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Tyler Kenneth Hornsby

Assistant Professor of Radiation Oncology
Radiation Oncology
40 Duke Medicine Circle 04205, Box 3295, Durham, NC 27710
40 Duke Medicine Circle, Box 3295, Durham, NC 27710

Overview


Tyler K. Hornsby is a Medical Physicist and Assistant Professor in the Department of Radiation Oncology at Duke University. He received his B.Sc. degree in Physics with a minor in Nanoscience from the University of Calgary (Calgary, AB, Canada) in 2017, followed by his M.Sc. and Ph.D. degrees in Biomedical Physics and CAMPEP Medical Physics from Toronto Metropolitan University (Toronto, ON, Canada) in 2019 and 2023, respectively. From 2023 to 2025, he completed his residency in Radiation Oncology Physics through McGill University stationed at St. Peter’s Hospital in Albany, New York.

He joined Duke in 2025 and works clinically in high dose rate gynecological brachytherapy, low dose rate eye plaque brachytherapy and intraoperative radiation therapy. His research interests include noninvasive ultrasound thermometry, therapeutic ultrasound hyperthermia, high intensity focused ultrasound (HIFU), nanoparticle-based drug delivery systems, targeted chemotherapy and combination therapy.

Current Appointments & Affiliations


Assistant Professor of Radiation Oncology · 2025 - Present Radiation Oncology, Clinical Science Departments

Recent Publications


Green synthesis of anti-cancer drug-loaded gold nanoparticles for low-intensity pulsed ultrasound targeted drug release.

Journal Article Drug Deliv Transl Res · September 2024 In the present work, we have designed a one-pot green protocol in which anti-cancer drugs (curcumin and doxorubicin) can be directly loaded on the surface of gold nanoparticles during their formation. We have further demonstrated that low-intensity pulsed ... Full text Link to item Cite

Ultrasound-mediated nano-sized drug delivery systems for cancer treatment: Multi-scale and multi-physics computational modeling.

Journal Article Wiley Interdiscip Rev Nanomed Nanobiotechnol · 2024 Computational modeling enables researchers to study and understand various complex biological phenomena in anticancer drug delivery systems (DDSs), especially nano-sized DDSs (NSDDSs). The combination of NSDDSs and therapeutic ultrasound (TUS), that is, fo ... Full text Link to item Cite

Kinetic modelling of ultrasound-triggered chemotherapeutic drug release from the surface of gold nanoparticles.

Journal Article Sci Rep · December 2, 2023 Therapeutic ultrasound can be used to trigger the on-demand release of chemotherapeutic drugs from gold nanoparticles (GNPs). In the previous work, our group achieved doxorubicin (DOX) release from the surface of GNPS under low-intensity pulsed ultrasound ... Full text Link to item Cite
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Education, Training & Certifications


Toronto Metropolitan University (Canada) · 2023 Ph.D.
Toronto Metropolitan University (Canada) · 2019 M.S.
University of Calgary (Canada) · 2017 B.S.

External Links


My Google Scholar