Stuart James McKinnon
Associate Professor of Ophthalmology
Stuart J. McKinnon, MD, PhD, specializes in the diagnosis and treatment of glaucoma and cataract. His areas of expertise include open and closed angle glaucomas, neovascular and other secondary glaucomas, and juvenile glaucoma. He is experienced in all forms of anterior segment procedures including laser therapy and filtering surgeries for glaucoma, as well as cataract surgery. He is integrally involved in the teaching of medical students, residents, and fellows. McKinnon's research activities include NIH-sponsored exploration of the basic mechanisms of retinal cell death in glaucoma. Other research areas include neuroprotective glaucoma therapies, non-invasive imaging of glaucoma damage, and relationships between glaucoma and other chronic neurodegenerations such as Alzheimer's disease.
Current Appointments & Affiliations
- Associate Professor of Ophthalmology, Ophthalmology, Glaucoma, Ophthalmology 2015
- Associate Professor in Neurobiology in Neurobiology, Neurobiology, Basic Science Departments 2015
Contact Information
- Box 3802 Erwin Road, Durham, NC 27710
- Box 3802 Med Ctr, Durham, NC 27710
-
stuart.mckinnon@duke.edu
(919) 684-8850
- Background
-
Education, Training, & Certifications
- Associate Professor, Ophthalmology, University of Texas Medical School at Houston 2004 - 2005
- Assistant Professor, Ophthalmology, University of Texas Medical School at Houston 1999 - 2004
- Assistant Professor, Ophthalmology, Johns Hopkins University 1996 - 1999
- Glaucoma Fellow, Ophthalmology, Johns Hopkins University 1995 - 1996
- Resident, Ophthalmology, Louisiana State University at Shreveport 1991 - 1995
- Intern, Baptist Medical Center (Birmingham, Al) 1990 - 1991
- M.D., Louisiana State University 1990
- Ph.D., University of New Orleans 1990
- M.S., University of New Orleans 1986
- B.S., University of Massachusetts at Amherst 1984
-
Duke Appointment History
- Associate Professor of Ophthalmology, Ophthalmology, Glaucoma, Ophthalmology 2005 - 2015
- Associate Professor in Neurobiology, Neurobiology, Basic Science Departments 2005 - 2015
- Instructor, Temporary in the Department of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery, Ophthalmology 2005
- Recognition
-
Awards & Honors
- Research
-
Selected Grants
- Neuroinflammation: the role of lymphocytes in glaucoma awarded by BrightFocus Foundation 2014 - 2016
- The Retroject Device: A Novel Approach to Glaucoma Drug Delivery awarded by Retroject, Inc 2014 - 2015
- Autophagic Lysosomal Pathway and Glaucoma awarded by National Institutes of Health 2010 - 2015
- Mechanisms of RGC Loss in a Murine Model of Glaucoma awarded by National Institutes of Health 2009 - 2012
- Retinal Ganglion Cell Apoptosis in Experimental Glaucoma awarded by National Institutes of Health 2005 - 2011
- Publications & Artistic Works
-
Selected Publications
-
Book Sections
- McKinnon, SJ. "Gene Therapy in Glaucoma." In Glaucoma: Second Edition, 657-665. September 3, 2014. Full Text
-
Conference Papers
- Hirt, J, Dixon, A, McKinnon, SJ, and Liton, PB. "Autophagy in the Neuroretina and Angle Region of DBA/2J Mice." June 2015. Link to Item
- McKinnon, SJ, and Pease, ME. "Immunohistochemical localization of the tyrosine kinase receptor TRKB in monkey photoreceptors." 1997.
- Pease, ME, McKinnon, SJ, Zack, DJ, and Quigley, HA. "Localization of the neurotrophin receptor trkb in normal and glaucomatous monkey optic nerve heads." 1997.
- Jacob-LaBarre, JT, McKinnon, SJ, and Tanji, T. "Biocompatibility response to modified Baerveldt glaucoma drains." 1996.
- Jacob-LaBarre, JT, McKinnon, SJ, and Tanji, T. "Biocompatibility response to modified Baerveldt glaucoma drains." 1996.
-
Journal Articles
- Li, G, Farsiu, S, Qiu, J, Dixon, A, Song, C, McKinnon, SJ, Yuan, F, Gonzalez, P, and Stamer, WD. "Disease progression in iridocorneal angle tissues of BMP2-induced ocular hypertensive mice with optical coherence tomography." Molecular vision 20 (January 2014): 1695-1709.
- Liu, S, Wang, B, Yin, B, Milner, TE, Markey, MK, McKinnon, SJ, and Rylander, HG. "Retinal nerve fiber layer reflectance for early glaucoma diagnosis." J Glaucoma 23, no. 1 (January 2014): e45-e52. Full Text Link to Item
- Samuels, BC, Hammes, NM, Johnson, PL, Shekhar, A, McKinnon, SJ, and Allingham, RR. "Dorsomedial/Perifornical hypothalamic stimulation increases intraocular pressure, intracranial pressure, and the translaminar pressure gradient. (Published online)" Invest Ophthalmol Vis Sci 53, no. 11 (October 23, 2012): 7328-7335. Full Text Link to Item
- McKinnon, SJ. "The cell and molecular biology of glaucoma: common neurodegenerative pathways and relevance to glaucoma. (Published online)" Invest Ophthalmol Vis Sci 53, no. 5 (May 4, 2012): 2485-2487. Full Text Link to Item
- Kipfer-Kauer, A, McKinnon, SJ, Frueh, BE, and Goldblum, D. "Distribution of amyloid precursor protein and amyloid-β in ocular hypertensive C57BL/6 mouse eyes." Current Eye Research 35, no. 9 (2010): 828-834. Full Text
- Stein, JD, McCoy, AN, Asrani, S, Herndon, LW, Lee, PP, McKinnon, SJ, Allingham, RR, and Challa, P. "Surgical management of hypotony owing to overfiltration in eyes receiving glaucoma drainage devices." J Glaucoma 18, no. 8 (October 2009): 638-641. Full Text Link to Item
- Walsh, MM, Yi, H, Friedman, J, Cho, K-I, Tserentsoodol, N, McKinnon, S, Searle, K, Yeh, A, and Ferreira, PA. "Gene and protein expression pilot profiling and biomarkers in an experimental mouse model of hypertensive glaucoma." Exp Biol Med (Maywood) 234, no. 8 (August 2009): 918-930. Full Text Link to Item
- McKinnon, SJ, Schlamp, CL, and Nickells, RW. "Mouse models of retinal ganglion cell death and glaucoma." Exp Eye Res 88, no. 4 (April 2009): 816-824. (Review) Full Text Link to Item
- Radhakrishnan, S, Quigley, HA, Jampel, HD, Friedman, DS, Ahmad, SI, Congdon, NG, and McKinnon, S. "Outcomes of Surgical Bleb Revision for Complications of Trabeculectomy." Ophthalmology 116, no. 9 (2009): 1713-1718. Full Text
- McKinnon, SJ, Goldberg, LD, Peeples, P, Walt, JG, and Bramley, TJ. "Current management of glaucoma and the need for complete therapy." Am J Manag Care 14, no. 1 Suppl (February 2008): S20-S27. (Review) Link to Item
- Ivanov, D, Dvoriantchikova, G, Nathanson, L, McKinnon, SJ, and Shestopalov, VI. "Microarray analysis of gene expression in adult retinal ganglion cells." FEBS Lett 580, no. 1 (January 9, 2006): 331-335. Full Text Link to Item
- Brandt, JD, Beiser, JA, Gordon, MO, Kass, MA, and Ocular Hypertension Treatment Study (OHTS) Group, . "Central corneal thickness and measured IOP response to topical ocular hypotensive medication in the Ocular Hypertension Treatment Study." Am J Ophthalmol 138, no. 5 (November 2004): 717-722. Full Text Link to Item
- Coleman, AL, Gordon, MO, Beiser, JA, Kass, MA, and Ocular Hypertension Treatment Study, . "Baseline risk factors for the development of primary open-angle glaucoma in the Ocular Hypertension Treatment Study." Am J Ophthalmol 138, no. 4 (October 2004): 684-685. Full Text Link to Item
- Reitsamer, HA, Kiel, JW, Harrison, JM, Ransom, NL, and McKinnon, SJ. "Tonopen measurement of intraocular pressure in mice." Exp Eye Res 78, no. 4 (April 2004): 799-804. Full Text Link to Item
- Tahzib, NG, Ransom, NL, Reitsamer, HA, and McKinnon, SJ. "Alpha-fodrin is cleaved by caspase-3 in a chronic ocular hypertensive (COH) rat model of glaucoma." Brain Res Bull 62, no. 6 (February 15, 2004): 491-495. Full Text Link to Item
- Mayo, GL, Melendez, RF, Kumar, N, McKinnon, SJ, and Glickman, RD. "Antibody-targeted photodynamic therapy." Am J Ophthalmol 136, no. 6 (December 2003): 1151-1152. Link to Item
- McKinnon, SJ. "Glaucoma: Ocular Alzheimer's disease?." Frontiers in Bioscience 8, no. SUPPL. (December 1, 2003). (Review)
- McKinnon, SJ. "Glaucoma: ocular Alzheimer's disease? (Published online)." Front Biosci 8 (September 1, 2003): s1140-s1156. (Review) Link to Item
- Keltner, JL, Johnson, CA, Cello, KE, Edwards, MA, Bandermann, SE, Kass, MA, Gordon, MO, and Ocular Hypertension Treatment Study Group, . "Classification of visual field abnormalities in the ocular hypertension treatment study." Arch Ophthalmol 121, no. 5 (May 2003): 643-650. Full Text Link to Item
- Mayo, GL, Carter, JE, and McKinnon, SJ. "Bilateral optic disk edema and blindness as initial presentation of acute lymphocytic leukemia." Am J Ophthalmol 134, no. 1 (July 2002): 141-142. Link to Item
- Gordon, MO, Beiser, JA, Brandt, JD, Heuer, DK, Higginbotham, EJ, Johnson, CA, Keltner, JL, Miller, JP, Parrish, RK, Wilson, MR, and Kass, MA. "The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma." Arch Ophthalmol 120, no. 6 (June 2002): 714-720. Link to Item
- Kass, MA, Heuer, DK, Higginbotham, EJ, Johnson, CA, Keltner, JL, Miller, JP, Parrish, RK, Wilson, MR, and Gordon, MO. "The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma." Arch Ophthalmol 120, no. 6 (June 2002): 701-713. Link to Item
- McKinnon, SJ, Lehman, DM, Tahzib, NG, Ransom, NL, Reitsamer, HA, Liston, P, LaCasse, E, Li, Q, Korneluk, RG, and Hauswirth, WW. "Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model." Mol Ther 5, no. 6 (June 2002): 780-787. Full Text Link to Item
- McKinnon, SJ, Lehman, DM, Kerrigan-Baumrind, LA, Merges, CA, Pease, ME, Kerrigan, DF, Ransom, NL, Tahzib, NG, Reitsamer, HA, Levkovitch-Verbin, H, Quigley, HA, and Zack, DJ. "Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension." Invest Ophthalmol Vis Sci 43, no. 4 (April 2002): 1077-1087. Link to Item
- Johnson, CA, Keltner, JL, Cello, KE, Edwards, M, Kass, MA, Gordon, MO, Budenz, DL, Gaasterland, DE, Werner, E, and Ocular Hypertension Study Group, . "Baseline visual field characteristics in the ocular hypertension treatment study." Ophthalmology 109, no. 3 (March 2002): 432-437. Link to Item
- Feuer, WJ, Parrish, RK, Schiffman, JC, Anderson, DR, Budenz, DL, Wells, M-C, Hess, DJ, Kass, MA, and Gordon, MO. "The Ocular Hypertension Treatment Study: reproducibility of cup/disk ratio measurements over time at an optic disc reading center." Am J Ophthalmol 133, no. 1 (January 2002): 19-28. Link to Item
- Sponsel, WE, Paris, G, Trigo, Y, Pena, M, Weber, A, Sanford, K, and McKinnon, S. "Latanoprost and brimonidine: therapeutic and physiologic assessment before and after oral nonsteroidal anti-inflammatory therapy." Am J Ophthalmol 133, no. 1 (January 2002): 11-18. Link to Item
- Brandt, JD, Beiser, JA, Kass, MA, and Gordon, MO. "Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS)." Ophthalmology 108, no. 10 (October 2001): 1779-1788. Link to Item
- Quigley, HA, McKinnon, SJ, Zack, DJ, Pease, ME, Kerrigan-Baumrind, LA, Kerrigan, DF, and Mitchell, RS. "Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats." Invest Ophthalmol Vis Sci 41, no. 11 (October 2000): 3460-3466. Link to Item
- Keltner, JL, Johnson, CA, Quigg, JM, Cello, KE, Kass, MA, and Gordon, MO. "Confirmation of visual field abnormalities in the Ocular Hypertension Treatment Study. Ocular Hypertension Treatment Study Group." Arch Ophthalmol 118, no. 9 (September 2000): 1187-1194. Link to Item
- Pease, ME, McKinnon, SJ, Quigley, HA, Kerrigan-Baumrind, LA, and Zack, DJ. "Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma." Invest Ophthalmol Vis Sci 41, no. 3 (March 2000): 764-774. Link to Item
- Gordon, MO, and Kass, MA. "The Ocular Hypertension Treatment Study: design and baseline description of the participants." Arch Ophthalmol 117, no. 5 (May 1999): 573-583. Link to Item
- Jacob, JT, Burgoyne, CF, McKinnon, SJ, Tanji, TM, LaFleur, PK, and Duzman, E. "Biocompatibility response to modified baerveldt glaucoma drains." Journal of Biomedical Materials Research 43, no. 2 (June 1, 1998): 99-107. Full Text
- Jacob, JT, Burgoyne, CF, McKinnon, SJ, Tanji, TM, LaFleur, PK, and Duzman, E. "Biocompatibility response to modified Baerveldt glaucoma drains." J Biomed Mater Res 43, no. 2 (1998): 99-107. Link to Item
- McKinnon, SJ. "Glaucoma, apoptosis, and neuroprotection." Curr Opin Ophthalmol 8, no. 2 (April 1997): 28-37. (Review) Link to Item
- Loewenstein, A, McKinnon, S, and DiBernardo, C. "Echographic diagnosis of scleral fold in hypotony." American Journal of Ophthalmology 124, no. 2 (1997): 260-261.
- McKinnon, SJ, Whittenburg, SL, and Brooks, B. "Nonequilibrium Molecular dynamics simulation of oxygen diffusion through hexadecane monolayers with varying concentrations of cholesterol." Journal of Physical Chemistry 96, no. 25 (1992): 10497-10506.
- Whittenburg, SL, Jain, VK, and McKinnon, SJ. "Depolarized Rayleigh scattering study of pyrimidine." Journal of Molecular Liquids 47, no. 1-3 (1990): 161-169.
- Goodman, MA, McKinnon, SJ, Jain, VK, and Whittenburg, SL. "Hypersonic attenuation in simple cresols." Journal of Physical Chemistry 93, no. 18 (1989): 6832-6835.
- Whittenburg, SL, McKinnon, SJ, Jain, VK, and Evilia, RF. "Depolarized Rayleigh light scattering and NMR spectroscopy of m-cresol and p-cresol." Journal of Physical Chemistry 92, no. 14 (1988): 4236-4241.
- Goodman, MA, Jain, VK, McKinnon, SJ, and Whittenburg, SL. "Hypersonic attenuation in the simple amides." Journal of Physical Chemistry 91, no. 6 (1987): 1634-1638.
- Homer, SR, McKinnon, SJ, and Whittenburg, SL. "A series of experiments with 2-methyl-2-nitrosopropane: A physical chemistry experiment." Journal of Chemical Education 63, no. 12 (1986): 1103-1104.
- Whittenburg, SL, Jain, VK, and McKinnon, SJ. "Depolarized Rayleigh scattering study of neat formamide." Journal of Physical Chemistry 90, no. 6 (1986): 1004-1005.
-
Other Articles
- McKinnon, SJ. "Rats! Hyperglycemia protects against glaucoma!." Archives of Ophthalmology 129, no. 10 (2011): 1366-1367. Full Text
- Sponsel, WE, and McKinnon, SJ. "Brain Research Bulletin: Preface." Brain Research Bulletin 62, no. 6 (2004): 435-437. Full Text
-
Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.
