Journal ArticleDermatology and Therapy · August 1, 2024
The Introduction section of abstract is missing the word ‘severe’ and hence the corrected sentence should read as, “This post hoc analysis reports musculoskeletal, skin, and nail outcomes through week 24 in patients from SPIRIT-P1 and SPIRIT-P2, stratified ...
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Journal ArticleDermatology and Therapy · June 1, 2024
Introduction: Skin involvement in patients with psoriatic arthritis (PsA) worsens the severity and burden of disease. Ixekizumab (IXE), a selective interleukin (IL)-17A antagonist, was compared to placebo (PBO) in the SPIRIT-P1 (NCT01695239) and SPIRIT-P2 ...
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Journal ArticleJ Eur Acad Dermatol Venereol · April 10, 2024
BACKGROUND: The hidradenitis suppurativa (HS) clinical response (HiSCR) has come under scrutiny as several HS clinical trials failed to meet primary endpoints with high placebo responses. This may be due to limitations of the tool and raters' ability to ac ...
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Journal ArticleImmuno · March 1, 2024
Hidradenitis Suppurativa (HS) is a debilitating cutaneous disease characterized by a vicious cycle of chronic inflammation and tissue destruction that stems from disruption of the skin microbiome and abnormal activation of both the innate and adaptive immu ...
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Journal ArticleJ Am Acad Dermatol · February 9, 2024
Skin color classification can have importance in skin health, pigmentary disorders, and oncologic condition assessments. It is also critical for evaluating disease course and response to a variety of therapeutic interventions and aids in accurate classific ...
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Journal ArticleJ Drugs Dermatol · December 1, 2023
BACKGROUND: The International Dermatology Outcome Measures (IDEOM) is a non-profit organization dedicated to the advancement of evidence-based, consensus-driven outcome measures in dermatological diseases. Researchers and stakeholders from various backgrou ...
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Journal ArticleJAMA Dermatol · July 1, 2023
IMPORTANCE: Clinical trials remain the cornerstone for determining the safety and efficacy of an intervention. A diverse participant pool in dermatology clinical trials is critical to ensure that results are generalizable among the patient population who w ...
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Journal ArticleBr J Dermatol · September 2022
In this case series, ustekinumab therapy demonstrated efficacy in some patients with severe hidradenitis suppurativa previously treated with adalimumab and/or infliximab. Larger prospective studies are needed to evaluate ustekinumab as a treatment option f ...
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Journal ArticleJ Am Acad Dermatol · May 2022
BACKGROUND: Hidradenitis suppurativa (HS) is associated with comorbidities that contribute to poor health, impaired life quality, and mortality risk. OBJECTIVE: To provide evidence-based screening recommendations for comorbidities linked to HS. METHODS: Sy ...
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Chapter · January 1, 2022
The pathophysiology of hidradenitis suppurativa (HS) has yet to be fully established. Hyperandrogenism, insulin resistance, and aberrant immune responses are all thought to play an important role in HS. Although many questions remain, our current understan ...
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Journal ArticleJAAD Int · September 2021
BACKGROUND: Hidradenitis suppurativa (HS) and atopic dermatitis (AD) are both chronic inflammatory skin diseases. An association between these 2 conditions can have important potential implications for elucidating pathogenesis, disease course, and treatmen ...
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Journal ArticleJID Innov · March 2021
Hidradenitis suppurativa (HS) is an inflammatory disease of the skin with a chronic, relapsing-remitting course. The pathogenesis of the disease is poorly understood and involves multiple factors, including genetics, environment, host-microbe interactions, ...
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Journal ArticleFront Med (Lausanne) · 2021
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent abscesses, nodules, and sinus tracts in areas of high hair follicle and sweat gland density. These sinus tracts can present with purulent drainage and scar form ...
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Journal ArticleDermatol Online J · June 15, 2020
Poorly controlled and long-standing hidradenitis suppurativa (HS) increases the risk of squamous cell carcinoma (SCC). We report a 54-year-old woman with an over 20-year history of HS, who had previously undergone wide perineal excision with secondary inte ...
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Journal ArticleJ Am Acad Dermatol · July 2019
Hidradenitis suppurativa is a severe and debilitating dermatologic disease. Clinical management is challenging and consists of both medical and surgical approaches, which must often be combined for best outcomes. Therapeutic approaches have evolved rapidly ...
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Journal ArticleDermatology and Therapy · August 1, 2024
The Introduction section of abstract is missing the word ‘severe’ and hence the corrected sentence should read as, “This post hoc analysis reports musculoskeletal, skin, and nail outcomes through week 24 in patients from SPIRIT-P1 and SPIRIT-P2, stratified ...
Full textCite
Journal ArticleDermatology and Therapy · June 1, 2024
Introduction: Skin involvement in patients with psoriatic arthritis (PsA) worsens the severity and burden of disease. Ixekizumab (IXE), a selective interleukin (IL)-17A antagonist, was compared to placebo (PBO) in the SPIRIT-P1 (NCT01695239) and SPIRIT-P2 ...
Full textCite
Journal ArticleJ Eur Acad Dermatol Venereol · April 10, 2024
BACKGROUND: The hidradenitis suppurativa (HS) clinical response (HiSCR) has come under scrutiny as several HS clinical trials failed to meet primary endpoints with high placebo responses. This may be due to limitations of the tool and raters' ability to ac ...
Full textLink to itemCite
Journal ArticleImmuno · March 1, 2024
Hidradenitis Suppurativa (HS) is a debilitating cutaneous disease characterized by a vicious cycle of chronic inflammation and tissue destruction that stems from disruption of the skin microbiome and abnormal activation of both the innate and adaptive immu ...
Full textCite
Journal ArticleJ Am Acad Dermatol · February 9, 2024
Skin color classification can have importance in skin health, pigmentary disorders, and oncologic condition assessments. It is also critical for evaluating disease course and response to a variety of therapeutic interventions and aids in accurate classific ...
Full textLink to itemCite
Journal ArticleJ Drugs Dermatol · December 1, 2023
BACKGROUND: The International Dermatology Outcome Measures (IDEOM) is a non-profit organization dedicated to the advancement of evidence-based, consensus-driven outcome measures in dermatological diseases. Researchers and stakeholders from various backgrou ...
Full textLink to itemCite
Journal ArticleJAMA Dermatol · July 1, 2023
IMPORTANCE: Clinical trials remain the cornerstone for determining the safety and efficacy of an intervention. A diverse participant pool in dermatology clinical trials is critical to ensure that results are generalizable among the patient population who w ...
Full textLink to itemCite
Journal ArticleBr J Dermatol · September 2022
In this case series, ustekinumab therapy demonstrated efficacy in some patients with severe hidradenitis suppurativa previously treated with adalimumab and/or infliximab. Larger prospective studies are needed to evaluate ustekinumab as a treatment option f ...
Full textLink to itemCite
Journal ArticleJ Am Acad Dermatol · May 2022
BACKGROUND: Hidradenitis suppurativa (HS) is associated with comorbidities that contribute to poor health, impaired life quality, and mortality risk. OBJECTIVE: To provide evidence-based screening recommendations for comorbidities linked to HS. METHODS: Sy ...
Full textLink to itemCite
Chapter · January 1, 2022
The pathophysiology of hidradenitis suppurativa (HS) has yet to be fully established. Hyperandrogenism, insulin resistance, and aberrant immune responses are all thought to play an important role in HS. Although many questions remain, our current understan ...
Full textCite
Journal ArticleJAAD Int · September 2021
BACKGROUND: Hidradenitis suppurativa (HS) and atopic dermatitis (AD) are both chronic inflammatory skin diseases. An association between these 2 conditions can have important potential implications for elucidating pathogenesis, disease course, and treatmen ...
Full textLink to itemCite
Journal ArticleJID Innov · March 2021
Hidradenitis suppurativa (HS) is an inflammatory disease of the skin with a chronic, relapsing-remitting course. The pathogenesis of the disease is poorly understood and involves multiple factors, including genetics, environment, host-microbe interactions, ...
Full textLink to itemCite
Journal ArticleFront Med (Lausanne) · 2021
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent abscesses, nodules, and sinus tracts in areas of high hair follicle and sweat gland density. These sinus tracts can present with purulent drainage and scar form ...
Full textOpen AccessLink to itemCite
Journal ArticleDermatol Online J · June 15, 2020
Poorly controlled and long-standing hidradenitis suppurativa (HS) increases the risk of squamous cell carcinoma (SCC). We report a 54-year-old woman with an over 20-year history of HS, who had previously undergone wide perineal excision with secondary inte ...
Link to itemCite
Journal ArticleJ Am Acad Dermatol · July 2019
Hidradenitis suppurativa is a severe and debilitating dermatologic disease. Clinical management is challenging and consists of both medical and surgical approaches, which must often be combined for best outcomes. Therapeutic approaches have evolved rapidly ...
Full textLink to itemCite
Journal ArticleJ Am Acad Dermatol · July 2019
Hidradenitis suppurativa is a chronic inflammatory disorder affecting hair follicles, with profoundly negative impact on patient quality of life. Evidence informing ideal evaluation and management of patients with hidradenitis suppurativa is still sparse i ...
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Journal ArticleJ Dermatolog Treat · June 2019
Objectives: This pilot retrospective study examined the role of continuous low-dose maintenance immunomodulatory treatment (IMT) as an adjunct to rituximab (RTX) rescue therapy in severe pemphigus vulgaris (PV) and pemphigus foliaceus (PF) after a complete ...
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Journal ArticleAllergy · May 2019
BACKGROUND: Eczema is a skin condition which affects up to 10% to 20% of people worldwide. Previous literature finds that low vitamin D levels may be a risk factor for eczema, but the association is not clear. METHODS: We used the cross-sectional data from ...
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Journal ArticlePLoS One · 2019
Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease resulting in non-healing wounds affecting body areas of high hair follicle and sweat gland density. The pathogenesis of HS is not well understood but appears to involve dysbi ...
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Journal ArticlePhysician Assistant Clinics · April 1, 2016
Some blistering eruptions are self-limited, but others are life threatening, and prompt diagnosis and management are critical. The clinical presentation of vesicles and bullae suggests a broad differential and this article (1) highlights some common diagno ...
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Journal ArticleExpert Rev Clin Pharmacol · 2016
Secukinumab (also known as AIN-457) is a human monoclonal antibody targeting IL-17A, which has been recently FDA-approved for the treatment of moderate to severe psoriasis and psoriatic arthritis with coexistent moderate to severe plaque psoriasis based on ...
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Journal ArticleMed Clin North Am · November 2015
Some blistering eruptions are self-limited, but others are life threatening, and prompt diagnosis and management are critical. The clinical presentation of vesicles and bullae suggests a broad differential and this article (1) highlights some common diagno ...
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Journal ArticleCosmetic Dermatology · August 1, 2012
Nail appearance has been an important aspect of overall beauty for centuries. Numerous products that improve nail quality are sold daily as a form of adornment and self-expression or to hide nail dystrophy; however, some nail products and services may lead ...
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Journal ArticleArch Biochem Biophys · April 15, 2011
UVB radiation is a potent immunosuppressive agent that inhibits cell-mediated immune responses. The mechanisms by which UVB radiation influences cell-mediated immune responses have been the subject of extensive investigation. However, the role of innate im ...
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Journal ArticleFertil Steril · January 2011
OBJECTIVE: To evaluate the effects and mechanisms of action of vitamin D on human uterine leiomyoma (HuLM) cell proliferation in vitro. DESIGN: Laboratory study. SETTING: University hospitals. PATIENTS(S): Not applicable. INTERVENTIONS(S): Not applicable. ...
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Journal ArticleJ Immunol · January 1, 2009
Proteomic analysis of murine skin has shown that a variety of heat shock proteins (HSPs) are constitutively expressed in the skin. Using murine allergic contact hypersensitivity as a model, we investigated the role of two heat shock proteins, HSP27 and HSP ...
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