Neuroimmune modulation of pain and regenerative pain medicine.
Publication
, Journal Article
Buchheit, T; Huh, Y; Maixner, W; Cheng, J; Ji, R-R
Published in: J Clin Invest
May 1, 2020
Regenerative pain medicine, which seeks to harness the body's own reparative capacity, is rapidly emerging as a field within pain medicine and orthopedics. It is increasingly appreciated that common analgesic mechanisms for these treatments depend on neuroimmune modulation. In this Review, we discuss recent progress in mechanistic understanding of nociceptive sensitization in chronic pain with a focus on neuroimmune modulation. We also examine the spectrum of regenerative outcomes, including preclinical and clinical outcomes. We further distinguish the analgesic mechanisms of regenerative therapies from those of cellular replacement, creating a conceptual and mechanistic framework to evaluate future research on regenerative medicine.
Duke Scholars
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Published In
J Clin Invest
DOI
EISSN
1558-8238
Publication Date
May 1, 2020
Volume
130
Issue
5
Start / End Page
2164 / 2176
Location
United States
Related Subject Headings
- Regenerative Medicine
- Neuroimmunomodulation
- Immunology
- Humans
- Chronic Pain
- Animals
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Buchheit, T., Huh, Y., Maixner, W., Cheng, J., & Ji, R.-R. (2020). Neuroimmune modulation of pain and regenerative pain medicine. J Clin Invest, 130(5), 2164–2176. https://doi.org/10.1172/JCI134439
Buchheit, Thomas, Yul Huh, William Maixner, Jianguo Cheng, and Ru-Rong Ji. “Neuroimmune modulation of pain and regenerative pain medicine.” J Clin Invest 130, no. 5 (May 1, 2020): 2164–76. https://doi.org/10.1172/JCI134439.
Buchheit T, Huh Y, Maixner W, Cheng J, Ji R-R. Neuroimmune modulation of pain and regenerative pain medicine. J Clin Invest. 2020 May 1;130(5):2164–76.
Buchheit, Thomas, et al. “Neuroimmune modulation of pain and regenerative pain medicine.” J Clin Invest, vol. 130, no. 5, May 2020, pp. 2164–76. Pubmed, doi:10.1172/JCI134439.
Buchheit T, Huh Y, Maixner W, Cheng J, Ji R-R. Neuroimmune modulation of pain and regenerative pain medicine. J Clin Invest. 2020 May 1;130(5):2164–2176.
Published In
J Clin Invest
DOI
EISSN
1558-8238
Publication Date
May 1, 2020
Volume
130
Issue
5
Start / End Page
2164 / 2176
Location
United States
Related Subject Headings
- Regenerative Medicine
- Neuroimmunomodulation
- Immunology
- Humans
- Chronic Pain
- Animals
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences