Umar Mehraj

Journal Article Cancer Research · April 21, 2025 AbstractBackground:Neuroendocrine Prostate Cancer (NEPC) is an aggressive and lethal prostate cancer subtype. Due to Androgen Receptor ... Full text Cite

Chloroquine sensitises hypoxic colorectal cancer cells to ROS-mediated cell death via structural disruption of pyruvate dehydrogenase kinase 1.

Journal Article Free radical biology & medicine · February 2025 Chloroquine (CQ), an autophagy antagonist, has been recently explored as a repurposable medicine for cancer; however the exact mechanism of its action is still not known. The present study investigated the effect of CQ on colorectal cancer cells to elucida ... Full text Cite

Topical retinoid drug Adapalene: A new frontier in cancer treatment

Journal Article Results in Chemistry · August 1, 2024 It is predicted that over 29 million individuals will receive a cancer diagnosis in 2040, making cancer one of the major causes of death globally. One of the biggest obstacles to being overcome in the treatment of cancer is drug resistance, which is mostly ... Full text Cite

Synthesis and Biological Evaluation of Novel Uracil Derivatives as Thymidylate Synthase Inhibitors.

Journal Article Applied biochemistry and biotechnology · October 2023 Cell division is driven by nucleic acid metabolism, and thymidylate synthase (TYMS) catalyzes a rate-limiting step in nucleotide synthesis. As a result, thymidylate synthase has emerged as a critical target in chemotherapy. 5-Fluorouracil (5-FU) is current ... Full text Cite

Chemokines in triple-negative breast cancer heterogeneity: New challenges for clinical implications.

Journal Article Seminars in cancer biology · November 2022 Tumor heterogeneity is a hallmark of cancer and one of the primary causes of resistance to therapies. Triple-negative breast cancer (TNBC), which accounts for 15-20% of all breast cancers and is the most aggressive subtype, is very diverse, connected to me ... Full text Cite

Adapalene inhibits the growth of triple-negative breast cancer cells by S-phase arrest and potentiates the antitumor efficacy of GDC-0941

Journal Article Frontiers in Pharmacology · August 8, 2022 Although advances in diagnostics and therapeutics have prolonged the survival of triple-negative breast cancer (TNBC) patients, metastasis, therapeutic resistance, and lack of targeted therapies remain the foremost hurdle in the effective management of TNB ... Full text Cite

Expression Pattern and Prognostic Significance of Chemokines in Breast cancer: An Integrated Bioinformatics Analysis.

Journal Article Clinical breast cancer · August 2022 BackgroundBreast cancer (BC), one of the most prevalent malignancies, is the second major cause of mortality from cancer among women worldwide. Even though substantial progress has been made in breast cancer treatment, metastasis still accounts fo ... Full text Cite

Adapalene and Doxorubicin Synergistically Promote Apoptosis of TNBC Cells by Hyperactivation of the ERK1/2 Pathway Through ROS Induction

Journal Article Frontiers in Oncology · July 6, 2022 Doxorubicin is a commonly used chemotherapeutic agent to treat several malignancies, including aggressive tumors like triple-negative breast cancer. It has a limited therapeutic index owing to its extreme toxicity and the emergence of drug resistance. As a ... Full text Cite

Expression pattern and prognostic significance of baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) in breast cancer: A comprehensive analysis

Journal Article Advances in Cancer Biology Metastasis · July 1, 2022 Background: Baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, member of the inhibitor of apoptosis (IAP), is a multitasking protein and among the top 100 deregulated genes in breast cancer patients. It negatively regulates apoptosis of tumor ... Full text Cite

Expression patterns and therapeutic implications of CDK4 across multiple carcinomas: a molecular docking and MD simulation study.

Journal Article Medical oncology (Northwood, London, England) · July 2022 The CDKs are known to play a critical role in cell cycle regulation process. Among the different groups of CDKs, CDK4 overexpression/hyperactivation is found to be present in many cancers and a specific CDK4 inhibitor, palbociclib has been recently approve ... Full text Cite

Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors.

Journal Article Medical oncology (Northwood, London, England) · June 2022 Cell cycle dysregulation is a characteristic hallmark of malignancies, which results in uncontrolled cell proliferation and eventual tumor formation. Cyclin-dependent kinase 1 (CDK1) is a member of the family of cell cycle regulatory proteins involved in c ... Full text Cite

Cyclin-dependent kinases in breast cancer: expression pattern and therapeutic implications.

Journal Article Medical oncology (Northwood, London, England) · April 2022 Presently, breast cancer (BC) is one of the most common malignancies diagnosed and the leading cause of tumor-related deaths among women worldwide. Cell cycle dysregulation is one of the hallmarks of cancer, resulting in uncontrolled cell proliferation. Cy ... Full text Cite

Cryptolepine Targets TOP2A and Inhibits Tumor Cell Proliferation in Breast Cancer Cells - An In vitro and In silico Study.

Journal Article Anti-cancer agents in medicinal chemistry · January 2022 BackgroundDNA Topoisomerase II Alpha (TOP2A), a protein-coding gene, is central to the replication process and has been found deregulated in several malignancies, including breast cancer. Several therapeutic regimens have been developed and approv ... Full text Cite

Expression pattern and prognostic significance of CDKs in breast cancer: An integrated bioinformatic study.

Journal Article Cancer biomarkers : section A of Disease markers · January 2022 BackgroundGlobally, breast cancer (BC) has become one of the most prevalent malignancies and the leading cause of tumor-related deaths among women. Dysregulation of the cell cycle is a well-known hallmark of cancer development and metastasis. CDKs ... Full text Cite

The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities.

Journal Article Cellular oncology (Dordrecht, Netherlands) · December 2021 BackgroundBreast cancer (BC), the second most common cause of cancer-related deaths, remains a significant threat to the health and wellness of women worldwide. The tumor microenvironment (TME), comprising cellular components, such as cancer-assoc ... Full text Cite

Prognostic significance and targeting tumor-associated macrophages in cancer: new insights and future perspectives.

Journal Article Breast cancer (Tokyo, Japan) · May 2021 Macrophages are phagocytic sentinel cells of the immune system that are central to both innate and adaptive immune responses and serve as the first line of defense against pathogenic insults to tissues. In the tumor microenvironment, tumor-derived factors ... Full text Cite

Tumor microenvironment promotes breast cancer chemoresistance.

Journal Article Cancer chemotherapy and pharmacology · February 2021 Breast cancer is presently the most predominant tumor type and the second leading cause of tumor-related deaths among women. Although advancements in diagnosis and therapeutics have momentously improved, chemoresistance remains an important challenge. Tumo ... Full text Cite

Development of New Therapeutics to Meet the Current Challenge of Drug Resistant Tuberculosis.

Journal Article Current pharmaceutical biotechnology · January 2021 Tuberculosis (TB) is a prominent infective disease and a major reason of mortality/ morbidity globally. Mycobacterium tuberculosis causes a long-lasting latent infection in a significant proportion of human population. The increasing burden of tuberculosis ... Full text Cite

Recent advances in chemotherapeutic implications of deguelin: A plant-derived retinoid

Journal Article Natural Products Journal · January 1, 2021 Deguelin, a plant retinoid has emerged to be a promising therapeutic agent in the treatment of different cancers. Recent studies demonstrate that deguelin has potential as an angiogenesis antagonist in malignant and endothelial cells by specifically target ... Full text Cite

Nanobodies: The "Magic Bullets" in therapeutics, drug delivery and diagnostics.

Journal Article Human antibodies · January 2020 Antibodies represent a well-established class of clinical diagnostics for medical applications as well as essential research and biotechnological tools. Although both polyclonal and monoclonal antibodies are indispensable reagents in basic research and dia ... Full text Cite

Targeting Different Pathways Using Novel Combination Therapy in Triple Negative Breast Cancer.

Journal Article Current cancer drug targets · January 2020 Triple negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer accounting for 15-20% of cases and is defined by the lack of hormonal receptors viz., estrogen receptor (ER), progesterone receptor (PR) and expression of human ep ... Full text Cite

Recent advances in metabolites from medicinal plants in cancer prevention and treatment

Journal Article Current Immunology Reviews · January 1, 2019 Cancer is the second leading cause of death and morbidity in the world among non-communicable diseases after cardiovascular ailments. With the advancement in science and research, a number of therapies have been developed to treat cancer, including chemoth ... Full text Cite

Study on the quality control analysis of antiepileptic drugs using high-performance liquid chromatography

Journal Article International Journal of Pharmaceutical Investigation · 2018 Full text Cite