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Zebulon Zachary Spector

Assistant Professor of Pediatrics
Pediatrics, Cardiology
2301 Erwin Drive, 7507 - A, Durham, NC 27710
2301 Erwin Drive, 7507 -A, Durham, NC 27710

Selected Publications


Utility of Cardiac Magnetic Resonance Imaging in Predicting Atrial Arrhythmias in Repaired Tetralogy of Fallot.

Journal Article Am J Cardiol · July 1, 2022 Arrhythmias are the leading cause of morbidity and mortality in repaired tetralogy of Fallot (TOF), and over 20% of these patients will develop a sustained atrial arrhythmia during their lifetimes. Cardiac magnetic resonance imaging (cMRI) is frequently pe ... Full text Link to item Cite

Exercise Capacity and Predictors of Performance After Fontan: Results from the Pediatric Heart Network Fontan 3 Study.

Journal Article Pediatr Cardiol · January 2021 Impaired exercise following Fontan is a surrogate of morbidity. Single-center longitudinal data exist, but there is a lack of contemporary multi-center data. Ramp cycle ergometry was re-performed in consented participants who had originally participated in ... Full text Link to item Cite

Pacing in Patients with Congenital Heart Disease: When Is It Helpful and When Is It Harmful?

Journal Article Curr Cardiol Rep · January 16, 2020 PURPOSE OF REVIEW: Pacing in pediatric and adult patients with congenital heart disease requires careful evaluation and thoughtful planning. Review of current guidelines with assessment of risk/benefit must be performed along with planning on a case-by-cas ... Full text Link to item Cite

Life-Threatening Event Risk in Children With Wolff-Parkinson-White Syndrome: A Multicenter International Study.

Journal Article JACC Clin Electrophysiol · April 2018 OBJECTIVES: This study sought to characterize risk in children with Wolff-Parkinson-White (WPW) syndrome by comparing those who had experienced a life-threatening event (LTE) with a control population. BACKGROUND: Children with WPW syndrome are at risk of ... Full text Link to item Cite

A Minimally Invasive Approach for Placing Sew-On Epicardial Leads in the Child.

Journal Article Innovations (Phila) · 2018 Traditionally, pacing leads are placed transvenously, although smaller pediatric patients who require permanent pacemakers may benefit from delaying tranvenous lead placement until they are larger. Alternative, minimally invasive atrioventricular pacing op ... Full text Link to item Cite

Arrhythmias and pacing

Chapter · January 1, 2018 The rapid recognition, diagnosis, and management of cardiac arrhythmias are essential skills in the intensive care unit (ICU). Outcomes can hinge on the timely initiation of arrhythmia therapy. The aim of this chapter is to serve as a useful, practical res ... Full text Cite

Premature ventricular contraction-induced cardiomyopathy in children.

Journal Article Cardiol Young · April 2016 BACKGROUND: Adults with high premature ventricular contraction burden can develop left ventricular dilation, dysfunction, and strain, consistent with a cardiomyopathy, which is reversible with radiofrequency ablation of the premature ventricular contractio ... Full text Link to item Cite

Perioperative donor risk

Chapter · April 27, 2007 Cite

Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging.

Journal Article Magn Reson Med · June 2005 In this experiment, Sprague-Dawley rats with elastase-induced emphysema were imaged using hyperpolarized (3)He MRI. Regional fractional ventilation r, the fraction of gas replaced with a single tidal breath, was calculated from a series of images in a wash ... Full text Link to item Cite

Hyperpolarized helium-3 MR imaging of pulmonary function.

Journal Article Radiol Clin North Am · January 2005 Recent advances in HP MR imaging contrast agents have led to novel tests of pulmonary function. Many of these tests show promise in the clinical arena. ... Full text Link to item Cite

Single-acquisition sequence for the measurement of oxygen partial pressure by hyperpolarized gas MRI.

Journal Article Magn Reson Med · October 2004 Magnetic resonance imaging (MRI) with hyperpolarized 3-helium gas (HP 3He) offers the possibility of studying functional lung parameters such as the alveolar oxygen concentration and oxygen depletion rate. Until now, a double-acquisition technique has been ... Full text Link to item Cite

A small animal model of regional alveolar ventilation using HP 3He MRI1.

Journal Article Acad Radiol · October 2004 RATIONALE AND OBJECTIVES: The aim of this study was to establish a standardized procedure for the measurement of regional fractional ventilation in a healthy rat model as a baseline for further studies of pulmonary disorder models. MATERIALS AND METHODS: T ... Full text Link to item Cite

Determination of regional VA/Q by hyperpolarized 3He MRI.

Journal Article Magn Reson Med · July 2004 Alveolar ventilation/perfusion ratio (VA/Q) is a key parameter in functional imaging of the lung. Herein, regional VA/Q was calculated from regional values of alveolar partial pressure of oxygen (PAO2) measured by hyperpolarized 3He gas MRI (HP 3He MRI). Y ... Full text Link to item Cite

An evaluation of pulmonary atelectasis and its re-expansion: hyperpolarized 3He MRI in the Yorkshire pig.

Journal Article Acad Radiol · November 2003 RATIONALE AND OBJECTIVES: Atelectasis, the collapse of small airways, is a significant clinical problem. We use hyperpolarized (HP) 3He magnetic resonance imaging (MRI), or HP 3He MRI, to describe atelectasis in the normal Yorkshire pig, the pig with atele ... Full text Link to item Cite