Scholars@Duke
Soheir Saeed Adam

Soheir Saeed Adam

Associate Professor of Medicine
Medicine, Hematology
soheir.adam@duke.edu
40 Medicine Circle, Box 3939, Durham, NC 27710

Selected Publications

Thromboprophylaxis for orthopedic surgery; An updated meta-analysis.

Journal Article Thromb Res · March 2021 BACKGROUND: Venous thromboembolism (VTE) is a serious complication of orthopedic surgery. Low molecular weight heparin (LMWH) has been the standard of care for thromboprophylaxis in this population. However, direct oral anticoagulants (DOACs) are increasin ... Full text Link to item Cite

Implementing remote triage in large health systems: A qualitative evidence synthesis.

Journal Article Res Nurs Health · February 2021 Remote triage (RT) allows interprofessional teams (e.g., nurses and physicians) to assess patients and make clinical decisions remotely. RT use has developed widespread interest due to the COVID-19 pandemic, and has future potential to address the needs of ... Full text Link to item Cite

Meta-analysis fever in the wake of CARAVAGGIO.

Journal Article Thromb Res · December 2020 Full text Link to item Cite

Direct oral anticoagulant versus low-molecular-weight heparin for treatment of venous thromboembolism in cancer patients: An updated meta-analysis of randomized controlled trials.

Journal Article Thromb Res · October 2020 BACKGROUND: Cancer associated venous thromboembolism (VTE) results in significant morbidity and mortality. Low molecular weight heparin (LMWH) has been standard of care for treatment of cancer-associated VTE, however direct oral anticoagulants (DOACs) are ... Full text Link to item Cite

Effectiveness of Acute Care Remote Triage Systems: a Systematic Review.

Journal Article J Gen Intern Med · July 2020 BACKGROUND: Technology-based systems can facilitate remote decision-making to triage patients to the appropriate level of care. Despite technologic advances, the effects of implementation of these systems on patient and utilization outcomes are unclear. We ... Full text Open Access Link to item Cite

Integrated outpatient palliative care for patients with advanced cancer: A systematic review and meta-analysis.

Journal Article Palliat Med · February 2019 BACKGROUND:: Despite increasing emphasis on integration of palliative care with disease-directed care for advanced cancer, the nature of this integration and its effects on patient and caregiver outcomes are not well-understood. AIM:: We evaluated the effe ... Full text Link to item Cite

Effectiveness of Remote Triage: A Systematic Review

Report · 2019 The US health care system currently faces several challenges including caring for an increasing elderly population, a large numbers of patients with multiple chronic conditions, and an uneven distribution of primary care providers across the country. The f ... Link to item Cite

Management of Menopause Symptoms with Acupuncture: An Umbrella Systematic Review and Meta-Analysis.

Journal Article J Altern Complement Med · April 2018 OBJECTIVES: Vasomotor symptoms (VMSs) are the most common symptoms reported during menopause. Although hormone therapy is effective for reducing VMSs, its use is restricted in some women. Many women with VMSs thus seek nonhormonal, nonpharmacologic treatme ... Full text Link to item Cite

iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.

Journal Article Cell Death Dis · January 26, 2018 Aplastic Anemia (AA) is a bone marrow failure (BMF) disorder, resulting in bone marrow hypocellularity and peripheral pancytopenia. Severe aplastic anemia (SAA) is a subset of AA defined by a more severe phenotype. Although the immunological nature of SAA ... Full text Open Access Link to item Cite

Depression, quality of life, and medical resource utilization in sickle cell disease.

Journal Article Blood Adv · October 24, 2017 Sickle cell disease (SCD) is a chronic, debilitating disorder. Chronically ill patients are at risk for depression, which can affect health-related quality of life (HRQoL), health care utilization, and cost. We performed an analytic epidemiologic prospecti ... Full text Open Access Link to item Cite

Improving vasomotor symptoms; psychological symptoms; and health-related quality of life in peri- or post-menopausal women through yoga: An umbrella systematic review and meta-analysis.

Journal Article Complement Ther Med · October 2017 OBJECTIVES: Vasomotor symptoms (VMS), commonly reported during menopausal transition, negatively affect psychological health and health-related quality of life (HRQoL). While hormone therapy is an effective treatment, its use is limited by concerns about p ... Full text Link to item Cite

Plasmapheresis in severe methemoglobinemia following occupational exposure.

Journal Article Transfus Apher Sci · June 2017 Ferrous iron can be converted to ferric iron by oxidative stress which results in the formation of methemoglobin. Consequently, the oxygen dissociation curve is shifted to the left, which leads to tissue hypoxia and ultimately may cause death. Acquired met ... Full text Link to item Cite

Use of mindfulness, meditation and relaxation to treat vasomotor symptoms.

Journal Article Climacteric · April 2017 Postmenopausal women with bothersome vasomotor symptoms (VMS) often seek alternatives to hormone-based treatment due to medication risks or personal preference. We sought to identify the effects of meditation, mindfulness, hypnosis and relaxation on VMS an ... Full text Link to item Cite

Markers of endothelial dysfunction and leucocyte activation in Saudi and non-Saudi haplotypes of sickle cell disease.

Journal Article Ann Hematol · January 2017 Sickle cell disease (SCD) is an autosomal recessive inherited hemoglobinopathy, characterized by chronic hemolysis and recurrent vaso-occlusive crisis (VOC). This study investigates changes in leucocyte subsets and the relationship between cell adhesion mo ... Full text Link to item Cite

Quality of Life Outcomes in a Pediatric Thalassemia Population in Egypt.

Journal Article Hemoglobin · January 2017 Thalassemia is a disorder of hemoglobin (Hb) synthesis characterized by chronic hemolysis. In β-thalassemias major (β-TM), patients require regular transfusion at an early age due to severe anemia. Subsequently, intensive chelation therapy is initiated to ... Full text Link to item Cite

Nonpharmacologic, nonherbal management of menopause-associated vasomotor symptoms: an umbrella systematic review (protocol).

Journal Article Syst Rev · April 7, 2016 BACKGROUND: Vasomotor symptoms such as hot flashes and night sweats are a common concern of perimenopausal and postmenopausal women and are associated with a decreased quality of life. These symptoms can be effectively managed with hormone therapy, but saf ... Full text Open Access Link to item Cite

Effectiveness of Intermittent Pneumatic Compression Devices for Venous Thromboembolism Prophylaxis in High-Risk Surgical Patients: A Systematic Review.

Journal Article J Arthroplasty · February 2016 BACKGROUND: Thromboprophylaxis regimens include pharmacologic and mechanical options such as intermittent pneumatic compression devices (IPCDs). There are a wide variety of IPCDs available, but it is uncertain if they vary in effectiveness or ease of use. ... Full text Link to item Cite

Coagulation activation in sickle cell trait: an exploratory study

Journal Article British Journal of Haematology · November 2015 SummaryRecent epidemiologic data suggest that sickle cell trait (HbAS; AS) is a risk factor for ven ... Full text Open Access Cite

Impact of sickle hemoglobinopathies on pregnancy-related venous thromboembolism.

Journal Article Am J Perinatol · October 2014 OBJECTIVE: The aim of the study is to examine the relationship between sickle cell trait (Hb AS) and other sickle hemoglobinopathies and the risk of thromboembolism during pregnancy or the puerperium. STUDY DESIGN: Retrospective cohort study of African Ame ... Full text Link to item Cite

Comparative effectiveness of new oral anticoagulants and standard thromboprophylaxis in patients having total hip or knee replacement: a systematic review.

Journal Article Ann Intern Med · August 20, 2013 BACKGROUND: Pharmacologic thromboprophylaxis reduces the risk for venous thromboembolism after total hip replacement (THR) or total knee replacement (TKR). New oral anticoagulants (NOACs), including direct thrombin inhibitors and factor Xa inhibitors, are ... Full text Link to item Cite

Potential role for statins in sickle cell disease.

Journal Article Pediatr Blood Cancer · April 2013 The complex pathophysiology of sickle cell disease (SCD) is remarkably similar to that observed in other chronic vascular diseases and involves multiple biologic pathways triggered by ischemia reperfusion injury, coagulation activation, and inflammation. S ... Full text Link to item Cite

Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism: a systematic review.

Journal Article Ann Intern Med · December 4, 2012 BACKGROUND: New oral anticoagulants (NOACs), including direct thrombin inhibitors (DTIs) and factor Xa (FXa) inhibitors, are emerging alternatives for prophylaxis and treatment of atrial fibrillation (AF) and venous thromboembolism (VTE). PURPOSE: To compa ... Full text Link to item Cite

Outcomes of congenital bleeding disorders

Journal Article Bahrain Medical Bulletin · 2012 Background: Hemophilia is an x-linked inherited bleeding disorder that requires lifelong medical support. Objective: To evaluatethe prevalence, presentation and management of inherited bleeding disorders. Setting: Hematology Department, King Abdulaziz Univ ... Cite

Successful long term eradication of factor VIII inhibitor in patients with acquired haemophilia a in Saudi Arabia

Journal Article Mediterranean Journal of Hematology and Infectious Diseases · 2012 Acquired haemophilia A is a serious and potentially fatal bleeding disorder. Diagnosis is difficult and maybe delayed due to its rarity. The high mortality rate and the complex nature of treatment necessitate patient management at a haemophilia centre, whe ... Full text Cite

The relationship of opioid analgesia to quality of life in an adult sickle cell population

Journal Article Health Outcomes Research in Medicine · July 1, 2010 Background: Pain is a limiting factor in the daily life activities of sickle cell disease (SCD) patients. Although opioid analgesics are widely used, to date there have been no studies on the relationship of daily opioid use to quality of life (QoL) measur ... Full text Cite

Urinary albumin excretion is associated with pulmonary hypertension in sickle cell disease: Potential role of soluble fms-like tyrosine kinase-1

Journal Article European Journal of Haematology · 2010 Background: Pulmonary hypertension (PHT) is reported to be associated with measures of renal function in patients with sickle cell disease (SCD). The purpose of this exploratory study was to determine the relationship between albuminuria and both clinical ... Full text Cite

D-dimer antigen: current concepts and future prospects.

Journal Article Blood · March 26, 2009 The D-dimer antigen is a unique marker of fibrin degradation that is formed by the sequential action of 3 enzymes: thrombin, factor XIIIa, and plasmin. First, thrombin cleaves fibrinogen producing fibrin monomers, which polymerize and serve as a template f ... Full text Link to item Cite

Surgical and obstetric outcomes in adults with sickle cell disease.

Journal Article Am J Med · October 2008 BACKGROUND: Sickle cell disease patients are more likely than the general population to undergo surgery and usually do so at a younger age. Female sickle cell disease patients also have special gynecological and obstetric issues related to their disease. M ... Full text Link to item Cite

The Effects of Chronic Opiates Pain Therapy in Sickle Cell Anemia.

Conference Blood · November 16, 2007 AbstractSickle cell disease (SCD) patients experience high rates of morbidity and early mortality. Hydroxyurea (HU) therapy is associated with decreased morbidity and mortality as well as improved patient he ... Full text Cite

Analysis of prognostic factors affecting response to treatment and survival in chronic myeloid leukemia patients

Journal Article Bahrain Medical Bulletin · 2007 Objective: To evaluate the prognostic significance of the disease features at presentation in chronic myeloid leukemia (CML) patients. Design: This is a retrospective study of sixty patients of CML and their follow up over 20 years. Ten clinical and labora ... Cite