Scholars@Duke
Sreekanth Vemulapalli

Sreekanth Vemulapalli

Associate Professor of Medicine
Medicine, Cardiology
sreekanth.vemulapalli@duke.edu
Box 3126 Medical Center, Durham, NC 27710
2301 Erwin Rd, Room 7451 D, Durham, NC 27710

Selected Publications

Economic Outcomes With Precision Diagnostic Testing Versus Usual Testing in Stable Chest Pain: Results From the PRECISE Randomized Trial.

Journal Article Circ Cardiovasc Qual Outcomes · February 3, 2025 BACKGROUND: The PRECISE (Prospective Randomized Trial of the Optimal Evaluation of Cardiac Symptoms and Revascularization) demonstrated that a precision diagnostic strategy reduced the primary composite of death, nonfatal myocardial infarction, or catheter ... Full text Link to item Cite

Quality of Life Outcomes With a Risk-Based Precision Testing Strategy Versus Usual Testing in Stable Patients With Suspected Coronary Disease: Results From the PRECISE Randomized Trial.

Journal Article Circ Cardiovasc Qual Outcomes · February 3, 2025 BACKGROUND: The PRECISE (Prospective Randomized Trial of the Optimal Evaluation of Cardiac Symptoms and Revascularization) trial compared an investigational precision diagnostic testing strategy (n=1057) with usual testing (n=1046) in patients with stable ... Full text Link to item Cite

Trends in Transcatheter Aortic Valve Replacement Outcomes: Insights From the STS/ACC TVT Registry.

Journal Article JAMA Cardiol · December 1, 2024 IMPORTANCE: Although transcatheter aortic valve replacement (TAVR) outcomes in the US have improved substantially since 2011, it is unknown whether these trends have continued since 2019. OBJECTIVE: To examine changes in risk-adjusted TAVR outcomes from 20 ... Full text Link to item Cite

Mitral Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation With Preserved Left Ventricular Function.

Journal Article JACC Cardiovasc Interv · November 11, 2024 BACKGROUND: Outcomes of mitral transcatheter edge-to-edge repair (MTEER) in patients with secondary mitral regurgitation (sMR) and preserved left ventricular ejection fraction (LVEF) are uncertain. OBJECTIVES: This study sought to describe outcomes of MTEE ... Full text Link to item Cite

Trends, Predictors, and Outcomes of Bleeding Complications After Mitral Transcatheter Edge-to-Edge Repair: TVT Registry Insights.

Journal Article JACC Cardiovasc Interv · October 28, 2024 BACKGROUND: Bleeding events after arterial transcatheter procedures are associated with increased morbidity and mortality. The frequency and clinical implications of bleeding after mitral transcatheter edge-to-edge repair (M-TEER) have not been well-studie ... Full text Link to item Cite

Clinical Outcomes in Relation to Total Hospital Surgical and Transcatheter Aortic Valve Replacement Volumes.

Journal Article J Am Heart Assoc · October 2024 BACKGROUND: There is a paucity of data regarding the relationship between overall hospital volumes for total aortic valve replacement (AVR; transcatheter AVR [TAVR] or surgical AVR [SAVR]) and patient outcomes. METHODS AND RESULTS: We queried the 2019 Nati ... Full text Link to item Cite

Impact of Cerebral Embolic Protection Devices on Disabling Stroke After TAVR: Updated Results From the STS/ACC TVT Registry.

Journal Article Circ Cardiovasc Interv · September 2024 BACKGROUND: Cerebral embolic protection devices (EPDs) were developed to mitigate the risk of stroke during transcatheter aortic valve replacement (TAVR), but their benefit remains unproven. In the PROTECTED-TAVR trial (Stroke Protection With Sentinel Duri ... Full text Link to item Cite

Association of Baseline Tricuspid Regurgitation With Health Status and Clinical Outcomes After TAVR and Mitral TEER.

Journal Article JACC Cardiovasc Interv · August 26, 2024 BACKGROUND: Tricuspid regurgitation (TR) is associated with worse clinical outcomes after transcatheter aortic valve replacement (TAVR) and mitral transcatheter edge-to-edge repair (M-TEER), but little is known about its association with health status outc ... Full text Link to item Cite

Impact of Tricuspid Regurgitation on Outcomes of Transcatheter Aortic Valve Replacement With Balloon-Expandable Valves.

Journal Article JACC Cardiovasc Interv · August 26, 2024 BACKGROUND: Tricuspid regurgitation (TR) is highly prevalent in the transcatheter aortic valve replacement (TAVR) population, but clear management guidelines are lacking. OBJECTIVES: The aims of this study were to elucidate the prevalence and consequences ... Full text Link to item Cite

Diagnostic Performance of Coronary Angiography Derived Computational Fractional Flow Reserve.

Journal Article J Am Heart Assoc · July 2, 2024 BACKGROUND: Computational fluid dynamics can compute fractional flow reserve (FFR) accurately. However, existing models are limited by either the intravascular hemodynamic phenomarkers that can be captured or the fidelity of geometries that can be modeled. ... Full text Open Access Link to item Cite

Impact of Elevated Gradients After Transcatheter Aortic Valve Implantation for Degenerated Surgical Aortic Valve Bioprostheses.

Journal Article Circ Cardiovasc Interv · July 2024 BACKGROUND: Elevated aortic valve gradients are common after transcatheter aortic valve implantation for degenerated surgical aortic valve replacement bioprostheses, but their clinical impact is uncertain. METHODS: A total of 12 122 patients who underwent ... Full text Link to item Cite

Procedure Volume and Outcomes With WATCHMAN Left Atrial Appendage Occlusion.

Journal Article Circ Cardiovasc Interv · June 2024 BACKGROUND: Procedure volumes are associated with outcomes for many cardiovascular procedures, leading to guidelines on minimum volume thresholds for certain procedures; however, the volume-outcome relationship with left atrial appendage occlusion is poorl ... Full text Link to item Cite

Comparison of Transcatheter Edge-to-Edge Mitral Valve Repair for Primary Mitral Regurgitation Outcomes to Hospital Volumes of Surgical Mitral Valve Repair.

Journal Article Circ Cardiovasc Interv · April 2024 BACKGROUND: Transcatheter edge-to-edge mitral valve (MV) repair (TEER) is an effective treatment for patients with primary mitral regurgitation at prohibitive risk for surgical MV repair (MVr). High-volume MVr centers and high-volume TEER centers have bett ... Full text Link to item Cite

Patient Risk-Benefit Preferences for Transcatheter Versus Surgical Mitral Valve Repair.

Journal Article J Am Heart Assoc · March 19, 2024 BACKGROUND: Transcatheter edge-to-edge repair (TEER) of mitral regurgitation is less invasive than surgery but has greater 5-year mortality and reintervention risks, and leads to smaller improvements in physical functioning. The study objective was to quan ... Full text Link to item Cite

National Variation in Hospital MTEER Outcomes and Correlation With TAVR Outcomes: STS/ACC TVT Registry Analysis.

Journal Article JACC Cardiovasc Interv · February 26, 2024 BACKGROUND: A single, multitiered valve center designation has been proposed to publicly identify centers with expertise for all valve therapies. The correlation between transcatheter aortic valve replacement (TAVR) and mitral transcatheter edge-to-edge re ... Full text Link to item Cite

National Variability in Pacemaker Implantation Rate Following TAVR: Insights From the STS/ACC TVT Registry.

Journal Article JACC Cardiovasc Interv · February 12, 2024 BACKGROUND: Although permanent pacemaker (PPM) implantation is a common complication of transcatheter aortic valve replacement (TAVR), hospital variation and change in PPM implantation rates are ill defined. OBJECTIVES: The aim of this study was to determi ... Full text Link to item Cite

Transcatheter Edge-to-Edge Repair in COAPT-Ineligible Patients With Functional Mitral Regurgitation.

Journal Article J Am Coll Cardiol · January 30, 2024 BACKGROUND: Mitral valve transcatheter edge-to-edge repair (MTEER) was approved in the United States for treatment of functional mitral regurgitation (FMR) based on results from the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Th ... Full text Link to item Cite

3-Year Outcomes for Degenerative Mitral Regurgitation Repair in a Medicare Population.

Journal Article Innovations (Phila) · 2024 OBJECTIVE: Mitral valve repair (MVr) has become the standard therapy for degenerative mitral regurgitation (DMR), but real-world late mortality, reintervention, and readmission data are lacking. This study estimates MVr outcomes for DMR to 3 years in the M ... Full text Link to item Cite

Leveraging Computational Fluid Dynamics for Next-Generation Preoperative Planning in Vascular Surgery

Conference Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS · January 1, 2024 Chronic limb-threatening ischemia (CLTI) is one of the leading causes of permanent disability and death in the United States and around the world. Surgical revascularization is the mainstay of treatment for CLTI, but patients still suffer high rates of lim ... Full text Cite

Benchmarking Outcomes of Surgical Aortic Valve Replacement in Patients With Bicuspid Aortic Valves.

Journal Article Ann Thorac Surg · December 2023 BACKGROUND: The relative roles for transcatheter and surgical aortic valve replacement (SAVR) for bicuspid aortic valve (AV) stenosis are debated. This study analyzes the 5-year longitudinal outcomes of isolated SAVR in bicuspid vs tricuspid AV patients, p ... Full text Link to item Cite

Association Between Polyvascular Disease and Transcatheter Aortic Valve Replacement Outcomes: Insights From the STS/ACC TVT Registry.

Journal Article Circ Cardiovasc Interv · December 2023 BACKGROUND: Atherosclerotic cardiovascular disease is highly prevalent in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). Polyvascular disease (PVD), defined as involvement of ≥2 vascular beds (VBs), that is, ... Full text Link to item Cite

Heart failure medical therapy prior to mitral transcatheter edge-to-edge repair: the STS/ACC Transcatheter Valve Therapy Registry.

Journal Article Eur Heart J · November 21, 2023 BACKGROUND AND AIMS: Guideline-directed medical therapy (GDMT) is recommended before mitral valve transcatheter edge-to-edge repair (MTEER) in patients with heart failure (HF) and severe functional mitral regurgitation (FMR). Whether MTEER is being perform ... Full text Link to item Cite

Outcomes of Transcatheter Aortic Valve Replacement in Asymptomatic or Minimally Symptomatic Aortic Stenosis.

Journal Article JACC Cardiovasc Interv · November 13, 2023 BACKGROUND: Little is known about the outcomes of transcatheter aortic valve replacement (TAVR) in minimally symptomatic patients. OBJECTIVES: The authors aimed to evaluate the outcomes of patients with minimally symptomatic severe aortic stenosis treated ... Full text Link to item Cite

Safety and Efficacy of Renal Denervation in Patients Taking Antihypertensive Medications.

Journal Article J Am Coll Cardiol · November 7, 2023 BACKGROUND: Renal denervation (RDN) reduces blood pressure (BP) in patients with uncontrolled hypertension in the absence of antihypertensive medications. OBJECTIVES: This trial assessed the safety and efficacy of RDN in the presence of antihypertensive me ... Full text Link to item Cite

Long-term Outcomes and Anticoagulation in Mitral Valve Surgery-A Report From The Society of Thoracic Surgeons Database.

Journal Article Ann Thorac Surg · November 2023 BACKGROUND: Anticoagulation after bioprosthetic mitral valve (MV) replacement (BMVR) and repair (MVrep) is controversial. We explore outcomes among BMVR and MVrep patients in The Society of Thoracic Surgeons Adult Cardiac Surgery Database based on discharg ... Full text Link to item Cite

Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints.

Journal Article Ann Thorac Surg · November 2023 Interest in the pathophysiology, etiology, management, and outcomes of patients with tricuspid regurgitation (TR) has grown in the wake of multiple natural history studies showing progressively worse outcomes associated with increasing TR severity, even af ... Full text Link to item Cite

Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints.

Journal Article J Am Coll Cardiol · October 24, 2023 Interest in the pathophysiology, etiology, management, and outcomes of patients with tricuspid regurgitation (TR) has grown in the wake of multiple natural history studies showing progressively worse outcomes associated with increasing TR severity, even af ... Full text Link to item Cite

Comparison of an Initial Risk-Based Testing Strategy vs Usual Testing in Stable Symptomatic Patients With Suspected Coronary Artery Disease: The PRECISE Randomized Clinical Trial.

Journal Article JAMA Cardiol · October 1, 2023 IMPORTANCE: Trials showing equivalent or better outcomes with initial evaluation using coronary computed tomography angiography (cCTA) compared with stress testing in patients with stable chest pain have informed guidelines but raise questions about overte ... Full text Link to item Cite

Deferred Testing in Stable Outpatients With Suspected Coronary Artery Disease: A Prespecified Secondary Analysis of the PRECISE Randomized Clinical Trial.

Journal Article JAMA Cardiol · October 1, 2023 IMPORTANCE: Guidelines recommend deferral of testing for symptomatic people with suspected coronary artery disease (CAD) and low pretest probability. To our knowledge, no randomized trial has prospectively evaluated such a strategy. OBJECTIVE: To assess pr ... Full text Link to item Cite

Artificial intelligence and heart failure: A state-of-the-art review.

Journal Article Eur J Heart Fail · September 2023 Heart failure (HF) is a heterogeneous syndrome affecting more than 60 million individuals globally. Despite recent advancements in understanding of the pathophysiology of HF, many issues remain including residual risk despite therapy, understanding the pat ... Full text Link to item Cite

Clinical and cost implications of deferred testing in low-risk patients with stable chest pain: a simulation using the PROMISE trial.

Journal Article Am Heart J · July 2023 Current guidelines recommend a deferred testing approach in low-risk patients presenting with stable chest pain. After simulating a deferred testing approach using the PROMISE Minimal Risk Score to identify 915 minimal risk participants with cost data from ... Full text Link to item Cite

Mediators of Improvement in TAVR Outcomes Over Time: Insights From the STS-ACC TVT Registry.

Journal Article Circ Cardiovasc Interv · July 2023 BACKGROUND: Over the past decade, there has been substantial improvement in outcomes after transcatheter aortic valve replacement. Many patient and procedural factors have also changed over that time, making it challenging to untangle the drivers of those ... Full text Link to item Cite

Minimum Core Data Elements for Transcatheter Mitral Therapies: Scientific Statement by PASSION CV, HVC, and TVTR.

Journal Article JACC Cardiovasc Interv · June 26, 2023 Mitral regurgitation is the most common valvular disease and is estimated to affect over 5 million Americans. Real-world data collection contributes to safety and effectiveness evidence for the U.S. Food and Drug Administration, quality evaluation for the ... Full text Link to item Cite

Long-term outcomes of phenoclusters in severe tricuspid regurgitation.

Journal Article Eur Heart J · June 1, 2023 AIMS: Severe tricuspid regurgitation (TR) exhibits high 1-year morbidity and mortality, yet long-term cardiovascular risk overall and by subgroups remains unknown. This study characterizes 5-year outcomes and identifies distinct clinical risk profiles of s ... Full text Link to item Cite

Transcatheter Mitral Valve Repair for Degenerative Mitral Regurgitation.

Journal Article JAMA · May 23, 2023 IMPORTANCE: There are limited data on the outcomes of transcatheter edge-to-edge mitral valve repair for degenerative mitral regurgitation (MR) in a real-world setting. OBJECTIVE: To evaluate the outcomes of transcatheter mitral valve repair for degenerati ... Full text Link to item Cite

Modeling the Association of Volume vs Composite Outcome Thresholds With Outcomes and Access to Transcatheter Aortic Valve Implantation in the US.

Journal Article JAMA Cardiol · May 1, 2023 IMPORTANCE: Professional societies and the Centers for Medicare & Medicaid Services suggest volume thresholds to ensure quality in transcatheter aortic valve implantation (TAVI). OBJECTIVE: To model the association of volume thresholds vs spoke-and-hub imp ... Full text Link to item Cite

Risk of Surgical Mitral Valve Repair for Primary Mitral Regurgitation.

Journal Article Ann Thorac Surg · March 2023 BACKGROUND: Risk estimation for surgical intervention is an essential component of heart team shared decision-making. However, current mitral valve (MV) surgery risk models used in practice lack etiologic or procedural specificity. The purpose of this stud ... Full text Link to item Cite

Risk of Surgical Mitral Valve Repair for Primary Mitral Regurgitation.

Journal Article J Am Coll Cardiol · February 21, 2023 BACKGROUND: Risk estimation for surgical intervention is an essential component of heart team shared decision-making. However, current mitral valve (MV) surgery risk models used in practice lack etiologic or procedural specificity. OBJECTIVES: The purpose ... Full text Link to item Cite

Impact of Transcatheter Mitral Valve Repair Availability on Volume and Outcomes of Surgical Repair.

Journal Article J Am Coll Cardiol · February 14, 2023 BACKGROUND: The impact of transcatheter edge-to-edge repair (TEER) on national surgical mitral valve repair (MVr) volume and outcomes is unknown. OBJECTIVES: This study aims to assess the impact of TEER availability on MVr volumes and outcomes for degenera ... Full text Link to item Cite

Comparing Consumer-Directed Hospital Rankings With STS Adult Cardiac Surgery Database Outcomes.

Journal Article Ann Thorac Surg · February 2023 BACKGROUND: Public interest in stratifying hospital performance has led to the proliferation of commercial, consumer-oriented hospital rankings. In cardiac surgery, little is known about how these rankings correlate with clinical registry quality ratings. ... Full text Link to item Cite

Initial Thoracic Endovascular Aortic Repair vs Medical Therapy for Acute Uncomplicated Type B Aortic Dissection.

Journal Article JAMA Cardiol · January 1, 2023 IMPORTANCE: Thoracic endovascular aortic repair (TEVAR) has increasingly been used for uncomplicated type B aortic dissection (uTBAD) despite limited supporting data. OBJECTIVE: To assess whether initial TEVAR following uTBAD is associated with reduced mor ... Full text Link to item Cite

Development and validation of an automated algorithm for end point adjudication for a large U.S. national registry.

Journal Article Am Heart J · December 2022 BACKGROUND: Clinical events committee (CEC) evaluation is the standard approach for end point adjudication in clinical trials. Due to resource constraints, large registries typically rely on site-reported end points without further confirmation, which may ... Full text Link to item Cite

Transcatheter Edge-to-Edge Mitral Valve Repair in Patients With Severe Mitral Regurgitation and Cardiogenic Shock.

Journal Article J Am Coll Cardiol · November 29, 2022 BACKGROUND: Data on the efficacy of transcatheter edge-to-edge repair (TEER) in patients with cardiogenic shock (CS) are limited. OBJECTIVES: This study investigated the characteristics and outcomes of consecutive patients with significant mitral regurgita ... Full text Link to item Cite

Association of Volume and Outcomes in 234 556 Patients Undergoing Surgical Aortic Valve Replacement.

Journal Article Ann Thorac Surg · October 2022 BACKGROUND: The relationship between institutional volume and operative mortality after surgical aortic valve replacement (SAVR) remains unclear. METHODS: From January 2013 to June 2018, 234 556 patients underwent isolated SAVR (n = 144 177) or SAVR with c ... Full text Link to item Cite

Outcomes After Acute Coronary Syndrome in Patients With Diabetes Mellitus and Peripheral Artery Disease (from the TRACER, TRILOGY-ACS, APPRAISE-2, and PLATO Clinical Trials).

Journal Article Am J Cardiol · September 1, 2022 Patients with acute coronary syndrome (ACS) are at risk for recurrent adverse events, and multiple reports suggest that this risk is increased in patients with concomitant diabetes mellitus (DM) and peripheral artery disease (PAD). The aim of this article ... Full text Link to item Cite

Left Atrial Appendage Occlusion Versus Oral Anticoagulation in Atrial Fibrillation : A Decision Analysis.

Journal Article Ann Intern Med · September 2022 BACKGROUND: Left atrial appendage occlusion (LAAO) is a potential alternative to oral anticoagulants in selected patients with atrial fibrillation (AF). Compared with anticoagulants, LAAO decreases major bleeding risk, but there is uncertainty regarding th ... Full text Open Access Link to item Cite

Association of Transcatheter Aortic Valve Replacement Reimbursement, New Technology Add-on Payment, and Procedure Volumes With Embolic Protection Device Use.

Journal Article JAMA Cardiol · September 1, 2022 IMPORTANCE: In the setting of uncertain efficacy and additional, unreimbursed cost, use of an embolic protection device (EPD) during transcatheter aortic valve replacement (TAVR) has had variable uptake. The Centers for Medicare & Medicaid Services (CMS) i ... Full text Link to item Cite

Imaging Considerations and Clinical Implications of Mitral Annular Disjunction.

Journal Article Circ Cardiovasc Imaging · September 2022 Mitral annular disjunction is increasingly recognized as an important anatomic feature of mitral valve disease. The presence of mitral annular disjunction, defined as separation between the left atrial wall at the point of mitral valve insertion and the le ... Full text Link to item Cite

Association Between Peripheral Versus Central Access for Alternative Access Transcatheter Aortic Valve Replacement and Mortality and Stroke: A Report From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article Circ Cardiovasc Interv · September 2022 BACKGROUND: In some patients, the alternative access route for transcatheter aortic valve replacement (TAVR) is utilized because the conventional transfemoral approach is not felt to be either feasible or optimal. However, accurate prognostication of patie ... Full text Link to item Cite

Anticoagulation in new-onset postoperative atrial fibrillation: An analysis from the Society of Thoracic Surgeons Adult Cardiac Surgery Database.

Journal Article Heart Rhythm O2 · August 2022 BACKGROUND: New-onset postoperative atrial fibrillation (POAF) is the most common complication after cardiac surgery and is associated with increased long-term stroke and mortality. Anticoagulation has been suggested as a potential therapy, but data on saf ... Full text Link to item Cite

Underutilization of Guideline-based Abdominal Aortic Aneurysm Screening in an Academic Health System.

Conference Ann Vasc Surg · July 2022 OBJECTIVES: The US Preventive Services Task Force (USPSTF) recommends a 1 time screening for AAA with ultrasonography in men aged 65-75 who have ever smoked. Our objectives were to identify the AAA screening rates in a large academic health system and asse ... Full text Link to item Cite

Sex Differences in Coronary Artery Bypass Grafting Techniques: A Society of Thoracic Surgeons Database Analysis.

Journal Article The Annals of thoracic surgery · June 2022 BackgroundFemale patients with coronary artery disease have inferior outcomes compared with male patients, including higher mortality after coronary artery bypass graft surgery (CABG). We aimed to evaluate the association of female sex with the us ... Full text Cite

Minimum Core Data Elements for Evaluation of TAVR: A Scientific Statement by PASSION CV, HVC, and TVT Registry.

Journal Article Ann Thorac Surg · May 2022 Transcatheter aortic valve replacement (TAVR) is the standard of care for severe, symptomatic aortic stenosis. Real-world TAVR data collection contributes to benefit/risk assessment and safety evidence for the U.S. Food and Drug Administration, quality eva ... Full text Link to item Cite

Minimum Core Data Elements for Evaluation of TAVR: A Scientific Statement by PASSION CV, HVC, and TVT Registry.

Journal Article JACC Cardiovasc Interv · April 11, 2022 Transcatheter aortic valve replacement (TAVR) is the standard of care for severe, symptomatic aortic stenosis. Real-world TAVR data collection contributes to benefit/risk assessment and safety evidence for the U.S. Food and Drug Administration, quality eva ... Full text Link to item Cite

Practice Patterns and Outcomes of Transcatheter Aortic Valve Replacement in the United States and Japan: A Report From Joint Data Harmonization Initiative of STS/ACC TVT and J-TVT.

Journal Article J Am Heart Assoc · March 15, 2022 Background The practice pattern and outcome of medical devices following their regulatory approval may differ by country. The aim of this study is to compare postapproval national clinical registry data on transcatheter aortic valve replacement between the ... Full text Link to item Cite

Patient-reported vs. physician-estimated symptoms before and after transcatheter aortic valve replacement.

Journal Article Eur Heart J Qual Care Clin Outcomes · March 2, 2022 AIMS: In contrast to patient-reported health status measures (such as the Kansas City Cardiomyopathy Questionnaire), the New York Heart Association class is based on a physician's assessment of heart failure symptoms and functional limitations on behalf of ... Full text Link to item Cite

Clinical trajectory of patients with a worsening heart failure event and reduced ventricular ejection fraction.

Journal Article Am Heart J · March 2022 BACKGROUND: Recent data suggest that patients with heart failure with reduced ejection fraction (HFrEF) and worsening heart failure (WHF) have potential for greater benefit from newer HF therapies. We investigated characteristics and outcomes of patients w ... Full text Link to item Cite

The prospective randomized trial of the optimal evaluation of cardiac symptoms and revascularization: Rationale and design of the PRECISE trial.

Journal Article Am Heart J · March 2022 BACKGROUND: Clinicians vary widely in their preferred diagnostic approach to patients with non-acute chest pain. Such variation exposes patients to potentially avoidable risks, as well as inefficient care with increased costs and unresolved patient concern ... Full text Link to item Cite

Tricuspid valve disease prevalence and the impact of tricuspid valve surgery on cardiovascular events and hospital resource use in medicare beneficiaries.

Journal Article Am Heart J · March 2022 BACKGROUND: Tricuspid valve disease (TVD) is presumed common, however, little is known about its prevalence or the impact of tricuspid valve surgery (TVS) on healthcare resource use. METHODS: To describe the prevalence of TVD and assess the impact of TVS o ... Full text Link to item Cite

Knowledge gaps in surgical management for aortic dissection.

Journal Article Semin Vasc Surg · March 2022 Aortic dissection (AD) is recognized as a potentially fatal condition and its standard treatment has been surgical intervention for acute type A AD (TAAD) and complicated acute type B AD (TBAD), and medical management for uncomplicated acute type B AD. Due ... Full text Link to item Cite

Executive Summary of the Aortic Dissection (AD) Collaborative

Journal Article Seminars in Vascular Surgery · March 1, 2022 Full text Cite

A mixed method approach to understanding the impact of COVID-19 on patients with or at risk for aortic dissection.

Journal Article Semin Vasc Surg · March 2022 Aortic dissection (AD) is a life-threatening rare disease that occurs as a spontaneous tear in the wall of the aorta. Survivors of AD go on to have a chronic disease process that requires lifelong follow-up and management. Although the COVID-19 pandemic ha ... Full text Link to item Cite

Lived experiences of people with or at risk for aortic dissection: A qualitative assessment.

Journal Article Semin Vasc Surg · March 2022 Aortic dissection (AD) is a life-changing event that is often accompanied by a loss of normal quality of life. Survivors of AD go on to have a chronic disease that requires lifestyle modification, medical management, and surgical repair of the aorta. Clini ... Full text Link to item Cite

An assessment of the current medical management of thoracic aortic disease: A patient-centered scoping literature review.

Journal Article Semin Vasc Surg · March 2022 Thoracic aortic aneurysm and dissection are complex diagnoses that require management by multidisciplinary providers using a variety of medical therapies, surgical interventions, and lifestyle modifications. Pharmacological agents, such as β-blockers (aten ... Full text Link to item Cite

Stakeholder perspectives on education in aortic dissection.

Journal Article Semin Vasc Surg · March 2022 The Aortic Dissection (AD) Collaborative was established to evaluate patient-centered research priorities in AD. Education was identified as a topic of interest by the stakeholders. The AD Collaborative Education Working Group evaluated existing educationa ... Full text Link to item Cite

Implementation of telemedicine in the care of patients with aortic dissection.

Journal Article Semin Vasc Surg · March 2022 Telemedicine uses telephone-based or any form of digital communication for remote clinical services. It has been a field of interest for the last century, with broader implementation of telemedicine technologies during the last 25 years. The COVID-19 pande ... Full text Link to item Cite

The Aortic Dissection Collaborative: Methods for building capacity for patient-centered outcomes research in the aortic dissection community.

Journal Article Semin Vasc Surg · March 2022 Understanding what matters most to patients can help guide research in a direction that is best situated to provide evidence that is responsive to their core concerns. This can better inform the treatment decision-making process for patients and their phys ... Full text Link to item Cite

The mental health impact of aortic dissection.

Journal Article Semin Vasc Surg · March 2022 Although the topics of surgical techniques and medical therapies have been widely studied in aortic dissection (AD), studies examining the short- and long-term impact of this event on mental health are largely lacking. Many of the studies have used the 36- ... Full text Link to item Cite

Racial, Ethnic, and Socioeconomic Disparities in Access to Transcatheter Aortic Valve Replacement Within Major Metropolitan Areas.

Journal Article JAMA Cardiol · February 1, 2022 IMPORTANCE: Despite the benefits of high-technology therapeutics, inequitable access to these technologies may generate disparities in care. OBJECTIVE: To examine the association between zip code-level racial, ethnic, and socioeconomic composition and rate ... Full text Link to item Cite

Use of Direct Oral Anticoagulant and Outcomes in Patients With Atrial Fibrillation after Transcatheter Aortic Valve Replacement: Insights From the STS/ACC TVT Registry.

Journal Article J Am Heart Assoc · January 4, 2022 Background Clinical evidence on the safety and effectiveness of using direct oral anticoagulants (DOACs) in patients with atrial fibrillation after transcatheter aortic valve replacement (TAVR) remains limited. The aim of this study was to investigate the ... Full text Link to item Cite

Transcatheter Mitral Valve Therapy in the United States: A Report from the STS/ACC TVT Registry.

Journal Article Ann Thorac Surg · January 2022 Data for nearly all patients undergoing transcatheter edge-to-edge repair (TEER) and transcatheter mitral valve replacement (TMVR) with an approved device in the United States is captured in the Society of Thoracic Surgeons/American College of Cardiology T ... Full text Link to item Cite

Quantifying Benefit-Risk Preferences for Heart Failure Devices: A Stated-Preference Study.

Journal Article Circ Heart Fail · January 2022 BACKGROUND: Regulatory and clinical decisions involving health technologies require judgements about relative importance of their expected benefits and risks. We sought to quantify heart-failure patients' acceptance of therapeutic risks in exchange for imp ... Full text Link to item Cite

Use of real-world data and clinical registries to identify new uses of existing vascular endografts: combined use of GORE EXCLUDER Iliac Branch Endoprosthesis and GORE VIABAHN VBX Balloon Expandable Endoprosthesis.

Journal Article BMJ Surg Interv Health Technol · 2022 OBJECTIVE: To assess the feasibility of collecting, examining and reporting observational, real-world evidence regarding the novel use of the GORE EXCLUDER Iliac Branch Endoprosthesis (IBE) in conjunction with the GORE VIABAHN VBX Balloon Expandable Endopr ... Full text Link to item Cite

Heart Watch Study: protocol for a pragmatic randomised controlled trial.

Journal Article BMJ Open · December 30, 2021 INTRODUCTION: Personal digital devices that provide health information, such as the Apple Watch, have developed an increasing array of cardiopulmonary tracking features which have received regulatory clearance and are directly marketed to consumers. Despit ... Full text Link to item Cite

Transcatheter Mitral Valve Therapy in the United States: A Report From the STS-ACC TVT Registry.

Journal Article J Am Coll Cardiol · December 7, 2021 Data for nearly all patients undergoing transcatheter edge-to-edge repair (TEER) and transcatheter mitral valve replacement (TMVR) with an approved device in the United States is captured in the Society of Thoracic Surgeons/American College of Cardiology T ... Full text Link to item Cite

Cardiovascular risk and outcomes in symptomatic patients with suspected coronary artery disease and non coronary vascular disease: A report from the PROMISE trial.

Journal Article Am Heart J · December 2021 BACKGROUND: Non-coronary vascular disease (NCVD) is associated with adverse cardiovascular events. Little is known about physician risk assessment, prevalence of coronary artery disease (CAD), cardiac catheterization, and the performance of the atheroscler ... Full text Link to item Cite

Socioeconomic and Geographic Characteristics of Hospitals Establishing Transcatheter Aortic Valve Replacement Programs, 2012-2018.

Journal Article Circ Cardiovasc Qual Outcomes · November 2021 BACKGROUND: Despite the benefits of novel therapeutics, inequitable diffusion of new technologies may generate disparities. We examined the growth of transcatheter aortic valve replacement (TAVR) in the United States to understand the characteristics of ho ... Full text Link to item Cite

Sex-Based Differences in Outcomes With Percutaneous Transcatheter Repair of Mitral Regurgitation With the MitraClip System: Transcatheter Valve Therapy Registry From 2011 to 2017.

Journal Article Circ Cardiovasc Interv · November 2021 BACKGROUND: Women have a higher rate of adverse events after mitral valve surgery. We sought to evaluate whether outcomes after transcatheter edge-to-edge repair intervention by sex have similar trends to mitral valve surgery. METHODS: The primary outcome ... Full text Link to item Cite

Community Size and Lung Cancer Resection Outcomes: Studying The Society of Thoracic Surgeons Database.

Journal Article Ann Thorac Surg · October 2021 BACKGROUND: Socioeconomic factors play key roles in surgical outcomes. Socioeconomic data within The Society of Thoracic Surgeons (STS) General Thoracic Surgery Database (GTSD) are limited. Therefore, we utilized community size as a surrogate to understand ... Full text Link to item Cite

Association Between Transcatheter Aortic Valve Replacement for Bicuspid vs Tricuspid Aortic Stenosis and Mortality or Stroke Among Patients at Low Surgical Risk.

Journal Article JAMA · September 21, 2021 IMPORTANCE: There are limited data on outcomes of transcatheter aortic valve replacement (TAVR) for bicuspid aortic stenosis in patients at low surgical risk. OBJECTIVE: To compare the outcomes of TAVR with a balloon-expandable valve for bicuspid vs tricus ... Full text Link to item Cite

Characteristics and Outcomes of Patients With Heart Failure With Reduced Ejection Fraction After a Recent Worsening Heart Failure Event.

Conference J Am Heart Assoc · September 7, 2021 Background Contemporary trials of patients with heart failure with reduced ejection fraction (HFrEF) required a recent worsening heart failure (WHF) event for inclusion. We aimed to describe characteristics and outcomes of patients with HFrEF and a recent ... Full text Link to item Cite

pKa Scale for Cyclopropenium Ions with Applications in CO2 Capture.

Journal Article J Org Chem · September 3, 2021 Molecular acid-base properties are core to understanding chemical systems and the prediction of reactivity. This axiom holds for cyclopropenium ions in terms of their broad use as (organo)catalysts, ligands, redox-flow batteries, and applications in materi ... Full text Link to item Cite

Estimating the real-world performance of the PROMISE minimal-risk tool.

Journal Article Am Heart J · September 2021 BACKGROUND: Stable chest pain is a common indication for cardiac catheterization. We assessed the prognostic value of the Prospective Multicenter Imaging Study for Evaluation (PROMISE) Minimal-Risk Tool in identifying patients who are at very low risk of o ... Full text Link to item Cite

Dissemination of Transcatheter Aortic Valve Replacement in the United States.

Journal Article J Am Coll Cardiol · August 24, 2021 BACKGROUND: Societal guidelines and payor coverage decisions for transcatheter aortic valve replacement (TAVR) attempt to strike a balance between providing access and maintaining quality. The extent to which dissemination of TAVR has achieved these ideals ... Full text Link to item Cite

Association Between Patient Survival and Clinician Variability in Treatment Rates for Aortic Valve Stenosis.

Journal Article J Am Heart Assoc · August 17, 2021 Background Patients with symptomatic severe aortic stenosis (ssAS) have a high mortality risk and compromised quality of life. Surgical/transcatheter aortic valve replacement (AVR) is a Class I recommendation, but it is unclear if this recommendation is un ... Full text Link to item Cite

National trends in repair for type B aortic dissection.

Journal Article Clin Cardiol · August 2021 BACKGROUND: Thoracic endovascular aortic repair (TEVAR) first gained in popularity for repair of type B aortic dissections (TBADs) in the early 2000's. We aimed to describe patients undergoing open repair, TEVAR, and no repair and analyze factors associate ... Full text Link to item Cite

Composite Metric for Benchmarking Site Performance in Transcatheter Aortic Valve Replacement: Results From the STS/ACC TVT Registry.

Journal Article Circulation · July 20, 2021 BACKGROUND: Transcatheter aortic valve replacement (TAVR) is a transformative therapy for aortic stenosis. Despite rapid improvements in technology and techniques, serious complications remain relatively common and are not well described by single outcome ... Full text Link to item Cite

Sex disparities in patients with symptomatic severe aortic stenosis.

Journal Article Am Heart J · July 2021 BACKGROUND: We evaluated whether there is equitable distribution across sexes of treatment and outcomes for aortic valve replacement (AVR), via surgical (SAVR) or transcatheter (TAVR) methods, in symptomatic severe aortic stenosis (ssAS) patients. METHODS: ... Full text Link to item Cite

Cerebral Embolic Protection and Outcomes of Transcatheter Aortic Valve Replacement: Results From the Transcatheter Valve Therapy Registry.

Journal Article Circulation · June 8, 2021 BACKGROUND: Stroke remains a devastating complication of transcatheter aortic valve replacement (TAVR), which has persisted despite refinements in technique and increased operator experience. While cerebral embolic protection devices (EPDs) have been devel ... Full text Link to item Cite

African American-Caucasian American differences in aortic valve replacement in patients with severe aortic stenosis.

Journal Article Am Heart J · April 2021 BACKGROUND: Among patients with severe aortic stenosis (AS), there are limited data on aortic valve replacement (AVR), reasons for nonreceipt and mortality by race. METHODS: Utilizing the Duke Echocardiography Laboratory Database, we analyzed data from 110 ... Full text Link to item Cite

Variation in Antithrombotic Therapy and Clinical Outcomes in Patients With Preexisting Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article Circ Cardiovasc Interv · April 2021 BACKGROUND: Optimal antithrombotic management of patients with preexisting atrial fibrillation undergoing transcatheter aortic valve replacement is challenging given the need to balance the risk of bleeding and thromboembolism. We aimed to examine variatio ... Full text Link to item Cite

Impact of short-term complications of transcatheter aortic valve replacement on longer-term outcomes: results from the STS/ACC Transcatheter Valve Therapy Registry.

Journal Article Eur Heart J Qual Care Clin Outcomes · March 15, 2021 AIMS: While complications of transcatheter aortic valve replacement (TAVR) have decreased, they still occur commonly and may negatively impact both short- and long-term outcomes. We sought to examine the association of complications after TAVR with surviva ... Full text Link to item Cite

Practical Application of Patient-Reported Health Status Measures for Transcatheter Valve Therapies: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapies Registry.

Journal Article Circ Cardiovasc Qual Outcomes · March 2021 BACKGROUND: Health status assessment is essential for documenting the benefit of transcatheter aortic valve replacement (TAVR) or transcatheter mitral valve repair on patients' symptoms, function, and quality of life. Health status can also be a powerful m ... Full text Link to item Cite

Evaluating Out-of-Hospital 30-Day Mortality After Transfemoral Transcatheter Aortic Valve Replacement: An STS/ACC TVT Analysis.

Journal Article JACC Cardiovasc Interv · February 8, 2021 OBJECTIVES: This study sought to better understand out-of-hospital 30-day mortality following transfemoral transcatheter aortic valve replacement (TAVR) and identify factors associated with poor outcomes. BACKGROUND: Despite improvements in outcomes with T ... Full text Link to item Cite

STS-ACC TVT Registry of Transcatheter Aortic Valve Replacement.

Journal Article Ann Thorac Surg · February 2021 The STS-ACC TVT Registry (Society of Thoracic Surgeons-American College of Cardiology Transcatheter Valve Therapy Registry) from 2011 to 2019 has collected data on 276,316 patients undergoing transcatheter aortic valve replacement (TAVR) at sites in all U. ... Full text Link to item Cite

Clinical Outcomes Among Patients With Severe Tricuspid Valve Regurgitation

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · 2021 Cite

Site-Level Variability in 30-Day Patient Outcomes After Transcatheter Mitral Valve Repair in the United States.

Journal Article Circ Cardiovasc Qual Outcomes · December 2020 BACKGROUND: Clinical trials have demonstrated health status benefit of transcatheter mitral valve repair (TMVr) with MitraClip in patients with mitral valve regurgitation. Real-world site-level variability in health status outcomes for TMVr, and factors as ... Full text Link to item Cite

STS-ACC TVT Registry of Transcatheter Aortic Valve Replacement.

Journal Article J Am Coll Cardiol · November 24, 2020 The STS-ACC TVT Registry (Society of Thoracic Surgeons-American College of Cardiology Transcatheter Valve Therapy Registry) from 2011 to 2019 has collected data on 276,316 patients undergoing transcatheter aortic valve replacement (TAVR) at sites in all U. ... Full text Link to item Cite

Volume-Outcome Association of Mitral Valve Surgery in the United States.

Journal Article JAMA Cardiol · October 1, 2020 IMPORTANCE: Early surgery for severe primary degenerative mitral regurgitation is recommended, provided optimal outcomes are achievable. Contemporary national data defining mitral valve surgery volume and outcomes are lacking. OBJECTIVE: To assess national ... Full text Link to item Cite

Outcomes of transcatheter aortic valve replacement for patients with severe aortic stenosis and concomitant aortic insufficiency: Insights from the TVT Registry.

Journal Article Am Heart J · October 2020 AIMS: Data regarding outcomes for patients with severe aortic stenosis (AS) with concomitant aortic insufficiency (AI), undergoing transcatheter aortic valve replacement (TAVR) are limited. This study aimed to analyze the prevalence of severe AS with conco ... Full text Link to item Cite

Geographic Access to Transcatheter Aortic Valve Replacement Centers in the United States: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article JAMA Cardiol · September 1, 2020 IMPORTANCE: Geographic access to transcatheter aortic replacement (TAVR) centers varies in the United States as a result of controlled expansion through minimum volume requirements. OBJECTIVE: To describe the current geographic access to TAVR centers in th ... Full text Link to item Cite

Cardiac Arrest in the Setting of Diffuse Coronary Ectasia: Perspectives on a Unique Ischemic Insult.

Journal Article JACC Case Rep · September 2020 A 69-year-old man with a history of coronary artery ectasia, potentially resulting from an underlying heritable connective tissue disorder, presented with ventricular fibrillation. Despite medical management of ischemia, he developed recurrent ventricular ... Full text Link to item Cite

Identification of Undetected Monogenic Cardiovascular Disorders.

Journal Article J Am Coll Cardiol · August 18, 2020 BACKGROUND: Monogenic diseases are individually rare but collectively common, and are likely underdiagnosed. OBJECTIVES: The purpose of this study was to estimate the prevalence of monogenic cardiovascular diseases (MCVDs) and potentially missed diagnoses ... Full text Link to item Cite

Racial Differences in the Use of Aortic Valve Replacement for Treatment of Symptomatic Severe Aortic Valve Stenosis in the Transcatheter Aortic Valve Replacement Era.

Journal Article J Am Heart Assoc · August 18, 2020 Background Aortic valve replacement (AVR) is a life-saving treatment for patients with symptomatic severe aortic valve stenosis. We sought to determine whether transcatheter AVR has resulted in a more equitable treatment rate by race in the United States. ... Full text Link to item Cite

Comparison of Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction With Versus Without Hyperuricemia or Gout.

Journal Article Am J Cardiol · July 15, 2020 Hyperuricemia and gout are common in patients with heart failure (HF) and are associated with poor outcomes. Data describing hyperuricemia and gout in patients with HF with preserved ejection fraction (HFpEF) are limited. We used data from the Duke Univers ... Full text Link to item Cite

Lipoprotein (a): An Update on a Marker of Residual Risk and Associated Clinical Manifestations.

Journal Article Am J Cardiol · July 1, 2020 Lipoprotein (a) [Lp(a)] is a low-density, cholesterol-containing lipoprotein that differs from other low-density lipoproteins due to the presence of apolipoprotein(a) bound to its surface apolipoprotein B100. Multiple epidemiologic studies, including Mende ... Full text Link to item Cite

A care pathway for the cardiovascular complications of COVID-19: Insights from an institutional response.

Journal Article Am Heart J · July 2020 The infection caused by severe acute respiratory syndrome coronavirus-2, or COVID-19, can result in myocardial injury, heart failure, and arrhythmias. In addition to the viral infection itself, investigational therapies for the infection can interact with ... Full text Link to item Cite

Geographic Access to Transcatheter Aortic Valve Replacement Centers in the United States: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article JAMA Cardiol · June 10, 2020 Importance: Geographic access to transcatheter aortic replacement (TAVR) centers varies in the United States as a result of controlled expansion through minimum volume requirements. Objective: To describe the current geographic access to TAVR centers in th ... Full text Link to item Cite

Demographics, Procedural Characteristics, and Clinical Outcomes When Cardiogenic Shock Precedes TAVR in the United States.

Journal Article JACC Cardiovasc Interv · June 8, 2020 OBJECTIVES: This paper details trends and outcomes in U.S. patients undergoing transcatheter aortic valve replacement (TAVR) who present pre-procedurally with cardiogenic shock. BACKGROUND: Demographic, procedural characteristics, and clinical outcomes in ... Full text Link to item Cite

Conscious Sedation Versus General Anesthesia for Transcatheter Aortic Valve Replacement: Variation in Practice and Outcomes.

Journal Article JACC Cardiovasc Interv · June 8, 2020 OBJECTIVES: The aims of this study were to examine variation in the use of conscious sedation (CS) for transcatheter aortic valve replacement (TAVR) across hospitals and over time and to evaluate outcomes of CS compared with general anesthesia (GA) using i ... Full text Link to item Cite

Mitral Valve Surgical Volume and Transcatheter Mitral Valve Repair Outcomes: Impact of a Proposed Volume Requirement on Geographic Access.

Journal Article J Am Heart Assoc · June 2, 2020 Background There is an open Centers for Medicare and Medicaid Services National Coverage Decision for Transcatheter Mitral Valve Repair (TMVr) and a recent multisociety consensus document suggesting that TMVr centers should achieve prespecified mitral valv ... Full text Link to item Cite

Transcatheter Aortic Valve Replacement After Prior Mitral Valve Surgery: Results From the Transcatheter Valve Therapy Registry.

Journal Article Ann Thorac Surg · June 2020 BACKGROUND: Due to perceived technical challenges, patients with previous surgical mitral valve repair or replacement (SMVR) have been excluded from most transcatheter aortic valve replacement (TAVR) trials. Our objective was to compare the 30-day and 1-ye ... Full text Link to item Cite

Appropriateness of Transcatheter Aortic Valve Replacement: Insight From the OCEAN-TAVI Registry.

Journal Article Circ Cardiovasc Qual Outcomes · April 2020 BACKGROUND: Transcatheter aortic valve replacement (TAVR) is widely used; however, its appropriateness is unknown. We sought to investigate the appropriateness of TAVR. METHODS AND RESULTS: We assigned appropriateness ratings to patients undergoing TAVR fo ... Full text Link to item Cite

Oral Anticoagulation and Cardiovascular Outcomes in Patients With Atrial Fibrillation and End-Stage Renal Disease.

Journal Article J Am Coll Cardiol · March 24, 2020 BACKGROUND: Atrial fibrillation (AF) is common in patients with end-stage renal disease (ESRD). The impact of oral anticoagulation (OAC) in ESRD patients is uncertain. OBJECTIVES: The purpose of this study was to describe patterns of OAC use in ESRD patien ... Full text Link to item Cite

ASSOCIATION OF BODY MASS INDEX AND OUTCOMES AFTER TRANSCATHETER MITRAL VALVE REPAIR

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 24, 2020 Link to item Cite

Thirty-Day Outcomes of Transcatheter Mitral Valve Replacement for Degenerated Mitral Bioprostheses (Valve-in-Valve), Failed Surgical Rings (Valve-in-Ring), and Native Valve With Severe Mitral Annular Calcification (Valve-in-Mitral Annular Calcification) in the United States: Data From the Society of Thoracic Surgeons/American College of Cardiology/Transcatheter Valve Therapy Registry.

Journal Article Circ Cardiovasc Interv · March 2020 BACKGROUND: Transcatheter mitral valve replacement using aortic transcatheter heart valves has recently become an alternative for patients with degenerated mitral bioprostheses, failed surgical repairs with annuloplasty rings or severe mitral annular calci ... Full text Link to item Cite

Major bleeding in patients with peripheral artery disease: Insights from the EUCLID trial.

Journal Article Am Heart J · February 2020 BACKGROUND: Rates and predictors of major bleeding in patients with peripheral artery disease (PAD) treated with antiplatelets have not been well studied. This post hoc analysis of EUCLID aimed to determine the incidence of major/minor bleeding, predictors ... Full text Open Access Link to item Cite

The Effect and Relationship of Frailty Indices on Survival After Transcatheter Aortic Valve Replacement.

Journal Article JACC Cardiovasc Interv · January 27, 2020 OBJECTIVES: This study sought to evaluate the ability of individual markers of frailty to predict outcomes after transcatheter aortic valve replacement (TAVR) and of their discriminatory value in different age groups. BACKGROUND: Appropriate patient select ... Full text Link to item Cite

Association of Pulmonary Hypertension With Clinical Outcomes of Transcatheter Mitral Valve Repair.

Journal Article JAMA Cardiol · January 1, 2020 IMPORTANCE: Pulmonary hypertension (pHTN) is associated with increased risk of mortality after mitral valve surgery for mitral regurgitation. However, its association with clinical outcomes in patients undergoing transcatheter mitral valve repair (TMVr) wi ... Full text Link to item Cite

Relationship of Body Mass Index With Outcomes After Transcatheter Aortic Valve Replacement: Results From the National Cardiovascular Data-STS/ACC TVT Registry.

Journal Article Mayo Clin Proc · January 2020 OBJECTIVE: To investigate the relationship of body mass index (BMI) with short- and long-term outcomes after transcatheter aortic valve replacement (TAVR). PATIENTS AND METHODS: The relationship between BMI and baseline characteristics and procedural chara ... Full text Link to item Cite

Incidence, Temporal Trends, and Associated Outcomes of Vascular and Bleeding Complications in Patients Undergoing Transfemoral Transcatheter Aortic Valve Replacement: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapies Registry.

Journal Article Circ Cardiovasc Interv · January 2020 BACKGROUND: Vascular and bleeding complications were commonly reported in transcatheter aortic valve replacement clinical trials. Little is known about complication rates in contemporary US clinical practice or clinical outcomes associated with these compl ... Full text Link to item Cite

Operator Experience and Outcomes of Transcatheter Mitral Valve Repair in the United States.

Journal Article J Am Coll Cardiol · December 17, 2019 BACKGROUND: Transcatheter mitral valve repair (TMVr) for the treatment of mitral regurgitation (MR) is a complex procedure that requires development of a unique skillset. OBJECTIVES: The purpose of this study was to examine the relationship between operato ... Full text Link to item Cite

Pre- Versus Post-Procedure Health Care Resource Utilization in Patients Undergoing Commercial Transcatheter Mitral Valve Repair.

Journal Article JACC Cardiovasc Interv · December 9, 2019 OBJECTIVES: The aim of this study was to assess the real-world impact of transcatheter mitral valve repair (TMVR) on hospitalizations and Medicare costs pre- versus post-TMVR. BACKGROUND: TMVR is effective in degenerative mitral regurgitation (MR) and appr ... Full text Link to item Cite

Patients' Willingness to Accept Mitral Valve Procedure-Associated Risks Varies Across Severity of Heart Failure Symptoms.

Journal Article Circ Cardiovasc Interv · December 2019 BACKGROUND: The Food and Drug Administration's Center for Drugs and Radiological Health issued Guidance in 2016 on generating patient preference information to aid evaluation of medical devices. Consistent with this guidance, we aimed to provide quantitati ... Full text Link to item Cite

Impact of Microbiological Organism Type on Surgically Managed Endocarditis.

Journal Article Ann Thorac Surg · November 2019 BACKGROUND: This study describes the impact of organism and valve type on surgically managed infective endocarditis (IE) from The Society of Thoracic Surgeons (STS) database. We developed a risk model for surgically managed endocarditis that includes the m ... Full text Link to item Cite

Patient and Hospital Characteristics of Mitral Valve Surgery in the United States.

Journal Article JAMA Cardiol · November 1, 2019 IMPORTANCE: Volume metrics may have relevance in the evaluation of valve center expertise. However, a paucity of data exists regarding the quantity, volume, and geographic location of mitral valve (MV) surgical centers in the United States and the proporti ... Full text Link to item Cite

Volume and Outcomes for Transcatheter Aortic-Valve Replacement Reply

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · October 3, 2019 Link to item Cite

Factors Associated With and Outcomes of Aborted Procedures During Elective Transcatheter Aortic Valve Replacement.

Journal Article JACC Cardiovasc Interv · September 23, 2019 OBJECTIVES: This study sought to evaluate the outcomes and factors associated with aborted procedures among patients undergoing elective transcatheter aortic valve replacement (TAVR). BACKGROUND: Elective TAVR procedures can be aborted because of device li ... Full text Link to item Cite

Incidence and Outcomes of Surgical Bailout During TAVR: Insights From the STS/ACC TVT Registry.

Journal Article JACC Cardiovasc Interv · September 23, 2019 OBJECTIVES: The aim of this study was to evaluate the incidence and outcomes of surgical bailout during transcatheter aortic valve replacement (TAVR). BACKGROUND: The incidence and outcomes of unplanned conversion to open heart surgery, or "surgical bailou ... Full text Link to item Cite

Relation of Postdischarge Care Fragmentation and Outcomes in Transcatheter Aortic Valve Implantation from the STS/ACC TVT Registry.

Journal Article Am J Cardiol · September 15, 2019 Fragmented care following elective surgery has been associated with poor outcomes. The association between fragmented care and outcomes in patients undergoing transcatheter aortic valve implantation (TAVI) is unknown. We examined patients who underwent TAV ... Full text Link to item Cite

Watchman implantation in a patient with left atrial appendage thrombus.

Journal Article J Cardiovasc Electrophysiol · September 2019 Full text Link to item Cite

Association of Smoking Status With Long-Term Mortality and Health Status After Transcatheter Aortic Valve Replacement: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article J Am Heart Assoc · August 20, 2019 Background Smoking is a significant risk factor for aortic stenosis but its impact on clinical and health status outcomes after transcatheter aortic valve replacement (TAVR) has not been described. Methods and Results Patients (n=72 165) undergoing TAVR at ... Full text Link to item Cite

Institutional Experience With Transcatheter Mitral Valve Repair and Clinical Outcomes: Insights From the TVT Registry.

Journal Article JACC Cardiovasc Interv · July 22, 2019 OBJECTIVES: The aim of this study was to examine the relation between institutional experience and procedural results of transcatheter mitral valve repair. BACKGROUND: Transcatheter mitral valve repair for the treatment of mitral regurgitation (MR) is a co ... Full text Link to item Cite

Procedural Volume and Outcomes for Transcatheter Aortic-Valve Replacement.

Journal Article N Engl J Med · June 27, 2019 BACKGROUND: During the introduction of transcatheter aortic-valve replacement (TAVR) in the United States, requirements regarding procedural volume were mandated by the Centers for Medicare and Medicaid Services as a condition of reimbursement. A better un ... Full text Link to item Cite

Association Between Transcatheter Aortic Valve Replacement and Early Postprocedural Stroke.

Journal Article JAMA · June 18, 2019 IMPORTANCE: Reducing postprocedural stroke is important to improve the safety of transcatheter aortic valve replacement (TAVR). OBJECTIVE: This study evaluated the trends of stroke occurring within 30 days after the procedure during the first 5 years TAVR ... Full text Link to item Cite

Association Between Transcatheter Aortic Valve Replacement for Bicuspid vs Tricuspid Aortic Stenosis and Mortality or Stroke.

Journal Article JAMA · June 11, 2019 IMPORTANCE: Transcatheter aortic valve replacement (TAVR) indications are expanding, leading to an increasing number of patients with bicuspid aortic stenosis undergoing TAVR. Pivotal randomized trials conducted to obtain US Food and Drug Administration ap ... Full text Link to item Cite

Racial Disparities in the Utilization and Outcomes of TAVR: TVT Registry Report.

Journal Article JACC Cardiovasc Interv · May 27, 2019 OBJECTIVES: This study sought to evaluate racial disparities in the performance and outcomes of transcatheter aortic valve replacement (TAVR). BACKGROUND: Racial disparities in cardiovascular diseases are well described. Whether the racial disparities obse ... Full text Link to item Cite

Blood Pressure Control and Cardiovascular Outcomes in Patients With Atrial Fibrillation (From the ORBIT-AF Registry).

Journal Article Am J Cardiol · May 15, 2019 Systolic blood pressure (SBP) and its association with clinical outcomes in atrial fibrillation (AF) patients in community practice are poorly characterized. In patients with AF, we sought to (1) examine the prevalence of baseline uncontrolled hypertension ... Full text Link to item Cite

The Incidence and Outcomes of Surgical Pulmonary Embolectomy in North America.

Journal Article Ann Thorac Surg · May 2019 BACKGROUND: There has been renewed interest in surgical pulmonary embolectomy (SPE) for the treatment of pulmonary embolism, but the real-world incidence and outcomes of SPE have yet to be well described using a large, granular data set. We examined the mo ... Full text Link to item Cite

Use of Medicare Claims to Identify Adverse Clinical Outcomes After Mitral Valve Repair.

Journal Article Circ Cardiovasc Interv · May 2019 BACKGROUND: Clinical event committees are commonly employed for event validation in clinical studies, but little is known about the comparative performance of administrative claims data versus clinician-triggered event adjudication for ascertainment of adv ... Full text Link to item Cite

Development and Application of a Risk Prediction Model for In-Hospital Stroke After Transcatheter Aortic Valve Replacement: A Report From The Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article Ann Thorac Surg · April 2019 BACKGROUND: Stroke is a serious complication after transcatheter aortic valve replacement (TAVR), yet predictive models are not available. A new risk model for in-hospital stroke after TAVR was developed and used to estimate site-specific performance. METH ... Full text Link to item Cite

The Prevalence and Impact of Atrial Fibrillation on 1-Year Outcomes in Patients Undergoing Transcatheter Mitral Valve Repair: Results From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article JACC Cardiovasc Interv · March 25, 2019 OBJECTIVES: The aim of this study was to compare 1-year outcomes following transcatheter mitral valve (MV) repair in patients with and without atrial fibrillation (AF). BACKGROUND: The development of AF in degenerative mitral regurgitation (MR) is consider ... Full text Link to item Cite

Hospital Resource Utilization Before and After Transcatheter Aortic Valve Replacement: The STS/ACC TVT Registry.

Journal Article J Am Coll Cardiol · March 19, 2019 BACKGROUND: Patients with severe aortic stenosis (AS) have repeat hospitalizations for multiple conditions. OBJECTIVES: The purpose of this study was to assess the effect of transcatheter aortic valve replacement (TAVR) on hospitalizations in severe AS. ME ... Full text Link to item Cite

Length of Stay After Transfemoral Transcatheter Aortic Valve Replacement: An Analysis of the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article JACC Cardiovasc Interv · March 11, 2019 OBJECTIVES: The goal of this study was to investigate the trends, predictors, and outcomes of delayed discharge (>72 h) after transcatheter aortic valve replacement. BACKGROUND: Length of stay post-transcatheter aortic valve replacement may have significan ... Full text Link to item Cite

Clinical Outcomes of Mitral Valve Reoperations in the United States: An Analysis of The Society of Thoracic Surgeons National Database.

Journal Article Ann Thorac Surg · March 2019 BACKGROUND: This study evaluated outcomes of reoperative mitral valve surgery (MVS) in the United States. METHODS: Adults undergoing isolated MVS with prior open-heart operation in The Society of Thoracic Surgeons (STS) National Database between July 2011 ... Full text Link to item Cite

Ankle-brachial index in patients with intermittent claudication is a poor indicator of patient-centered and clinician-based evaluations of functional status.

Journal Article J Vasc Surg · March 2019 BACKGROUND: The association between the severity of ankle-brachial index (ABI), a traditional measure of the severity of peripheral artery disease (PAD), and patients' perceptions of their health status is poorly characterized. In Patient-Centered Outcomes ... Full text Link to item Cite

Predictors and Changes in Cardiac Hemodynamics and Geometry With Transcatheter Aortic Valve Implantation.

Journal Article Am J Cardiol · March 1, 2019 The introduction of transcatheter aortic valve implantation (TAVI) has revolutionized the treatment of patients with severe aortic stenosis (AS). However, despite the great clinical success of TAVI, less is known about the cardiac hemodynamics and structur ... Full text Link to item Cite

COMORBIDITIES AND OUTCOMES IN PATIENTS WITH NON-RHEUMATIC TRICUSPID VALVE DISEASE

Conference Journal of the American College of Cardiology · March 2019 Full text Cite

Left Ventricular Hypertrophy Does Not Affect 1-Year Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement.

Journal Article JACC Cardiovasc Interv · February 25, 2019 OBJECTIVES: The aim of this study was to evaluate the association between pre-procedural left ventricular hypertrophy (LVH) patterns and clinical outcomes after transcatheter aortic valve replacement (TAVR). BACKGROUND: The association between pre-procedur ... Full text Link to item Cite

Contemporary Surgical Management of Hypertrophic Cardiomyopathy in the United States.

Journal Article Ann Thorac Surg · February 2019 BACKGROUND: The primary surgical therapy for hypertrophic cardiomyopathy with obstruction is septal myectomy (SM). The current outcomes of SM with and without concomitant mitral operations in the United States was examined using The Society of Thoracic Sur ... Full text Link to item Cite

Predictive Model for High-Risk Coronary Artery Disease.

Journal Article Circ Cardiovasc Imaging · February 2019 BACKGROUND: Patients with high-risk coronary artery disease (CAD) may be difficult to identify. METHODS: Using the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) cohort randomized to coronary computed tomographic angiography ( ... Full text Link to item Cite

Outcomes After Transcatheter Mitral Valve Repair in Patients With Renal Disease.

Journal Article Circ Cardiovasc Interv · February 2019 BACKGROUND: Renal disease is associated with poor prognosis despite guideline-directed cardiovascular therapy, and outcomes by sex in this population remain uncertain. METHODS AND RESULTS: Patients (n=5213) who underwent a MitraClip procedure in the Nation ... Full text Link to item Cite

Prosthesis-Patient Mismatch in Patients Undergoing Transcatheter Aortic Valve Replacement: From the STS/ACC TVT Registry.

Journal Article J Am Coll Cardiol · December 4, 2018 BACKGROUND: Prosthesis-patient mismatch (PPM) after surgical aortic valve replacement (AVR) for aortic stenosis is generally associated with worse outcomes. Transcatheter AVR (TAVR) can achieve a larger valve orifice and the effects of PPM after TAVR are l ... Full text Link to item Cite

Association of Renin-Angiotensin Inhibitor Treatment With Mortality and Heart Failure Readmission in Patients With Transcatheter Aortic Valve Replacement.

Journal Article JAMA · December 4, 2018 IMPORTANCE: Data are lacking on the effect of a renin-angiotensin system (RAS) inhibitor prescribed after transcatheter aortic valve replacement (TAVR). Treatment with a RAS inhibitor may reverse left ventricular remodeling and improve function. OBJECTIVE: ... Full text Link to item Cite

Association of Transcatheter Mitral Valve Repair With Quality of Life Outcomes at 30 Days and 1 Year: Analysis of the Transcatheter Valve Therapy Registry.

Journal Article JAMA Cardiol · December 1, 2018 IMPORTANCE: Improvements in symptoms, functional capacity, and quality of life are among the key goals of edge-to-edge transcatheter mitral valve repair (TMVR) for mitral regurgitation. OBJECTIVE: To examine health status outcomes among patients undergoing ... Full text Link to item Cite

Transcatheter Aortic Valve Replacement in the Era of Quality Assessment.

Journal Article Circ Cardiovasc Qual Outcomes · December 2018 Full text Link to item Cite

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial.

Journal Article Lancet · October 27, 2018 BACKGROUND: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine t ... Full text Link to item Cite

Variation in post-TAVR antiplatelet therapy utilization and associated outcomes: Insights from the STS/ACC TVT Registry.

Journal Article Am Heart J · October 2018 BACKGROUND: Dual antiplatelet therapy (DAPT) is recommended following transcatheter aortic valve replacement (TAVR); however, the optimal antiplatelet strategy is undefined, and little is known about practice patterns. We aimed to describe contemporary pra ... Full text Link to item Cite

Incidence, Management, and Associated Clinical Outcomes of New-Onset Atrial Fibrillation Following Transcatheter Aortic Valve Replacement: An Analysis From the STS/ACC TVT Registry.

Journal Article JACC Cardiovasc Interv · September 10, 2018 OBJECTIVES: The aim of this study was to evaluate incidence, care patterns, and clinical outcomes in patients developing new-onset atrial fibrillation (AF) following transcatheter aortic valve replacement (TAVR). BACKGROUND: Pre-procedural AF has been asso ... Full text Link to item Cite

Isolated Mitral Valve Surgery: The Society of Thoracic Surgeons Adult Cardiac Surgery Database Analysis.

Journal Article Ann Thorac Surg · September 2018 BACKGROUND: Data from The Society of Thoracic Surgeons Adult Cardiac Surgery Database were analyzed to identify trends in patient characteristics and outcomes of mitral valve operations in North America. METHODS: All patients with isolated primary mitral v ... Full text Link to item Cite

TCT-453 Appropriateness of Transcatheter Aortic Valve Replacement: Insight from the OCEAN-TAVI Registry

Conference Journal of the American College of Cardiology · September 2018 Full text Cite

Transcatheter Aortic Valve Replacement of Failed Surgically Implanted Bioprostheses: The STS/ACC Registry.

Journal Article J Am Coll Cardiol · July 24, 2018 BACKGROUND: Valve-in-valve (ViV) transcatheter aortic valve replacement (TAVR) has been shown to be feasible, yet the safety and efficacy in relation to native valve (NV) TAVR are not known. OBJECTIVES: This study sought to evaluate the safety and effectiv ... Full text Link to item Cite

Incidence, timing, and type of first and recurrent ischemic events in patients with and without peripheral artery disease after an acute coronary syndrome.

Journal Article Am Heart J · July 2018 BACKGROUND: Patients with peripheral artery disease (PAD) are known to have an increased risk of ischemic cardiovascular events. However, the influence of concomitant PAD on first and subsequent recurrent ischemic events after an acute coronary syndrome (A ... Full text Link to item Cite

Outcomes Following Urgent/Emergent Transcatheter Aortic Valve Replacement: Insights From the STS/ACC TVT Registry.

Journal Article JACC Cardiovasc Interv · June 25, 2018 OBJECTIVES: The authors sought to examine outcomes and identify independent predictors of mortality among patients undergoing urgent/emergent transcatheter aortic valve replacement (TAVR). BACKGROUND: Data on urgent/emergent TAVR as a rescue therapy for de ... Full text Link to item Cite

Stroke and Cardiovascular Outcomes in Patients With Carotid Disease Undergoing Transcatheter Aortic Valve Replacement.

Journal Article Circ Cardiovasc Interv · June 2018 BACKGROUND: Stroke is a serious complication of both transcatheter aortic valve replacement (TAVR) and carotid artery disease (CD). The implications of CD in patients undergoing TAVR are unclear. METHODS AND RESULTS: The Society of Thoracic Surgeons and Am ... Full text Link to item Cite

Prevalence and Outcomes of Mitral Stenosis in Patients Undergoing Transcatheter Aortic Valve Replacement: Findings From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapies Registry.

Journal Article JACC Cardiovasc Interv · April 9, 2018 OBJECTIVES: This study sought to examine the prevalence of mitral stenosis (MS) and its impact on in-hospital and 1-year clinical outcomes among patients undergoing transcatheter aortic valve replacement (TAVR). BACKGROUND: Patients with coexisting severe ... Full text Link to item Cite

Association of Tricuspid Regurgitation With Transcatheter Aortic Valve Replacement Outcomes: A Report From The Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article Ann Thorac Surg · April 2018 BACKGROUND: The purpose of this study is to evaluate the association of tricuspid regurgitation (TR) severity with outcomes after transcatheter aortic valve replacement (TAVR). METHODS: We analyzed data from 34,576 patients who underwent TAVR at 365 US hos ... Full text Link to item Cite

Inclusion of Functional Status Measures in the Risk Adjustment of 30-Day Mortality After Transcatheter Aortic Valve Replacement: A Report From the Society of Thoracic Surgeons/American College of Cardiology TVT Registry.

Journal Article JACC Cardiovasc Interv · March 26, 2018 OBJECTIVES: The aim of this study was to develop and validate a risk adjustment model for 30-day mortality after transcatheter aortic valve replacement (TAVR) that accounted for both standard clinical factors and pre-procedural health status and frailty. B ... Full text Link to item Cite

ELECTRONIC HEALTH RECORD ALGORITHMS TO DETECT PAD

Conference Journal of the American College of Cardiology · March 2018 Full text Cite

MAJOR BLEEDING IN PATIENTS WITH PERIPHERAL ARTERY DISEASE: INSIGHTS FROM THE EUCLID TRIAL

Conference Journal of the American College of Cardiology · March 2018 Full text Cite

Systematic review and meta-analysis of endovascular and surgical revascularization for patients with chronic lower extremity venous insufficiency and varicose veins.

Journal Article Am Heart J · February 2018 BACKGROUND: Chronic lower extremity venous disease (LECVD) is twice as prevalent as coronary heart disease, and invasive therapies to treat LECVD accounted for an estimated $290 million in Medicare expenditures in 2015. Despite increasing use of these inva ... Full text Link to item Cite

Valve hemodynamic deterioration and cardiovascular outcomes in TAVR: A report from the STS/ACC TVT Registry.

Journal Article Am Heart J · January 2018 BACKGROUND: Recent reports of leaflet abnormalities (detected using advanced imaging) have raised questions regarding transcatheter aortic valve replacement (TAVR) durability. We sought to determine the incidence of valve hemodynamic deterioration (VHD) an ... Full text Link to item Cite

Surgical predictive planning using 3D printing

Chapter · January 1, 2018 Cardiovascular outcomes, either through percutaneous therapy or surgical intervention, have seen tremendous improvements over the past decade, primarily through the enhanced ability to risk stratify patients pre- or postprocedurally. Furthermore, 3D printi ... Full text Cite

Transcatheter Aortic Valve Replacement in Patients With Aortic Stenosis and Mitral Regurgitation.

Journal Article Ann Thorac Surg · December 2017 BACKGROUND: Many patients undergoing transcatheter aortic valve replacement (TAVR) for aortic stenosis also have significant mitral regurgitation (MR). We sought to understand the association of concomitant MR with TAVR clinical outcomes, as well changes i ... Full text Link to item Cite

Conscious Sedation Versus General Anesthesia for Transcatheter Aortic Valve Replacement: Insights from the National Cardiovascular Data Registry Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article Circulation · November 28, 2017 BACKGROUND: Conscious sedation is used during transcatheter aortic valve replacement (TAVR) with limited evidence as to the safety and efficacy of this practice. METHODS: The National Cardiovascular Data Registry Society of Thoracic Surgeons/American Colle ... Full text Link to item Cite

Outcomes With Transcatheter Mitral Valve Repair in the United States: An STS/ACC TVT Registry Report.

Journal Article J Am Coll Cardiol · November 7, 2017 BACKGROUND: Post-market surveillance is needed to evaluate the real-world clinical effectiveness and safety of U.S. Food and Drug Administration-approved devices. OBJECTIVES: The authors examined the commercial experience with transcatheter mitral valve re ... Full text Link to item Cite

Clinical Impact of Diabetes Mellitus on Outcomes After Transcatheter Aortic Valve Replacement: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article Circ Cardiovasc Interv · November 2017 BACKGROUND: Diabetes mellitus (DM) adversely affects morbidity and mortality for cardiovascular diseases and procedures. Data evaluating the outcomes of transcatheter aortic valve replacement (TAVR) in diabetic patients are limited by small sample size and ... Full text Link to item Cite

Death and Dialysis After Transcatheter Aortic Valve Replacement: An Analysis of the STS/ACC TVT Registry.

Journal Article JACC Cardiovasc Interv · October 23, 2017 OBJECTIVES: The authors sought to elucidate the true incidence of renal replacement therapy (RRT) after transcatheter aortic valve replacement (TAVR). BACKGROUND: There is a wide discrepancy in the reported rate of RRT after TAVR (1.4% to 40%). The true in ... Full text Link to item Cite

Peripheral Artery Disease and Transcatheter Aortic Valve Replacement Outcomes: A Report From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Therapy Registry.

Journal Article Circ Cardiovasc Interv · October 2017 BACKGROUND: Peripheral artery disease (PAD) is associated with increased cardiovascular mortality, and PAD risk factors overlap with those for aortic stenosis. The prevalence and outcomes associated with PAD in a population undergoing transcatheter aortic ... Full text Link to item Cite

Hospital Practice of Direct-Home Discharge and 30-Day Readmission After Transcatheter Aortic Valve Replacement in the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy (STS/ACC TVT) Registry.

Journal Article J Am Heart Assoc · August 21, 2017 BACKGROUND: Nearly 17% of patients are readmitted within 30 days of discharge after transcatheter aortic valve replacement. Selected patients are discharged to skilled nursing facilities, yet the association between a hospital's practice to discharge home ... Full text Link to item Cite

Trends and Outcomes of Off-label Use of Transcatheter Aortic Valve Replacement: Insights From the NCDR STS/ACC TVT Registry.

Journal Article JAMA Cardiol · August 1, 2017 IMPORTANCE: Transcatheter aortic valve replacement (TAVR) was approved by the US Food and Drug Administration for severe aortic stenosis in patients who cannot undergo surgery and for patients at high operative risk. Use of TAVR for off-label indications h ... Full text Link to item Cite

Procedural Experience for Transcatheter Aortic Valve Replacement and Relation to Outcomes: The STS/ACC TVT Registry.

Journal Article J Am Coll Cardiol · July 4, 2017 BACKGROUND: Transcatheter aortic valve replacement (TAVR) has been introduced into U.S. clinical practice with efforts to optimize outcomes and minimize the learning curve. OBJECTIVES: The goal of this study was to assess the degree to which increasing exp ... Full text Link to item Cite

Cardiovascular events and hospital resource utilization pre- and post-transcatheter mitral valve repair in high-surgical risk patients.

Journal Article Am Heart J · July 2017 UNLABELLED: MitraClip is an approved therapy for mitral regurgitation (MR); however, health care resource utilization pre- and post-MitraClip remains understudied. METHODS: Patients with functional and degenerative MR at high surgical risk in the EVEREST I ... Full text Link to item Cite

The Effect of Clinical Care Location on Clinical Outcomes After Peripheral Vascular Intervention in Medicare Beneficiaries.

Journal Article JACC Cardiovasc Interv · June 12, 2017 OBJECTIVES: Modifications in reimbursement rates by Medicare in 2008 have led to peripheral vascular interventions (PVI) being performed more commonly in outpatient and office-based clinics. The objective of this study was to determine the effects of this ... Full text Link to item Cite

Quality-of-Life Outcomes After Transcatheter Aortic Valve Replacement in an Unselected Population: A Report From the STS/ACC Transcatheter Valve Therapy Registry.

Journal Article JAMA Cardiol · April 1, 2017 IMPORTANCE: In clinical trials, transcatheter aortic valve replacement (TAVR) has been shown to improve symptoms and quality of life. As this technology moves into general clinical practice, evaluation of the health status outcomes among unselected patient ... Full text Link to item Cite

National patterns in intensity and frequency of outpatient care for apparent treatment-resistant hypertension.

Journal Article Am Heart J · April 2017 BACKGROUND: Apparent treatment-resistant hypertension (aTRH) is associated with an increased risk of adverse cardiovascular outcomes. We studied the frequency and intensity of care for aTRH among participants aged 65 years and older in the US-based REGARDS ... Full text Link to item Cite

2016 Annual Report of The Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article J Am Coll Cardiol · March 14, 2017 BACKGROUND: The Society of Thoracic Surgeons (STS)/American College of Cardiology Transcatheter Valve Therapy (TVT) Registry captures all procedures with Food and Drug Administration-approved transcatheter valve devices performed in the United States, and ... Full text Link to item Cite

2016 Annual Report of The Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article Ann Thorac Surg · March 2017 BACKGROUND: The Society of Thoracic Surgeons (STS)/American College of Cardiology Transcatheter Valve Therapy (TVT) Registry captures all procedures with Food and Drug Administration-approved transcatheter valve devices performed in the United States, and ... Full text Link to item Cite

Peripheral Artery Disease and Cardiovascular Risk in Patients Presenting With Chest Pain: Insights From the PROMISE Trial

Conference · 2017 Introduction: Peripheral artery disease (PAD) is considered a coronary risk equivalent and is associated with increased risk of adverse cardiovascular (CV) events. Yet, as compared to other high-risk groups, little is known about the relative risk of adver ... Cite

Sex-Based Differences in Outcomes With Transcatheter Aortic Valve Therapy: TVT Registry From 2011 to 2014.

Journal Article J Am Coll Cardiol · December 27, 2016 BACKGROUND: A differential impact of sex has been observed in transcatheter aortic valve replacement (TAVR) outcomes from small observational studies and subgroup analyses of randomized trials. OBJECTIVES: The goal of this study was to compare the in-hospi ... Full text Link to item Cite

The Society of Thoracic Surgeons National Database 2016 Annual Report.

Journal Article Ann Thorac Surg · December 2016 The art and science of outcomes analysis, quality improvement, and patient safety continue to evolve, and cardiothoracic surgery leads many of these advances. The Society of Thoracic Surgeons (STS) National Database is one of the principal reasons for this ... Full text Link to item Cite

Incidence, Predictors, and Outcomes of Permanent Pacemaker Implantation Following Transcatheter Aortic Valve Replacement: Analysis From the U.S. Society of Thoracic Surgeons/American College of Cardiology TVT Registry.

Journal Article JACC Cardiovasc Interv · November 14, 2016 OBJECTIVES: The purpose of this study was to evaluate the incidence, predictors, and clinical outcomes of permanent pacemaker (PPM) implantation following transcatheter aortic valve replacement (TAVR). BACKGROUND: Conduction abnormalities leading to PPM im ... Full text Link to item Cite

Significant variation in P2Y12 inhibitor use after peripheral vascular intervention in Medicare beneficiaries.

Journal Article Am Heart J · September 2016 UNLABELLED: There is no consensus regarding whether to use antithrombotic medications in patients with peripheral artery disease after lower-extremity peripheral vascular intervention. OBJECTIVES: The main hypothesis is that significant variation exists re ... Full text Link to item Cite

Blood pressure control and stroke or bleeding risk in anticoagulated patients with atrial fibrillation: Results from the ROCKET AF Trial.

Journal Article Am Heart J · August 2016 BACKGROUND: We conducted a retrospective analysis examining the association between systolic blood pressure (SBP) or hypertension bracket and stroke risk in patients with atrial fibrillation (AF). METHODS: The study included 14,256 anticoagulated patients ... Full text Link to item Cite

Gait Speed Predicts 30-Day Mortality After Transcatheter Aortic Valve Replacement: Results From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal Article Circulation · April 5, 2016 BACKGROUND: Surgical risk scores do not include frailty assessments (eg, gait speed), which are of particular importance for patients with severe aortic stenosis considering transcatheter aortic valve replacement. METHODS AND RESULTS: We assessed the assoc ... Full text Link to item Cite

No Time to Waste: in Support of Aggressive and Immediate Management of Hypertension.

Journal Article Curr Hypertens Rep · April 2016 Untreated and uncontrolled hypertension (HTN) presents a major public health burden in the USA and worldwide. Despite the known risk for increased cardiovascular (CV) morbidity and mortality, blood pressure remains untreated and uncontrolled at alarming ra ... Full text Link to item Cite

Should Transcatheter Aortic Valve Replacement Be Performed in Nonagenarians?: Insights From the STS/ACC TVT Registry.

Journal Article J Am Coll Cardiol · March 29, 2016 BACKGROUND: Data demonstrating the outcome of transcatheter aortic valve replacement (TAVR) in the very elderly patients are limited, as they often represent only a small proportion of the trial populations. OBJECTIVES: The purpose of this study was to com ... Full text Link to item Cite

Initial Experience With Commercial Transcatheter Mitral Valve Repair in the United States.

Journal Article J Am Coll Cardiol · March 15, 2016 BACKGROUND: Transcatheter mitral valve (MV) repair with the MitraClip received approval in 2013 for the treatment of prohibitive-risk patients with primary mitral regurgitation (MR). OBJECTIVES: The aim of this study was to report the initial U.S. commerci ... Full text Link to item Cite

Annual Outcomes With Transcatheter Valve Therapy: From the STS/ACC TVT Registry.

Journal Article Ann Thorac Surg · February 2016 BACKGROUND: The Society of Thoracic Surgeons (STS)/American College of Cardiology (ACC) Transcatheter Valve Therapy (TVT) Registry has been a joint initiative of the STS and the ACC in concert with multiple stakeholders. The TVT Registry has important info ... Full text Link to item Cite

Annual Outcomes With Transcatheter Valve Therapy: From the STS/ACC TVT Registry.

Journal Article J Am Coll Cardiol · December 29, 2015 BACKGROUND: The Society of Thoracic Surgeons (STS)/American College of Cardiology (ACC) Transcatheter Valve Therapy (TVT) Registry has been a joint initiative of the STS and the ACC in concert with multiple stakeholders. The TVT Registry has important info ... Full text Link to item Cite

Association of Patient-Reported Health Status With Long-Term Mortality After Transcatheter Aortic Valve Replacement: Report From the STS/ACC TVT Registry.

Journal Article Circ Cardiovasc Interv · December 2015 BACKGROUND: Although transcatheter aortic valve replacement (TAVR) is an effective treatment for aortic stenosis, long-term mortality after TAVR remains high and challenging to predict. The Kansas City Cardiomyopathy Questionnaire (KCCQ) is a health status ... Full text Link to item Cite

Transapical and Transaortic Transcatheter Aortic Valve Replacement in the United States.

Journal Article Ann Thorac Surg · November 2015 BACKGROUND: When transcatheter aortic valve replacement (TAVR) cannot be carried out through transfemoral access, alternative access TAVR is indicated. The purpose of this study was to explore inhospital and 1-year outcomes of patients undergoing alternati ... Full text Link to item Cite

TCT-618 Outcomes of TAVR in Nonagenarians in the U.S.: Insights from the STS/ACC TVT Registry

Conference Journal of the American College of Cardiology · October 2015 Full text Cite

Letter response.

Journal Article Am Heart J · August 2015 Full text Link to item Cite

Limb ischemia: cardiovascular diagnosis and management from head to toe.

Journal Article Curr Cardiol Rep · July 2015 Peripheral arterial disease (PAD) affects an estimated 27 million people in Europe and North America. Limb ischemia, defined as ischemic rest pain, ischemic ulcerations, or ischemic gangrene, represents the most severe manifestation of PAD and is associate ... Full text Link to item Cite

Supervised vs unsupervised exercise for intermittent claudication: A systematic review and meta-analysis.

Journal Article Am Heart J · June 2015 BACKGROUND: Supervised exercise (SE) is widely accepted as an effective therapy for intermittent claudication (IC), but its use is limited by cost. Unsupervised exercise (UE) represents a less costly alternative. We assessed the comparative effectiveness o ... Full text Link to item Cite

Comparative Effectiveness of Medical Therapy, Supervised Exercise, and Revascularization for Patients With Intermittent Claudication: A Network Meta-analysis.

Journal Article Clin Cardiol · June 2015 BACKGROUND: There are limited data on the comparative effectiveness of medical therapy, supervised exercise, and revascularization to improve walking and quality of life in patients with intermittent claudication (IC). HYPOTHESIS: Supervised exercise and r ... Full text Link to item Cite

Trends in settings for peripheral vascular intervention and the effect of changes in the outpatient prospective payment system.

Journal Article J Am Coll Cardiol · March 10, 2015 BACKGROUND: Peripheral vascular intervention (PVI) is an effective treatment option for patients with peripheral artery disease (PAD). In 2008, Medicare modified reimbursement rates to encourage more efficient outpatient use of PVI in the United States. OB ... Full text Link to item Cite

Clinical outcomes at 1 year following transcatheter aortic valve replacement.

Journal Article JAMA · March 10, 2015 IMPORTANCE: Introducing new medical devices into routine practice raises concerns because patients and outcomes may differ from those in randomized trials. OBJECTIVE: To update the previous report of 30-day outcomes and present 1-year outcomes following tr ... Full text Link to item Cite

NATIONAL PATTERNS IN INTENSITY OF OUTPATIENT CARE FOR APPARENT TREATMENT RESISTANT HYPERTENSION

Conference Journal of the American College of Cardiology · March 2015 Full text Cite

Machine learning methods for credibility assessment of interviewees based on posturographic data.

Journal Article Annu Int Conf IEEE Eng Med Biol Soc · 2015 This paper discusses the advantages of using posturographic signals from force plates for non-invasive credibility assessment. The contributions of our work are two fold: first, the proposed method is highly efficient and non invasive. Second, feasibility ... Full text Link to item Cite

Apparent treatment-resistant hypertension and chronic kidney disease: another cardiovascular-renal syndrome?

Journal Article Adv Chronic Kidney Dis · November 2014 To identify patients at increased risk of cardiovascular (CV) outcomes, apparent treatment-resistant hypertension (aTRH) is defined as having a blood pressure above goal despite the use of 3 or more antihypertensive therapies of different classes at maxima ... Full text Open Access Link to item Cite

Proceedings from Duke resistant hypertension think tank.

Journal Article Am Heart J · June 2014 To identify patients at increased risk for cardiovascular outcomes, apparent treatment resistant hypertension (aTRH) is defined as having a blood pressure (BP) above goal despite the use of ≥3 antihypertensive therapies of different classes at maximally to ... Full text Link to item Cite

Comparative effectiveness of endovascular and surgical revascularization for patients with peripheral artery disease and critical limb ischemia: systematic review of revascularization in critical limb ischemia.

Journal Article Am Heart J · April 2014 BACKGROUND: For patients with critical limb ischemia (CLI), the optimal treatment to enhance limb preservation, prevent death, and improve functional status is unknown. We performed a systematic review and meta-analysis to assess the comparative effectiven ... Full text Link to item Cite

Peripheral arterial testing before lower extremity amputation among Medicare beneficiaries, 2000 to 2010.

Journal Article Circ Cardiovasc Qual Outcomes · January 2014 BACKGROUND: Despite mild reductions in rates of lower extremity amputation over the past decade, few data exist on the use of arterial testing in patients before amputation. METHODS AND RESULTS: Using Medicare claims from 2000 through 2010, we examined rat ... Full text Link to item Cite

Lower extremity amputation in peripheral artery disease: improving patient outcomes.

Journal Article Vasc Health Risk Manag · 2014 Peripheral artery disease affects over eight million Americans and is associated with an increased risk of mortality, cardiovascular disease, functional limitation, and limb loss. In its most severe form, critical limb ischemia, patients are often treated ... Full text Link to item Cite

Importance of total ischemic time and preprocedural infarct-related artery blood flow in predicting infarct size in patients with anterior wall myocardial infarction (from the CRISP-AMI Trial).

Journal Article Am J Cardiol · October 1, 2013 The goal of this study was to characterize determinants of infarct size in the multicenter randomized Counterpulsation to Reduce Infarct Size Pre-PCI Acute Myocardial Infarction (CRISP-AMI) trial. Contemporary determinants of infarct size in patients prese ... Full text Link to item Cite

Fibroblast growth factor-2 (FGF2) and syndecan-1 (SDC1) are potential biomarkers for putative circulating CD15+/CD30+ cells in poor outcome Hodgkin lymphoma patients.

Journal Article J Hematol Oncol · August 29, 2013 BACKGROUND: High risk, unfavorable classical Hodgkin lymphoma (cHL) includes those patients with primary refractory or early relapse, and progressive disease. To improve the availability of biomarkers for this group of patients, we investigated both tumor ... Full text Link to item Cite

Forelimb amputation-induced reorganization in the cuneate nucleus (CN) is not reflected in large-scale reorganization in rat forepaw barrel subfield cortex (FBS).

Journal Article Brain Res · August 14, 2013 We examined reorganization in cuneate nucleus (CN) in juvenile rat following forelimb amputation (n=34) and in intact controls (n=5) to determine whether CN forms a substrate for large-scale reorganization in forepaw barrel subfield (FBS) cortex. New input ... Full text Link to item Cite

Interventional treatment of hypertension: a new paradigm.

Journal Article Curr Cardiol Rep · May 2013 Hypertension is thought to contribute to more than 7 million deaths worldwide each year and contributes to the development of atherosclerotic lesions that lead to myocardial infarction and stroke. While lifestyle modifications (diet, exercise, weight loss) ... Full text Link to item Cite

High mortality risks after major lower extremity amputation in Medicare patients with peripheral artery disease.

Journal Article Am Heart J · May 2013 BACKGROUND: Little is known regarding the contemporary outcomes of older patients with peripheral artery disease (PAD) undergoing major lower extremity (LE) amputation in the United States. We sought to characterize clinical outcomes and factors associated ... Full text Link to item Cite

PERIPHERAL ARTERIAL DISEASE TESTING PRIOR TO AMPUTATION IN MEDICARE PATIENTS

Conference Journal of the American College of Cardiology · March 2013 Full text Cite

Prosthetic valve thrombosis: when and how should we lyse?

Journal Article JACC Cardiovasc Imaging · February 2013 Full text Link to item Cite

Clinical activity of mammalian target of rapamycin inhibitors in solid tumors.

Journal Article Target Oncol · June 2011 The phosphatidylinositol 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) pathway is vital for cell metabolism, growth, and proliferation. mTOR is frequently upregulated in many tumor types and hence has become an important target in cancer treatme ... Full text Link to item Cite

The emerging role of mammalian target of rapamycin inhibitors in the treatment of sarcomas.

Journal Article Target Oncol · March 2011 The mammalian target of rapamycin (mTOR) is a protein kinase that functions as a key regulator of cell growth, proliferation and differentiation, cell-cycle progression, angiogenesis, protein degradation, and apoptosis. Following activation by a number of ... Full text Link to item Cite

Feasibility of whole-body functional mouse imaging using helical pinhole SPECT.

Journal Article Mol Imaging Biol · 2010 PURPOSE: Detailed in vivo whole-body biodistributions of radiolabeled tracers may characterize the longitudinal progression of disease, and changes with therapeutic interventions. Small-animal imaging in mice is particularly attractive due to the wide arra ... Full text Link to item Cite

Clinical outcomes and factors predicting development of venous thromboembolic complications in patients with advanced refractory cancer in a Phase I Clinic: the M. D. Anderson Cancer Center experience.

Journal Article Am J Hematol · July 2009 Venous thromboembolism (VTE) is common in patients with advanced cancer and may influence patient eligibility for clinical studies, quality of life, and survival. We reviewed the medical records of 220 consecutive patients seen in the Phase I Clinical Tria ... Full text Link to item Cite

Recurrent malignant melanoma of the penis.

Journal Article Urology · November 2008 We report the case of a 72-year-old man with arcal-lentiginous type melanoma of the penis who had undergone local excision and bilateral inguinal lymphadenectomy but developed recurrence at the subcoronal ridge of the glans penis. To our knowledge, this is ... Full text Link to item Cite

Left ventricular functional assessment in mice: feasibility of high spatial and temporal resolution ECG-gated blood pool SPECT.

Journal Article Radiology · November 2007 PURPOSE: To prospectively determine feasibility of evaluating murine left ventricular (LV) function with electrocardiographically (ECG)-gated blood pool single photon emission computed tomography (SPECT). MATERIALS AND METHODS: All animal studies had insti ... Full text Link to item Cite

Cell therapy in murine atherosclerosis: in vivo imaging with high-resolution helical SPECT.

Journal Article Radiology · January 2007 PURPOSE: To determine the feasibility of in vivo localization and quantification of indium 111 (111In)-oxine-labeled bone marrow (BM) with high-resolution whole-body helical single photon emission computed tomography (SPECT) in an established murine model ... Full text Link to item Cite

Outer membrane vesicle production by Escherichia coli is independent of membrane instability.

Journal Article J Bacteriol · August 2006 It has been long noted that gram-negative bacteria produce outer membrane vesicles, and recent data demonstrate that vesicles released by pathogenic strains can transmit virulence factors to host cells. However, the mechanism of vesicle release has remaine ... Full text Link to item Cite

Syncope: A focused approach to the workup and management

Journal Article Consultant · June 1, 2006 Structural heart disease is the most important risk factor for mortality in patients with syncope. A workup that includes a thorough history taking, focused physical examination, and electrocardiography yields a diagnosis in nearly half of cases. Echocardi ... Cite

Molecular imaging of small animals with a triple-head SPECT system using pinhole collimation.

Journal Article IEEE Trans Med Imaging · July 2005 Pinhole collimation yields high sensitivity when the distance from the object to the aperture is small, as in the case of imaging small animals. Fine-resolution images may be obtained when the magnification is large since this mitigates the effect of detec ... Full text Link to item Cite