5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain.
Publication
, Journal Article
Chamessian, AG; Qadri, YJ; Cummins, M; Hendrickson, M; Berta, T; Buchheit, T; Van de Ven, T
Published in: Somatosens Mot Res
June 2017
Epigenetic mechanisms are increasingly implicated in chronic pain pathology. In this study, we demonstrate that the novel epigenetic mark 5-hydroxymethylcytosine (5hmC) is present in dorsal root ganglia (DRG) neurons and glia, and its levels increase following nerve injury. Furthermore, we show that the 5hmC-generating Ten-eleven translocation 1-3 (TET1-3) proteins are expressed in a cell-type specific manner in the DRG, with Tet3 displaying differential upregulation after injury, suggesting a potential role in neuropathic pain.
Duke Scholars
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Published In
Somatosens Mot Res
DOI
EISSN
1369-1651
Publication Date
June 2017
Volume
34
Issue
2
Start / End Page
72 / 79
Location
England
Related Subject Headings
- Proto-Oncogene Proteins
- Neurology & Neurosurgery
- Neuralgia
- Mice, Inbred C57BL
- Mice
- Male
- Ganglia, Spinal
- Epigenesis, Genetic
- Dioxygenases
- DNA-Binding Proteins
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Chamessian, A. G., Qadri, Y. J., Cummins, M., Hendrickson, M., Berta, T., Buchheit, T., & Van de Ven, T. (2017). 5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain. Somatosens Mot Res, 34(2), 72–79. https://doi.org/10.1080/08990220.2017.1292237
Chamessian, Alexander G., Yawar J. Qadri, Matthew Cummins, Michele Hendrickson, Temugin Berta, Thomas Buchheit, and Thomas Van de Ven. “5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain.” Somatosens Mot Res 34, no. 2 (June 2017): 72–79. https://doi.org/10.1080/08990220.2017.1292237.
Chamessian AG, Qadri YJ, Cummins M, Hendrickson M, Berta T, Buchheit T, et al. 5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain. Somatosens Mot Res. 2017 Jun;34(2):72–9.
Chamessian, Alexander G., et al. “5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain.” Somatosens Mot Res, vol. 34, no. 2, June 2017, pp. 72–79. Pubmed, doi:10.1080/08990220.2017.1292237.
Chamessian AG, Qadri YJ, Cummins M, Hendrickson M, Berta T, Buchheit T, Van de Ven T. 5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain. Somatosens Mot Res. 2017 Jun;34(2):72–79.
Published In
Somatosens Mot Res
DOI
EISSN
1369-1651
Publication Date
June 2017
Volume
34
Issue
2
Start / End Page
72 / 79
Location
England
Related Subject Headings
- Proto-Oncogene Proteins
- Neurology & Neurosurgery
- Neuralgia
- Mice, Inbred C57BL
- Mice
- Male
- Ganglia, Spinal
- Epigenesis, Genetic
- Dioxygenases
- DNA-Binding Proteins