Jennifer Lilly Turi | Scholars@Duke

Jennifer Lilly Turi
Associate Professor of Pediatrics

A primary goal of my research to date has been to elucidate the impact of inflammation on disordered iron handling in the lung, both as a mechanism of oxidant injury and persistent infection as well as an etiology of inflammatory lung disease itself. In particular, I have focused on the importance of cellular iron transport regulation in airway epithelial cells as a means to detoxify the lungs against metal containing particulates and iron liberated from microbes. Clinically, hemolysis following cardiopulmonary presents an excessive iron and heme load to the body and may overwhelm the body’s protective mechanisms. The oxidant generation and cellular toxicity that result may contribute to the generation of multi-organ dysfunction. Therefore, more recent translational investigation has focused on acute lung and kidney injury following CPB-induced hemolysis and as well as potential mechanisms to mitigate this effect.

Current Appointments & Affiliations

Associate Professor of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2016

Contact Information

Box 3046 Med Ctr, Durham, NC 27710
Duke North 5269D, Durham, NC 27710
turi0002@mc.duke.edu (919) 681-5560

Background
Education, Training, & Certifications
- Fellow, Pediatric Critical Care Medicine, Pediatrics, Duke University 1998 - 2001
- Resident, Pediatric, U Mass Memorial Medical Center 1996 - 1998
- Intern, Pediatrics, U Mass Memorial Medical Center 1995 - 1996
- M.D., U Mass Memorial Medical Center 1995
Duke Appointment History
- Interim Chief of the Section of Pediatric Cardiac Critical Care, Pediatrics, Critical Care Medicine, Pediatrics 2018
- Assistant Professor of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2014 - 2016
- Assistant Professor of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2008 - 2014
- Medical Instructor in the Department of Pediatrics, Pediatrics, Critical Care Medicine, Pediatrics 2001 - 2007
Expertise
Subject Headings
Research
Selected Grants
- Mechanisms of Intracellular Iron Accumulation in Cystic Fibrosis awarded by National Institutes of Health 2006 - 2011
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Badheka, Aditya, Jodi Bloxham, April Schmitz, Barbara Freyenberger, Tong Wang, Sankeerth Rampa, Jennifer Turi, Veerasathpurush Allareddy, Marcelo Auslender, and Veerajalandhar Allareddy. “Outcomes associated with peripherally inserted central catheters in hospitalised children: a retrospective 7-year single-centre experience.” Bmj Open 9, no. 8 (August 22, 2019): e026031. https://doi.org/10.1136/bmjopen-2018-026031.
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  - “Corrigendum.” Am J Physiol Lung Cell Mol Physiol 315, no. 5 (November 1, 2018): L919. https://doi.org/10.1152/ajplung.zh5-7547-corr.2018.
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  - Williams, Duane C., Jennifer L. Turi, Christoph P. Hornik, Desiree K. Bonadonna, Walter L. Williford, Richard J. Walczak, Kevin M. Watt, and Ira M. Cheifetz. “Circuit oxygenator contributes to extracorporeal membrane oxygenation-induced hemolysis.” Asaio J 61, no. 2 (March 2015): 190–95. https://doi.org/10.1097/MAT.0000000000000173.
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  - Mamikonian, Lara S., Lisa B. Mamo, P Brian Smith, Jeannie Koo, Andrew J. Lodge, and Jennifer L. Turi. “Cardiopulmonary bypass is associated with hemolysis and acute kidney injury in neonates, infants, and children*.” Pediatr Crit Care Med 15, no. 3 (March 2014): e111–19. https://doi.org/10.1097/PCC.0000000000000047.
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  - Ghio, Andrew J., Haiyan Tong, Joleen M. Soukup, Lisa A. Dailey, Wan-Yun Cheng, James M. Samet, Matthew J. Kesic, et al. “Sequestration of mitochondrial iron by silica particle initiates a biological effect.” Am J Physiol Lung Cell Mol Physiol 305, no. 10 (November 15, 2013): L712–24. https://doi.org/10.1152/ajplung.00099.2013.
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  - Ozment, Caroline P., Lisa B. Mamo, Mary Lee Campbell, Yuliya Lokhnygina, Andrew J. Ghio, and Jennifer L. Turi. “Transfusion-related biologic effects and free hemoglobin, heme, and iron.” Transfusion 53, no. 4 (April 2013): 732–40. https://doi.org/10.1111/j.1537-2995.2012.03837.x.
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  - Ghio, Andrew J., Joleen M. Soukup, Lisa A. Dailey, Judy H. Richards, Jennifer L. Turi, Elizabeth N. Pavlisko, and Victor L. Roggli. “Disruption of iron homeostasis in mesothelial cells after talc pleurodesis.” Am J Respir Cell Mol Biol 46, no. 1 (January 2012): 80–86. https://doi.org/10.1165/rcmb.2011-0168OC.
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  - Frazier, Marie D., Lisa B. Mamo, Andrew J. Ghio, and Jennifer L. Turi. “Hepcidin expression in human airway epithelial cells is regulated by interferon-γ.” Respir Res 12 (August 2, 2011): 100. https://doi.org/10.1186/1465-9921-12-100.
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  - Ozment, Caroline P., and Jennifer L. Turi. “Iron overload following red blood cell transfusion and its impact on disease severity.” Biochim Biophys Acta 1790, no. 7 (July 2009): 694–701. https://doi.org/10.1016/j.bbagen.2008.09.010.
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  - Turi, Jennifer L., Claude A. Piantadosi, Jackie D. Stonehuerner, and Andrew J. Ghio. “Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport.” Biometals 21, no. 5 (October 2008): 571–80. https://doi.org/10.1007/s10534-008-9143-x.
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  - Ghio, Andrew J., Jennifer L. Turi, Michael C. Madden, Lisa A. Dailey, Judy D. Richards, Jacqueline G. Stonehuerner, Daniel L. Morgan, Steven Singleton, Laura M. Garrick, and Michael D. Garrick. “Lung injury after ozone exposure is iron dependent.” Am J Physiol Lung Cell Mol Physiol 292, no. 1 (January 2007): L134–43. https://doi.org/10.1152/ajplung.00534.2005.
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  - Turi, Jennifer L., Xinchao Wang, Andrew T. McKie, Eva Nozik-Grayck, Lisa B. Mamo, Kay Crissman, Claude A. Piantadosi, and Andrew J. Ghio. “Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells.” Am J Physiol Lung Cell Mol Physiol 291, no. 2 (August 2006): L272–80. https://doi.org/10.1152/ajplung.00342.2005.
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  - Ghio, Andrew J., Jennifer L. Turi, Funmei Yang, Laura M. Garrick, and Michael D. Garrick. “Iron homeostasis in the lung.” Biol Res 39, no. 1 (2006): 67–77. https://doi.org/10.4067/s0716-97602006000100008.
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  - Mistry, K. P., J. Turi, R. Hueckel, J. M. Mericle, and J. N. Meliones. “Pediatric Rapid Response Teams in the Academic Medical Center.” Clinical Pediatric Emergency Medicine 7, no. 4 (January 1, 2006): 241–47. https://doi.org/10.1016/j.cpem.2006.08.010.
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  - Turi, Jennifer L., Funmei Yang, Michael D. Garrick, Claude A. Piantadosi, and Andrew J. Ghio. “The iron cycle and oxidative stress in the lung.” Free Radic Biol Med 36, no. 7 (April 1, 2004): 850–57. https://doi.org/10.1016/j.freeradbiomed.2003.12.008.
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  - Turi, Jennifer L., and Ira M. Cheifetz. “Does improved oxygenation really imply increased benefit?” Crit Care Med 32, no. 4 (April 2004): 1089–91. https://doi.org/10.1097/01.ccm.0000121431.64219.9a.
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  - Ghio, Andrew J., Eva Nozik-Grayck, Jennifer Turi, Ilona Jaspers, Danielle R. Mercatante, Ryszard Kole, and Claude A. Piantadosi. “Superoxide-dependent iron uptake: a new role for anion exchange protein 2.” Am J Respir Cell Mol Biol 29, no. 6 (December 2003): 653–60. https://doi.org/10.1165/rcmb.2003-0070OC.
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  - Turi, Jennifer L., Ilona Jaspers, Lisa A. Dailey, Michael C. Madden, Luisa E. Brighton, Jacqueline D. Carter, Eva Nozik-Grayck, Claude A. Piantadosi, and Andrew J. Ghio. “Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells.” Am J Physiol Lung Cell Mol Physiol 283, no. 4 (October 2002): L791–98. https://doi.org/10.1152/ajplung.00398.2001.
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- Book Sections
  - Rehder, K. J., J. L. Turi, and I. M. Cheifetz. “Acute respiratory failure.” In Pediatric Critical Care Medicine: Volume 1: Care of the Critically Ill or Injured Child, Second Edition, 401–12, 2014. https://doi.org/10.1007/978-1-4471-6362-6_31.
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Education, Training, & Certifications

Duke Appointment History

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Book Sections