Scholars@Duke
Tetsu Ohnuma

Tetsu Ohnuma

Assistant Professor in Anesthesiology
Anesthesiology, Critical Care Medicine
tetsu.ohnuma@duke.edu
905 LaSalle Street, Durham, NC 27705

Selected Publications

Perioperative Albumin Among Adults Undergoing Thoracic Surgery in the United States: Utilization, Associations With Clinical Outcomes, and Contribution to Hospital Costs.

Journal Article J Cardiothorac Vasc Anesth · November 2024 OBJECTIVES: To estimate the use of albumin among adults undergoing thoracic surgery in the United States, compare baseline characteristics, clinical and cost outcomes of recipients versus nonrecipients, and determine albumin's contribution to total hospita ... Full text Link to item Cite

Association of Area Deprivation Index With Mortality in Critically Ill Adults With COVID-19.

Journal Article Am J Crit Care · November 1, 2024 BACKGROUND: Various social determinants of health have been established as significant risk factors for COVID-19 transmission, prevalence, incidence, and mortality. Area deprivation index (ADI, a composite score made up of educational, housing, and poverty ... Full text Link to item Cite

Hospital Outcomes in Patients Who Developed Acute Respiratory Distress Syndrome After Community-Acquired Pneumonia.

Journal Article J Intensive Care Med · October 2024 Purpose: To identify risk factors for and outcomes in acute respiratory distress syndrome (ARDS) in patients hospitalized with community-acquired pneumonia (CAP). Methods: This is a retrospective study using the Premier Healthcare Database between 2016 and ... Full text Link to item Cite

Impact of Wildfire Smoke on Acute Illness.

Journal Article Anesthesiology · October 1, 2024 Full text Open Access Link to item Cite

Early Beta-Blocker Utilization in Critically Ill Patients With Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study.

Journal Article J Intensive Care Med · September 2024 BACKGROUND: There is limited evidence that beta-blockers may provide benefit for patients with moderate-severe traumatic brain injury (TBI) during the acute injury period. Larger studies on utilization patterns and impact on outcomes in clinical practice a ... Full text Link to item Cite

Trends in the Utilization of Multiorgan Support Among Adults Undergoing High-risk Cardiac Surgery in the United States.

Journal Article J Cardiothorac Vasc Anesth · September 2024 OBJECTIVES: To examine trends in the prevalence of multiorgan dysfunction (MODS), utilization of multi-organ support (MOS), and mortality among patients undergoing cardiac surgery with MODS who received MOS in the United States. DESIGN: Retrospective cohor ... Full text Link to item Cite

Maternal outcomes by mode of delivery among pregnant patients with eclampsia: a retrospective cohort study.

Journal Article American journal of obstetrics & gynecology MFM · September 2024 Full text Cite

Association of Early Dexmedetomidine Utilization With Clinical Outcomes After Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study.

Journal Article Anesth Analg · August 1, 2024 BACKGROUND: Traumatic brain injury (TBI) is an expensive and common public health problem. Management of TBI oftentimes includes sedation to facilitate mechanical ventilation (MV) for airway protection. Dexmedetomidine has emerged as a potential candidate ... Full text Link to item Cite

Association of early dexmedetomidine exposure with brain injury biomarker levels following moderate - Severe traumatic brain injury: A TRACK-TBI study.

Journal Article J Clin Neurosci · August 2024 BACKGROUND: Traumatic brain injury (TBI) triggers autonomic dysfunction and inflammatory response that can result in secondary brain injuries. Dexmedetomidine is an alpha-2 agonist that may modulate autonomic function and inflammation and has been increasi ... Full text Link to item Cite

Use of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study.

Journal Article Crit Care Explor · July 1, 2024 OBJECTIVES: To describe the utilization of early ketamine use among patients mechanically ventilated for COVID-19, and examine associations with in-hospital mortality and other clinical outcomes. DESIGN: Retrospective cohort study. SETTING: Six hundred ten ... Full text Link to item Cite

Maternal Morbidity According to Mode of Delivery Among Pregnant Patients With Pulmonary Hypertension.

Journal Article Anesth Analg · May 1, 2024 BACKGROUND: Patients with pulmonary hypertension have a high risk of maternal morbidity and mortality. It is unknown if a trial of labor carries a lower risk of morbidity in these patients compared to a planned cesarean delivery. The objective of this stud ... Full text Link to item Cite

Safety, Efficacy, and Clinical Outcomes of Dexmedetomidine for Sedation in Traumatic Brain Injury: A Scoping Review.

Journal Article J Neurosurg Anesthesiol · April 1, 2024 Dexmedetomidine is a promising alternative sedative agent for moderate-severe Traumatic brain injury (TBI) patients. Although the data are limited, the posited benefits of dexmedetomidine in this population are a reduction in secondary brain injury compare ... Full text Link to item Cite

Association of Early Dexmedetomidine Utilization With Clinical and Functional Outcomes Following Moderate-Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study.

Journal Article Crit Care Med · April 1, 2024 OBJECTIVE: To examine early sedation patterns, as well as the association of dexmedetomidine exposure, with clinical and functional outcomes among mechanically ventilated patients with moderate-severe traumatic brain injury (msTBI). DESIGN: Retrospective c ... Full text Link to item Cite

Malnutrition and Adverse Outcomes After Surgery for Head and Neck Cancer.

Journal Article JAMA Otolaryngol Head Neck Surg · January 1, 2024 IMPORTANCE: Patients with head and neck cancer (HNC) have an increased risk of malnutrition, partly due to disease location and treatment sequelae. Although malnutrition is associated with adverse outcomes, there is little data on the extent of outcomes an ... Full text Open Access Link to item Cite

Incidence of Myocardial Injury and Cardiac Dysfunction After Adult Traumatic Brain Injury: A Systematic Review and Meta-analysis.

Journal Article J Neurosurg Anesthesiol · November 20, 2023 Myocardial injury and cardiac dysfunction after traumatic brain injury (TBI) have been reported in observational studies, but there is no robust estimate of their incidences. We conducted a systematic review and meta-analysis to estimate the pooled inciden ... Full text Link to item Cite

Abstract 17729: When Do Black and White Patients Die After Coronary Artery Bypass Surgery: Insights From the United States Veterans Health Administration

Conference Circulation · November 7, 2023 Introduction: Black patients continue to have disproportionately higher rates of death after Coronary Artery Bypass Graft (CABG) procedures. Data are needed to guide interventions to eliminate inequit ... Full text Cite

Early enteral nutrition is associated with improved outcomes in critically ill mechanically ventilated medical and surgical patients.

Journal Article Clin Nutr ESPEN · October 2023 BACKGROUND AND AIMS: Data suggest that guidelines for enteral nutrition (EN) initiation are not closely followed in clinical practice. In addition, critically ill mechanically ventilated (MV) patients have varying metabolic needs, which often increase and ... Full text Link to item Cite

Change to Mixed-Lipid Emulsion From Soybean Oil-Based Lipid Emulsion in Pediatric Patients.

Journal Article JAMA Netw Open · September 5, 2023 IMPORTANCE: Critically ill pediatric patients often require parenteral nutrition (PN) in the intensive care unit (ICU). Literature suggests mixed lipid emulsions (LE) with soybean oil reduction strategies may improve outcomes. OBJECTIVE: To examine the ass ... Full text Open Access Link to item Cite

Epidemiology, Resistance Profiles, and Outcomes of Bloodstream Infections in Community-Onset Sepsis in the United States.

Journal Article Critical care medicine · September 2023 ObjectivesTo describe frequency of positive blood cultures, patterns of pathogens' characteristics and their resistance profile in patients with blood cultures drawn due to a presumed diagnosis of community-onset sepsis, and to examine the associa ... Full text Cite

The Quality Improvement Fellow: Educating on Making the Difference.

Journal Article A A Pract · September 1, 2023 The critical care medicine (CCM) fellowship is an opportunity for advanced anesthesiology trainees to refine their quality improvement (QI) skills. However, the short training period and inconsistent curricula make this challenging. The QI fellow (QIF) is ... Full text Link to item Cite

Association of Early Beta-Blocker Exposure and Functional Outcomes in Critically Ill Patients With Moderate to Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study.

Journal Article Crit Care Explor · September 2023 OBJECTIVES: We aimed to 1) describe patterns of beta-blocker utilization among critically ill patients following moderate-severe traumatic brain injury (TBI) and 2) examine the association of early beta-blocker exposure with functional and clinical outcome ... Full text Open Access Link to item Cite

Opioid-Sparing Multimodal Analgesia Use After Cesarean Delivery Under General Anesthesia: A Retrospective Cohort Study in 729 US Hospitals.

Journal Article Anesth Analg · August 1, 2023 BACKGROUND: Optimizing analgesia after cesarean delivery is essential to quality of patient recovery. The American Society of Anesthesiologists and the Society for Obstetric Anesthesia and Perinatology recommend multimodal analgesia (MMA). However, little ... Full text Link to item Cite

Association of Brain Injury Biomarkers and Circulatory Shock Following Moderate-Severe Traumatic Brain Injury: A TRACK-TBI Study.

Journal Article J Neurosurg Anesthesiol · July 1, 2023 INTRODUCTION: Early circulatory shock following traumatic brain injury (TBI) is a multifactorial process; however, the impact of brain injury biomarkers on the risk of shock has not been evaluated. We examined the association between neuronal injury biomar ... Full text Open Access Link to item Cite

Utilization and Outcomes of Extracorporeal Membrane Oxygenation Following Traumatic Brain Injury in the United States.

Journal Article J Intensive Care Med · May 2023 Objectives: Describe contemporary ECMO utilization patterns among patients with traumatic brain injury (TBI) and examine clinical outcomes among TBI patients requiring ECMO. Design: Retrospective cohort study. Setting: Premier Healthcare Database (PHD) bet ... Full text Link to item Cite

Maternal Cardiovascular Morbidity Events Following Preeclampsia: A Retrospective Cohort Study.

Journal Article Anesth Analg · April 1, 2023 BACKGROUND: Patients with preeclampsia are at high risk for long-term cardiovascular events, yet the short-term, acute cardiovascular complications that follow preeclampsia are understudied. The objective of this study was to compare the short-term, acute ... Full text Link to item Cite

Postoperative Acute Kidney Injury by Age and Sex: A Retrospective Cohort Association Study.

Journal Article Anesthesiology · February 1, 2023 BACKGROUND: Acute kidney injury (AKI) after noncardiac surgery is common and has substantial health impact. Preclinical and clinical studies examining the influence of sex on AKI have yielded conflicting results, although they typically do not account for ... Full text Link to item Cite

Association of Appropriate Empirical Antimicrobial Therapy With In-Hospital Mortality in Patients With Bloodstream Infections in the US.

Journal Article JAMA Netw Open · January 3, 2023 IMPORTANCE: Bloodstream infections (BSIs) are a major public health problem associated with high morbidity. Little evidence exists regarding the epidemiology of BSIs and the use of appropriate empirical antimicrobial therapy. OBJECTIVE: To estimate the ass ... Full text Link to item Cite

Outcomes in ARDS in Patients Hospitalized with CAP

Conference ANESTHESIA AND ANALGESIA · 2023 Cite

Risk Factors for ARDS in Patients Hospitalized with CAP

Conference ANESTHESIA AND ANALGESIA · 2023 Cite

The QI Fellow: Educating on Making the Difference

Conference ANESTHESIA AND ANALGESIA · 2023 Cite

Early Vasopressor Utilization Strategies and Outcomes in Critically Ill Patients With Severe Traumatic Brain Injury.

Journal Article Anesth Analg · December 1, 2022 BACKGROUND: Early hypotension after severe traumatic brain injury (sTBI) is associated with increased mortality and poor long-term outcomes. Current guidelines suggest the use of intravenous vasopressors, commonly norepinephrine and phenylephrine, to suppo ... Full text Link to item Cite

Racial and Ethnic Differences in the Prevalence of Do-Not-Resuscitate Orders among Older Adults with Severe Traumatic Brain Injury.

Journal Article J Intensive Care Med · December 2022 BACKGROUND: Older adults suffering from traumatic brain injury (TBI) are subject to higher injury burden and mortality. Do Not Resuscitate (DNR) orders are used to provide care aligned with patient wishes, but they may not be equitably distributed across r ... Full text Open Access Link to item Cite

Failure to Rescue After Severe Acute Kidney Injury in Patients Undergoing Non-Cardiac Surgery.

Journal Article J Surg Res · November 2022 INTRODUCTION: Many deaths after surgery can be attributed to "failure to rescue," which may be a better surgical quality indicator than the occurrence of a postoperative complication. Acute kidney injury (AKI) is one such postoperative complication associa ... Full text Link to item Cite

Hospital change to mixed lipid emulsion from soybean oil-based lipid emulsion for parenteral nutrition in hospitalized and critically ill adults improves outcomes: a pre-post-comparative study.

Journal Article Crit Care · October 18, 2022 INTRODUCTION: Early data suggest use of a mixed lipid emulsion (LE) with a soybean oil reduction strategy in parenteral nutrition (PN) may improve clinical outcomes. Duke University Hospital made a full switch to a Soybean oil/MCT/Olive/Fish Oil lipid (4-O ... Full text Open Access Link to item Cite

Temporal trends in clinical characteristics and in-hospital mortality among patients with COVID-19 in Japan for waves 1, 2, and 3: A retrospective cohort study.

Journal Article J Infect Chemother · October 2022 INTRODUCTION: Little information is available on the temporal trends in the clinical epidemiology and in-hospital mortality of patients with coronavirus disease 2019 (COVID-19) in Japan for waves 1, 2, and 3. METHODS: A national claims database was used to ... Full text Link to item Cite

Risk Factors and Neurological Outcomes Associated With Circulatory Shock After Moderate-Severe Traumatic Brain Injury: A TRACK-TBI Study.

Journal Article Neurosurgery · September 1, 2022 BACKGROUND: Extracranial multisystem organ failure is a common sequela of severe traumatic brain injury (TBI). Risk factors for developing circulatory shock and long-term functional outcomes of this patient subset are poorly understood. OBJECTIVE: To ident ... Full text Link to item Cite

No Association of Early Postoperative Heart Rate With Outcomes After Coronary Artery Bypass Grafting.

Journal Article Am J Crit Care · September 1, 2022 BACKGROUND: Elevated perioperative heart rate potentially causes perioperative myocardial injury because of imbalance in oxygen supply and demand. However, large multicenter studies evaluating early postoperative heart rate and major adverse cardiac and ce ... Full text Link to item Cite

Underutilization of Acetaminophen in Older Adult Trauma Patients.

Journal Article Am Surg · August 2022 INTRODUCTION: Older adults are more vulnerable to opioid-associated morbidity. The purpose of this study was to determine the frequency and timing of acetaminophen and opioid use in the postoperative period. METHODS: Older adult trauma patients (≥65 years) ... Full text Link to item Cite

Association Between Gabapentinoids and Postoperative Pulmonary Complications in Patients Undergoing Thoracic Surgery.

Journal Article J Cardiothorac Vasc Anesth · August 2022 OBJECTIVE: Perioperative gabapentinoids in general surgery have been associated with an increased risk of postoperative pulmonary complications (PPCs), while resulting in equivocal pain relief. This study's aim was to examine the utilization of gabapentino ... Full text Link to item Cite

Micronutrient deficiencies in critically ill patients receiving continuous renal replacement therapy.

Journal Article Clin Nutr ESPEN · August 2022 BACKGROUND & AIMS: Continuous renal replacement therapy (CRRT) is essential to the management of acute kidney injury (AKI) in critical illness. Unfortunately, large quantities of micronutrients are shown to be lost in CRRT effluent. Current literature desc ... Full text Link to item Cite

Mechanical thrombectomy for perioperative ischemic stroke following elective inpatient surgery in the United States.

Journal Article J Clin Neurosci · July 2022 Perioperative ischemic stroke significantly increases morbidity and mortality in patients undergoing elective surgery. Mechanical thrombectomy can improve ischemic stroke outcomes, but frequency and trend of its utilization for treatment of perioperative i ... Full text Open Access Link to item Cite

Utilization of Brain Tissue Oxygenation Monitoring and Association with Mortality Following Severe Traumatic Brain Injury.

Journal Article Neurocrit Care · April 2022 BACKGROUND: The aim of this study was to describe the utilization patterns of brain tissue oxygen (PbtO2) monitoring following severe traumatic brain injury (TBI) and determine associations with mortality, health care use, and pulmonary toxicity. METHODS: ... Full text Open Access Link to item Cite

Role of Early Enteral Nutrition in Mechanically Ventilated COVID-19 Patients.

Journal Article Critical care explorations · April 2022 Current guidance recommends initiation of early enteral nutrition (early EN) within 24-36 hours of ICU admission in critically ill COVID-19 patients. Despite this recommendation, there is quite limited evidence describing the effect of early EN on outcomes ... Full text Cite

Association of Vasopressor Choice with Clinical and Functional Outcomes Following Moderate to Severe Traumatic Brain Injury: A TRACK-TBI Study.

Journal Article Neurocrit Care · February 2022 BACKGROUND: Early hypotension following moderate to severe traumatic brain injury (TBI) is associated with increased mortality and poor long-term outcomes. Current guidelines suggest the use of intravenous vasopressors to support blood pressure following T ... Full text Link to item Cite

Postoperative Acute Kidney Injury Is Associated With Progression of Chronic Kidney Disease Independent of Severity.

Journal Article Anesth Analg · January 1, 2022 BACKGROUND: Both postoperative acute kidney injury (AKI) and preoperative chronic kidney disease (CKD) are associated with significantly worse outcomes following surgery. The relationship of both of these conditions with each other and with CKD progression ... Full text Link to item Cite

Racial and Ethnic Disparities among Thoracic Surgery Patients

Conference ANESTHESIA AND ANALGESIA · 2022 Cite

Analgesia After Cesarean Delivery in the United States 2008-2018: A Retrospective Cohort Study.

Journal Article Anesth Analg · December 1, 2021 BACKGROUND: Optimizing analgesia after cesarean delivery is a priority and requires balancing adequate pain relief with the risk of analgesics-associated adverse effects. Current recommendations are for use of a multimodal, opioid-sparing analgesic regimen ... Full text Link to item Cite

Association of Severe Acute Kidney Injury with Mortality and Healthcare Utilization Following Isolated Traumatic Brain Injury.

Journal Article Neurocrit Care · October 2021 BACKGROUND/OBJECTIVE: Traumatic brain injury (TBI) is a leading cause of morbidity, mortality, and disability in the USA. While cardiopulmonary dysfunction can result in poor outcomes following severe TBI, the impact of acute kidney injury (AKI) is poorly ... Full text Open Access Link to item Cite

Acute Care Resource Use After Elective Surgery in the United States: Implications During the COVID-19 Pandemic.

Journal Article Am J Crit Care · July 1, 2021 BACKGROUND: The COVID-19 pandemic created pressure to delay inpatient elective surgery to increase US health care capacity. This study examined the extent to which common inpatient elective operations consume acute care resources. METHODS: This cross-secti ... Full text Link to item Cite

Changes in analgesic strategies for lobectomy from 2009 to 2018.

Journal Article JTCVS Open · June 2021 OBJECTIVE: To evaluate trends in the use of epidural analgesia and nonopioid and opioid analgesics for patients undergoing lobectomy from 2009 to 2018. METHODS: We queried the Premier database for adult patients undergoing open, video-assisted, and robotic ... Full text Open Access Link to item Cite

Association of gabapentinoid utilization with postoperative pulmonary complications in gynecologic surgery: a retrospective cohort study.

Journal Article Curr Med Res Opin · May 2021 OBJECTIVE: To investigate gabapentinoid utilization and association with postoperative pulmonary complications after gynecologic surgery. METHODS: After Institutional Review Board approval, we performed this retrospective cohort study using the Premier Hea ... Full text Link to item Cite

Trends in Comorbidities and Complications Using ICD-9 and ICD-10 in Total Hip and Knee Arthroplasties.

Journal Article J Bone Joint Surg Am · April 21, 2021 BACKGROUND: The transition to the new ICD-10 (International Classification of Diseases, Tenth Revision) coding system in the U.S. poses challenges to the ability to consistently and accurately measure trends in comorbidities and complications. We examined ... Full text Link to item Cite

Postoperative Utilization of Oral Nutrition Supplements in Surgical Patients in US Hospitals.

Journal Article JPEN J Parenter Enteral Nutr · March 2021 BACKGROUND: Postoperative nutrition delivery is essential to surgical recovery; unfortunately, postoperative dietary intake is often poor. Recent surgical guidelines recommend use of oral nutritional supplements (ONS) to improve nutrition delivery. Our aim ... Full text Link to item Cite

Association between early postoperative nutritional supplement utilisation and length of stay in malnourished hip fracture patients.

Journal Article Br J Anaesth · March 2021 BACKGROUND: Malnutrition in older hip fracture patients is associated with increased complication rates and mortality. As postoperative nutrition delivery is essential to surgical recovery, postoperative nutritional supplements including oral nutritional s ... Full text Link to item Cite

Abstract P527: Temporal Trend of Mechanical Thrombectomy Utilization in Treatment of Perioperative Ischemic Stroke Following Elective Inpatient Surgery in the United States

Conference Stroke · March 2021 Background: Perioperative ischemic stroke (PIS) significantly increases morbidity and mortality in patients undergoing elective surgery. Mechanical thrombectomy (MT) can improve outcomes of ischemic s ... Full text Cite

Perioperative colloid choice and bleeding in patients undergoing musculoskeletal surgery: An observational administrative database study.

Journal Article Int J Crit Illn Inj Sci · 2021 BACKGROUND: The synthetic colloid hydroxyethyl starch (HES) received a black box warning, issued by the US Food and Drug Administration (FDA) in June 2013, in patients with sepsis, due to increased risk of bleeding, renal injury, and death. Risks of HES in ... Full text Link to item Cite

Changes in analgesic strategies for lobectomy from 2009 to 2018

Conference ANESTHESIA AND ANALGESIA · 2021 Cite

The Impact of Nonsteroidal Anti-inflammatory Drugs on Older Adult Trauma Patients With Hip Fractures.

Journal Article J Surg Res · November 2020 BACKGROUND: Nonsteroidal anti-inflammatory drug (NSAID) use is frequently recommended for multimodal analgesia to reduce opioid use. We hypothesized that increased NSAID utilization will decrease opioid requirements without leading to significant complicat ... Full text Link to item Cite

Effects of Acetaminophen, NSAIDs, Gabapentinoids, and Their Combinations on Postoperative Pulmonary Complications After Total Hip or Knee Arthroplasty.

Journal Article Pain Med · October 1, 2020 OBJECTIVE: Multimodal analgesia has gained popularity in total hip arthroplasty (THA) and total knee arthroplasty (TKA), but large multicenter studies evaluating specific analgesic combinations are lacking. DESIGN: A retrospective study using the Premier H ... Full text Open Access Link to item Cite

Bleeding After Musculoskeletal Surgery in Hospitals That Switched From Hydroxyethyl Starch to Albumin Following a Food and Drug Administration Warning.

Journal Article Anesth Analg · October 2020 BACKGROUND: While US Food and Drug Administration (FDA) black box warnings are common, their impact on perioperative outcomes is unclear. Hydroxyethyl starch (HES) is associated with increased bleeding and kidney injury in patients with sepsis, leading to ... Full text Link to item Cite

Causal inference in perioperative medicine observational research: part 2, advanced methods.

Journal Article Br J Anaesth · September 2020 Although RCTs represent the gold standard in clinical research, most clinical questions cannot be answered using this technique, because of ethical considerations, time, and cost. The goal of observational research in clinical medicine is to gain insight i ... Full text Link to item Cite

Causal inference in perioperative medicine observational research: part 1, a graphical introduction.

Journal Article Br J Anaesth · September 2020 Graphical models have emerged as a tool to map out the interplay between multiple measured and unmeasured variables, and can help strengthen the case for a causal association between exposures and outcomes in observational studies. In Part 1 of this method ... Full text Link to item Cite

Associations Between Perioperative Crystalloid Volume and Adverse Outcomes in Five Surgical Populations.

Journal Article J Surg Res · July 2020 BACKGROUND: Optimal administration of fluids is an important part of enhanced recovery after surgery (ERAS) protocols. We sought to examine the relationship between perioperative crystalloid volume and adverse outcomes in five common types of surgical proc ... Full text Link to item Cite

Bleeding After Musculoskeletal Surgery in Hospitals That Switched From Hydroxyethyl Starch to Albumin Following a Food and Drug Administration Warning.

Journal Article Anesth Analg · June 10, 2020 BACKGROUND: While US Food and Drug Administration (FDA) black box warnings are common, their impact on perioperative outcomes is unclear. Hydroxyethyl starch (HES) is associated with increased bleeding and kidney injury in patients with sepsis, leading to ... Full text Link to item Cite

Dose-Dependent Association of Gabapentinoids with Pulmonary Complications After Total Hip and Knee Arthroplasties.

Journal Article J Bone Joint Surg Am · February 5, 2020 BACKGROUND: Gabapentinoids are commonly prescribed in perioperative multimodal analgesia protocols. Despite widespread use, the optimal dose to reduce opioid consumption while minimizing risks is unknown. We assessed dose-dependent effects of gabapentinoid ... Full text Link to item Cite

Impact of early postoperative oral nutritional supplement utilization on clinical outcomes in colorectal surgery.

Journal Article Perioper Med (Lond) · 2020 BACKGROUND: Small randomized trials of early postoperative oral nutritional supplementation (ONS) suggest various health benefits following colorectal surgery (CRS). However, real-world evidence of the impact of early ONS on clinical outcomes in CRS is lac ... Full text Open Access Link to item Cite

Evaluating the seasonality of growth in infants using a mobile phone application.

Journal Article NPJ Digit Med · 2020 It has been observed that growth velocity of toddlers and school children shows seasonal variation, while such seasonality is unknown in infants. The aim of this study was to examine whether growth velocity (length and weight) of infants differs by seasons ... Full text Link to item Cite

Association 'Between Gabapentinoids on the Day of Colorectal Surgery and Adverse Postoperative Respiratory Outcomes.

Journal Article Ann Surg · December 2019 OBJECTIVE: The aim of this study was to determine the association between gabapentinoids on the day of surgery and adverse postoperative outcomes in patients undergoing colorectal surgery in the United States. BACKGROUND: Gabapentinoids, gabapentin and pre ... Full text Link to item Cite

Volume effect in paediatric brain tumour resection surgery: analysis of data from the Japanese national inpatient database.

Journal Article Eur J Cancer · March 2019 BACKGROUND: Paediatric brain tumours are the second most common type of malignancies that occur during childhood. Surgical resection is usually the first step in the treatment of these patients; however, evidence pertaining to a 'volume effect' in paediatr ... Full text Link to item Cite

Risk factors for early unplanned readmission in patients with bipolar disorder: A retrospective observational study.

Journal Article Gen Hosp Psychiatry · 2019 OBJECTIVES: Evidence regarding the relationships between patient, hospital, and regional factors and early unplanned readmission (short-term outcome) in patients with bipolar disorder is lacking. This study aimed to examine risk factors associated with ear ... Full text Link to item Cite

A nationwide survey of intravenous antimicrobial use in intensive care units in Japan.

Journal Article Int J Antimicrob Agents · April 2018 Although most patients in the intensive care unit (ICU) receive antibiotics, little is known about patterns of antibiotic use in ICUs in Japan. The objective of this study was to evaluate the pattern of antibiotic use in ICUs. A nationwide one-day cross-se ... Full text Open Access Link to item Cite

Physician attire in the intensive care unit in Japan influences visitors' perception of care.

Journal Article J Crit Care · February 2018 PURPOSE: The objective of this study is to evaluate the impact of physician attire and behavior on perceptions of care by ICU visitors in Japan. MATERIALS AND METHODS: Visitors were surveyed including 117 at a community hospital and 106 at a university hos ... Full text Link to item Cite

Predictors associated with unplanned hospital readmission of medical and surgical intensive care unit survivors within 30 days of discharge.

Journal Article J Intensive Care · 2018 BACKGROUND: Reducing the 30-day unplanned hospital readmission rate is a goal for physicians and policymakers in order to improve quality of care. However, data on the readmission rate of critically ill patients in Japan and knowledge of the predictors ass ... Full text Link to item Cite

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016).

Journal Article J Intensive Care · 2018 BACKGROUND AND PURPOSE: The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of I ... Full text Link to item Cite

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016).

Journal Article Acute Med Surg · January 2018 BACKGROUND AND PURPOSE: The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of I ... Full text Link to item Cite

Factors affecting prolonged length of stay in psychiatric patients in Japan: A retrospective observational study.

Journal Article Psychiatry Clin Neurosci · August 2017 AIM: Hospital length of stay (LOS) is one of the stratified measures of health-care efficiency and is commonly used to assess performance of psychiatric care. The aim of this study was to identify risk factors for prolonged LOS of psychiatric patients. MET ... Full text Link to item Cite

The optimal timing of continuous renal replacement therapy according to the modified rifle classification in critically ill patients with acute kidney injury: A retrospective observational study

Journal Article Renal Replacement Therapy · July 10, 2017 Background: Acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is associated with high mortality in critically ill patients. However, the optimal timing to initiate CRRT in patients with AKI is unknown. The purpose of this stud ... Full text Cite

Effects of low-dose atrial natriuretic peptide infusion on cardiac surgery-associated acute kidney injury: A multicenter randomized controlled trial.

Journal Article J Crit Care · April 2017 PURPOSE: To evaluate the effects of atrial natriuretic peptide (ANP) on renal function and medical costs in patients with acute kidney injury (AKI) associated with cardiac surgery. MATERIALS AND METHODS: The Japanese trial for AKI in Post-cardiovascular su ... Full text Link to item Cite

Prediction Models and Their External Validation Studies for Mortality of Patients with Acute Kidney Injury: A Systematic Review.

Journal Article PLoS One · 2017 OBJECTIVES: To systematically review AKI outcome prediction models and their external validation studies, to describe the discrepancy of reported accuracy between the results of internal and external validations, and to identify variables frequently includ ... Full text Link to item Cite

Long-Term Survival in Patients With Acute Kidney Injury After Acute Type A Aortic Dissection Repair.

Journal Article Ann Thorac Surg · December 2016 BACKGROUND: Although acute kidney injury (AKI) is known as a serious complication after operation for acute type A aortic dissection (AAAD), the long-term impact of AKI remains unclear. The aim of the present study is to investigate the long-term survival ... Full text Link to item Cite

Observational Research Using Propensity Scores.

Journal Article Adv Chronic Kidney Dis · November 2016 In most observational studies, treatments or other "exposures" (in an epidemiologic sense) do not occur at random. Instead, treatments or other such interventions depend on several patient-related and patient-independent characteristics. Such factors, asso ... Full text Open Access Link to item Cite

Hospital mortality of patients aged 80 and older after surgical repair for type A acute aortic dissection in Japan.

Journal Article Medicine (Baltimore) · August 2016 To evaluate whether patients aged 80 and older have higher risk of hospital mortality after repair of type A acute aortic dissection (TAAAD).Emergency surgery for TAAAD in patients aged 80 and older remains a controversial issue because of its high surgica ... Full text Open Access Link to item Cite

Factors predicting successful discontinuation of continuous renal replacement therapy.

Journal Article Anaesth Intensive Care · July 2016 This multicentre, retrospective observational study was conducted from January 2010 to December 2010 to determine the optimal time for discontinuing continuous renal replacement therapy (CRRT) by evaluating factors predictive of successful discontinuation ... Full text Open Access Link to item Cite

Sepsis may not be a risk factor for mortality in patients with acute kidney injury treated with continuous renal replacement therapy.

Journal Article J Crit Care · October 2015 PURPOSE: We aimed to study the clinical characteristics, courses, and outcomes of critically ill patients with septic acute kidney injury (AKI) treated with continuous renal replacement therapy (CRRT) in comparison with nonseptic AKI treated with CRRT. MET ... Full text Link to item Cite

Lower heart rate in the early postoperative period does not correlate with long-term outcomes after repair of type A acute aortic dissection.

Journal Article Heart Vessels · May 2015 Little evidence exists regarding the need for a reduction in postoperative heart rate after repair of type A acute aortic dissection. This single-center retrospective study was conducted to determine if lower heart rate during the early postoperative phase ... Full text Link to item Cite

External Validation for Acute Kidney Injury Severity Scores: A Multicenter Retrospective Study in 14 Japanese ICUs.

Journal Article Am J Nephrol · 2015 BACKGROUND/AIMS: Acute kidney injury (AKI) is associated with high mortality. Multiple AKI severity scores have been derived to predict patient outcome. We externally validated new AKI severity scores using the Japanese Society for Physicians and Trainees ... Full text Link to item Cite

The lower limit of intensity to control uremia during continuous renal replacement therapy.

Journal Article Crit Care · October 7, 2014 INTRODUCTION: The recommended lower limit of intensity during continuous renal replacement therapy (CRRT) is 20 or 25 mL/kg/h. However, limited information is available to support this threshold. We aimed to evaluate the impact of different intensities of ... Full text Link to item Cite

Utility of the Penn classification in predicting outcomes of surgery for acute type a aortic dissection.

Journal Article Am J Cardiol · February 15, 2014 The Penn classification, a risk assessment system for acute type A aortic dissection (AAAD), is based on preoperative ischemic conditions. We investigated whether Penn classes predict outcomes after surgery for AAAD. Three hundred fifty-one patients with D ... Full text Link to item Cite

Validity of low-intensity continuous renal replacement therapy*.

Journal Article Crit Care Med · November 2013 OBJECTIVE: To study the hospital mortality of patients with severe acute kidney injury treated with low-intensity continuous renal replacement therapy. DESIGN: Multicenter retrospective observational study (Japanese Society for Physicians and Trainees in I ... Full text Open Access Link to item Cite

Who may not benefit from continuous renal replacement therapy in acute kidney injury?

Journal Article Hemodial Int · October 2013 This study aimed to identify factors that may predict early kidney recovery (less than 48 hours) or early death (within 48 hours) after initiating continuous renal replacement therapy (CRRT) in acute kidney injury (AKI) patients. This is a multicenter retr ... Full text Link to item Cite

Maternal outcomes by mode of delivery among pregnant patients with eclampsia: a retrospective cohort study.

Conference Maternal outcomes by mode of delivery among pregnant patients with eclampsia: a retrospective cohort study. ... Cite