Jennifer Lilly Turi | Scholars@Duke

Jennifer Lilly Turi
Associate Professor of Pediatrics

A primary goal of my research to date has been to elucidate the impact of inflammation on disordered iron handling in the lung, both as a mechanism of oxidant injury and persistent infection as well as an etiology of inflammatory lung disease itself. In particular, I have focused on the importance of cellular iron transport regulation in airway epithelial cells as a means to detoxify the lungs against metal containing particulates and iron liberated from microbes. Clinically, hemolysis following cardiopulmonary presents an excessive iron and heme load to the body and may overwhelm the body’s protective mechanisms. The oxidant generation and cellular toxicity that result may contribute to the generation of multi-organ dysfunction. Therefore, more recent translational investigation has focused on acute lung and kidney injury following CPB-induced hemolysis and as well as potential mechanisms to mitigate this effect.

Current Appointments & Affiliations

Associate Professor of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2016

Contact Information

371 Sands, Durham, NC 27710
Box 3046 Med Ctr, Durham, NC 27710
turi0002@mc.duke.edu (919) 681-5560

Background
Education, Training, & Certifications
- Fellow, Pediatric Critical Care Medicine, Pediatrics, Duke University 1998 - 2001
- Resident, Pediatric, U Mass Memorial Medical Center 1996 - 1998
- Intern, Pediatrics, U Mass Memorial Medical Center 1995 - 1996
- M.D., U Mass Memorial Medical Center 1995
Duke Appointment History
- Interim Chief of the Section of Pediatric Cardiac Critical Care, Pediatrics, Critical Care Medicine, Pediatrics 2018
- Assistant Professor of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2014 - 2016
- Assistant Professor of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2008 - 2014
- Medical Instructor in the Department of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2001 - 2007
Expertise
Subject Headings
Research
Selected Grants
- Mechanisms of Intracellular Iron Accumulation in Cystic Fibrosis awarded by National Institutes of Health 2006 - 2011
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Ghio, AJ, Tong, H, Soukup, J, Dailey, LA, Cheng, W, Samet, JM, Kesic, MJ, Bromberg, PA, Turi, JL, Upadhyay, D, Budinger, GR, and Mutlu, GM. "Sequestration of mitochondrial iron by silica particle initiates a biological effect (Am J Physiol Lung Cell Mol Physiol, 305, (L712-L724), (2013), 10.1152/ajplung.00099.2013)." American Journal of Physiology Lung Cellular and Molecular Physiology 315, no. 5 (November 1, 2018): L919-null. Full Text
  - Williams, DC, Turi, JL, Hornik, CP, Bonadonna, DK, Williford, WL, Walczak, RJ, Watt, KM, and Cheifetz, IM. "Circuit oxygenator contributes to extracorporeal membrane oxygenation-induced hemolysis." Asaio Journal (American Society for Artificial Internal Organs : 1992) 61, no. 2 (March 2015): 190-195. Full Text
  - Williams, DC, Turi, JL, Hornik, CP, Bonadonna, DK, Williford, WL, Walczak, RJ, Watt, KM, and Cheifetz, IM. "Circuit Oxygenator Contributes to Extracorporeal Membrane Oxygenation-Induced Hemolysis." Asaio Journal 61, no. 2 (January 1, 2015): 190-195. Full Text
  - Mamikonian, LS, Mamo, LB, Smith, PB, Koo, J, Lodge, AJ, and Turi, JL. "Cardiopulmonary bypass is associated with hemolysis and acute kidney injury in neonates, infants, and children*." Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 15, no. 3 (March 2014): e111-e119. Full Text
  - Mamikonian, LS, Mamo, LB, Smith, PB, Koo, J, Lodge, AJ, and Turi, JL. "Cardiopulmonary bypass is associated with hemolysis and acute kidney injury in neonates, infants, and children*." Pediatric Critical Care Medicine 15, no. 3 (January 1, 2014). Full Text
  - Ghio, AJ, Tong, H, Soukup, JM, Dailey, LA, Cheng, W-Y, Samet, JM, Kesic, MJ, Bromberg, PA, Turi, JL, Upadhyay, D, Scott Budinger, GR, and Mutlu, GM. "Sequestration of mitochondrial iron by silica particle initiates a biological effect." American Journal of Physiology. Lung Cellular and Molecular Physiology 305, no. 10 (November 2013): L712-L724. Full Text
  - Ozment, CP, Mamo, LB, Campbell, ML, Lokhnygina, Y, Ghio, AJ, and Turi, JL. "Transfusion-related biologic effects and free hemoglobin, heme, and iron." Transfusion 53, no. 4 (April 2013): 732-740. Full Text Link to Item
  - Ghio, AJ, Soukup, JM, Dailey, LA, Richards, JH, Turi, JL, Pavlisko, EN, and Roggli, VL. "Disruption of iron homeostasis in mesothelial cells after talc pleurodesis." Am J Respir Cell Mol Biol 46, no. 1 (January 2012): 80-86. Full Text Link to Item
  - Frazier, MD, Mamo, LB, Ghio, AJ, and Turi, JL. "Hepcidin expression in human airway epithelial cells is regulated by interferon-γ. (Published online)" Respir Res 12 (August 2, 2011): 100-. Full Text Link to Item
  - Ozment, CP, and Turi, JL. "Iron overload following red blood cell transfusion and its impact on disease severity." Biochim Biophys Acta 1790, no. 7 (July 2009): 694-701. (Review) Full Text Link to Item
  - Turi, JL, Piantadosi, CA, Stonehuerner, JD, and Ghio, AJ. "Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport." Biometals 21, no. 5 (October 2008): 571-580. Full Text Link to Item
  - Ghio, AJ, Turi, JL, Madden, MC, Dailey, LA, Richards, JD, Stonehuerner, JG, Morgan, DL, Singleton, S, Garrick, LM, and Garrick, MD. "Lung injury after ozone exposure is iron dependent." Am J Physiol Lung Cell Mol Physiol 292, no. 1 (January 2007): L134-L143. Full Text Link to Item
  - Mistry, KP, Turi, J, Hueckel, R, Mericle, JM, and Meliones, JN. "Pediatric Rapid Response Teams in the Academic Medical Center." Clinical Pediatric Emergency Medicine 7, no. 4 (December 1, 2006): 241-247. Full Text
  - Turi, JL, Wang, X, McKie, AT, Nozik-Grayck, E, Mamo, LB, Crissman, K, Piantadosi, CA, and Ghio, AJ. "Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells." American Journal of Physiology. Lung Cellular and Molecular Physiology 291, no. 2 (August 2006): L272-L280. Full Text
  - Ghio, AJ, Turi, JL, Yang, F, Garrick, LM, and Garrick, MD. "Iron homeostasis in the lung." Biol Res 39, no. 1 (2006): 67-77. (Review) Link to Item
  - Turi, JL, Yang, F, Garrick, MD, Piantadosi, CA, and Ghio, AJ. "The iron cycle and oxidative stress in the lung." Free Radical Biology & Medicine 36, no. 7 (April 2004): 850-857. (Review) Full Text
  - Turi, JL, and Cheifetz, IM. "Does improved oxygenation really imply increased benefit?." Crit Care Med 32, no. 4 (April 2004): 1089-1091. Link to Item
  - Ghio, AJ, Nozik-Grayck, E, Turi, J, Jaspers, I, Mercatante, DR, Kole, R, and Piantadosi, CA. "Superoxide-dependent iron uptake: a new role for anion exchange protein 2." American Journal of Respiratory Cell and Molecular Biology 29, no. 6 (December 2003): 653-660. Full Text
  - Turi, JL, Jaspers, I, Dailey, LA, Madden, MC, Brighton, LE, Carter, JD, Nozik-Grayck, E, Piantadosi, CA, and Ghio, AJ. "Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells." American Journal of Physiology. Lung Cellular and Molecular Physiology 283, no. 4 (October 2002): L791-L798. Full Text
- Book Sections
  - Rehder, KJ, Turi, JL, and Cheifetz, IM. "Acute respiratory failure." In Pediatric Critical Care Medicine: Volume 1: Care of the Critically Ill or Injured Child, Second Edition, 401-412. January 1, 2014. Full Text

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Education, Training, & Certifications

Duke Appointment History

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Book Sections