Scholars@Duke
Thomas John Van de Ven

Thomas John Van de Ven

Associate Professor of Anesthesiology
Anesthesiology, VA Anesthesiology Service
thomas.vandeven@duke.edu
Box 3904 Med Ctr, Durham, NC 27710
Med Ctr, Box 3904, Durham, NC 27710

Selected Publications

Developing a risk stratification tool for predicting opioid-related respiratory depression after non-cardiac surgery: a retrospective study.

Journal Article BMJ Open · September 5, 2022 OBJECTIVES: Accurately assessing the probability of significant respiratory depression following opioid administration can potentially enhance perioperative risk assessment and pain management. We developed and validated a risk prediction tool to estimate ... Full text Link to item Cite

Association Between Gabapentinoids and Postoperative Pulmonary Complications in Patients Undergoing Thoracic Surgery.

Journal Article J Cardiothorac Vasc Anesth · August 2022 OBJECTIVE: Perioperative gabapentinoids in general surgery have been associated with an increased risk of postoperative pulmonary complications (PPCs), while resulting in equivocal pain relief. This study's aim was to examine the utilization of gabapentino ... Full text Link to item Cite

A Role for Protease Activated Receptor Type 3 (PAR3) in Nociception Demonstrated Through Development of a Novel Peptide Agonist.

Journal Article J Pain · June 2021 The protease activated receptor (PAR) family is a group of G-protein coupled receptors (GPCRs) activated by proteolytic cleavage of the extracellular domain. PARs are expressed in a variety of cell types with crucial roles in homeostasis, immune responses, ... Full text Link to item Cite

Changes in analgesic strategies for lobectomy from 2009 to 2018.

Journal Article JTCVS Open · June 2021 OBJECTIVE: To evaluate trends in the use of epidural analgesia and nonopioid and opioid analgesics for patients undergoing lobectomy from 2009 to 2018. METHODS: We queried the Premier database for adult patients undergoing open, video-assisted, and robotic ... Full text Open Access Link to item Cite

Post-Thoracotomy Pain: Current Strategies for Prevention and Treatment.

Journal Article Drugs · November 2020 Treating acute pain after thoracotomy surgery and preventing the development of chronic post-thoracotomy pain syndrome (PTPS) remain significant challenges in this surgical population. While appropriately treated acute thoracotomy pain often resolves, a si ... Full text Link to item Cite

AAAPT Diagnostic Criteria for Acute Pain Following Breast Surgery.

Journal Article J Pain · 2020 Acute pain after breast surgery decreases the quality of life of cancer survivors. Previous studies using a variety of definitions and methods report prevalence rates between 10% and 80%, which suggests the need for a comprehensive framework that can be us ... Full text Link to item Cite

The Impact of Surgical Amputation and Valproic Acid on Pain and Functional Trajectory: Results from the Veterans Integrated Pain Evaluation Research (VIPER) Randomized, Double-Blinded Placebo-Controlled Trial.

Journal Article Pain Med · October 1, 2019 OBJECTIVE: To determine if the perioperative administration of valproic acid reduces the incidence of chronic pain three months after amputation or revision surgery. DESIGN: Multicenter, randomized, double-blind, placebo-controlled trial. SETTING: Academic ... Full text Open Access Link to item Cite

DNA methylation profiles are associated with complex regional pain syndrome after traumatic injury.

Journal Article Pain · October 2019 Factors contributing to development of complex regional pain syndrome (CRPS) are not fully understood. This study examined possible epigenetic mechanisms that may contribute to CRPS after traumatic injury. DNA methylation profiles were compared between ind ... Full text Open Access Link to item Cite

Is Optogenetic Activation of Vglut1-Positive Aβ Low-Threshold Mechanoreceptors Sufficient to Induce Tactile Allodynia in Mice after Nerve Injury?

Journal Article J Neurosci · July 31, 2019 Mechanical allodynia is a cardinal feature of pathological pain. Recent work has demonstrated the necessity of Aβ-low-threshold mechanoreceptors (Aβ-LTMRs) for mechanical allodynia-like behaviors in mice, but it remains unclear whether these neurons are su ... Full text Link to item Cite

Postsurgical pain syndromes

Chapter · December 28, 2018 Full text Cite

Acute Pain Is Associated With Chronic Opioid Use After Total Knee Arthroplasty.

Journal Article Reg Anesth Pain Med · October 2018 BACKGROUND AND OBJECTIVES: Pain scores are routinely reported in clinical practice, and we wanted to examine whether this routinely measured, patient-reported variable provides prognostic information, especially with regard to chronic opioid use, after tak ... Full text Link to item Cite

Implementation of Perioperative Music Using the Consolidated Framework for Implementation Research.

Journal Article Anesth Analg · September 2018 BACKGROUND: Complementary integrative health therapies have a perioperative role in the reduction of pain, analgesic use, and anxiety, and increasing patient satisfaction. However, long implementation lags have been quantified. The Consolidated Framework f ... Full text Link to item Cite

Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn.

Journal Article Sci Rep · May 1, 2018 The spinal dorsal horn (SDH) is comprised of distinct neuronal populations that process different somatosensory modalities. Somatostatin (SST)-expressing interneurons in the SDH have been implicated specifically in mediating mechanical pain. Identifying th ... Full text Link to item Cite

5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain.

Journal Article Somatosens Mot Res · June 2017 Epigenetic mechanisms are increasingly implicated in chronic pain pathology. In this study, we demonstrate that the novel epigenetic mark 5-hydroxymethylcytosine (5hmC) is present in dorsal root ganglia (DRG) neurons and glia, and its levels increase follo ... Full text Link to item Cite

Perioperative Pain Management Strategies for Amputation: A Topical Review.

Journal Article Pain Med · March 1, 2017 OBJECTIVE: To review acute pain management strategies in patients undergoing amputation with consideration of preoperative patient factors, pharmacologic/interventional modalities, and multidisciplinary care models to alleviate suffering in the immediate p ... Full text Link to item Cite

Differential expression of systemic inflammatory mediators in amputees with chronic residual limb pain.

Journal Article Pain · January 2017 Chronic postsurgical pain impacts most amputees, with more than half experiencing neuralgic residual limb pain. The transition from normal acute postamputation pain to chronic residual limb pain likely involves both peripheral and central inflammatory mech ... Full text Open Access Link to item Cite

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord.

Journal Article Brain Behav Immun · July 2016 Previous studies have shown that activation of p38 mitogen-activating kinase (MAPK) in spinal microglia participates in the generation of inflammatory and neuropathic pain in various rodent models. However, these studies focused on male mice to avoid confo ... Full text Link to item Cite

Pain Phenotypes and Associated Clinical Risk Factors Following Traumatic Amputation: Results from Veterans Integrated Pain Evaluation Research (VIPER).

Journal Article Pain Med · January 2016 OBJECTIVE: To define clinical phenotypes of postamputation pain and identify markers of risk for the development of chronic pain. DESIGN: Cross-sectional study of military service members enrolled 3-18 months after traumatic amputation injury. SETTING: Mil ... Full text Open Access Link to item Cite

Epigenetics of chronic pain after thoracic surgery.

Journal Article Curr Opin Anaesthesiol · February 2014 PURPOSE OF REVIEW: Chronic pain after surgery is a major public health problem and a major concern for perioperative physicians. Thoracic surgery presents a unique challenge, as thoracotomy is among the highest risk surgeries to develop persistent postsurg ... Full text Link to item Cite

Epigenetics and the transition from acute to chronic pain.

Journal Article Pain Med · November 2012 OBJECTIVE: The objective of this study was to review the epigenetic modifications involved in the transition from acute to chronic pain and to identify potential targets for the development of novel, individualized pain therapeutics. BACKGROUND: Epigenetic ... Full text Open Access Link to item Cite

Causes and prevention of chronic postsurgical pain.

Journal Article Curr Opin Crit Care · August 2012 PURPOSE OF REVIEW: Surgical incision invariably causes some measure of nerve damage and inflammatory response that, in most cases, heals quickly without long-term negative consequence. However, a subset of these patients go on to develop lasting neuropathi ... Full text Link to item Cite

Secrets of the perioptome: new tools for a new concept.

Journal Article Curr Opin Crit Care · August 2010 PURPOSE OF REVIEW: The field of perioperative genomics is developing rapidly, and by now most practitioners are familiar with the idea that the host response to surgery and trauma is at least in part genetically determined. The precise way in which genetic ... Full text Link to item Cite

The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density.

Journal Article J Neurosci · October 12, 2005 Abnormalities in dendritic spines have long been associated with cognitive dysfunction and neurodevelopmental delay, whereas rapid changes in spine shape underlie synaptic plasticity. The key regulators of cytoskeletal reorganization in dendrites and spine ... Full text Link to item Cite

Interaction of Carbon Dioxide with Transition-Metal-Substituted Heteropolyanions in Nonpolar Solvents. Spectroscopic Evidence for Complex Formation.

Journal Article Inorg Chem · August 24, 1998 Tetraheptylammonium salts of various transition-metal-substituted heteropolyanions with alpha-Keggin ([XW(11)O(39)M](n)()(-)), alpha-Wells-Dawson ([P(2)W(17)O(61)M](m)(-)), and Weakley and Finke structures ([P(2)W(18)O(68)Co(4)](10)(-)) were investigated w ... Full text Link to item Cite