Timothy James Amrhein | Scholars@Duke

Timothy James Amrhein
Assistant Professor of Radiology

Current Appointments & Affiliations

Assistant Professor of Radiology, Radiology, Neuroradiology, Radiology 2014

Contact Information

Box 3808 Med Ctr, Durham, NC 27710
Dept of Radiology, Durham, NC 27710
(919) 684-8111

Background
Education, Training, & Certifications
- M.D., New York Medical College 2006
Research
Selected Grants
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Kranz, PG, Gray, L, and Amrhein, TJ. "Decubitus CT Myelography for Detecting Subtle CSF Leaks in Spontaneous Intracranial Hypotension." Ajnr. American Journal of Neuroradiology 40, no. 4 (April 2019): 754-756. Full Text
  - Amrhein, Timothy J., and Peter G. Kranz. “Spontaneous Intracranial Hypotension: Imaging in Diagnosis and Treatment..” Radiologic Clinics of North America 57, no. 2 (March 2019): 439–51. https://doi.org/10.1016/j.rcl.2018.10.004.
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  - Kranz, Peter G., and Timothy J. Amrhein. “Imaging Approach to Myelopathy: Acute, Subacute, and Chronic..” Radiologic Clinics of North America 57, no. 2 (March 2019): 257–79. https://doi.org/10.1016/j.rcl.2018.09.006.
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  - Rajpurkar, P, Irvin, J, Ball, RL, Zhu, K, Yang, B, Mehta, H, Duan, T, Ding, D, Bagul, A, Langlotz, CP, Patel, BN, Yeom, KW, Shpanskaya, K, Blankenberg, FG, Seekins, J, Amrhein, TJ, Mong, DA, Halabi, SS, Zucker, EJ, Ng, AY, and Lungren, MP. "Deep learning for chest radiograph diagnosis: A retrospective comparison of the CheXNeXt algorithm to practicing radiologists." Plos Medicine 15, no. 11 (November 20, 2018): e1002686-null. Full Text
  - Haskell, Gloria T., Mari Mori, Cynthia Powell, Timothy J. Amrhein, Gillian I. Rice, Lauren Bailey, Natasha Strande, et al. “Combination of exome sequencing and immune testing confirms Aicardi-Goutières syndrome type 5 in a challenging pediatric neurology case..” Cold Spring Harbor Molecular Case Studies 4, no. 5 (October 2018). https://doi.org/10.1101/mcs.a002758.
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  - Kranz, Peter G., Michael D. Malinzak, and Timothy J. Amrhein. “Approach to Imaging in Patients with Spontaneous Intracranial Hemorrhage..” Neuroimaging Clinics of North America 28, no. 3 (August 2018): 353–74. https://doi.org/10.1016/j.nic.2018.03.003.
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  - Parivash, SN, Kranz, PG, Gray, L, and Amrhein, TJ. "CT Fluoroscopy-Guided Interlaminar Epidural Steroid Injections in the Cervical Spine: Rate of Nontarget Injection Into the Retrodural Space of Okada." Ajr. American Journal of Roentgenology 211, no. 2 (August 2018): 426-431. Full Text
  - Kranz, Peter G., Linda Gray, and Timothy J. Amrhein. “Spontaneous Intracranial Hypotension: 10 Myths and Misperceptions..” Headache 58, no. 7 (July 2018): 948–59. https://doi.org/10.1111/head.13328.
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  - Chen, Matthew C., Robyn L. Ball, Lingyao Yang, Nathaniel Moradzadeh, Brian E. Chapman, David B. Larson, Curtis P. Langlotz, Timothy J. Amrhein, and Matthew P. Lungren. “Deep Learning to Classify Radiology Free-Text Reports..” Radiology 286, no. 3 (March 2018): 845–52. https://doi.org/10.1148/radiol.2017171115.
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  - Banerjee, I., Y. Ling, M. C. Chen, S. A. Hasan, C. P. Langlotz, N. Moradzadeh, B. Chapman, et al. “Comparative effectiveness of convolutional neural network (CNN) and recurrent neural network (RNN) architectures for radiology text report classification.” Artificial Intelligence in Medicine, January 1, 2018. https://doi.org/10.1016/j.artmed.2018.11.004.
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  - Kranz, Peter G., Timothy J. Amrhein, and Linda Gray. “CSF Venous Fistulas in Spontaneous Intracranial Hypotension: Imaging Characteristics on Dynamic and CT Myelography..” Ajr. American Journal of Roentgenology 209, no. 6 (December 2017): 1360–66. https://doi.org/10.2214/ajr.17.18351.
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  - Amrhein, T. J., S. N. Parivash, L. Gray, and P. G. Kranz. “Incidence of Inadvertent Dural Puncture During CT Fluoroscopy-Guided Interlaminar Epidural Corticosteroid Injections in the Cervical Spine: An Analysis of 974 Cases..” Ajr. American Journal of Roentgenology 209, no. 3 (September 2017): 656–61. https://doi.org/10.2214/ajr.16.17738.
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  - Kranz, Peter G., Michael D. Malinzak, Timothy J. Amrhein, and Linda Gray. “Update on the Diagnosis and Treatment of Spontaneous Intracranial Hypotension..” Current Pain and Headache Reports 21, no. 8 (August 2017). https://doi.org/10.1007/s11916-017-0639-3.
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  - Hassanpour, Saeed, Curtis P. Langlotz, Timothy J. Amrhein, Nicholas T. Befera, and Matthew P. Lungren. “Performance of a Machine Learning Classifier of Knee MRI Reports in Two Large Academic Radiology Practices: A Tool to Estimate Diagnostic Yield..” Ajr. American Journal of Roentgenology 208, no. 4 (April 2017): 750–53. https://doi.org/10.2214/ajr.16.16128.
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  - Amrhein, Timothy J., William Mostertz, Maria Gisele Matheus, Genevieve Maass-Bolles, Komal Sharma, Heather R. Collins, and Peter G. Kranz. “Reformatted images improve the detection rate of acute traumatic subdural hematomas on brain CT compared with axial images alone..” Emergency Radiology 24, no. 1 (February 2017): 39–45. https://doi.org/10.1007/s10140-016-1440-z.
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  - Kranz, P. G., A. B. Joshi, L. A. Roy, K. R. Choudhury, and T. J. Amrhein. “Inadvertent Intrafacet Injection during Lumbar Interlaminar Epidural Steroid Injection: A Comparison of CT Fluoroscopic and Conventional Fluoroscopic Guidance..” Ajnr. American Journal of Neuroradiology 38, no. 2 (February 2017): 398–402. https://doi.org/10.3174/ajnr.a5000.
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  - Ceponis, Peter J., William Fox, Tina D. Tailor, Lynne M. Hurwitz, Timothy J. Amrhein, and Richard E. Moon. “Non-dysbaric arterial gas embolism associated with chronic necrotizing pneumonia, bullae and coughing: a case report..” Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc 44, no. 1 (January 2017): 73–77.
  - Kranz, Peter G., Timothy J. Amrhein, Kingshuk Roy Choudhury, Teerath Peter Tanpitukpongse, and Linda Gray. “Time-Dependent Changes in Dural Enhancement Associated With Spontaneous Intracranial Hypotension..” Ajr. American Journal of Roentgenology 207, no. 6 (December 2016): 1283–87. https://doi.org/10.2214/ajr.16.16381.
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  - Kranz, Peter G., Teerath P. Tanpitukpongse, Kingshuk Roy Choudhury, Timothy J. Amrhein, and Linda Gray. “How common is normal cerebrospinal fluid pressure in spontaneous intracranial hypotension?.” Cephalalgia : An International Journal of Headache 36, no. 13 (November 2016): 1209–17. https://doi.org/10.1177/0333102415623071.
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  - Amrhein, T. J., N. T. Befera, L. Gray, and P. G. Kranz. “CT Fluoroscopy-Guided Blood Patching of Ventral CSF Leaks by Direct Needle Placement in the Ventral Epidural Space Using a Transforaminal Approach..” Ajnr. American Journal of Neuroradiology 37, no. 10 (October 2016): 1951–56. https://doi.org/10.3174/ajnr.a4842.
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  - Amrhein, Timothy J., Anand B. Joshi, and Peter G. Kranz. “Technique for CT Fluoroscopy-Guided Lumbar Medial Branch Blocks and Radiofrequency Ablation..” Ajr. American Journal of Roentgenology 207, no. 3 (September 2016): 631–34. https://doi.org/10.2214/ajr.15.15694.
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  - Ruth, N. M., T. Amrhein, M. Passo, and G. Gilkeson. “Childhood-onset Systemic Lupus Erythematosus Complicated by Posterior Reversible Encephalopathy Syndrome in the Context of Kidney Dialysis and Plasma Exchange in Pediatric Lupus.” Journal of Pediatric Neurology 14, no. 3 (September 1, 2016): 105–9. https://doi.org/10.1055/s-0036-1587600.
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  - Kranz, P. G., T. J. Amrhein, W. I. Schievink, I. O. Karikari, and L. Gray. “The "Hyperdense Paraspinal Vein" Sign: A Marker of CSF-Venous Fistula..” Ajnr. American Journal of Neuroradiology 37, no. 7 (July 2016): 1379–81. https://doi.org/10.3174/ajnr.a4682.
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  - Kranz, P. G., T. P. Tanpitukpongse, K. R. Choudhury, T. J. Amrhein, and L. Gray. “Imaging Signs in Spontaneous Intracranial Hypotension: Prevalence and Relationship to CSF Pressure..” Ajnr. American Journal of Neuroradiology 37, no. 7 (July 2016): 1374–78. https://doi.org/10.3174/ajnr.a4689.
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  - Amrhein, Timothy J., J Scott Schauberger, Peter G. Kranz, and Jenny K. Hoang. “Reducing Patient Radiation Exposure From CT Fluoroscopy-Guided Lumbar Spine Pain Injections by Targeting the Planning CT..” Ajr. American Journal of Roentgenology 206, no. 2 (February 2016): 390–94. https://doi.org/10.2214/ajr.15.14436.
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  - Kranz, Peter G., Patrick H. Luetmer, Felix E. Diehn, Timothy J. Amrhein, Teerath Peter Tanpitukpongse, and Linda Gray. “Myelographic Techniques for the Detection of Spinal CSF Leaks in Spontaneous Intracranial Hypotension..” Ajr. American Journal of Roentgenology 206, no. 1 (January 2016): 8–19. https://doi.org/10.2214/ajr.15.14884.
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  - Kranz, P. G., T. J. Amrhein, and L. Gray. “Incidence of Inadvertent Intravascular Injection during CT Fluoroscopy-Guided Epidural Steroid Injections..” Ajnr. American Journal of Neuroradiology 36, no. 5 (May 2015): 1000–1007. https://doi.org/10.3174/ajnr.a4219.
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  - Kranz, Peter G., Timothy J. Amrhein, and James M. Provenzale. “Spontaneous brain parenchymal hemorrhage: an approach to imaging for the emergency room radiologist..” Emergency Radiology 22, no. 1 (February 2015): 53–63. https://doi.org/10.1007/s10140-014-1245-x.
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  - Amrhein, Timothy J., Ali Tabesh, Heather R. Collins, Leonie L. Gordon, Joseph A. Helpern, and Jens H. Jensen. “Instituting a radiology residency scholarly activity program..” Education for Health (Abingdon, England) 28, no. 1 (January 2015): 68–73. https://doi.org/10.4103/1357-6283.161906.
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  - Amrhein, T. J., B. E. Paxton, M. P. Lungren, N. T. Befera, H. R. Collins, C. Yurko, J. D. Eastwood, and R. K. Kilani. “Physician self-referral and imaging use appropriateness: negative cervical spine MRI frequency as an assessment metric..” Ajnr. American Journal of Neuroradiology 35, no. 12 (December 2014): 2248–53. https://doi.org/10.3174/ajnr.a4076.
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  - Kranz, P. G., T. J. Amrhein, and L. Gray. “Rebound intracranial hypertension: a complication of epidural blood patching for intracranial hypotension..” Ajnr. American Journal of Neuroradiology 35, no. 6 (June 2014): 1237–40. https://doi.org/10.3174/ajnr.a3841.
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  - Kranz, P. G., T. J. Amrhein, and J. M. Provenzale. “Spontaneous brain parenchymal hemorrhage: an approach to imaging for the emergency room radiologist.” Emergency Radiology 22, no. 1 (2014): 53–63. https://doi.org/10.1007/s10140-014-1245-x.
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  - Lungren, Matthew P., Timothy J. Amrhein, Ben E. Paxton, Ramesh C. Srinivasan, Heather R. Collins, James D. Eastwood, and Ramsey K. Kilani. “Physician self-referral: frequency of negative findings at MR imaging of the knee as a marker of appropriate utilization..” Radiology 269, no. 3 (December 2013): 810–15. https://doi.org/10.1148/radiol.13130281.
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  - Amrhein, Timothy J., Matthew P. Lungren, Ben E. Paxton, Ramesh Srinivasan, Sin-Ho Jung, Miao Yu, James D. Eastwood, and Ramsey K. Kilani. “Journal Club: Shoulder MRI utilization: relationship of physician MRI equipment ownership to negative study frequency..” Ajr. American Journal of Roentgenology 201, no. 3 (September 2013): 605–10. https://doi.org/10.2214/ajr.12.9977.
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  - Mouraviev, Vladimir, Talaignair N. Venkatraman, Artak Tovmasyan, Masaki Kimura, Matvey Tsivian, Vladimira Mouravieva, Tom J. Polascik, et al. “Mn porphyrins as novel molecular magnetic resonance imaging contrast agents..” Journal of Endourology 26, no. 11 (November 2012): 1420–24. https://doi.org/10.1089/end.2012.0171.
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  - Mouraviev, Vladimir, Talaignair N. Venkatraman, Artak Tovmasyan, Masaki Kimura, Matvey Tsivian, Vladimira Mouravieva, Tom J. Polascik, et al. “Mn-porphyrins as novel molecular magnetic resonance imaging contrast agents..” Journal of Endourology, November 3, 2011, 1420–24. https://doi.org/10.1089/end.2011.0133.
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  - Amrhein, Timothy J., Charles Kim, Tony P. Smith, and L. Washington. “Bronchial artery arising from the left vertebral artery: case report and review of the literature..” Journal of Clinical Imaging Science 1 (January 2011). https://doi.org/10.4103/2156-7514.91135.
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  - Cosetti, Maura, Timothy Amrhein, and Christopher Linstrom. “Perioperative management of intracranial aneurysms and otologic disease..” The Laryngoscope 117, no. 1 (January 2007): 35–39. https://doi.org/10.1097/01.mlg.0000246695.16366.c5.
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- Book Sections
  - Amrhein, T. J., J. P. Jennings, C. M. Carr, and W. S. Bartynski. “Back pain.” In Imaging Acute Neurologic Disease: A Symptom-Based Approach, 76–90, 2014. https://doi.org/10.1017/CBO9781139565653.006.
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  - Amrhein, T. J., and C. Y. Kim. “Vascular radiology: Case 20.” In Duke Radiology Case Review: Imaging, Differential Diagnosis, and Discussion: 2nd Edition, 420–21, 2012.
  - Kim, C. Y., G. E. Newman, T. P. Smith, D. J. Stackhouse, P. V. Suhocki, C. S. Payne, K. Husum, et al. “Vascular radiology.” In Duke Radiology Case Review: Imaging, Differential Diagnosis, and Discussion: 2nd Edition, 2012.

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Education, Training, & Certifications

Selected Grants

Selected Publications

Academic Articles

Book Sections