Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., New York Medical College 2006
• 

  Duke Appointment History

  • Assistant Professor of Radiology, Radiology, Neuroradiology, Radiology 2014 - 2019
• Research
• 

  Selected Grants

  • Applied Deep Learning in Pulmonary Embolism Outcome Prediction Using Imaging and Clinical Data: A Multicenter Study awarded by Stanford University 2018 - 2022
  • Development of a Novel Flexible Needle for Targeted Epidural Blood Patch of Ventral CSF Leaks 2020
  • Duke-Stanford Multicenter Investigation Predicting Imaging Outcomes of Pulmonary Embolism CT awarded by Stanford University 2017 - 2020
  • Comparison of cervical transforaminal epidural corticosteroid injections with lateralized interlaminar epidural corticosteroid injections for treatment of cervicogenic upper extremity radiculopathy 2017 - 2019
  • Deep Learning for Pulmonary Embolism Imaging Decision Support: A Multi-institutional Collaboration awarded by Stanford University 2018 - 2019
  • A randomized trial of CT fluoroscopy-guided targeted autologous blood and fibrin glue patching for treatment of imaging-confirmed CSF leaks in patients with spontaneous intracranial hypotension. awarded by Radiological Society of North America 2017 - 2018
  • An Anatomic and Radiologic Study to Define the Source and Course of the Articular Branches to the Thoracic Zygapophysial Joints awarded by Spine Intervention Society 2017
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Martín Noguerol, Teodoro, Rafael Barousse, Timothy J. Amrhein, Javier Royuela-Del-Val, Paula Montesinos, and Antonio Luna. “Optimizing Diffusion-Tensor Imaging Acquisition for Spinal Cord Assessment: Physical Basis and Technical Adjustments.” Radiographics 40, no. 2 (March 2020): 403–27. https://doi.org/10.1148/rg.2020190058.
       Full Text  Link to Item
    • Joshi, Anand, Timothy J. Amrhein, Megan A. Holmes, Joel Talsma, Megan Shonyo, and Andrea B. Taylor. “The Source and the Course of the Articular Branches to the T4-T8 Zygapophysial Joints.” Pain Med 20, no. 12 (December 1, 2019): 2371–76. https://doi.org/10.1093/pm/pnz116.
       Full Text  Link to Item
    • Griffin, Andrew S., Lucy Lu, Stephanie Peacock, Linda Gray, Peter G. Kranz, and Timothy J. Amrhein. “CSF volume provocation maneuvers during lumbar puncture as a possible predictive tool for diagnosing spontaneous intracranial hypotension.” Clin Neurol Neurosurg 186 (November 2019): 105552. https://doi.org/10.1016/j.clineuro.2019.105552.
       Full Text  Link to Item
    • Kranz, Peter G., Linda Gray, Michael D. Malinzak, and Timothy J. Amrhein. “Spontaneous Intracranial Hypotension: Pathogenesis, Diagnosis, and Treatment.” Neuroimaging Clin N Am 29, no. 4 (November 2019): 581–94. https://doi.org/10.1016/j.nic.2019.07.006.
       Full Text  Link to Item
    • Amrhein, Timothy J., Erol Bozdogan, Sunit Vekaria, Prasad Patel, Reginald Lerebours, Sheng Luo, and Peter G. Kranz. “Cross-sectional CT Assessment of the Extent of Injectate Spread at CT Fluoroscopy-guided Cervical Epidural Interlaminar Steroid Injections.” Radiology 292, no. 3 (September 2019): 723–29. https://doi.org/10.1148/radiol.2019182795.
       Full Text  Open Access Copy  Link to Item
    • Banerjee, Imon, Miji Sofela, Jaden Yang, Jonathan H. Chen, Nigam H. Shah, Robyn Ball, Alvin I. Mushlin, et al. “Development and Performance of the Pulmonary Embolism Result Forecast Model (PERFORM) for Computed Tomography Clinical Decision Support.” Jama Netw Open 2, no. 8 (August 2, 2019): e198719. https://doi.org/10.1001/jamanetworkopen.2019.8719.
       Full Text  Link to Item
    • Kranz, Peter G., Linda Gray, and Timothy J. Amrhein. “Spontaneous Intracranial Hypotension: 10 Myths and Misperceptions - An Editorial Comment.” Headache 59, no. 7 (July 2019): 977–78. https://doi.org/10.1111/head.13571.
       Full Text  Link to Item
    • Banerjee, Imon, Yuan Ling, Matthew C. Chen, Sadid A. Hasan, Curtis P. Langlotz, Nathaniel Moradzadeh, Brian Chapman, et al. “Comparative effectiveness of convolutional neural network (CNN) and recurrent neural network (RNN) architectures for radiology text report classification.” Artif Intell Med 97 (June 2019): 79–88. https://doi.org/10.1016/j.artmed.2018.11.004.
       Full Text  Link to Item
    • Kranz, P. G., L. Gray, and T. J. Amrhein. “Decubitus CT Myelography for Detecting Subtle CSF Leaks in Spontaneous Intracranial Hypotension.” Ajnr Am J Neuroradiol 40, no. 4 (April 2019): 754–56. https://doi.org/10.3174/ajnr.A5995.
       Full Text  Link to Item
    • Amrhein, Timothy J., and Peter G. Kranz. “Spontaneous Intracranial Hypotension: Imaging in Diagnosis and Treatment.” Radiol Clin North Am 57, no. 2 (March 2019): 439–51. https://doi.org/10.1016/j.rcl.2018.10.004.
       Full Text  Link to Item
    • Kranz, Peter G., and Timothy J. Amrhein. “Imaging Approach to Myelopathy: Acute, Subacute, and Chronic.” Radiol Clin North Am 57, no. 2 (March 2019): 257–79. https://doi.org/10.1016/j.rcl.2018.09.006.
       Full Text  Link to Item
    • Patel, Bhavik N., Louis Rosenberg, Gregg Willcox, David Baltaxe, Mimi Lyons, Jeremy Irvin, Pranav Rajpurkar, et al. “Human-machine partnership with artificial intelligence for chest radiograph diagnosis.” Npj Digit Med 2 (2019): 111. https://doi.org/10.1038/s41746-019-0189-7.
       Full Text  Link to Item
    • Patel, Bhavik N., Louis Rosenberg, Gregg Willcox, David Baltaxe, Mimi Lyons, Jeremy Irvin, Pranav Rajpurkar, et al. “Erratum: Author Correction: Human-machine partnership with artificial intelligence for chest radiograph diagnosis.” Npj Digit Med 2 (2019): 129. https://doi.org/10.1038/s41746-019-0198-6.
       Full Text  Link to Item
    • Rajpurkar, Pranav, Jeremy Irvin, Robyn L. Ball, Kaylie Zhu, Brandon Yang, Hershel Mehta, Tony Duan, et al. “Deep learning for chest radiograph diagnosis: A retrospective comparison of the CheXNeXt algorithm to practicing radiologists.” Plos Med 15, no. 11 (November 2018): e1002686. https://doi.org/10.1371/journal.pmed.1002686.
       Full Text  Link to Item
    • Haskell, Gloria T., Mari Mori, Cynthia Powell, Timothy J. Amrhein, Gillian I. Rice, Lauren Bailey, Natasha Strande, et al. “Combination of exome sequencing and immune testing confirms Aicardi-Goutières syndrome type 5 in a challenging pediatric neurology case.” Cold Spring Harb Mol Case Stud 4, no. 5 (October 2018). https://doi.org/10.1101/mcs.a002758.
       Full Text  Link to Item
    • Kranz, Peter G., Michael D. Malinzak, and Timothy J. Amrhein. “Approach to Imaging in Patients with Spontaneous Intracranial Hemorrhage.” Neuroimaging Clin N Am 28, no. 3 (August 2018): 353–74. https://doi.org/10.1016/j.nic.2018.03.003.
       Full Text  Link to Item
    • Parivash, Sherveen N., Peter G. Kranz, Linda Gray, and Timothy J. Amrhein. “CT Fluoroscopy-Guided Interlaminar Epidural Steroid Injections in the Cervical Spine: Rate of Nontarget Injection Into the Retrodural Space of Okada.” Ajr Am J Roentgenol 211, no. 2 (August 2018): 426–31. https://doi.org/10.2214/AJR.18.19606.
       Full Text  Link to Item
    • Kranz, Peter G., Linda Gray, and Timothy J. Amrhein. “Spontaneous Intracranial Hypotension: 10 Myths and Misperceptions.” Headache 58, no. 7 (July 2018): 948–59. https://doi.org/10.1111/head.13328.
       Full Text  Link to Item
    • Chen, Matthew C., Robyn L. Ball, Lingyao Yang, Nathaniel Moradzadeh, Brian E. Chapman, David B. Larson, Curtis P. Langlotz, Timothy J. Amrhein, and Matthew P. Lungren. “Deep Learning to Classify Radiology Free-Text Reports.” Radiology 286, no. 3 (March 2018): 845–52. https://doi.org/10.1148/radiol.2017171115.
       Full Text  Link to Item
    • Kranz, Peter G., Timothy J. Amrhein, and Linda Gray. “CSF Venous Fistulas in Spontaneous Intracranial Hypotension: Imaging Characteristics on Dynamic and CT Myelography.” Ajr Am J Roentgenol 209, no. 6 (December 2017): 1360–66. https://doi.org/10.2214/AJR.17.18351.
       Full Text  Link to Item
    • Amrhein, T. J., S. N. Parivash, L. Gray, and P. G. Kranz. “Incidence of Inadvertent Dural Puncture During CT Fluoroscopy-Guided Interlaminar Epidural Corticosteroid Injections in the Cervical Spine: An Analysis of 974 Cases.” Ajr Am J Roentgenol 209, no. 3 (September 2017): 656–61. https://doi.org/10.2214/AJR.16.17738.
       Full Text  Link to Item
    • Kranz, Peter G., Michael D. Malinzak, Timothy J. Amrhein, and Linda Gray. “Update on the Diagnosis and Treatment of Spontaneous Intracranial Hypotension.” Curr Pain Headache Rep 21, no. 8 (August 2017): 37. https://doi.org/10.1007/s11916-017-0639-3.
       Full Text  Link to Item
    • Hassanpour, Saeed, Curtis P. Langlotz, Timothy J. Amrhein, Nicholas T. Befera, and Matthew P. Lungren. “Performance of a Machine Learning Classifier of Knee MRI Reports in Two Large Academic Radiology Practices: A Tool to Estimate Diagnostic Yield.” Ajr Am J Roentgenol 208, no. 4 (April 2017): 750–53. https://doi.org/10.2214/AJR.16.16128.
       Full Text  Link to Item
    • Amrhein, Timothy J., William Mostertz, Maria Gisele Matheus, Genevieve Maass-Bolles, Komal Sharma, Heather R. Collins, and Peter G. Kranz. “Reformatted images improve the detection rate of acute traumatic subdural hematomas on brain CT compared with axial images alone.” Emerg Radiol 24, no. 1 (February 2017): 39–45. https://doi.org/10.1007/s10140-016-1440-z.
       Full Text  Link to Item
    • Kranz, P. G., A. B. Joshi, L. A. Roy, K. R. Choudhury, and T. J. Amrhein. “Inadvertent Intrafacet Injection during Lumbar Interlaminar Epidural Steroid Injection: A Comparison of CT Fluoroscopic and Conventional Fluoroscopic Guidance.” Ajnr Am J Neuroradiol 38, no. 2 (February 2017): 398–402. https://doi.org/10.3174/ajnr.A5000.
       Full Text  Link to Item
    • Ceponis, Peter J., William Fox, Tina D. Tailor, Lynne M. Hurwitz, Timothy J. Amrhein, and Richard E. Moon. “Non-dysbaric arterial gas embolism associated with chronic necrotizing pneumonia, bullae and coughing: a case report.” Undersea Hyperb Med 44, no. 1 (January 2017): 73–77. https://doi.org/10.22462/1.2.2017.16.
       Full Text  Link to Item
    • Kranz, Peter G., Timothy J. Amrhein, Kingshuk Roy Choudhury, Teerath Peter Tanpitukpongse, and Linda Gray. “Time-Dependent Changes in Dural Enhancement Associated With Spontaneous Intracranial Hypotension.” Ajr Am J Roentgenol 207, no. 6 (December 2016): 1283–87. https://doi.org/10.2214/AJR.16.16381.
       Full Text  Link to Item
    • Kranz, Peter G., Teerath P. Tanpitukpongse, Kingshuk Roy Choudhury, Timothy J. Amrhein, and Linda Gray. “How common is normal cerebrospinal fluid pressure in spontaneous intracranial hypotension?” Cephalalgia 36, no. 13 (November 2016): 1209–17. https://doi.org/10.1177/0333102415623071.
       Full Text  Link to Item
    • Amrhein, T. J., N. T. Befera, L. Gray, and P. G. Kranz. “CT Fluoroscopy-Guided Blood Patching of Ventral CSF Leaks by Direct Needle Placement in the Ventral Epidural Space Using a Transforaminal Approach.” Ajnr Am J Neuroradiol 37, no. 10 (October 2016): 1951–56. https://doi.org/10.3174/ajnr.A4842.
       Full Text  Link to Item
    • Amrhein, Timothy J., Anand B. Joshi, and Peter G. Kranz. “Technique for CT Fluoroscopy-Guided Lumbar Medial Branch Blocks and Radiofrequency Ablation.” Ajr Am J Roentgenol 207, no. 3 (September 2016): 631–34. https://doi.org/10.2214/AJR.15.15694.
       Full Text  Link to Item
    • Ruth, N. M., T. Amrhein, M. Passo, and G. Gilkeson. “Childhood-onset Systemic Lupus Erythematosus Complicated by Posterior Reversible Encephalopathy Syndrome in the Context of Kidney Dialysis and Plasma Exchange in Pediatric Lupus.” Journal of Pediatric Neurology 14, no. 3 (September 1, 2016): 105–9. https://doi.org/10.1055/s-0036-1587600.
       Full Text
    • Kranz, P. G., T. J. Amrhein, W. I. Schievink, I. O. Karikari, and L. Gray. “The "Hyperdense Paraspinal Vein" Sign: A Marker of CSF-Venous Fistula.” Ajnr Am J Neuroradiol 37, no. 7 (July 2016): 1379–81. https://doi.org/10.3174/ajnr.A4682.
       Full Text  Link to Item
    • Kranz, P. G., T. P. Tanpitukpongse, K. R. Choudhury, T. J. Amrhein, and L. Gray. “Imaging Signs in Spontaneous Intracranial Hypotension: Prevalence and Relationship to CSF Pressure.” Ajnr Am J Neuroradiol 37, no. 7 (July 2016): 1374–78. https://doi.org/10.3174/ajnr.A4689.
       Full Text  Link to Item
    • Amrhein, Timothy J., J Scott Schauberger, Peter G. Kranz, and Jenny K. Hoang. “Reducing Patient Radiation Exposure From CT Fluoroscopy-Guided Lumbar Spine Pain Injections by Targeting the Planning CT.” Ajr Am J Roentgenol 206, no. 2 (February 2016): 390–94. https://doi.org/10.2214/AJR.15.14436.
       Full Text  Link to Item
    • Kranz, Peter G., Patrick H. Luetmer, Felix E. Diehn, Timothy J. Amrhein, Teerath Peter Tanpitukpongse, and Linda Gray. “Myelographic Techniques for the Detection of Spinal CSF Leaks in Spontaneous Intracranial Hypotension.” Ajr Am J Roentgenol 206, no. 1 (January 2016): 8–19. https://doi.org/10.2214/AJR.15.14884.
       Full Text  Link to Item
    • Kranz, P. G., T. J. Amrhein, and L. Gray. “Incidence of Inadvertent Intravascular Injection during CT Fluoroscopy-Guided Epidural Steroid Injections.” Ajnr Am J Neuroradiol 36, no. 5 (May 2015): 1000–1007. https://doi.org/10.3174/ajnr.A4219.
       Full Text  Link to Item
    • Kranz, Peter G., Timothy J. Amrhein, and James M. Provenzale. “Spontaneous brain parenchymal hemorrhage: an approach to imaging for the emergency room radiologist.” Emerg Radiol 22, no. 1 (February 2015): 53–63. https://doi.org/10.1007/s10140-014-1245-x.
       Full Text  Link to Item
    • Amrhein, Timothy J., Ali Tabesh, Heather R. Collins, Leonie L. Gordon, Joseph A. Helpern, and Jens H. Jensen. “Instituting a radiology residency scholarly activity program.” Educ Health (Abingdon) 28, no. 1 (January 2015): 68–73. https://doi.org/10.4103/1357-6283.161906.
       Full Text  Link to Item
    • Amrhein, T. J., B. E. Paxton, M. P. Lungren, N. T. Befera, H. R. Collins, C. Yurko, J. D. Eastwood, and R. K. Kilani. “Physician self-referral and imaging use appropriateness: negative cervical spine MRI frequency as an assessment metric.” Ajnr Am J Neuroradiol 35, no. 12 (December 2014): 2248–53. https://doi.org/10.3174/ajnr.A4076.
       Full Text  Link to Item
    • Kranz, P. G., T. J. Amrhein, and L. Gray. “Rebound intracranial hypertension: a complication of epidural blood patching for intracranial hypotension.” Ajnr Am J Neuroradiol 35, no. 6 (June 2014): 1237–40. https://doi.org/10.3174/ajnr.A3841.
       Full Text  Link to Item
    • Lungren, Matthew P., Timothy J. Amrhein, Ben E. Paxton, Ramesh C. Srinivasan, Heather R. Collins, James D. Eastwood, and Ramsey K. Kilani. “Physician self-referral: frequency of negative findings at MR imaging of the knee as a marker of appropriate utilization.” Radiology 269, no. 3 (December 2013): 810–15. https://doi.org/10.1148/radiol.13130281.
       Full Text  Link to Item
    • Amrhein, Timothy J., Matthew P. Lungren, Ben E. Paxton, Ramesh Srinivasan, Sin-Ho Jung, Miao Yu, James D. Eastwood, and Ramsey K. Kilani. “Journal Club: Shoulder MRI utilization: relationship of physician MRI equipment ownership to negative study frequency.” Ajr Am J Roentgenol 201, no. 3 (September 2013): 605–10. https://doi.org/10.2214/AJR.12.9977.
       Full Text  Link to Item
    • Mouraviev, Vladimir, Talaignair N. Venkatraman, Artak Tovmasyan, Masaki Kimura, Matvey Tsivian, Vladimira Mouravieva, Tom J. Polascik, et al. “Mn porphyrins as novel molecular magnetic resonance imaging contrast agents.” J Endourol 26, no. 11 (November 2012): 1420–24. https://doi.org/10.1089/end.2012.0171.
       Full Text  Link to Item
    • Mouraviev, Vladimir, Talaignair N. Venkatraman, Artak Tovmasyan, Masaki Kimura, Matvey Tsivian, Vladimira Mouravieva, Tom J. Polascik, et al. “Mn-porphyrins as novel molecular magnetic resonance imaging contrast agents.” J Endourol, November 3, 2011, 1420–24. https://doi.org/10.1089/end.2011.0133.
       Full Text  Link to Item
    • Amrhein, Timothy J., Charles Kim, Tony P. Smith, and L. Washington. “Bronchial artery arising from the left vertebral artery: case report and review of the literature.” J Clin Imaging Sci 1 (2011): 62. https://doi.org/10.4103/2156-7514.91135.
       Full Text  Link to Item
    • Cosetti, Maura, Timothy Amrhein, and Christopher Linstrom. “Perioperative management of intracranial aneurysms and otologic disease.” Laryngoscope 117, no. 1 (January 2007): 35–39. https://doi.org/10.1097/01.mlg.0000246695.16366.c5.
       Full Text  Link to Item

  • Book Sections

    • Amrhein, T. J., J. P. Jennings, C. M. Carr, and W. S. Bartynski. “Back pain.” In Imaging Acute Neurologic Disease: A Symptom-Based Approach, 76–90, 2014. https://doi.org/10.1017/CBO9781139565653.006.
       Full Text
    • Amrhein, T. J., and C. Y. Kim. “Vascular radiology: Case 20.” In Duke Radiology Case Review: Imaging, Differential Diagnosis, and Discussion: 2nd Edition, 420–21, 2012.
    • Kim, C. Y., G. E. Newman, T. P. Smith, D. J. Stackhouse, P. V. Suhocki, C. S. Payne, K. Husum, et al. “Vascular radiology.” In Duke Radiology Case Review: Imaging, Differential Diagnosis, and Discussion: 2nd Edition, 2012.

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.