Health · February 2021
Remote triage (RT) allows interprofessional teams (e.g., nurses and physicians) to assess patients and make clinical decisions remotely. RT use has developed widespread interest due to the COVID-19 pandemic, and has future potential to address the needs of ...
Full textLink to itemCite
Journal ArticleThromb Res · October 2020
BACKGROUND: Cancer associated venous thromboembolism (VTE) results in significant morbidity and mortality. Low molecular weight heparin (LMWH) has been standard of care for treatment of cancer-associated VTE, however direct oral anticoagulants (DOACs) are ...
Full textLink to itemCite
Journal ArticleJ Gen Intern Med · July 2020
BACKGROUND: Technology-based systems can facilitate remote decision-making to triage patients to the appropriate level of care. Despite technologic advances, the effects of implementation of these systems on patient and utilization outcomes are unclear. We ...
Full textOpen AccessLink to itemCite
Journal ArticlePalliat Med · February 2019
BACKGROUND:: Despite increasing emphasis on integration of palliative care with disease-directed care for advanced cancer, the nature of this integration and its effects on patient and caregiver outcomes are not well-understood. AIM:: We evaluated the effe ...
Full textLink to itemCite
Report · 2019
The US health care system currently faces several challenges including caring for an increasing elderly population, a large numbers of patients with multiple chronic conditions, and an uneven distribution of primary care providers across the country. The f ...
Link to itemCite
Journal ArticleJ Altern Complement Med · April 2018
OBJECTIVES: Vasomotor symptoms (VMSs) are the most common symptoms reported during menopause. Although hormone therapy is effective for reducing VMSs, its use is restricted in some women. Many women with VMSs thus seek nonhormonal, nonpharmacologic treatme ...
Full textLink to itemCite
Journal ArticleCell Death Dis · January 26, 2018
Aplastic Anemia (AA) is a bone marrow failure (BMF) disorder, resulting in bone marrow hypocellularity and peripheral pancytopenia. Severe aplastic anemia (SAA) is a subset of AA defined by a more severe phenotype. Although the immunological nature of SAA ...
Full textOpen AccessLink to itemCite
Journal ArticleBlood Adv · October 24, 2017
Sickle cell disease (SCD) is a chronic, debilitating disorder. Chronically ill patients are at risk for depression, which can affect health-related quality of life (HRQoL), health care utilization, and cost. We performed an analytic epidemiologic prospecti ...
Full textOpen AccessLink to itemCite
Journal ArticleComplement Ther Med · October 2017
OBJECTIVES: Vasomotor symptoms (VMS), commonly reported during menopausal transition, negatively affect psychological health and health-related quality of life (HRQoL). While hormone therapy is an effective treatment, its use is limited by concerns about p ...
Full textLink to itemCite
Journal ArticleTransfus Apher Sci · June 2017
Ferrous iron can be converted to ferric iron by oxidative stress which results in the formation of methemoglobin. Consequently, the oxygen dissociation curve is shifted to the left, which leads to tissue hypoxia and ultimately may cause death. Acquired met ...
Full textLink to itemCite
Journal ArticleClimacteric · April 2017
Postmenopausal women with bothersome vasomotor symptoms (VMS) often seek alternatives to hormone-based treatment due to medication risks or personal preference. We sought to identify the effects of meditation, mindfulness, hypnosis and relaxation on VMS an ...
Full textLink to itemCite
Journal ArticleAnn Hematol · January 2017
Sickle cell disease (SCD) is an autosomal recessive inherited hemoglobinopathy, characterized by chronic hemolysis and recurrent vaso-occlusive crisis (VOC). This study investigates changes in leucocyte subsets and the relationship between cell adhesion mo ...
Full textLink to itemCite
Journal ArticleHemoglobin · January 2017
Thalassemia is a disorder of hemoglobin (Hb) synthesis characterized by chronic hemolysis. In β-thalassemias major (β-TM), patients require regular transfusion at an early age due to severe anemia. Subsequently, intensive chelation therapy is initiated to ...
Full textLink to itemCite
Journal ArticleSyst Rev · April 7, 2016
BACKGROUND: Vasomotor symptoms such as hot flashes and night sweats are a common concern of perimenopausal and postmenopausal women and are associated with a decreased quality of life. These symptoms can be effectively managed with hormone therapy, but saf ...
Full textOpen AccessLink to itemCite
Journal ArticleJ Arthroplasty · February 2016
BACKGROUND: Thromboprophylaxis regimens include pharmacologic and mechanical options such as intermittent pneumatic compression devices (IPCDs). There are a wide variety of IPCDs available, but it is uncertain if they vary in effectiveness or ease of use. ...
Full textLink to itemCite
Journal ArticleBritish Journal of Haematology · November 2015
SummaryRecent epidemiologic data suggest that sickle cell trait (HbAS; AS) is a risk factor for ven ...
Full textOpen AccessCite
Journal ArticleAm J Perinatol · October 2014
OBJECTIVE: The aim of the study is to examine the relationship between sickle cell trait (Hb AS) and other sickle hemoglobinopathies and the risk of thromboembolism during pregnancy or the puerperium. STUDY DESIGN: Retrospective cohort study of African Ame ...
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Journal ArticleAnn Intern Med · August 20, 2013
BACKGROUND: Pharmacologic thromboprophylaxis reduces the risk for venous thromboembolism after total hip replacement (THR) or total knee replacement (TKR). New oral anticoagulants (NOACs), including direct thrombin inhibitors and factor Xa inhibitors, are ...
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Journal ArticlePediatr Blood Cancer · April 2013
The complex pathophysiology of sickle cell disease (SCD) is remarkably similar to that observed in other chronic vascular diseases and involves multiple biologic pathways triggered by ischemia reperfusion injury, coagulation activation, and inflammation. S ...
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Journal ArticleAnn Intern Med · December 4, 2012
BACKGROUND: New oral anticoagulants (NOACs), including direct thrombin inhibitors (DTIs) and factor Xa (FXa) inhibitors, are emerging alternatives for prophylaxis and treatment of atrial fibrillation (AF) and venous thromboembolism (VTE). PURPOSE: To compa ...
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Journal ArticleBahrain Medical Bulletin · 2012
Background: Hemophilia is an x-linked inherited bleeding disorder that requires lifelong medical support. Objective: To evaluatethe prevalence, presentation and management of inherited bleeding disorders. Setting: Hematology Department, King Abdulaziz Univ ...
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Journal ArticleMediterranean Journal of Hematology and Infectious Diseases · 2012
Acquired haemophilia A is a serious and potentially fatal bleeding disorder. Diagnosis is difficult and maybe delayed due to its rarity. The high mortality rate and the complex nature of treatment necessitate patient management at a haemophilia centre, whe ...
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Journal ArticleHealth Outcomes Research in Medicine · July 1, 2010
Background: Pain is a limiting factor in the daily life activities of sickle cell disease (SCD) patients. Although opioid analgesics are widely used, to date there have been no studies on the relationship of daily opioid use to quality of life (QoL) measur ...
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Journal ArticleEuropean Journal of Haematology · 2010
Background: Pulmonary hypertension (PHT) is reported to be associated with measures of renal function in patients with sickle cell disease (SCD). The purpose of this exploratory study was to determine the relationship between albuminuria and both clinical ...
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Journal ArticleBlood · March 26, 2009
The D-dimer antigen is a unique marker of fibrin degradation that is formed by the sequential action of 3 enzymes: thrombin, factor XIIIa, and plasmin. First, thrombin cleaves fibrinogen producing fibrin monomers, which polymerize and serve as a template f ...
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Journal ArticleAm J Med · October 2008
BACKGROUND: Sickle cell disease patients are more likely than the general population to undergo surgery and usually do so at a younger age. Female sickle cell disease patients also have special gynecological and obstetric issues related to their disease. M ...
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ConferenceBlood · November 16, 2007
AbstractSickle cell disease (SCD) patients experience high rates of morbidity and early mortality. Hydroxyurea (HU) therapy is associated with decreased morbidity and mortality as well as improved patient he ...
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Journal ArticleBahrain Medical Bulletin · 2007
Objective: To evaluate the prognostic significance of the disease features at presentation in chronic myeloid leukemia (CML) patients. Design: This is a retrospective study of sixty patients of CML and their follow up over 20 years. Ten clinical and labora ...
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