Theresa Marie Coles
Assistant Professor in Population Health Sciences
Theresa Coles, PhD, is a health outcomes methodologist with a focus on measuring and evaluating patient-reported outcomes (PROs), integrating PRO measures in clinical care, and improving interpretation of patient-centered outcome scores.
Current Research Interests
- development and evaluation of patient-reported outcomes (PRO) measures using psychometric and qualitative methods
- evaluating the impact of PRO measures in clinical care on patient outcomes and resource utilization
- interpretation of PRO scores, including meaningful differences and meaningful change
- measuring physical function
- patient goals
- health services research
Current Appointments & Affiliations
- Assistant Professor in Population Health Sciences, Population Health Sciences, Basic Science Departments 2018
Contact Information
- 215 Morris Street, Durham, NC 27701
- DUMC 104023, Durham, NC 27701
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theresa.coles@duke.edu
(919) 613-7994
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Center for Health Measurement
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Department of Population Health Sciences
- Background
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Education, Training, & Certifications
- Ph.D., University of North Carolina - Chapel Hill 2017
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Duke Appointment History
- Instructor in the Department of Population Health Sciences, Population Health Sciences, Basic Science Departments 2018
- Recognition
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Awards & Honors
- Expertise
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Subject Headings
- Research
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Selected Grants
- Optimizing the Management and Outcomes for Cancer Survivors Transitioning to Follow-up Care awarded by National Institutes of Health 2020 - 2025
- Addressing the clinical dilemma and patient preference for unilateral versus bilateral hearing aids awarded by Patient Centered Outcomes Research Institute 2021 - 2025
- Evaluating physical functioning using patient-reported outcome measures: How does the question form and recall period influence patients' interpretation? awarded by Food and Drug Administration 2020 - 2023
- Gathering Evidence to Determine Whether Modifications are Necessary to the Kansas City Cardiomyopathy Questionnaire (KCCQ) to Address Possible Interpretation Differences by Men and Women awarded by Food and Drug Administration 2019 - 2021
- Evaluating Outcomes of the Rosalynn Carter Institute for Caregiving (RCI) Caregiver Support Programs awarded by Georgia Southwestern Foundation, Inc. 2020 - 2021
- A novel approach to measuring and managing chronic pain, fatigue, and depression in systemic lupus erythematosus. awarded by Pfizer, Inc. 2019 - 2020
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Zigler, Christina K., Heidi Jacobe, Kaveh Ardalan, Theresa M. Coles, Suzane Lane, Kaila L. Schollaert, and Kathryn S. Torok. “The importance of development standards for anchoring vignettes: an illustrative example from pediatric localized scleroderma quality of life.” Qual Life Res 29, no. 12 (December 2020): 3263–72. https://doi.org/10.1007/s11136-020-02575-6.Full Text Link to Item
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Malay, Morven R., Trevor A. Lentz, Jonathan O’Donnell, Theresa Coles, Richard Chad Mather Iii, and William A. Jiranek. “Development of a Comprehensive, Nonsurgical Joint Health Program for People With Osteoarthritis: A Case Report.” Phys Ther 100, no. 1 (January 23, 2020): 127–35. https://doi.org/10.1093/ptj/pzz150.Full Text Link to Item
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Coles, Theresa M., Lesley H. Curtis, and L Ebony Boulware. “Measuring Health.” Prim Care 46, no. 4 (December 2019): 485–91. https://doi.org/10.1016/j.pop.2019.07.002.Full Text Link to Item
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Lewis, E. F., T. M. Coles, S. Lewis, L. M. Nelson, A. Barrett, C. D. M. Romano, D. E. Stull, S. J. Turner, and C. G. Chang. “Development, psychometric evaluation, and initial feasibility assessment of a symptom tracker for use by patients with heart failure (HFaST).” Journal of Patient Reported Outcomes 3, no. 1 (December 1, 2019). https://doi.org/10.1186/s41687-019-0113-6.Full Text
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Coles, Theresa M., Sarah M. Wilson, Bo Kim, Jean C. Beckham, and Warren A. Kinghorn. “From obligation to opportunity: future of patient-reported outcome measures at the Veterans Health Administration.” Transl Behav Med 9, no. 6 (November 25, 2019): 1157–62. https://doi.org/10.1093/tbm/ibz121.Full Text Link to Item
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Coles, Theresa, Kristina Chen, Lauren Nelson, Nimanee Harris, Montserrat Vera-Llonch, Alan Krasner, and Susan Martin. “Psychometric evaluation of the hypoparathyroidism symptom diary.” Patient Relat Outcome Meas 10 (2019): 25–36. https://doi.org/10.2147/PROM.S179310.Full Text Link to Item
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Coles, Theresa, Valerie Williams, Kim Dwyer, and Margaret Mordin. “Psychometric Evaluation of the Patient's Knee Implant Performance Questionnaire.” Value Health 21, no. 11 (November 2018): 1305–12. https://doi.org/10.1016/j.jval.2018.05.006.Full Text Link to Item
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Coles, Theresa, Antonia V. Bennett, Xianming Tan, Claudio L. Battaglini, Hanna K. Sanoff, Ethan Basch, Roxanne E. Jensen, and Bryce B. Reeve. “Relationship between sleep and exercise as colorectal cancer survivors transition off treatment.” Support Care Cancer 26, no. 8 (August 2018): 2663–73. https://doi.org/10.1007/s00520-018-4110-8.Full Text Open Access Copy Link to Item
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Coles, Theresa, Xianming Tan, Antonia V. Bennett, Hanna K. Sanoff, Ethan Basch, Roxanne E. Jensen, and Bryce B. Reeve. “Sleep quality in individuals diagnosed with colorectal cancer: Factors associated with sleep disturbance as patients transition off treatment.” Psychooncology 27, no. 3 (March 2018): 1050–56. https://doi.org/10.1002/pon.4595.Full Text Link to Item
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Lewis, Eldrin, Amy Barrett, Sandy Lewis, Theresa Coles, Carla DeMuro, Donald Stull, Stuart Turner, Engels Obi, Chun-Lan Chang, and Katherine Waltman Johnson. “5 Development of a Symptom Tracker for Use by Patients with Heart Failure.” Heart & Lung 46, no. 3 (May 2017): 216–17. https://doi.org/10.1016/j.hrtlng.2017.04.025.Full Text
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Wysham, Weiya Z., Elisabeth M. Schaffer, Theresa Coles, Dario R. Roque, Stephanie B. Wheeler, and Kenneth H. Kim. “Adding bevacizumab to single agent chemotherapy for the treatment of platinum-resistant recurrent ovarian cancer: A cost effectiveness analysis of the AURELIA trial.” Gynecol Oncol 145, no. 2 (May 2017): 340–45. https://doi.org/10.1016/j.ygyno.2017.02.039.Full Text Link to Item
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Williams, Valerie, Theresa Coles, Ari Gnanasakthy, Carla Demuro, Stuart Yarr, Nicole Williams, Linda Lowes, Lindsay Alfano, and Brian Tseng. “Psychometric validation of a patient-reported measure of physical functioning in sporadic inclusion body myositis.” Muscle Nerve 54, no. 4 (October 2016): 658–65. https://doi.org/10.1002/mus.25080.Full Text Link to Item
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Wysham, W. Z., E. M. Schaffer, T. M. Coles, D. R. Roque, S. B. Wheeler, and K. H. Kim. “Adding bevacizumab to single-agent chemotherapy for the treatment of platinum-resistant recurrent ovarian cancer: A cost-effectiveness analysis of the AURELIA trial.” Gynecologic Oncology 141 (June 2016): 36–36. https://doi.org/10.1016/j.ygyno.2016.04.116.Full Text
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Bantug, Elissa T., Theresa Coles, Katherine C. Smith, Claire F. Snyder, Julie Rouette, Michael D. Brundage, and Michael D. PRO Data Presentation Stakeholder Advisory Board. “Graphical displays of patient-reported outcomes (PRO) for use in clinical practice: What makes a pro picture worth a thousand words?” Patient Educ Couns 99, no. 4 (April 2016): 483–90. https://doi.org/10.1016/j.pec.2015.10.027.Full Text Link to Item
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DiBenedetti, D. B., T. M. Coles, T. Sharma, L. Pericleous, and R. Kulkarni. “Assessing patients' and caregivers' perspectives on stability of factor VIII products for haemophilia A: a web-based study in the United States and Canada.” Haemophilia 20, no. 4 (July 2014): e296–303. https://doi.org/10.1111/hae.12459.Full Text Link to Item
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Coles, Theresa, Cheryl Coon, Carla DeMuro, Lori McLeod, and Ari Gnanasakthy. “Psychometric evaluation of the Sheehan Disability Scale in adult patients with attention-deficit/hyperactivity disorder.” Neuropsychiatr Dis Treat 10 (2014): 887–95. https://doi.org/10.2147/NDT.S55220.Full Text Link to Item
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Chandran, Arthi B., Cheryl D. Coon, Susan A. Martin, Lori D. McLeod, Theresa M. Coles, and Lesley M. Arnold. “Sphygmomanometry-evoked allodynia in chronic pain patients with and without fibromyalgia.” Nurs Res 61, no. 5 (September 2012): 363–68. https://doi.org/10.1097/NNR.0b013e318259b6cc.Full Text Link to Item
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Williams, Valerie, Matthew D. Rousculp, Mark Price, Theresa Coles, Michelle Therrien, Jane Griffin, Kelly Hollis, and Seth Toback. “Elementary school-located influenza vaccine programs: key stakeholder experiences from initiation to continuation.” J Sch Nurs 28, no. 4 (August 2012): 256–67. https://doi.org/10.1177/1059840512438776.Full Text Link to Item
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Dalal, Anand A., Lauren Nelson, Theresa Gilligan, Lori McLeod, Sandy Lewis, and Carla DeMuro-Mercon. “Evaluating patient-reported outcome measurement comparability between paper and alternate versions, using the lung function questionnaire as an example.” Value Health 14, no. 5 (July 2011): 712–20. https://doi.org/10.1016/j.jval.2010.12.007.Full Text Link to Item
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Dalal, Anand A., Carla Demuro-Mercon, Sandy Lewis, Lauren Nelson, Theresa Gilligan, and Lori McLeod. “Validation of alternate modes of administration of the lung function questionnaire (LFQ) in subjects with smoking history.” Int J Chron Obstruct Pulmon Dis 5 (December 7, 2010): 425–34. https://doi.org/10.2147/COPD.S13900.Full Text Link to Item
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Coles, Theresa, Kristina Chen, Lauren Nelson, Nimanee I. Harris, Montserrat Vera-Llonch, and Susan Martin. “Psychometric evaluation of the newly developed hypoparathyroidism symptom diary.” Endocrine Abstracts, n.d. https://doi.org/10.1530/endoabs.49.ep1263.Full Text
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Conference Papers
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Eudy, Amanda, Bryce Reeve, Theresa Coles, Li Lin, Jennifer Rogers, Lisa Criscione-Schreiber, Jayanth Doss, et al. “Using Patient-Reported Outcomes Measures to Classify Patients with Systemic Lupus Erythematous.” In Arthritis & Rheumatology, Vol. 72, 2020.Link to Item
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Wolfe, Madison, Amanda Robinson, Jin-Shei Lai, Theresa Coles, Elizabeth Gray, Rowland Chang, David Cella, and Kaveh Ardalan. “Estimation of Clinically Important Differences in Patient-Reported Outcomes Measurement Information System (PROMIS) Measures in Juvenile Myositis.” In Arthritis & Rheumatology, Vol. 72, 2020.Link to Item
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Coles, T., L. Lin, B. B. Reeve, J. A. Spertus, I. Pina, F. Bocell, R. J. Mentz, et al. “DO MEN AND WOMEN INTERPRET THE KANSAS CITY CARDIOMYOPATHY QUESTIONNAIRE (KCCQ) DIFFERENTLY?” In Value in Health, 23:S90–S90, 2020.Link to Item
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Lewis, Eldrin F., Amy Barrett, Sandy Lewis, Theresa Coles, Carla DeMuro, Donald Stull, Stuart Turner, Engels N. Obi, Chun-Lan Chang, and Katherine Waltman Johnson. “Development of a Symptom Tracker for Use by Patients With Heart Failure.” In Journal of Cardiac Failure, 22:S82–S82. Elsevier BV, 2016. https://doi.org/10.1016/j.cardfail.2016.06.263.Full Text
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Williams, Valerie, Theresa Coles, Carla Demuro, Sandra Lewis, Nicole Williams, Stuart Yarr, Victoria Barghout, et al. “Validation of the Sporadic Inclusion Body Myositis Physical Functioning Assessment.” In Neurology, Vol. 86, 2016.Link to Item
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- Teaching & Mentoring
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Recent Courses
- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- Introduction to Patient-Reported Outcomes Assessments. ISPOR Europe. November 2, 2019 2019
- Introduction to Patient-Reported Outcomes Assessments. Patient Engagement and Clinical Practice Special Interest Group Symposium: Patient engagement with PRO completion in clinical practice: Challenges and solutions. 26th Annual International Society for Quality of Life Research . October 20, 2019 2019
- Development and validation of the IG patient experience with treatment (IGPET), a novel patient-reported measure for individuals with primary immunodeficiency.. Annual International Society for Pharmacoeconomics and Outcomes Research Meeting. May 18, 2019 - May 22, 2019 2019
- Gender variation in the predictive validity of the Kansas City Cardiomyopathy Questionnaire.. American College of Cardiology’s 68th Annual Scientific Session & Expo. March 18, 2019 - March 18, 2019 2019
- Experience with immunoglobulin treatment among patients with PIDD in the US. the American Academy of Allergy, Asthma & Immunology Annual Meeting. February 2019 - February 2019 2019
- Psychometric Evaluation of the Immunoglobulin Patient Experience with Treatment (IgPET) in Primary Immunodeficiency Diseases.. Presented at the 25th Annual International Society for Quality of Life Research. October 26, 2018 - October 26, 2018 2018
- Using Patient-reported Outcome Measures for Screening or Diagnostic Purposes: Advantages and Challenges. . Presented as part of the International Society for Quality of Life Research (ISOQOL) webinar. June 11, 2018 - June 11, 2018 2018
- Engaging the Strengths and Limits of Patient-Centered Outcomes Assessment. Presented at Prescribing Wisely: Psychiatric Medications and the Whole Person. June 7, 2018 - June 9, 2018 2018
- CDFs and PDFs: Comparing Visual Methods Supporting Responder Thresholds in Clinical TrialsQin . ISPOR 23nd Annual International Meeting. May 19, 2018 - May 23, 2018 2018
- What impacts the stability of anchor-based responder definitions?. October 18, 2017 - October 21, 2017 2017
- Factors associated with sleep disturbance as individuals diagnosed with colorectal cancer transition to early survivorship. HealthMeasures Users Conference. September 27, 2017 - September 28, 2017 2017
- Psychometric evaluation of the newly developed Hypoparathyroidism Symptom Diary. 19th European Congress of Endocrinology. May 20, 2017 - May 23, 2017 2017
- Psychometric evaluation of the newly developed hypoparathyroidism symptom diary Endocrine Abstracts . 19th European Congress of Endocrinology . May 20, 2017 - May 23, 2017 2017
- Psychometric evaluation and health care provider feedback on a symptom tracker for use by patients with heart failure.. the European Society of Cardiology (ESD) Heart Failure. April 30, 2017 2017
- Evaluating power in regression mixture models: a simulation study using patient-reported outcome data. the 23rd Annual International Society for Quality of Life Research Conference. October 19, 2016 - October 22, 2016 2016
- Development of a symptom tracker for use by patients with heart failure. the Heart Failure Society of America. September 17, 2016 - September 20, 2016 2016
- Adding bevacizumab to single-agent chemotherapy for the treatment of platinum-resistant recurrent ovarian cancer: a cost-effectiveness analysis of the AURELIA trial.. Society of Gynecologic Oncology. March 19, 2016 - March 22, 2016 2016
- Adding Bevacizumab To Single-Agent Chemotherapy For The Treatment Of Platinum-Resistant Recurrent Ovarian Cancer: A Cost-Effectiveness Analysis Of The Aurelia Trial. 18th Annual European Conference for the International Society for Pharmacoeconomics and Outcomes Research. November 7, 2015 - November 11, 2015 2015
- Greater psoriasis area and severity index response leads to greater improvement in patient-reported overall impact of psoriasis. . 24th European Academy of Dermatology and Venereology Congress. October 2015 2015
- Psoriasis treatment response as measured by skin clearance is strongly related to patient-reported change in psoriasis impact.. 24th European Academy of Dermatology and Venereology Congress. October 2015 2015
- Psychometric evaluation of the Sporadic Inclusion Body Myositis (sIBM) Physical Functioning Assessment (sIFA). 1st Annual International Conference on Myositis. May 2015 2015
- Current sample size practices in the psychometric evaluation of patient reported outcomes for use in clinical trials.. Poster presented at the 17th Annual European Conference for the International Society for Pharmacoeconomics and Outcomes Research. November 8, 2014 - November 12, 2014 2014
- Psychometric evaluation of the patient's knee implant performance (PKIP) questionnaire for the assessment of primary total knee arthroplasty.. Poster presented at the 17th Annual European Conference for the International Society for Pharmacoeconomics and Outcomes Research. November 8, 2014 - November 12, 2014 2014
- Rasch First? Factor First? . Poster presented at the 17th Annual European Conference for the International Society for Pharmacoeconomics and Outcomes Research. November 8, 2014 - November 12, 2014 2014
- Interpretation of patient-reported outcome results in routine clinical oncology practice: a literature review of presentation considerations. . Poster presented at the 20th Annual Conference for the International Society for Quality of Life Researc. October 9, 2013 - October 12, 2013 2013
- Patients' and caregivers' perspectives on stability of factor VIII products for hemophilia A: a web-based study in the United States and Canada.. Poster presented at the 65th Annual International Meeting of the National Hemophilia Foundation. October 3, 2013 - October 5, 2013 2013
- Recruiting patients with a rare blood disorder and their caregivers through social media.. Poster presented at the 18th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research. May 18, 2013 - May 22, 2013 2013
- Web-based study of patients and caregivers in the United States and Canada: perspectives on improvements in stability of factor VIII products for hemophilia A.. Poster presented at the 18th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research. May 18, 2013 - May 22, 2013 2013
- Improvements in health-related quality of life in acromegaly: results from a large, randomized double-blind phase 3 trial.. Presented at the 15th Annual European Congress of the International Society for Pharmacoeconomics and Outcomes Research. November 3, 2012 - November 7, 2012 2012
- Clinical and patient-reported outcomes associated to pasireotide in patients with Cushing's disease.. Presented at the 15th Annual Congress of the European Neuroendocrine Association. September 12, 2012 - September 15, 2012 2012
- Advanced psychometric methods for PRO development - factor analysis.. Workshop presented at the 18th Annual Conference for the International Society for Quality of Life Research. October 26, 2011 - October 29, 2011 2011
- Examining the relationship between changes in PRO measures of chronic constipation symptoms and the PAC-QOL: results from two phase 3 trials of linaclotide. . Poster presented at the 18th Annual Conference of the International Society for Quality of Life Research. October 26, 2011 - October 29, 2011 2011
- Psychometric evaluation of the Cushing's Quality of Life Questionnaire (CushingQOL).. Presented at the 18th Annual Conference of the International Society for Quality of Life Research. October 26, 2011 - October 29, 2011 2011
- The relationship between changes in PRO measures of IBS-C symptoms and the IBS-QOL: Results from two phase 3 trials of linaclotide. . Poster presented at the 18th Annual Conference of the International Society for Quality of Life Research. October 26, 2011 - October 29, 2011 2011
- A comparison of factors influencing patient knowledge: results across selected REMS surveys. Presented at the 27th International Conference on Pharmacoepidemiology and Therapeutic Risk Management. August 2011 2011
- Pérez-Gutthann S, Andrews E. Quinolones REMS Evaluation Surveys. Poster presented at the 27th International Conference on Pharmacoepidemiology and Therapeutic Risk Management. August 2011 2011
- Measurement comparability between paper and alternate versions: recommended assessment steps using the lung function questionnaire as an example.. Poster presented at the 16th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research. May 21, 2011 - May 25, 2011 2011
- Visually evaluating the measurement comparability between paper-based and alternate versions of administration of the lung function questionnaire.. Poster presented at the 16th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research. May 21, 2011 - May 25, 2011 2011
- Mixed modes of administration of the lung function questionnaire: validation in subjects with smoking history. Poster presented at the American Thoracic Society International Conference. May 13, 2011 - May 18, 2011 2011
- Elementary school-based influenza vaccination programs: findings to inform pandemic vaccination campaigns.. Poster presented at the Pediatric Academic Society Annual Meeting. May 1, 2010 - May 4, 2010 2010
- Elementary school-based influenza vaccination programs: findings to inform pandemic vaccination campaigns. Poster presented at the 44th Annual National Immunization Conference. April 19, 2010 - April 22, 2010 2010
- Let SAS do the work: correlation crossroads. . Presented at the SAS Global Forum. April 2010 2010
- Stacked cumulative percent plots.. Presented at the Pharmaceutical Industry SAS Users Group Conference (PharmaSUG). June 2009 2009
- Longitudinal data exploration with stacked cumulative percent plots for categorical data.. Poster presented at the 14th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research. May 2009 2009
- Examining the effectiveness of telephone prompting in increasing self-administered Web participation.. Presented at the Annual Southern Association for Public Opinion Research Conference. October 2006 2006
- BPS:04/06 field test interview outcomes.. Presented at the BPS:04/06 Technical Review Panel Meeting. September 2005 2005
- Exercise and its association with depressive symptoms. . Presented at the 5th Annual Celebration of Student Research and Creative Endeavors. May 2003 2003
- Physical Activity and depression in a college student sample. Presented at the North Carolina Psychological Association Spring Conference. May 2003 2003
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