Thomas Edward Buchheit | Scholars@Duke

Thomas Edward Buchheit
Associate Professor of Anesthesiology

Dr. Buchheit serves as Director of the Regenerative Pain Therapies Program in the Duke Center for Translational Pain Medicine (CTPM), and practices Pain Medicine at both Duke University and the Durham VAMC. His research focus is on the local and systemic inflammatory mechanisms that drive pain in arthritis and nerve injury. He has led and participated in several multicenter research projects that have studied patients at Duke, the Durham VAMC, and Walter Reed National Military Medical Center, clarifying post-amputation pain phenotypes and mechanisms that drive the chronification of pain. These research pursuits have guided the clinical and translational programs of CTPM that strive develop biologically-based methods for the treatment of arthritis and degenerative musculoskeletal conditions. The program’s overarching goal is to move beyond opioids, steroids and anti-inflammatory medications for the treatment of pain.

Dr. Buchheit currently serves on the Editorial Board of Pain Medicine and recently completed service as Pain Medicine Division Chief in the Duke Department of Anesthesiology. He also serves on the Board of The Pain Society of the Carolinas and previously on the American Society of Anesthesiologists Pain Medicine Committee, (2012-2014), as an American Board of Anesthesiology Question Author (2011-2014), and President of Pain Society of the Carolinas (2015-2017).

Current Appointments & Affiliations

Associate Professor of Anesthesiology, Anesthesiology, Pain Management, Anesthesiology 2021
Director, Duke Regenerative Pain Therapies Program, Anesthesiology, Pain Management, Anesthesiology 2012

Contact Information

4309 Medical Park Drive, Durham, NC 27705
Box 3094 Med Ctr, Durham, NC 27710
thomas.buchheit@duke.edu (919) 668-7246
Regenerative Pain Therapies Program

Background
Education, Training, & Certifications
- M.D., Emory University 1994
Previous Appointments & Affiliations
- Associate Professor of Anesthesiology, Anesthesiology, Pain Management, Anesthesiology 2020
- Associate Professor of Anesthesiology, Anesthesiology, VA Anesthesiology Service, Anesthesiology 2010 - 2020
Leadership & Clinical Positions at Duke
- Director, Regenerative Pain Therapies
  Center for Translational Pain Medicine
  Department of Anesthesiology
Recognition
In the News
- MAY 22, 2023 Duke Health News
  
  Biologic Used by Athletes Could Also Ease Nerve Pain from Chemo, Diabetes
Awards & Honors
- Best Doctors in America. Best Doctors. 2019
Expertise
Subject Headings
Research
Selected Grants
- Neurobiological Effects of Long-Term Opioid Therapy in the Brain and Spinal Cord awarded by National Institutes of Health 2022 - 2027
- Duke Pain Early-phase Research Clinical Center (PERC) awarded by National Institutes of Health 2019 - 2024
- Single Nucleus Expression Profiling of Human Sciatic Nerve after Traumatic Amputation: Predicting Pain and Functional Outcomes awarded by Department of Defense 2019 - 2023
- Neuronal and glial interactions of neuropathic pain awarded by National Institutes of Health 2006 - 2023
- USWM - Lucemyra awarded by US WorldMeds, LLC 2019 - 2021
- Analgesic effects of perioperative propranolol administration for spine surgery awarded by Foundation for Anesthesia Education and Research 2020
- Germline epigenetic effects of opioids (GEEO) awarded by Research Triangle Institute International 2017 - 2018
External Relationships
- Mainstay Medical
- North Carolina Medical Board
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Buchheit, Thomas, Yul Huh, Andrew Breglio, Sangsu Bang, Jing Xu, Yutaka Matsuoka, Ran Guo, et al. “Intrathecal administration of conditioned serum from different species resolves Chemotherapy-Induced neuropathic pain in mice via secretory exosomes.” Brain Behav Immun 111 (July 2023): 298–311. https://doi.org/10.1016/j.bbi.2023.04.013.
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  - Zetlaoui, Paul J., Thomas Buchheit, and Dan Benhamou. “Epidural blood patch: A narrative review.” Anaesth Crit Care Pain Med 41, no. 5 (October 2022): 101138. https://doi.org/10.1016/j.accpm.2022.101138.
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  - Buchheit, Thomas, Christine Hunt, Jason Eldrige, Yashar Eshraghi, and Dmitri Souza. “Product characteristics should be reported in all biological therapy publications.” Reg Anesth Pain Med 47, no. 7 (July 2022): 449. https://doi.org/10.1136/rapm-2022-103557.
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  - Hunt, Christine, David A. Provenzano, Yashar Eshraghi, Nimish Mittal, Dmitri Souza, and Thomas Buchheit. “Should intra-articular hyaluronic acid be used routinely for knee osteoarthritis pain?” Pm R 14, no. 7 (July 2022): 879–85. https://doi.org/10.1002/pmrj.12740.
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  - Gaynor, Sheila M., Andrey Bortsov, Eric Bair, Roger B. Fillingim, Joel D. Greenspan, Richard Ohrbach, Luda Diatchenko, et al. “Phenotypic profile clustering pragmatically identifies diagnostically and mechanistically informative subgroups of chronic pain patients.” Pain 162, no. 5 (May 1, 2021): 1528–38. https://doi.org/10.1097/j.pain.0000000000002153.
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  - Buchheit, Thomas, Yul Huh, William Maixner, Jianguo Cheng, and Ru-Rong Ji. “Neuroimmune modulation of pain and regenerative pain medicine.” J Clin Invest 130, no. 5 (May 1, 2020): 2164–76. https://doi.org/10.1172/JCI134439.
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  - Bruehl, Stephen, Eric R. Gamazon, Thomas Van de Ven, Thomas Buchheit, Colin G. Walsh, Puneet Mishra, Krishnan Ramanujan, and Andrew Shaw. “DNA methylation profiles are associated with complex regional pain syndrome after traumatic injury.” Pain 160, no. 10 (October 2019): 2328–37. https://doi.org/10.1097/j.pain.0000000000001624.
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  - Buchheit, Thomas, Hung-Lun John Hsia, Mary Cooter, Cynthia Shortell, Michael Kent, Mary McDuffie, Andrew Shaw, Chester Trip Buckenmaier, and Thomas Van de Ven. “The Impact of Surgical Amputation and Valproic Acid on Pain and Functional Trajectory: Results from the Veterans Integrated Pain Evaluation Research (VIPER) Randomized, Double-Blinded Placebo-Controlled Trial.” Pain Med 20, no. 10 (October 1, 2019): 2004–17. https://doi.org/10.1093/pm/pnz067.
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  - Chen, Qi, Hung-Lun Hsia, Robert Overman, William Bryan, Marc Pepin, Edward R. Mariano, Seshadri C. Mudumbai, et al. “Impact of an Opioid Safety Initiative on Patients Undergoing Total Knee Arthroplasty: A Time Series Analysis.” Anesthesiology 131, no. 2 (August 2019): 369–80. https://doi.org/10.1097/ALN.0000000000002771.
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  - Hsia, Hung-Lun, Steven Takemoto, Thomas van de Ven, Srinivas Pyati, Thomas Buchheit, Neil Ray, Samuel Wellman, Alfred Kuo, Arthur Wallace, and Karthik Raghunathan. “Acute Pain Is Associated With Chronic Opioid Use After Total Knee Arthroplasty.” Reg Anesth Pain Med 43, no. 7 (October 2018): 705–11. https://doi.org/10.1097/AAP.0000000000000831.
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  - Buchheit, Thomas, Robert Zura, Zhe Wang, Samir Mehta, Gregory J. Della Rocca, and R Grant Steen. “Opioid exposure is associated with nonunion risk in a traumatically injured population: An inception cohort study.” Injury 49, no. 7 (July 2018): 1266–71. https://doi.org/10.1016/j.injury.2018.05.004.
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  - Yin, Changshik, Thomas E. Buchheit, and Jongbae J. Park. “Acupuncture for chronic pain: an update and critical overview.” Curr Opin Anaesthesiol 30, no. 5 (October 2017): 583–92. https://doi.org/10.1097/ACO.0000000000000501.
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  - Chamessian, Alexander G., Yawar J. Qadri, Matthew Cummins, Michele Hendrickson, Temugin Berta, Thomas Buchheit, and Thomas Van de Ven. “5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain.” Somatosens Mot Res 34, no. 2 (June 2017): 72–79. https://doi.org/10.1080/08990220.2017.1292237.
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  - Kent, Michael L., Hung-Lun John Hsia, Thomas J. Van de Ven, and Thomas E. Buchheit. “Perioperative Pain Management Strategies for Amputation: A Topical Review.” Pain Med 18, no. 3 (March 1, 2017): 504–19. https://doi.org/10.1093/pm/pnw110.
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  - Chamessian, Alexander, Thomas Van de Ven, Thomas Buchheit, Hung-Lun Hsia, Mary McDuffie, Eric R. Gamazon, Colin Walsh, Stephen Bruehl, Chester “Trip” Buckenmaier, and Andrew Shaw. “Differential expression of systemic inflammatory mediators in amputees with chronic residual limb pain.” Pain 158, no. 1 (January 2017): 68–74. https://doi.org/10.1097/j.pain.0000000000000728.
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  - Buchheit, Thomas. “Future therapies and the expanding role for diagnostic ultrasound.” Curr Opin Anaesthesiol 29, no. 5 (October 2016): 582–83. https://doi.org/10.1097/ACO.0000000000000380.
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  - Buchheit, Thomas, Thomas Van de Ven, Hung-Lun John Hsia, Mary McDuffie, David B. MacLeod, William White, Alexander Chamessian, Francis J. Keefe, Chester Trip Buckenmaier, and Andrew D. Shaw. “Pain Phenotypes and Associated Clinical Risk Factors Following Traumatic Amputation: Results from Veterans Integrated Pain Evaluation Research (VIPER).” Pain Med 17, no. 1 (January 2016): 149–61. https://doi.org/10.1111/pme.12848.
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  - Clarke, Collin, David R. Lindsay, Srinivas Pyati, and Thomas Buchheit. “Residual limb pain is not a diagnosis: a proposed algorithm to classify postamputation pain.” Clin J Pain 29, no. 6 (June 2013): 551–62. https://doi.org/10.1097/AJP.0b013e318261c9f9.
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  - Buchheit, Thomas, Thomas Van de Ven, and Andrew Shaw. “Epigenetics and the transition from acute to chronic pain.” Pain Med 13, no. 11 (November 2012): 1474–90. https://doi.org/10.1111/j.1526-4637.2012.01488.x.
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  - Buchheit, Thomas, and Srinivas Pyati. “Prevention of chronic pain after surgical nerve injury: amputation and thoracotomy.” Surg Clin North Am 92, no. 2 (April 2012): 393–x. https://doi.org/10.1016/j.suc.2012.01.005.
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  - Azari, Pari, David R. Lindsay, Dean Briones, Collin Clarke, Thomas Buchheit, and Srinivas Pyati. “Efficacy and safety of ketamine in patients with complex regional pain syndrome: a systematic review.” Cns Drugs 26, no. 3 (March 1, 2012): 215–28. https://doi.org/10.2165/11595200-000000000-00000.
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  - Lindsay, David R., Srinivas Pyati, Thomas E. Buchheit, and Andrew Shaw. “Residual limb pain: more than a single entity?” Anesthesiology 116, no. 1 (January 2012): 224. https://doi.org/10.1097/ALN.0b013e31823bbfcd.
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  - Kittelberger, Keith P., Thomas E. Buchheit, and Shirley F. Rice. “Self-extraction of intrathecal pump opioid.” Anesthesiology 101, no. 3 (September 2004): 807. https://doi.org/10.1097/00000542-200409000-00044.
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  - Buchheit, T., and J. C. Crews. “Lateral cervical epidural catheter placement for continuous unilateral upper extremity analgesia and sympathetic block.” Reg Anesth Pain Med 25, no. 3 (2000): 313–17. https://doi.org/10.1016/s1098-7339(00)90019-1.
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  - Buchheit, T., and R. Rauck. “Subarachnoid Techniques for Cancer Pain Therapy: When, Why, and How?” Curr Rev Pain 3, no. 3 (1999): 198–205. https://doi.org/10.1007/s11916-999-0014-0.
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  - Buchheit, T. E., and M. Tytell. “Transfer of molecules from glia to axon in the squid may be mediated by glial vesicles.” J Neurobiol 23, no. 3 (April 1992): 217–30. https://doi.org/10.1002/neu.480230303.
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- Book Sections
  - Ray, Neil, and Thomas Buchheit. “Improving Pain & Outcomes in the Perioperative Setting.” In Perioperative Medicine Managing for Outcome, edited by Mark Newman, Lee Fleisher, Clifford Ko, and Michael Mythen. Elsevier, 2021.
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- Conference Papers
  - Anderson, Jennifer, Kathryn Komaki, Steven Prakken, Lance Roy, Thomas Buchheit, John Hunting, and Padma Gulur. “ROLE OF PAIN SPECIALISTS IN REDUCING HEALTHCARE COSTS FOR PATIENTS WITH CHRONIC PAIN.” In Anesthesia and Analgesia, 126:452–54. LIPPINCOTT WILLIAMS & WILKINS, 2018.
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  - Pleticha, Josef, Steven Prakken, Thomas Buchheit, Padma Gulur, Scott Bearrows, Julie Westover, and Solomon Aronson. “Financial Impact of Intensive Outpatient Pain Management of Duke Health System High Utilizers.” In Anesthesia and Analgesia, 124:786–88. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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Scholarly, Clinical, & Service Activities
Outreach & Engaged Scholarship
- Bass Connections Faculty Team Member. Reconsidering Addiction and Opioid Abuse: Is There a Causal Chain between Opioid Addiction, Morbidity and Mortality?. August 2016 - May 2017 2016 - 2017

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Education, Training, & Certifications

Previous Appointments & Affiliations

Leadership & Clinical Positions at Duke

In the News

Awards & Honors

Subject Headings

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers

Outreach & Engaged Scholarship