Neuroimmune modulation of pain and regenerative pain medicine.
Publication
, Journal Article
Buchheit, T; Huh, Y; Maixner, W; Cheng, J; Ji, R-R
Published in: The Journal of Clinical Investigation
May 2020
Regenerative pain medicine, which seeks to harness the body's own reparative capacity, is rapidly emerging as a field within pain medicine and orthopedics. It is increasingly appreciated that common analgesic mechanisms for these treatments depend on neuroimmune modulation. In this Review, we discuss recent progress in mechanistic understanding of nociceptive sensitization in chronic pain with a focus on neuroimmune modulation. We also examine the spectrum of regenerative outcomes, including preclinical and clinical outcomes. We further distinguish the analgesic mechanisms of regenerative therapies from those of cellular replacement, creating a conceptual and mechanistic framework to evaluate future research on regenerative medicine.
Duke Scholars
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Published In
The Journal of Clinical Investigation
DOI
EISSN
1558-8238
ISSN
0021-9738
Publication Date
May 2020
Volume
130
Issue
5
Start / End Page
2164 / 2176
Related Subject Headings
- Regenerative Medicine
- Neuroimmunomodulation
- Immunology
- Humans
- Chronic Pain
- Animals
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Buchheit, T., Huh, Y., Maixner, W., Cheng, J., & Ji, R.-R. (2020). Neuroimmune modulation of pain and regenerative pain medicine. The Journal of Clinical Investigation, 130(5), 2164–2176. https://doi.org/10.1172/jci134439
Buchheit, Thomas, Yul Huh, William Maixner, Jianguo Cheng, and Ru-Rong Ji. “Neuroimmune modulation of pain and regenerative pain medicine.” The Journal of Clinical Investigation 130, no. 5 (May 2020): 2164–76. https://doi.org/10.1172/jci134439.
Buchheit T, Huh Y, Maixner W, Cheng J, Ji R-R. Neuroimmune modulation of pain and regenerative pain medicine. The Journal of Clinical Investigation. 2020 May;130(5):2164–76.
Buchheit, Thomas, et al. “Neuroimmune modulation of pain and regenerative pain medicine.” The Journal of Clinical Investigation, vol. 130, no. 5, May 2020, pp. 2164–76. Epmc, doi:10.1172/jci134439.
Buchheit T, Huh Y, Maixner W, Cheng J, Ji R-R. Neuroimmune modulation of pain and regenerative pain medicine. The Journal of Clinical Investigation. 2020 May;130(5):2164–2176.
Published In
The Journal of Clinical Investigation
DOI
EISSN
1558-8238
ISSN
0021-9738
Publication Date
May 2020
Volume
130
Issue
5
Start / End Page
2164 / 2176
Related Subject Headings
- Regenerative Medicine
- Neuroimmunomodulation
- Immunology
- Humans
- Chronic Pain
- Animals
- 11 Medical and Health Sciences