Ting Yang

Journal Article Br J Anaesth · February 2023 BACKGROUND: Peripheral surgical trauma can trigger neuroinflammation and ensuing neurological complications, such as delirium. The mechanisms whereby surgery contributes to postoperative neuroinflammation remain unclear and without effective therapies. Her ... Full text Link to item Cite

CRISPR mediated transactivation in the human disease vector Aedes aegypti.

Journal Article PLoS Pathog · January 2023 As a major insect vector of multiple arboviruses, Aedes aegypti poses a significant global health and economic burden. A number of genetic engineering tools have been exploited to understand its biology with the goal of reducing its impact. For example, cu ... Full text Link to item Cite

Conserved YKL-40 changes in mice and humans after postoperative delirium.

Journal Article Brain Behav Immun Health · December 2022 Delirium is a common postoperative neurologic complication among older adults. Despite its prevalence (14%-50%) and likely association with inflammation, the exact mechanisms that underpin postoperative delirium are unclear. This project aimed to character ... Full text Link to item Cite

Cell-Specific Actions of the Prostaglandin E-Prostanoid Receptor 4 Attenuating Hypertension: A Dominant Role for Kidney Epithelial Cells Compared With Macrophages.

Journal Article J Am Heart Assoc · October 4, 2022 Background A beneficial role for prostanoids in hypertension is suggested by clinical studies showing nonsteroidal anti-inflammatory drugs, which block the production of all prostanoids, cause sodium retention and exacerbate hypertension. Among prostanoids ... Full text Link to item Cite

Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome.

Journal Article Front Immunol · 2022 Neuroinflammation is a growing hallmark of perioperative neurocognitive disorders (PNDs), including delirium and longer-lasting cognitive deficits. We have developed a clinically relevant orthopedic mouse model to study the impact of a common surgical proc ... Full text Link to item Cite

Ubiquitous and Tissue-specific RNA Targeting in Drosophila Melanogaster using CRISPR/CasRx.

Journal Article J Vis Exp · February 5, 2021 CasRx, a member of the RNA-targeting Cas13 family, is a promising new addition of the CRISPR/Cas technologies in efficient gene transcript reduction with an attractive off-target profile at both cellular and organismal levels. It is recently reported that ... Full text Link to item Cite

Neuroinflammation after surgery: from mechanisms to therapeutic targets.

Journal Article Nat Immunol · November 2020 Injury is a key driver of inflammation, a critical yet necessary response involving several mediators that is aimed at restoring tissue homeostasis. Inflammation in the central nervous system can be triggered by a variety of stimuli, some intrinsic to the ... Full text Link to item Cite

Programmable RNA Targeting Using CasRx in Flies.

Journal Article CRISPR J · June 2020 CRISPR-Cas genome editing technologies have revolutionized the fields of functional genetics and genome engineering, but with the recent discovery and optimization of RNA-targeting Cas ribonucleases, we may soon see a similar revolution in the study of RNA ... Full text Link to item Cite

Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia.

Journal Article Alzheimers Dement · May 2020 OBJECTIVE: The present work evaluates the relationship between postoperative immune and neurovascular changes and the pathogenesis of surgery-induced delirium superimposed on dementia. BACKGROUND AND RATIONALE: Postoperative delirium is a common complicati ... Full text Link to item Cite

Live calcium imaging of Aedes aegypti neuronal tissues reveals differential importance of chemosensory systems for life-history-specific foraging strategies.

Journal Article BMC Neurosci · June 17, 2019 BACKGROUND: The mosquito Aedes aegypti has a wide variety of sensory pathways that have supported its success as a species as well as a highly competent vector of numerous debilitating infectious pathogens. Investigations into mosquito sensory systems and ... Full text Link to item Cite

Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders.

Journal Article Br J Anaesth · March 2019 BACKGROUND: Resolution of inflammation is an active and dynamic process after surgery. Maresin 1 (MaR1) is one of a growing number of specialised pro-resolving lipids biosynthesised by macrophages that regulates acute inflammation. We investigated the effe ... Full text Link to item Cite

Complex Role for E-Prostanoid 4 Receptors in Hypertension.

Journal Article J Am Heart Assoc · February 19, 2019 Background Prostaglandin E2 ( PGE 2) is a major prostanoid with multiple actions that potentially affect blood pressure ( BP ). PGE 2 acts through 4 distinct E-prostanoid ( EP ) receptor isoforms: EP 1 to EP 4. The EP 4 receptor ( EP 4R) promotes PGE 2-dep ... Full text Open Access Link to item Cite

The Evolving Role of Specialized Pro-resolving Mediators in Modulating Neuroinflammation in Perioperative Neurocognitive Disorders.

Journal Article Adv Exp Med Biol · 2019 Surgery can be a life-saving procedure; however, significant complications may occur after routine procedures especially in older and more frail patients. Perioperative neurocognitive disorders (PNDs), including delirium and postoperative cognitive dysfunc ... Full text Link to item Cite

New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis.

Journal Article Redox Biol · January 2019 Oxidative stress and inflammation interact in the development of diabetic atherosclerosis. Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species (ROS), increased formation of intracellular advanced glycation end-products, ... Full text Link to item Cite

Organ uptake and release of inorganic nitrate and nitrite in the pig.

Journal Article Nitric Oxide · May 1, 2018 Numerous studies have shown beneficial cardiovascular and metabolic effects of dietary nitrate but the release or uptake of these anions on an organ level is still poorly elucidated. Here we administered sodium nitrate in the pig and measured acute changes ... Full text Link to item Cite

Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress.

Journal Article Redox Biol · October 2017 Ischemia-reperfusion (IR) injury involves complex pathological processes in which reduction of nitric oxide (NO) bioavailability is suggested as a key factor. Inorganic nitrate can form NO in vivo via NO synthase-independent pathways and may thus provide b ... Full text Link to item Cite

Resistance to hypertension mediated by intercalated cells of the collecting duct.

Journal Article JCI Insight · April 6, 2017 The renal collecting duct (CD), as the terminal segment of the nephron, is responsible for the final adjustments to the amount of sodium excreted in urine. While angiotensin II modulates reabsorptive functions of the CD, the contribution of these actions t ... Full text Link to item Cite

Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels.

Journal Article Proc Natl Acad Sci U S A · October 25, 2016 Pain is a critical component hindering recovery and regaining of function after surgery, particularly in the elderly. Understanding the role of pain signaling after surgery may lead to novel interventions for common complications such as delirium and posto ... Full text Link to item Cite

Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction.

Journal Article J Neuroinflammation · October 12, 2016 BACKGROUND: Postoperative cognitive dysfunction (POCD) is a common complication after surgery, especially amongst elderly patients. Neuroinflammation and iron homeostasis are key hallmarks of several neurological disorders. In this study, we investigated t ... Full text Open Access Link to item Cite

Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension.

Journal Article J Am Heart Assoc · July 18, 2016 BACKGROUND: Early-life reduction in nephron number (uninephrectomy [UNX]) and chronic high salt (HS) intake increase the risk of hypertension and chronic kidney disease. Adenosine signaling via its different receptors has been implicated in modulating rena ... Full text Open Access Link to item Cite

Protective effects of omega-3 fatty acids in a blood-brain barrier-on-chip model and on postoperative delirium-like behaviour in mice.

CRISPR mediated transactivation in the human disease vector Aedes aegypti.

Conserved YKL-40 changes in mice and humans after postoperative delirium.

Cell-Specific Actions of the Prostaglandin E-Prostanoid Receptor 4 Attenuating Hypertension: A Dominant Role for Kidney Epithelial Cells Compared With Macrophages.

Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome.

Ubiquitous and Tissue-specific RNA Targeting in Drosophila Melanogaster using CRISPR/CasRx.

Neuroinflammation after surgery: from mechanisms to therapeutic targets.

Programmable RNA Targeting Using CasRx in Flies.

Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia.

Live calcium imaging of Aedes aegypti neuronal tissues reveals differential importance of chemosensory systems for life-history-specific foraging strategies.

Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders.

Complex Role for E-Prostanoid 4 Receptors in Hypertension.

The Evolving Role of Specialized Pro-resolving Mediators in Modulating Neuroinflammation in Perioperative Neurocognitive Disorders.

New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis.

Organ uptake and release of inorganic nitrate and nitrite in the pig.

Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress.

Resistance to hypertension mediated by intercalated cells of the collecting duct.

Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels.

Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction.

Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension.

Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats.

Journal Article Front Aging Neurosci · 2016 Systemic inflammation, for example as a result of infection, often contributes to long-term complications. Neuroinflammation and cognitive decline are key hallmarks of several neurological conditions, including advance age. The contribution of systemic inf ... Full text Open Access Link to item Cite

Systemic HMGB1 Neutralization Prevents Postoperative Neurocognitive Dysfunction in Aged Rats.

Journal Article Front Immunol · 2016 Postoperative neurocognitive disorders are common complications in elderly patients following surgery or critical illness. High mobility group box 1 protein (HMGB1) is rapidly released after tissue trauma and critically involved in response to sterile inju ... Full text Link to item Cite

Renal denervation attenuates NADPH oxidase-mediated oxidative stress and hypertension in rats with hydronephrosis.

Journal Article Am J Physiol Renal Physiol · January 1, 2016 Hydronephrosis is associated with the development of salt-sensitive hypertension. Studies have suggested that increased sympathetic nerve activity and oxidative stress play important roles in hypertension and the modulation of salt sensitivity. The present ... Full text Link to item Cite

Cross-talk Between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis.

Journal Article Antioxid Redox Signal · August 1, 2015 AIMS: Inorganic nitrate and nitrite from endogenous and dietary sources have emerged as alternative substrates for nitric oxide (NO) formation in addition to the classic L-arginine NO synthase (NOS)-dependent pathway. Here, we investigated a potential cros ... Full text Link to item Cite

Abrogation of adenosine A1 receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses.

Journal Article Diabetologia · July 2015 AIMS/HYPOTHESIS: Adenosine is an important regulator of metabolism; however, the role of the A1 receptor during ageing and obesity is unclear. The aim of this study was to investigate the effects of A1 signalling in modulating metabolic function during age ... Full text Link to item Cite

Inorganic nitrite attenuates NADPH oxidase-derived superoxide generation in activated macrophages via a nitric oxide-dependent mechanism.

Journal Article Free Radic Biol Med · June 2015 Oxidative stress contributes to the pathogenesis of many disorders, including diabetes and cardiovascular disease. Immune cells are major sources of superoxide (O2(∙-)) as part of the innate host defense system, but exaggerated and sustained O2(∙-) generat ... Full text Link to item Cite

Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.

Journal Article Mol Med · March 17, 2015 Surgery and critical illness often associate with cognitive decline. Surgical trauma or infection can lead independently to learning and memory impairments via similar, but not identical, cellular signaling of the innate immune system that promotes neuroin ... Full text Link to item Cite

NADPH oxidase in the renal microvasculature is a primary target for blood pressure-lowering effects by inorganic nitrate and nitrite.

Journal Article Hypertension · January 2015 Renal oxidative stress and nitric oxide (NO) deficiency are key events in hypertension. Stimulation of a nitrate-nitrite-NO pathway with dietary nitrate reduces blood pressure, but the mechanisms or target organ are not clear. We investigated the hypothesi ... Full text Link to item Cite

Prolonged neuroinflammation after lipopolysaccharide exposure in aged rats.

Journal Article PLoS One · 2014 Inflammation is a hallmark of several disease states ranging from neurodegeneration to sepsis but is also implicated in physiological processes like ageing. Non-resolving inflammation and prolonged neuroinflammation are unclear processes implicated in seve ... Full text Link to item Cite

Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline.

Journal Article FASEB J · September 2013 Hospitalization for major surgery or critical illness often associates with cognitive decline. Inflammation and dysregulation of the innate immune system can exert broad effects in the periphery and central nervous system (CNS), yet the mechanisms underlyi ... Full text Link to item Cite

L-arginine or tempol supplementation improves renal and cardiovascular function in rats with reduced renal mass and chronic high salt intake.

Journal Article Acta Physiol (Oxf) · April 2013 AIM: Early life reduction in nephron number and chronic high salt intake cause development of renal and cardiovascular disease, which has been associated with oxidative stress and nitric oxide (NO) deficiency. We investigated the hypothesis that interventi ... Full text Link to item Cite

The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats.

Journal Article Crit Care Med · June 2012 OBJECTIVE: Xenon provides neuroprotection in multiple animal models; however, little is known about the other noble gases. The aim of the current study was to compare xenon, argon, and helium neuroprotection in a neonatal asphyxia model in rats. DESIGN: Ra ... Full text Link to item Cite

Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia.

Journal Article PLoS One · 2012 It is not possible to identify all pregnancies at risk of neonatal hypoxic-ischemic encephalopathy (HIE). Many women use some form of analgesia during childbirth and some anesthetic agents have been shown to be neuroprotective when used as analgesics at su ... Full text Open Access Link to item Cite

Resolving postoperative neuroinflammation and cognitive decline.

Journal Article Ann Neurol · December 2011 OBJECTIVE: Cognitive decline accompanies acute illness and surgery, especially in the elderly. Surgery engages the innate immune system that launches a systemic inflammatory response that, if unchecked, can cause multiple organ dysfunction. We sought to un ... Full text Link to item Cite

A clinically relevant model of perinatal global ischemic brain damage in rats.

Journal Article Brain Res · April 6, 2011 We have designed a clinically relevant model of perinatal asphyxia providing intrapartum hypoxia in rats. On gestation day 22 SD rats were anesthetized and the uterine horns were exteriorized and placed in a water bath at 37°C for up to 20min. After this, ... Full text Link to item Cite