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Antonius M. J. VanDongen

Associate Professor of Pharmacology & Cancer Biology
Pharmacology & Cancer Biology
308 Research Drive LSRC C334, DUMC 3813, Durham, NC 27710
1 Kingswear Avenue, Singapore, SG, SG 557183


We have discovered a new connection between the memory gene Arc (Activity Regulated, Cytoskeletal-associated protein) and Alzheimer's disease. Arc is a master regulator of of synaptic plasticity and epigenetically controls the transcription of 1900 genes associated with with synaptic function, neuronal plasticity, intrinsic excitability (channels, receptors, transporters), and signaling pathways (transcription factors/regulators). Approximately 100 genes whose activity-dependent expression level depends on Arc are associated with the pathophysiology of Alzheimer’s disease, suggesting a critical role for Arc in the development of neurodegenerative disorders.

Current Appointments & Affiliations

Associate Professor of Pharmacology & Cancer Biology · 1998 - Present Pharmacology & Cancer Biology, Basic Science Departments

Education, Training & Certifications

Leiden University (The Netherlands) · 1988 Ph.D.
Utrecht University (The Netherlands) · 1982 M.S.
Utrecht University (The Netherlands) · 1979 B.S.