Scholars@Duke
Jennifer Lilly Turi

Jennifer Lilly Turi

Associate Professor of Pediatrics
Pediatrics, Critical Care Medicine
jennifer.turi@duke.edu
Box 3046 Med Ctr, Durham, NC 27710
Duke North 5269D, Durham, NC 27710

Selected Publications

Implementation of Bundled Interventions to Reduce Surgical Site Infections in Pediatric Patients Undergoing Cardiothoracic Surgery: A Quality Improvement Project.

Journal Article AORN J · February 2025 Pediatric patients undergoing cardiothoracic surgery are at increased risk for health care-associated infections, especially surgical site infections (SSIs). Delayed sternal closures are associated with prolonged lengths of stay and contribute to infection ... Full text Link to item Cite

Extending the radius of family-centered care in the pediatric cardiac intensive care unit through virtual rounding.

Journal Article J Am Assoc Nurse Pract · May 18, 2021 BACKGROUND: The arrival of COVID-19 brought urgent limitation of visitation in hospitals across the country. Family-centered care and its delivery rapidly changed and left the family behind-unable to actively participate in their loved one's care. LOCAL PR ... Full text Link to item Cite

The effect of intraoperative methadone during pediatric cardiac surgery on postoperative opioid requirements.

Journal Article Paediatr Anaesth · July 2020 BACKGROUND: Pain control in pediatric patients undergoing cardiac surgery presents a unique challenge. Postoperatively, many of these patients require long-term opioid infusions and sedation leading to need for prolonged weaning from opioids and longer hos ... Full text Link to item Cite

Outcomes associated with peripherally inserted central catheters in hospitalised children: a retrospective 7-year single-centre experience.

Journal Article BMJ Open · August 22, 2019 OBJECTIVES: The use of peripherally inserted central catheters (PICCs) are an integral part of caring for hospitalised children. We sought to estimate the incidence of and identify the risk factors for complications associated with PICCs in an advanced reg ... Full text Link to item Cite

Corrigendum.

Journal Article Am J Physiol Lung Cell Mol Physiol · November 1, 2018 Full text Link to item Cite

Initial management and stabilization: Emergency department transport

Chapter · January 1, 2018 Infants and children with congenital and acquired heart disease frequently present with nonspecific complaints, and therefore it is essential to have a high index of suspicion for a cardiac cause. This is particularly true for a neonate presenting with sev ... Full text Cite

Circuit oxygenator contributes to extracorporeal membrane oxygenation-induced hemolysis.

Journal Article ASAIO J · 2015 Hemolysis can occur as a consequence of extracorporeal membrane oxygenation (ECMO) and is associated with increased mortality and morbidity. Shear stress generated by flow through the circuit and oxygenator is believed to cause ECMO-induced hemolysis. We h ... Full text Link to item Cite

Cardiopulmonary bypass is associated with hemolysis and acute kidney injury in neonates, infants, and children*.

Journal Article Pediatr Crit Care Med · March 2014 OBJECTIVES: This pilot study assesses the degree of hemolysis induced by cardiopulmonary bypass and determines its association with acute kidney injury in pediatric patients. Further, it evaluates the degree to which the use of urinary biomarkers neutrophi ... Full text Link to item Cite

Acute respiratory failure

Chapter · January 1, 2014 Acute respiratory failure is a common diagnosis among critically ill children and a leading cause of morbidity, mortality, and health care expenditures in the pediatric critical care setting. This chapter examines the anatomic, developmental, and physiolog ... Full text Cite

Sequestration of mitochondrial iron by silica particle initiates a biological effect.

Journal Article Am J Physiol Lung Cell Mol Physiol · November 15, 2013 Featured Publication Inhalation of particulate matter has presented a challenge to human health for thousands of years. The underlying mechanism for biological effect following particle exposure is incompletely understood. We tested the postulate that particle sequestration of ... Full text Link to item Cite

Disruption of iron homeostasis in mesothelial cells after talc pleurodesis.

Journal Article Am J Respir Cell Mol Biol · January 2012 The mechanism for biological effects after exposure to particles is incompletely understood. One postulate proposed to explain biological effects after exposure to particles involves altered iron homeostasis in the host. The fibro-inflammatory properties o ... Full text Link to item Cite

Hepcidin expression in human airway epithelial cells is regulated by interferon-γ.

Journal Article Respir Res · August 2, 2011 Featured Publication BACKGROUND: Hepcidin serves as a major regulator of systemic iron metabolism and immune function. Airway epithelial cells have an extensive interface with the environment, and so must be able to respond locally to the presence of particulates, infection, a ... Full text Link to item Cite

Iron overload following red blood cell transfusion and its impact on disease severity.

Journal Article Biochim Biophys Acta · July 2009 Featured Publication Transfusion of red blood cells can be a life-saving therapy both for patients with chronic anemias and for those who are critically ill with acute blood loss. However, transfusion has been associated with significant morbidity. Chronic transfusion results ... Full text Link to item Cite

Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport.

Journal Article Biometals · October 2008 Featured Publication Airway epithelial cells prevent damaging effects of extracellular iron by taking up the metal and sequestering it within intracellular ferritin. Epithelial iron transport is associated with transcellular movement of other cations including changes in the e ... Full text Link to item Cite

Lung injury after ozone exposure is iron dependent.

Journal Article Am J Physiol Lung Cell Mol Physiol · January 2007 We tested the hypothesis that oxidative stress and biological effect after ozone (O3) exposure are dependent on changes in iron homeostasis. After O3 exposure, healthy volunteers demonstrated increased lavage concentrations of iron, transferrin, lactoferri ... Full text Link to item Cite

Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells.

Journal Article Am J Physiol Lung Cell Mol Physiol · August 2006 Featured Publication Catalytically active iron in the lung causes oxidative stress and promotes microbial growth that can be limited by intracellular sequestration of iron within ferritin. Because cellular iron uptake requires membrane ferrireductase activity that in the gut c ... Full text Link to item Cite

Iron homeostasis in the lung.

Journal Article Biol Res · 2006 Featured Publication Iron is essential for many aspects of cellular function. However, it also can generate oxygen-based free radicals that result in injury to biological molecules. For this reason, iron acquisition and distribution are tightly regulated. Constant exposure to ... Full text Link to item Cite

Pediatric Rapid Response Teams in the Academic Medical Center

Journal Article Clinical Pediatric Emergency Medicine · January 1, 2006 With increased awareness of the prevalence of medical error, efforts to improve health care delivery have focused not only on the study of new therapies to combat disease, but also on the process of patient care. As a result, improved patient outcomes are ... Full text Cite

The iron cycle and oxidative stress in the lung.

Journal Article Free Radic Biol Med · April 1, 2004 Featured Publication Iron is critical for many aspects of cellular function, but it can also generate reactive oxygen species that can damage biological macromolecules. To limit oxidative stress, iron acquisition and its distribution must be tightly regulated. In the lungs, wh ... Full text Link to item Cite

Superoxide-dependent iron uptake: a new role for anion exchange protein 2.

Journal Article Am J Respir Cell Mol Biol · December 2003 Lung cells import iron across the plasma membrane as ferrous (Fe2+) ion by incompletely understood mechanisms. We tested the hypothesis that human bronchial epithelial (HBE) cells import non-transferrin-bound iron (NTBI) using superoxide-dependent ferri-re ... Full text Link to item Cite