Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Postdoctoral Fellow, Nephrology, Duke University School of Medicine 2015 - 2018
  • Postdoctoral Fellow, Karolinska Institutet (Sweden) 2012 - 2015
  • Honorary Research Associate, Imperial College London (United Kingdom) 2009 - 2012
  • Assistant Specialist, University of California - San Francisco 2010 - 2011
  • Resident, Peking University First Hospital, Peking University (China) 2005 - 2010
  • Ph.D., Peking University (China) 2010
  • M.S., Peking University (China) 2007
  • M.D., Peking University (China) 2005
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Medicine, Medicine, Nephrology, Medicine 2020
  • Medical Instructor in the Department of Medicine, Medicine, Nephrology, Medicine 2018 - 2020
• Recognition
• 

  Awards & Honors

  • DOM Chair's Research Award. Department of Medicine, Duke University School of Medicine. 2018
  • POLM Young Investigator Award. 17th International Winter Eicosanoid Conference. 2018
  • AHA Hypertension Council New Investigator Award. American Heart Association High Blood Pressure Research 2016 Scientific Session. 2016
  • AHA Kidney Council New Investigator Award. American Heart Association High Blood Pressure Research 2014 Scientific Session. 2014
  • International Chinese Academy of Anesthesiology Annual Meeting, Best Presentation Award. International Chinese Academy of Anesthesiology Annual Meeting. 2014
  • Scholarship for Academic Training at Imperial College London. Chinese Society of Anestheisologists. 2009
  • Peking University Student Excellence Awards. Peking Univeristy. 2004
  • Medical Excellence Awards. Peking University. 2003
• Expertise
• 

  Subject Headings

  • Essential hypertension
  • Hypertension
  • Hypertension, Renal
  • Hypertension, Renovascular
  • Hypertension--Animal models--Congresses
• Research
• 

  Selected Grants

  • Renal epithelial actions of the prostaglandin EP4 receptor in blood pressure control awarded by ASN Foundation for Kidney Research 2020 - 2022
  • TEST THE EFFICACY OF EXALYS EP4 ANTAGONIST TO PREVENT NEUROINFLAMMATION AND DELIRIUM IN A PRECLINICAL MODEL awarded by Exalys Therapeutics, Inc 2020 - 2021
  • Paracrine Control of Blood Pressure by Renal Intercalated Cells awarded by National Institutes of Health 2015 - 2020
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Yang, Ting, Ravikanth Velagapudi, and Niccolò Terrando. “Neuroinflammation after surgery: from mechanisms to therapeutic targets.” Nat Immunol 21, no. 11 (November 2020): 1319–26. https://doi.org/10.1038/s41590-020-00812-1.
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    • Wang, Ping, Ravikanth Velagapudi, Cuicui Kong, Ramona M. Rodriguiz, William C. Wetsel, Ting Yang, Miles Berger, Harris A. Gelbard, Carol A. Colton, and Niccolò Terrando. “Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia.” Alzheimers Dement 16, no. 5 (May 2020): 734–49. https://doi.org/10.1002/alz.12064.
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    • Yang, T., G. Xu, P. T. Newton, A. S. Chagin, S. Mkrtchian, M. Carlström, X. -. M. Zhang, et al. “Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders.” Br J Anaesth 122, no. 3 (March 2019): 350–60. https://doi.org/10.1016/j.bja.2018.10.062.
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    • Herrera, Marcela, Ting Yang, Matthew A. Sparks, Michael W. Manning, Beverly H. Koller, and Thomas M. Coffman. “Complex Role for E-Prostanoid 4 Receptors in Hypertension.” J Am Heart Assoc 8, no. 4 (February 19, 2019): e010745. https://doi.org/10.1161/JAHA.118.010745.
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    • Yang, Ting, and Niccolò Terrando. “The Evolving Role of Specialized Pro-resolving Mediators in Modulating Neuroinflammation in Perioperative Neurocognitive Disorders.” Adv Exp Med Biol 1161 (2019): 27–35. https://doi.org/10.1007/978-3-030-21735-8_4.
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    • Yuan, Ting, Ting Yang, Huan Chen, Danli Fu, Yangyang Hu, Jing Wang, Qing Yuan, Hong Yu, Wenfeng Xu, and Xiang Xie. “New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis.” Redox Biol 20 (January 2019): 247–60. https://doi.org/10.1016/j.redox.2018.09.025.
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    • Eriksson, Karin E., Ting Yang, Mattias Carlström, and Eddie Weitzberg. “Organ uptake and release of inorganic nitrate and nitrite in the pig.” Nitric Oxide 75 (May 1, 2018): 16–26. https://doi.org/10.1016/j.niox.2018.02.001.
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    • Yang, Ting, Xing-Mei Zhang, Laura Tarnawski, Maria Peleli, Zhengbing Zhuge, Niccolo Terrando, Robert A. Harris, et al. “Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress.” Redox Biol 13 (October 2017): 320–30. https://doi.org/10.1016/j.redox.2017.06.002.
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    • Stegbauer, Johannes, Daian Chen, Marcela Herrera, Matthew A. Sparks, Ting Yang, Eva Königshausen, Susan B. Gurley, and Thomas M. Coffman. “Resistance to hypertension mediated by intercalated cells of the collecting duct.” Jci Insight 2, no. 7 (April 6, 2017): e92720. https://doi.org/10.1172/jci.insight.92720.
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    • Zhang, Ming-Dong, Swapnali Barde, Ting Yang, Beilei Lei, Lars I. Eriksson, Joseph P. Mathew, Thomas Andreska, et al. “Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels.” Proc Natl Acad Sci U S A 113, no. 43 (October 25, 2016): E6686–95. https://doi.org/10.1073/pnas.1614017113.
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    • Li, Yuping, Ke Pan, Lin Chen, Jiao-Lin Ning, Xiaojun Li, Ting Yang, Niccolò Terrando, Jianteng Gu, and Guocai Tao. “Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction.” J Neuroinflammation 13, no. 1 (October 12, 2016): 268. https://doi.org/10.1186/s12974-016-0740-2.
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    • Yang, Ting, Christa Zollbrecht, Malin E. Winerdal, Zhengbing Zhuge, Xing-Mei Zhang, Niccolo Terrando, Antonio Checa, et al. “Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension.” J Am Heart Assoc 5, no. 7 (July 18, 2016). https://doi.org/10.1161/JAHA.116.003868.
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    • Kan, Min Hui, Ting Yang, Hui Qun Fu, Long Fan, Yan Wu, Niccolò Terrando, and Tian-Long Wang. “Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats.” Front Aging Neurosci 8 (2016): 175. https://doi.org/10.3389/fnagi.2016.00175.
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    • Peleli, Maria, Ammar Al-Mashhadi, Ting Yang, Erik Larsson, Nils Wåhlin, Boye L. Jensen, A Erik G Persson, and Mattias Carlström. “Renal denervation attenuates NADPH oxidase-mediated oxidative stress and hypertension in rats with hydronephrosis.” Am J Physiol Renal Physiol 310, no. 1 (January 1, 2016): F43–56. https://doi.org/10.1152/ajprenal.00345.2015.
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    • Terrando, Niccolò, Ting Yang, Xueqin Wang, Jiakai Fang, Mengya Cao, Ulf Andersson, Harris Helena Erlandsson, Wen Ouyang, and Jianbin Tong. “Systemic HMGB1 Neutralization Prevents Postoperative Neurocognitive Dysfunction in Aged Rats.” Front Immunol 7 (2016): 441. https://doi.org/10.3389/fimmu.2016.00441.
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    • Carlström, Mattias, Ming Liu, Ting Yang, Christa Zollbrecht, Liyue Huang, Maria Peleli, Sara Borniquel, et al. “Cross-talk Between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis.” Antioxid Redox Signal 23, no. 4 (August 1, 2015): 295–306. https://doi.org/10.1089/ars.2013.5481.
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    • Yang, Ting, Xiang Gao, Monica Sandberg, Christa Zollbrecht, Xing-Mei Zhang, Michael Hezel, Ming Liu, et al. “Abrogation of adenosine A1 receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses.” Diabetologia 58, no. 7 (July 2015): 1610–20. https://doi.org/10.1007/s00125-015-3570-3.
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    • Yang, Ting, Maria Peleli, Christa Zollbrecht, Alessia Giulietti, Niccolo Terrando, Jon O. Lundberg, Eddie Weitzberg, and Mattias Carlström. “Inorganic nitrite attenuates NADPH oxidase-derived superoxide generation in activated macrophages via a nitric oxide-dependent mechanism.” Free Radic Biol Med 83 (June 2015): 159–66. https://doi.org/10.1016/j.freeradbiomed.2015.02.016.
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    • Terrando, Niccolò, Ting Yang, Jae Kyu Ryu, Phillip T. Newton, Claudia Monaco, Marc Feldmann, Daqing Ma, Katerina Akassoglou, and Mervyn Maze. “Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.” Mol Med 20 (March 17, 2015): 667–75. https://doi.org/10.2119/molmed.2014.00143.
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    • Gao, Xiang, Ting Yang, Ming Liu, Maria Peleli, Christa Zollbrecht, Eddie Weitzberg, Jon O. Lundberg, A Erik G. Persson, and Mattias Carlström. “NADPH oxidase in the renal microvasculature is a primary target for blood pressure-lowering effects by inorganic nitrate and nitrite.” Hypertension 65, no. 1 (January 2015): 161–70. https://doi.org/10.1161/HYPERTENSIONAHA.114.04222.
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    • Fu, Hui Qun, Ting Yang, Wei Xiao, Long Fan, Yan Wu, Niccolò Terrando, and Tian Long Wang. “Prolonged neuroinflammation after lipopolysaccharide exposure in aged rats.” Plos One 9, no. 8 (2014): e106331. https://doi.org/10.1371/journal.pone.0106331.
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    • Terrando, Niccolò, Marta Gómez-Galán, Ting Yang, Mattias Carlström, Daniel Gustavsson, Ralph E. Harding, Maria Lindskog, and Lars I. Eriksson. “Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline.” Faseb J 27, no. 9 (September 2013): 3564–71. https://doi.org/10.1096/fj.13-230276.
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    • Carlström, M., R. D. Brown, T. Yang, M. Hezel, E. Larsson, P. G. Scheffer, T. Teerlink, J. O. Lundberg, and A. E. G. Persson. “L-arginine or tempol supplementation improves renal and cardiovascular function in rats with reduced renal mass and chronic high salt intake.” Acta Physiol (Oxf) 207, no. 4 (April 2013): 732–41. https://doi.org/10.1111/apha.12079.
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    • Zhuang, Lei, Ting Yang, Hailin Zhao, António Rei Fidalgo, Marcela P. Vizcaychipi, Robert D. Sanders, Buwei Yu, Masao Takata, Mark R. Johnson, and Daqing Ma. “The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats.” Crit Care Med 40, no. 6 (June 2012): 1724–30. https://doi.org/10.1097/CCM.0b013e3182452164.
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    • Yang, Ting, Lei Zhuang, António M. Rei Fidalgo, Evgenia Petrides, Niccolo Terrando, Xinmin Wu, Robert D. Sanders, et al. “Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia.” Plos One 7, no. 5 (2012): e37020. https://doi.org/10.1371/journal.pone.0037020.
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    • Terrando, Niccolò, Lars I. Eriksson, Jae Kyu Ryu, Ting Yang, Claudia Monaco, Marc Feldmann, Malin Jonsson Fagerlund, Israel F. Charo, Katerina Akassoglou, and Mervyn Maze. “Resolving postoperative neuroinflammation and cognitive decline.” Ann Neurol 70, no. 6 (December 2011): 986–95. https://doi.org/10.1002/ana.22664.
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    • Yang, Ting, Lei Zhuang, Niccolò Terrando, Xinmin Wu, Mark R. Jonhson, Mervyn Maze, and Daqing Ma. “A clinically relevant model of perinatal global ischemic brain damage in rats.” Brain Res 1383 (April 6, 2011): 317–23. https://doi.org/10.1016/j.brainres.2011.01.081.
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