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Depression, quality of life, and medical resource utilization in sickle cell disease.

Publication ,  Journal Article
Adam, SS; Flahiff, CM; Kamble, S; Telen, MJ; Reed, SD; De Castro, LM
Published in: Blood Adv
October 24, 2017

Sickle cell disease (SCD) is a chronic, debilitating disorder. Chronically ill patients are at risk for depression, which can affect health-related quality of life (HRQoL), health care utilization, and cost. We performed an analytic epidemiologic prospective study to determine the prevalence of depression in adult patients with SCD and its association with HRQoL and medical resource utilization. Depression was measured by the Beck Depression Inventory and clinical history in adult SCD outpatients at a comprehensive SCD center. HRQoL was assessed using the SF36 form, and data were collected on medical resource utilization and corresponding cost. Neurocognitive functions were assessed using the CNS Vital Signs tool. Pain diaries were used to record daily pain. Out of 142 enrolled patients, 42 (35.2%) had depression. Depression was associated with worse physical and mental HRQoL scores (P < .0001 and P < .0001, respectively). Mean total inpatient costs ($25 000 vs $7487, P = .02) and total health care costs ($30 665 vs $13 016, P = .01) were significantly higher in patients with depression during the 12 months preceding diagnosis. Similarly, during the 6 months following diagnosis, mean total health care costs were significantly higher in depressed patients than in nondepressed patients ($13 766 vs $8670, P = .04). Depression is prevalent in adult patients with SCD and is associated with worse HRQoL and higher total health care costs. Efforts should focus on prevention, early diagnosis, and therapy for depression in SCD.

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Published In

Blood Adv

DOI

ISSN

2473-9529

Publication Date

October 24, 2017

Volume

1

Issue

23

Start / End Page

1983 / 1992

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Adam, S. S., Flahiff, C. M., Kamble, S., Telen, M. J., Reed, S. D., & De Castro, L. M. (2017). Depression, quality of life, and medical resource utilization in sickle cell disease. Blood Adv, 1(23), 1983–1992. https://doi.org/10.1182/bloodadvances.2017006940
Adam, Soheir S., Charlene M. Flahiff, Shital Kamble, Marilyn J. Telen, Shelby D. Reed, and Laura M. De Castro. “Depression, quality of life, and medical resource utilization in sickle cell disease.Blood Adv 1, no. 23 (October 24, 2017): 1983–92. https://doi.org/10.1182/bloodadvances.2017006940.
Adam SS, Flahiff CM, Kamble S, Telen MJ, Reed SD, De Castro LM. Depression, quality of life, and medical resource utilization in sickle cell disease. Blood Adv. 2017 Oct 24;1(23):1983–92.
Adam, Soheir S., et al. “Depression, quality of life, and medical resource utilization in sickle cell disease.Blood Adv, vol. 1, no. 23, Oct. 2017, pp. 1983–92. Pubmed, doi:10.1182/bloodadvances.2017006940.
Adam SS, Flahiff CM, Kamble S, Telen MJ, Reed SD, De Castro LM. Depression, quality of life, and medical resource utilization in sickle cell disease. Blood Adv. 2017 Oct 24;1(23):1983–1992.

Published In

Blood Adv

DOI

ISSN

2473-9529

Publication Date

October 24, 2017

Volume

1

Issue

23

Start / End Page

1983 / 1992

Location

United States