Overview
Theresa Coles, Ph.D., is a health outcomes methodologist with a focus on measuring and evaluating patient-reported outcomes (PROs) and other clinical outcomes assessments (COAs), integrating PRO measures for screening of symptoms in clinical care (PROMs for screening), and improving interpretation of patient-centered outcome scores for use in healthcare delivery and clinical research settings to inform decision making. I am excited by opportunities to use COA scores to support actionable decision-making in clinical care.
My research program is comprised of 2 pillars:
- Enhance the assessment of function (e.g., physical function, cognitive function) to inform decision-making
- Design patient-reported screening questionnaires to improve patient-centered care by measuring what matters
Applications of my work are in a range of conditions such as cancer, heart failure, orthopedics, hearing healthcare, sinusitis, Eustachian tube dysfunction, migraine, autoimmune conditions, and hematologic conditions.
Current Duke Appointments & Affiliations
Associate Professor in Population Health Sciences
·
2024 - Present
Population Health Sciences,
Basic Science Departments
Recent Scholarly Works
Development of the Sinus Headache Screener (SHS).
Journal article Laryngoscope · June 23, 2026 OBJECTIVES: Facial pain or pressure is often non-rhinogenic but is frequently misdiagnosed as sinusitis, leading to inappropriate treatment with antibiotics and surgery. The objective of this study was to develop and validate a brief self-administered ques ... Full text Link to item CiteDevelopment of Machine Learning Algorithms Predicting Psychological Distress After Total Joint Arthroplasty.
Journal article J Arthroplasty · May 27, 2026 BACKGROUND: Psychological distress is associated with suboptimal outcomes after total joint arthroplasty (TJA). This study aimed to develop and evaluate machine learning (ML) models to predict a high psychological distress phenotype using only preoperative ... Full text Link to item CiteWhat patients would have liked to have known in advance about physical function due to cancer treatment.
Journal article Support Care Cancer · May 4, 2026 PURPOSE: As cancer survivorship rises, provision of information during cancer care is increasingly important, especially regarding potential impacts on patients' health-related quality of life. We sought to understand information needs patients had before ... Full text Link to item CiteRecent Grants
FDA - BAA Clinical Evidence on the impact of osseointegrated limb prostheses
ResearchCo Investigator · Awarded by Food and Drug Administration · 2023 - 2026A Clinical Trial Readiness Study of Patient Reported Outcome Measures in Thrombotic Thrombocytopenic Purpura (TTP)
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2024 - 2026Optimizing the Management and Outcomes for Cancer Survivors Transitioning to Follow-up Care
ResearchCo Investigator · Awarded by National Cancer Institute · 2020 - 2026View All Grants
Education
University of North Carolina, Chapel Hill ·
2017
Ph.D.
External Links
Center for Health Measurement Department of Population Health Sciences Evaluating physical functioning using patient-reported outcome measures: how does the question form and recall period influence patients’ interpretation? Enabling Patient-Reported Outcome Measures (PROMs) in Clinical Trials, Exemplified by Cardiovascular Trials Recall of patient-reported symptoms and function in episodic disease/conditions, specifically temporomandibular disorders