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Theresa Marie Coles

Associate Professor in Population Health Sciences
Population Health Sciences
DUMC 104023, Durham, NC 27701
215 Morris Street, Suite 210, Durham, NC 27701

Overview


Theresa Coles, Ph.D., is a health outcomes methodologist with a focus on measuring and evaluating patient-reported outcomes (PROs) and other clinical outcomes assessments (COAs), integrating PRO measures for screening of symptoms in clinical care (PROMs for screening), and improving interpretation of patient-centered outcome scores for use in healthcare delivery and clinical research settings to inform decision making. I am excited by opportunities to use COA scores to support actionable decision-making in clinical care.

My research program is comprised of 2 pillars:

  1. Enhance the assessment of function (e.g., physical function, cognitive function) to inform decision-making
  2. Design patient-reported screening questionnaires to improve patient-centered care by measuring what matters
I use qualitative (concept elicitation and cognitive interviews) and quantitative (psychometric) methods in my work. I've also been exploring consensus methodologies. At the core of my work is questionnaire design.

Applications of my work are in a range of conditions such as cancer, heart failure, orthopedics, hearing healthcare, sinusitis, Eustachian tube dysfunction, migraine, autoimmune conditions, and hematologic conditions.

Current Appointments & Affiliations


Associate Professor in Population Health Sciences · 2024 - Present Population Health Sciences, Basic Science Departments

In the News


Published August 10, 2023
Evaluating physical functioning using patient-reported outcome measures: how does the question form and recall period influence patients’ interpretation?
Published March 26, 2021
Centering Patients and Expanding Access in the Opioid Epidemic

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Recent Publications


Transitions in Psychological Distress Phenotypes and Patient-Reported Outcomes Among Patients Undergoing Total Joint Arthroplasty.

Journal Article ACR Open Rheumatol · January 2026 Psychological distress is common in individuals undergoing total joint arthroplasty (TJA). Understanding psychological phenotypes and their transitions from before to after surgery can inform risk stratification and targeted care. This study aimed to chara ... Full text Link to item Cite

Development of the Sinus Headache Screener to identify patients with non-rhinogenic facial pain compared with chronic rhinosinusitis in rhinology clinics.

Journal Article J Patient Rep Outcomes · November 6, 2025 PURPOSE: To develop a patient-reported screening tool, the Sinus Headache Screener (SHS), to differentiate non-rhinogenic facial pain (NRFP) from chronic rhinosinusitis (CRS) using qualitative research methods. METHODS: We conducted semi-structured intervi ... Full text Link to item Cite

Utility of Existing Patient-Reported Outcome Measures for Identifying Non-Rhinogenic Facial Pain.

Journal Article Laryngoscope · August 2025 OBJECTIVE: Facial pain/pressure is often non-rhinogenic and migraine-related in etiology. However, this is frequently misdiagnosed as sinusitis, leading to inappropriate antibiotic utilization and unnecessary procedures. We assessed the utility of the 3-It ... Full text Link to item Cite
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Recent Grants


FDA - BAA Clinical Evidence on the impact of osseointegrated limb prostheses

ResearchCo Investigator · Awarded by Food and Drug Administration · 2023 - 2026

A Clinical Trial Readiness Study of Patient Reported Outcome Measures in Thrombotic Thrombocytopenic Purpura (TTP)

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2024 - 2026

Optimizing the Management and Outcomes for Cancer Survivors Transitioning to Follow-up Care

ResearchCo Investigator · Awarded by National Cancer Institute · 2020 - 2026

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Education, Training & Certifications


University of North Carolina, Chapel Hill · 2017 Ph.D.