Scholars@Duke
Thomas Edward Buchheit

Thomas Edward Buchheit

Adjunct Associate Professor in the Department of Anesthesiology
Anesthesiology, Pain Management
thomas.buchheit@duke.edu
Box 3094 Med Ctr, Durham, NC 27710
4309 Medical Park Drive, Durham, NC 27705

Selected Publications

Evidence-Based Clinical Practice Guidelines on Regenerative Medicine Treatment for Chronic Pain: A Consensus Report from a Multispecialty Working Group.

Journal Article J Pain Res · 2024 PURPOSE: Injectable biologics have not only been described and developed to treat dermal wounds, cardiovascular disease, and cancer, but have also been reported to treat chronic pain conditions. Despite emerging evidence supporting regenerative medicine th ... Full text Link to item Cite

Intrathecal administration of conditioned serum from different species resolves Chemotherapy-Induced neuropathic pain in mice via secretory exosomes.

Journal Article Brain, behavior, and immunity · July 2023 Chemotherapy-induced peripheral neuropathy (CIPN) is the most prevalent neurological complication of chemotherapy for cancer, and has limited effective treatment options. Autologous conditioned serum (ACS) is an effective biologic therapy used by intra-art ... Full text Cite

Platelet-Rich Plasma and Autologous Conditioned Serum: Non-Cellular Biologic Therapies for Neuroimmune Modulation and the Treatment of Arthritis Pain

Chapter · January 1, 2023 Osteoarthritis (OA) affects more than 50 million in the United States (Lawrence et al Part II Arthritis Rheum 58(1):26-35, 2008); however, most of these individuals are not considered surgical candidates. Alternative treatment options such as medications, ... Full text Cite

Epidural blood patch: A narrative review.

Journal Article Anaesth Crit Care Pain Med · October 2022 The epidural blood patch (EBP) is one of the most effective treatments for intracranial hypotension. Anesthesiologists are familiar with performing EBPs for the treatment of dural puncture-associated intracranial hypotension following spinal anesthesia, co ... Full text Link to item Cite

Opioid Tapering for Acute on Chronic Non-cancer Pain

Chapter · January 1, 2022 Patients with chronic non-cancer pain on opioid therapy can present with acute pain, most often after surgery. Escalations in opioid dosing often occur in these patients, and weaning of opioids after the acute event can be challenging due to fear of worsen ... Full text Cite

Phenotypic profile clustering pragmatically identifies diagnostically and mechanistically informative subgroups of chronic pain patients.

Journal Article Pain · May 1, 2021 Traditional classification and prognostic approaches for chronic pain conditions focus primarily on anatomically based clinical characteristics not based on underlying biopsychosocial factors contributing to perception of clinical pain and future pain traj ... Full text Open Access Link to item Cite

Improving Pain & Outcomes in the Perioperative Setting

Chapter · February 2021 Written and edited by recognized authorities in anesthesiology and surgical critical care, this fully updated edition helps you think critically about complex, long-term issues surrounding the care of the surgical patient, providing ... ... Link to item Cite

Neuroimmune modulation of pain and regenerative pain medicine.

Journal Article J Clin Invest · May 1, 2020 Regenerative pain medicine, which seeks to harness the body's own reparative capacity, is rapidly emerging as a field within pain medicine and orthopedics. It is increasingly appreciated that common analgesic mechanisms for these treatments depend on neuro ... Full text Link to item Cite

The Impact of Surgical Amputation and Valproic Acid on Pain and Functional Trajectory: Results from the Veterans Integrated Pain Evaluation Research (VIPER) Randomized, Double-Blinded Placebo-Controlled Trial.

Journal Article Pain Med · October 1, 2019 OBJECTIVE: To determine if the perioperative administration of valproic acid reduces the incidence of chronic pain three months after amputation or revision surgery. DESIGN: Multicenter, randomized, double-blind, placebo-controlled trial. SETTING: Academic ... Full text Open Access Link to item Cite

DNA methylation profiles are associated with complex regional pain syndrome after traumatic injury.

Journal Article Pain · October 2019 Factors contributing to development of complex regional pain syndrome (CRPS) are not fully understood. This study examined possible epigenetic mechanisms that may contribute to CRPS after traumatic injury. DNA methylation profiles were compared between ind ... Full text Open Access Link to item Cite

Impact of an Opioid Safety Initiative on Patients Undergoing Total Knee Arthroplasty: A Time Series Analysis.

Journal Article Anesthesiology · August 2019 BACKGROUND: The Opioid Safety Initiative decreased high-dose prescriptions across the Veterans Health Administration. This study sought to examine the impact of this intervention (i.e., the Opioid Safety Initiative) on pain scores and opioid prescriptions ... Full text Link to item Cite

Acute Pain Is Associated With Chronic Opioid Use After Total Knee Arthroplasty.

Journal Article Reg Anesth Pain Med · October 2018 BACKGROUND AND OBJECTIVES: Pain scores are routinely reported in clinical practice, and we wanted to examine whether this routinely measured, patient-reported variable provides prognostic information, especially with regard to chronic opioid use, after tak ... Full text Link to item Cite

Opioid exposure is associated with nonunion risk in a traumatically injured population: An inception cohort study.

Journal Article Injury · July 2018 INTRODUCTION: Certain common medications are associated with an elevated risk of fracture and recent data suggests that medications can also increase nonunion risk. Medication use is a modifiable nonunion risk factor, but it is unknown whether risk accrues ... Full text Link to item Cite

Acupuncture for chronic pain: an update and critical overview.

Journal Article Curr Opin Anaesthesiol · October 2017 PURPOSE OF REVIEW: Acupuncture is now recommended for several chronic pain conditions. Despite supportive evidence of its effectiveness, this ancient approach is often misunderstood, and may still be underused in mainstream practice. A critical review on i ... Full text Link to item Cite

5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain.

Journal Article Somatosens Mot Res · June 2017 Epigenetic mechanisms are increasingly implicated in chronic pain pathology. In this study, we demonstrate that the novel epigenetic mark 5-hydroxymethylcytosine (5hmC) is present in dorsal root ganglia (DRG) neurons and glia, and its levels increase follo ... Full text Link to item Cite

Perioperative Pain Management Strategies for Amputation: A Topical Review.

Journal Article Pain Med · March 1, 2017 OBJECTIVE: To review acute pain management strategies in patients undergoing amputation with consideration of preoperative patient factors, pharmacologic/interventional modalities, and multidisciplinary care models to alleviate suffering in the immediate p ... Full text Link to item Cite

Differential expression of systemic inflammatory mediators in amputees with chronic residual limb pain.

Journal Article Pain · January 2017 Chronic postsurgical pain impacts most amputees, with more than half experiencing neuralgic residual limb pain. The transition from normal acute postamputation pain to chronic residual limb pain likely involves both peripheral and central inflammatory mech ... Full text Open Access Link to item Cite

Pain Phenotypes and Associated Clinical Risk Factors Following Traumatic Amputation: Results from Veterans Integrated Pain Evaluation Research (VIPER).

Journal Article Pain Med · January 2016 OBJECTIVE: To define clinical phenotypes of postamputation pain and identify markers of risk for the development of chronic pain. DESIGN: Cross-sectional study of military service members enrolled 3-18 months after traumatic amputation injury. SETTING: Mil ... Full text Open Access Link to item Cite

Residual limb pain is not a diagnosis: a proposed algorithm to classify postamputation pain.

Journal Article Clin J Pain · June 2013 Featured Publication BACKGROUND: Although postamputation pain (PAP) syndromes have been described since the 16th century, taxonomy of these conditions remains ill-defined. The term "Residual Limb Pain" fails to distinguish between distinct diagnostic entities such as neuroma, ... Full text Open Access Link to item Cite

Epigenetics and the transition from acute to chronic pain.

Journal Article Pain Med · November 2012 Featured Publication OBJECTIVE: The objective of this study was to review the epigenetic modifications involved in the transition from acute to chronic pain and to identify potential targets for the development of novel, individualized pain therapeutics. BACKGROUND: Epigenetic ... Full text Open Access Link to item Cite

Prevention of chronic pain after surgical nerve injury: amputation and thoracotomy.

Journal Article Surg Clin North Am · April 2012 Featured Publication Although techniques for acute pain management have improved in recent years, a dramatic reduction in the incidence and severity of chronic pain following surgery has not occurred. Amputation and thoracotomy, although technically different, share the common ... Full text Link to item Cite

Efficacy and safety of ketamine in patients with complex regional pain syndrome: a systematic review.

Journal Article CNS Drugs · March 1, 2012 Featured Publication Despite being a recognized clinical entity for over 140 years, complex regional pain syndrome (CRPS) remains a difficult-to-treat condition. While there have been multiple therapies explored in the treatment of CRPS, NMDA antagonists such as ketamine conti ... Full text Link to item Cite

Residual limb pain: more than a single entity?

Journal Article Anesthesiology · January 2012 Featured Publication Full text Link to item Cite

Self-extraction of intrathecal pump opioid.

Journal Article Anesthesiology · September 2004 Full text Link to item Cite

Lateral cervical epidural catheter placement for continuous unilateral upper extremity analgesia and sympathetic block.

Journal Article Reg Anesth Pain Med · 2000 Featured Publication BACKGROUND AND OBJECTIVES: The use of the laterally directed cervical epidural catheter for the treatment of acute and chronic pain has not been previously described. We have used this technique in a series of 30 patients to produce unilateral upper extrem ... Full text Link to item Cite

Subarachnoid Techniques for Cancer Pain Therapy: When, Why, and How?

Journal Article Curr Rev Pain · 1999 Featured Publication For cancer patients who obtain inadequate pain relief with conservative treatment, there is a growing list of effective options for subarachnoid therapy. Morphine and bupivacaine have been the most frequently used drugs for intrathecal infusion, and their ... Full text Link to item Cite

Transfer of molecules from glia to axon in the squid may be mediated by glial vesicles.

Journal Article J Neurobiol · April 1992 Although the transfer of glial proteins into the squid giant axon is well documented, the mechanism of the transfer remains unknown. We examined the possibility that the transfer involved membrane-bound vesicles, by taking advantage of the fact that the fl ... Full text Link to item Cite