Scholars@Duke
Tyler Kenneth Hornsby

Tyler Kenneth Hornsby

Assistant Professor of Radiation Oncology
Radiation Oncology
tyler.hornsby@duke.edu
40 Duke Medicine Circle 04205, Box 3295, Durham, NC 27710
40 Duke Medicine Circle, Box 3295, Durham, NC 27710

Selected Publications

Green synthesis of anti-cancer drug-loaded gold nanoparticles for low-intensity pulsed ultrasound targeted drug release.

Journal Article Drug Deliv Transl Res · September 2024 In the present work, we have designed a one-pot green protocol in which anti-cancer drugs (curcumin and doxorubicin) can be directly loaded on the surface of gold nanoparticles during their formation. We have further demonstrated that low-intensity pulsed ... Full text Link to item Cite

Ultrasound-mediated nano-sized drug delivery systems for cancer treatment: Multi-scale and multi-physics computational modeling.

Journal Article Wiley Interdiscip Rev Nanomed Nanobiotechnol · 2024 Computational modeling enables researchers to study and understand various complex biological phenomena in anticancer drug delivery systems (DDSs), especially nano-sized DDSs (NSDDSs). The combination of NSDDSs and therapeutic ultrasound (TUS), that is, fo ... Full text Link to item Cite

Kinetic modelling of ultrasound-triggered chemotherapeutic drug release from the surface of gold nanoparticles.

Journal Article Sci Rep · December 2, 2023 Therapeutic ultrasound can be used to trigger the on-demand release of chemotherapeutic drugs from gold nanoparticles (GNPs). In the previous work, our group achieved doxorubicin (DOX) release from the surface of GNPS under low-intensity pulsed ultrasound ... Full text Link to item Cite

A Quantitative Study of Thermal and Non-thermal Mechanisms in Ultrasound-Induced Nano-drug Delivery.

Journal Article Ultrasound Med Biol · May 2023 OBJECTIVE: The primary objective of this study was to quantify the contributions to drug release for thermal and non-thermal mechanisms in ultrasound-induced release from gold nanoparticles (GNPs) for the first time. METHODS: We studied doxorubicin (DOX) a ... Full text Link to item Cite

Ultrasound-mediated nano drug delivery for treating cancer: Fundamental physics to future directions.

Journal Article J Control Release · March 2023 The application of biocompatible nanocarriers in medicine has provided several benefits over conventional treatment methods. However, achieving high treatment efficacy and deep penetration of nanocarriers in tumor tissue is still challenging. To address th ... Full text Link to item Cite

Multiphysics Modeling of Low-Intensity Pulsed Ultrasound Induced Chemotherapeutic Drug Release from the Surface of Gold Nanoparticles.

Journal Article Cancers (Basel) · January 14, 2023 Currently, no numerical model for low-intensity pulsed ultrasound (LIPUS)-triggered anticancer drug release from gold nanoparticle (GNP) drug carriers exists in the literature. In this work, LIPUS-induced doxorubicin (DOX) release from GNPs was achieved in ... Full text Link to item Cite

Integrating Therapeutic Ultrasound With Nanosized Drug Delivery Systems in the Battle Against Cancer.

Journal Article Technol Cancer Res Treat · 2023 Controlled, localized, and timely activation of nanosized drug delivery systems (NSDDSs), using an external stimulus such as therapeutic ultrasound (TUS), can improve the efficacy of cancer treatments compared to either conventional chemotherapy methods or ... Full text Link to item Cite

Measuring Drug Release Induced by Thermal and Non-thermal Effects of Ultrasound in a Nanodrug Delivery System

Conference 2022 IEEE International Ultrasonics Symposium (IUS) · October 10, 2022 Full text Cite

Significance of Non-Thermal Effects in LIPUS Induced Drug Release from Gold Nanoparticle Drug Carriers

Conference 2021 IEEE UFFC Latin America Ultrasonics Symposium (LAUS) · October 4, 2021 Full text Cite

Development of an ultrasonic nonlinear frequency compounding method with applications in tissue thermometry.

Journal Article J Acoust Soc Am · October 2021 Frequency compounding is an ultrasound imaging technique used to improve signal-to-noise ratio (SNR). In this work, a nonlinear frequency compounding (NLFC) method was introduced, and its application in noninvasive tissue thermometry investigated. The NLFC ... Full text Link to item Cite

Development of an Ultrasonic Nonlinear Frequency Compounding Method for Use in Noninvasive Tissue Thermometry

Conference 2020 IEEE International Ultrasonics Symposium (IUS) · September 7, 2020 Full text Cite

A Novel Gold Nanoparticles Drug Delivery System: Design and Ex Vivo Tissue Testing

Conference 2020 IEEE International Ultrasonics Symposium (IUS) · September 7, 2020 Full text Cite