Scholars@Duke
Tarannum Jaleel

Tarannum Jaleel

Assistant Professor of Dermatology
Dermatology
Manage Profile
Embed Profile Data

Selected Publications

Ixekizumab Demonstrates Rapid and Consistent Efficacy for Patients with Psoriatic Arthritis, Regardless of Psoriasis Severity

Journal Article Dermatology and Therapy · June 1, 2024 Introduction: Skin involvement in patients with psoriatic arthritis (PsA) worsens the severity and burden of disease. Ixekizumab (IXE), a selective interleukin (IL)-17A antagonist, was compared to placebo (PBO) in the SPIRIT-P1 (NCT01695239) and SPIRIT-P2 ... Full text Cite

Discrepancies in hidradenitis suppurativa lesion characterization by providers and patients.

Journal Article J Eur Acad Dermatol Venereol · April 10, 2024 BACKGROUND: The hidradenitis suppurativa (HS) clinical response (HiSCR) has come under scrutiny as several HS clinical trials failed to meet primary endpoints with high placebo responses. This may be due to limitations of the tool and raters' ability to ac ... Full text Link to item Cite

Immune Dysregulation and Current Targeted Biologics in Hidradenitis Suppurativa

Journal Article Immuno · March 1, 2024 Hidradenitis Suppurativa (HS) is a debilitating cutaneous disease characterized by a vicious cycle of chronic inflammation and tissue destruction that stems from disruption of the skin microbiome and abnormal activation of both the innate and adaptive immu ... Full text Cite

Integrating skin color assessments into clinical practice and research: A review of current approaches.

Journal Article J Am Acad Dermatol · February 9, 2024 Skin color classification can have importance in skin health, pigmentary disorders, and oncologic condition assessments. It is also critical for evaluating disease course and response to a variety of therapeutic interventions and aids in accurate classific ... Full text Link to item Cite

Correction: Ixekizumab Demonstrates Rapid and Consistent Efficacy for Patients with Psoriatic Arthritis, Regardless of Psoriasis Severity (Dermatology and Therapy, (2024), 14, 6, (1615-1631), 10.1007/s13555-024-01188-y)

Journal Article Dermatology and Therapy · January 1, 2024 The Introduction section of abstract is missing the word ‘severe’ and hence the corrected sentence should read as, “This post hoc analysis reports musculoskeletal, skin, and nail outcomes through week 24 in patients from SPIRIT-P1 and SPIRIT-P2, stratified ... Full text Cite

International Dermatology Outcome Measures (IDEOM) - Report from the 2022 Annual Meeting.

Journal Article J Drugs Dermatol · December 1, 2023 BACKGROUND: The International Dermatology Outcome Measures (IDEOM) is a non-profit organization dedicated to the advancement of evidence-based, consensus-driven outcome measures in dermatological diseases. Researchers and stakeholders from various backgrou ... Full text Link to item Cite

The Skin of Color Society's Meeting the Challenge Summit, 2022: Diversity in Dermatology Clinical Trials Proceedings.

Journal Article JAMA Dermatol · July 1, 2023 IMPORTANCE: Clinical trials remain the cornerstone for determining the safety and efficacy of an intervention. A diverse participant pool in dermatology clinical trials is critical to ensure that results are generalizable among the patient population who w ... Full text Link to item Cite

High-dose, high-frequency ustekinumab therapy for patients with severe hidradenitis suppurativa.

Journal Article Br J Dermatol · September 2022 In this case series, ustekinumab therapy demonstrated efficacy in some patients with severe hidradenitis suppurativa previously treated with adalimumab and/or infliximab. Larger prospective studies are needed to evaluate ustekinumab as a treatment option f ... Full text Link to item Cite

Comorbidity screening in hidradenitis suppurativa: Evidence-based recommendations from the US and Canadian Hidradenitis Suppurativa Foundations.

Journal Article J Am Acad Dermatol · May 2022 BACKGROUND: Hidradenitis suppurativa (HS) is associated with comorbidities that contribute to poor health, impaired life quality, and mortality risk. OBJECTIVE: To provide evidence-based screening recommendations for comorbidities linked to HS. METHODS: Sy ... Full text Link to item Cite

Non-Antibiotic and Non-Biologic Systemic Therapeutics

Chapter · January 1, 2022 The pathophysiology of hidradenitis suppurativa (HS) has yet to be fully established. Hyperandrogenism, insulin resistance, and aberrant immune responses are all thought to play an important role in HS. Although many questions remain, our current understan ... Full text Cite

Atopic dermatitis is associated with hidradenitis suppurativa diagnosis: A single institution retrospective cohort study.

Journal Article JAAD Int · September 2021 BACKGROUND: Hidradenitis suppurativa (HS) and atopic dermatitis (AD) are both chronic inflammatory skin diseases. An association between these 2 conditions can have important potential implications for elucidating pathogenesis, disease course, and treatmen ... Full text Link to item Cite

Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions.

Journal Article JID innovations : skin science from molecules to population health · March 2021 Hidradenitis suppurativa (HS) is an inflammatory disease of the skin with a chronic, relapsing-remitting course. The pathogenesis of the disease is poorly understood and involves multiple factors, including genetics, environment, host-microbe interactions, ... Full text Cite

Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa.

Journal Article Front Med (Lausanne) · 2021 Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent abscesses, nodules, and sinus tracts in areas of high hair follicle and sweat gland density. These sinus tracts can present with purulent drainage and scar form ... Full text Open Access Link to item Cite

Vulvar and perineal verrucous changes complicating hidradenitis suppurativa after wide excision: a case and literature review.

Journal Article Dermatol Online J · June 15, 2020 Poorly controlled and long-standing hidradenitis suppurativa (HS) increases the risk of squamous cell carcinoma (SCC). We report a 54-year-old woman with an over 20-year history of HS, who had previously undergone wide perineal excision with secondary inte ... Link to item Cite

North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations: Part II: Topical, intralesional, and systemic medical management.

Journal Article J Am Acad Dermatol · July 2019 Hidradenitis suppurativa is a severe and debilitating dermatologic disease. Clinical management is challenging and consists of both medical and surgical approaches, which must often be combined for best outcomes. Therapeutic approaches have evolved rapidly ... Full text Link to item Cite

Ixekizumab Demonstrates Rapid and Consistent Efficacy for Patients with Psoriatic Arthritis, Regardless of Psoriasis Severity

Journal Article Dermatology and Therapy · June 1, 2024 Introduction: Skin involvement in patients with psoriatic arthritis (PsA) worsens the severity and burden of disease. Ixekizumab (IXE), a selective interleukin (IL)-17A antagonist, was compared to placebo (PBO) in the SPIRIT-P1 (NCT01695239) and SPIRIT-P2 ... Full text Cite

Discrepancies in hidradenitis suppurativa lesion characterization by providers and patients.

Journal Article J Eur Acad Dermatol Venereol · April 10, 2024 BACKGROUND: The hidradenitis suppurativa (HS) clinical response (HiSCR) has come under scrutiny as several HS clinical trials failed to meet primary endpoints with high placebo responses. This may be due to limitations of the tool and raters' ability to ac ... Full text Link to item Cite

Immune Dysregulation and Current Targeted Biologics in Hidradenitis Suppurativa

Journal Article Immuno · March 1, 2024 Hidradenitis Suppurativa (HS) is a debilitating cutaneous disease characterized by a vicious cycle of chronic inflammation and tissue destruction that stems from disruption of the skin microbiome and abnormal activation of both the innate and adaptive immu ... Full text Cite

Integrating skin color assessments into clinical practice and research: A review of current approaches.

Journal Article J Am Acad Dermatol · February 9, 2024 Skin color classification can have importance in skin health, pigmentary disorders, and oncologic condition assessments. It is also critical for evaluating disease course and response to a variety of therapeutic interventions and aids in accurate classific ... Full text Link to item Cite

Correction: Ixekizumab Demonstrates Rapid and Consistent Efficacy for Patients with Psoriatic Arthritis, Regardless of Psoriasis Severity (Dermatology and Therapy, (2024), 14, 6, (1615-1631), 10.1007/s13555-024-01188-y)

Journal Article Dermatology and Therapy · January 1, 2024 The Introduction section of abstract is missing the word ‘severe’ and hence the corrected sentence should read as, “This post hoc analysis reports musculoskeletal, skin, and nail outcomes through week 24 in patients from SPIRIT-P1 and SPIRIT-P2, stratified ... Full text Cite

International Dermatology Outcome Measures (IDEOM) - Report from the 2022 Annual Meeting.

Journal Article J Drugs Dermatol · December 1, 2023 BACKGROUND: The International Dermatology Outcome Measures (IDEOM) is a non-profit organization dedicated to the advancement of evidence-based, consensus-driven outcome measures in dermatological diseases. Researchers and stakeholders from various backgrou ... Full text Link to item Cite

The Skin of Color Society's Meeting the Challenge Summit, 2022: Diversity in Dermatology Clinical Trials Proceedings.

Journal Article JAMA Dermatol · July 1, 2023 IMPORTANCE: Clinical trials remain the cornerstone for determining the safety and efficacy of an intervention. A diverse participant pool in dermatology clinical trials is critical to ensure that results are generalizable among the patient population who w ... Full text Link to item Cite

High-dose, high-frequency ustekinumab therapy for patients with severe hidradenitis suppurativa.

Journal Article Br J Dermatol · September 2022 In this case series, ustekinumab therapy demonstrated efficacy in some patients with severe hidradenitis suppurativa previously treated with adalimumab and/or infliximab. Larger prospective studies are needed to evaluate ustekinumab as a treatment option f ... Full text Link to item Cite

Comorbidity screening in hidradenitis suppurativa: Evidence-based recommendations from the US and Canadian Hidradenitis Suppurativa Foundations.

Journal Article J Am Acad Dermatol · May 2022 BACKGROUND: Hidradenitis suppurativa (HS) is associated with comorbidities that contribute to poor health, impaired life quality, and mortality risk. OBJECTIVE: To provide evidence-based screening recommendations for comorbidities linked to HS. METHODS: Sy ... Full text Link to item Cite

Non-Antibiotic and Non-Biologic Systemic Therapeutics

Chapter · January 1, 2022 The pathophysiology of hidradenitis suppurativa (HS) has yet to be fully established. Hyperandrogenism, insulin resistance, and aberrant immune responses are all thought to play an important role in HS. Although many questions remain, our current understan ... Full text Cite

Atopic dermatitis is associated with hidradenitis suppurativa diagnosis: A single institution retrospective cohort study.

Journal Article JAAD Int · September 2021 BACKGROUND: Hidradenitis suppurativa (HS) and atopic dermatitis (AD) are both chronic inflammatory skin diseases. An association between these 2 conditions can have important potential implications for elucidating pathogenesis, disease course, and treatmen ... Full text Link to item Cite

Hidradenitis Suppurativa: Host-Microbe and Immune Pathogenesis Underlie Important Future Directions.

Journal Article JID innovations : skin science from molecules to population health · March 2021 Hidradenitis suppurativa (HS) is an inflammatory disease of the skin with a chronic, relapsing-remitting course. The pathogenesis of the disease is poorly understood and involves multiple factors, including genetics, environment, host-microbe interactions, ... Full text Cite

Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa.

Journal Article Front Med (Lausanne) · 2021 Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent abscesses, nodules, and sinus tracts in areas of high hair follicle and sweat gland density. These sinus tracts can present with purulent drainage and scar form ... Full text Open Access Link to item Cite

Vulvar and perineal verrucous changes complicating hidradenitis suppurativa after wide excision: a case and literature review.

Journal Article Dermatol Online J · June 15, 2020 Poorly controlled and long-standing hidradenitis suppurativa (HS) increases the risk of squamous cell carcinoma (SCC). We report a 54-year-old woman with an over 20-year history of HS, who had previously undergone wide perineal excision with secondary inte ... Link to item Cite

North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations: Part II: Topical, intralesional, and systemic medical management.

Journal Article J Am Acad Dermatol · July 2019 Hidradenitis suppurativa is a severe and debilitating dermatologic disease. Clinical management is challenging and consists of both medical and surgical approaches, which must often be combined for best outcomes. Therapeutic approaches have evolved rapidly ... Full text Link to item Cite

North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations: Part I: Diagnosis, evaluation, and the use of complementary and procedural management.

Journal Article J Am Acad Dermatol · July 2019 Hidradenitis suppurativa is a chronic inflammatory disorder affecting hair follicles, with profoundly negative impact on patient quality of life. Evidence informing ideal evaluation and management of patients with hidradenitis suppurativa is still sparse i ... Full text Link to item Cite

Rituximab and low dose oral immune modulating treatment to maintain a sustained response in severe pemphigus patients.

Journal Article J Dermatolog Treat · June 2019 Objectives: This pilot retrospective study examined the role of continuous low-dose maintenance immunomodulatory treatment (IMT) as an adjunct to rituximab (RTX) rescue therapy in severe pemphigus vulgaris (PV) and pemphigus foliaceus (PF) after a complete ... Full text Link to item Cite

Inverted U-shaped relationship between vitamin D and ever-reported eczema in US adults.

Journal Article Allergy · May 2019 BACKGROUND: Eczema is a skin condition which affects up to 10% to 20% of people worldwide. Previous literature finds that low vitamin D levels may be a risk factor for eczema, but the association is not clear. METHODS: We used the cross-sectional data from ... Full text Link to item Cite

The skin transcriptome in hidradenitis suppurativa uncovers an antimicrobial and sweat gland gene signature which has distinct overlap with wounded skin.

Journal Article PLoS One · 2019 Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease resulting in non-healing wounds affecting body areas of high hair follicle and sweat gland density. The pathogenesis of HS is not well understood but appears to involve dysbi ... Full text Link to item Cite

LB1497 Association between hidradenitis suppurativa and atopic dermatitis

Conference Journal of Investigative Dermatology · September 2018 Full text Cite

1280 The role of surgery in hidradenitis suppurativa management

Conference Journal of Investigative Dermatology · May 2018 Full text Cite

A case of scurvy associated with nilotinib.

Journal Article J Cutan Pathol · August 2016 Full text Link to item Cite

Keloidal scleroderma: Case report and review

Conference JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY · May 1, 2016 Link to item Cite

Clinical Approach to Diffuse Blisters

Journal Article Physician Assistant Clinics · April 1, 2016 Some blistering eruptions are self-limited, but others are life threatening, and prompt diagnosis and management are critical. The clinical presentation of vesicles and bullae suggests a broad differential and this article (1) highlights some common diagno ... Full text Cite

Secukinumab (AIN-457) for the treatment of Psoriasis.

Journal Article Expert Rev Clin Pharmacol · 2016 Secukinumab (also known as AIN-457) is a human monoclonal antibody targeting IL-17A, which has been recently FDA-approved for the treatment of moderate to severe psoriasis and psoriatic arthritis with coexistent moderate to severe plaque psoriasis based on ... Full text Link to item Cite

Clinical Approach to Diffuse Blisters.

Journal Article Med Clin North Am · November 2015 Some blistering eruptions are self-limited, but others are life threatening, and prompt diagnosis and management are critical. The clinical presentation of vesicles and bullae suggests a broad differential and this article (1) highlights some common diagno ... Full text Link to item Cite

A new mouse model for studying the development of melanomas

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · May 1, 2013 Link to item Cite

Cosmetic aspects of nail products and services

Journal Article Cosmetic Dermatology · August 1, 2012 Nail appearance has been an important aspect of overall beauty for centuries. Numerous products that improve nail quality are sold daily as a form of adornment and self-expression or to hide nail dystrophy; however, some nail products and services may lead ... Cite

Regulation of ultraviolet radiation induced cutaneous photoimmunosuppression by toll-like receptor-4.

Journal Article Arch Biochem Biophys · April 15, 2011 UVB radiation is a potent immunosuppressive agent that inhibits cell-mediated immune responses. The mechanisms by which UVB radiation influences cell-mediated immune responses have been the subject of extensive investigation. However, the role of innate im ... Full text Link to item Cite

Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase.

Journal Article Fertil Steril · January 2011 OBJECTIVE: To evaluate the effects and mechanisms of action of vitamin D on human uterine leiomyoma (HuLM) cell proliferation in vitro. DESIGN: Laboratory study. SETTING: University hospitals. PATIENTS(S): Not applicable. INTERVENTIONS(S): Not applicable. ... Full text Link to item Cite

Dietary vitamin D3 protects against bacterial skin infection

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · September 1, 2010 Link to item Cite

Dietary vitamin D3 protects against bacterial skin infection

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · April 1, 2010 Link to item Cite

Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity.

Journal Article J Immunol · January 1, 2009 Proteomic analysis of murine skin has shown that a variety of heat shock proteins (HSPs) are constitutively expressed in the skin. Using murine allergic contact hypersensitivity as a model, we investigated the role of two heat shock proteins, HSP27 and HSP ... Full text Link to item Cite