Antonius M. J. VanDongen

Antonius M. J. VanDongen
Associate Professor of Pharmacology & Cancer Biology

We have discovered a new connection between the memory gene Arc (Activity Regulated, Cytoskeletal-associated protein) and Alzheimer's disease. Arc is a master regulator of of synaptic plasticity and epigenetically controls the transcription of 1900 genes associated with with synaptic function, neuronal plasticity, intrinsic excitability (channels, receptors, transporters), and signaling pathways (transcription factors/regulators). Approximately 100 genes whose activity-dependent expression level depends on Arc are associated with the pathophysiology of Alzheimer’s disease, suggesting a critical role for Arc in the development of neurodegenerative disorders.

Current Appointments & Affiliations

Associate Professor of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 1998

Contact Information

308 Research Drive LSRC C334, DUMC 3813, Durham, NC 27710
1 Kingswear Avenue, Singapore, SG 557183
antonius.vandongen@duke.edu

Background
Education, Training, & Certifications
- Ph.D., Leiden University (The Netherlands) 1988
- M.S., Utrecht University (The Netherlands) 1982
- B.S., Utrecht University (The Netherlands) 1979
Previous Appointments & Affiliations
- Associate Professor of Neurobiology, Neurobiology, Basic Science Departments 1999 - 2009
- Assistant Professor of Pharmacology, Pharmacology & Cancer Biology, Basic Science Departments 1992 - 1998
Recognition
In the News
- JUL 17, 2015 Science News
  
  How the brain perceives time
Expertise
Global Scholarship
- Research
  - Singapore (Country)
Research
Selected Grants
- Molecular Mechanism of activation and gating in the NMDA receptor awarded by National Institutes of Health 2005 - 2007
- Characterization of N-Chimaerin awarded by National Institutes of Health 2004 - 2006
- Customs Plasmids Project awarded by National Institute of Environmental Health Science 2005 - 2006
- The Molecular Basis of Ion Channel Opening awarded by National Institutes of Health 2001 - 2005
- NMDA Receptor-- Agonist Affinity, Efficacy/Transduction awarded by National Institutes of Health 2001 - 2005
- Translational Regulation of Glutamate Receptors awarded by National Institutes of Health 2001 - 2004
- The Molecular Basis of Affinity and Efficacy in the N-methyl-D-aspartate Receptor awarded by National Institutes of Health 2001 - 2002
- Same awarded by National Institutes of Health 1993 - 2001
- Molecular Pharmacology And Physiology Of Nicotine awarded by National Institutes of Health 1997 - 1999
- Same awarded by National Institutes of Health 1997 - 1999
- The Stuctural Basis Of Ion Channel Opening awarded by National Institutes of Health 1997 - 1999
- Sructural Basis Of Ion Channel Opening awarded by National Institutes of Health 1994 - 1997
- The Structural Basis Of Ion Channel Opening awarded by National Institutes of Health 1993 - 1997
- Structural Basis Of Ion Channel Opening awarded by National Institutes of Health 1996 - 1997
Publications & Artistic Works
Selected Publications
- Books
  - VanDongen, A. M. Biology of the NMDA receptor, 2008.
  - VanDongen, A. M. J. Preface, 2008.
- Academic Articles
  - Oey, Nicodemus E., Lei Zhou, Christine Hui Shan Chan, Antonius M. J. VanDongen, and Eng King Tan. “A Proteome-Wide Effect of PHF8 Knockdown on Cortical Neurons Shows Downregulation of Parkinson's Disease-Associated Protein Alpha-Synuclein and Its Interactors.” Biomedicines 11, no. 2 (February 8, 2023). https://doi.org/10.3390/biomedicines11020486.
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  - Leung, How-Wing, Gabriel Foo, and Antonius VanDongen. “Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer's Disease.” Biomedicines 10, no. 8 (August 11, 2022). https://doi.org/10.3390/biomedicines10081946.
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  - Jiang, Yuheng, and Antonius M. J. VanDongen. “Selective increase of correlated activity in Arc-positive neurons after chemically induced long-term potentiation in cultured hippocampal neurons.” Eneuro 8, no. 6 (November 12, 2021). https://doi.org/10.1523/ENEURO.0540-20.2021.
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  - Yin, Juan, and Antonius M. VanDongen. “Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimer's Disease.” Acs Biomater Sci Eng 7, no. 1 (January 11, 2021): 254–64. https://doi.org/10.1021/acsbiomaterials.0c01583.
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  - Zhang, Xiaoyu, Fang-Chin Yeh, Han Ju, Yuheng Jiang, Gabriel Foo Wei Quan, and Antonius M. J. VanDongen. “Familiarity Detection and Memory Consolidation in Cortical Assemblies.” Eneuro 7, no. 3 (2020). https://doi.org/10.1523/ENEURO.0006-19.2020.
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  - Oey, Nicodemus Edrick, Geoffrey Sithamparapillai Samuel, Joseph Kai Wei Lim, Antonius Mj VanDongen, Yee Sien Ng, and Juan Zhou. “Whole Brain White Matter Microstructure and Upper Limb Function: Longitudinal Changes in Fractional Anisotropy and Axial Diffusivity in Post-Stroke Patients.” J Cent Nerv Syst Dis 11 (2019): 1179573519863428. https://doi.org/10.1177/1179573519863428.
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  - Samuel, Geoffrey Sithamparapillai, Nicodemus Edrick Oey, Min Choo, Han Ju, Wai Yin Chan, Stanley Kok, Yu Ge, Antonius M. Van Dongen, and Yee Sien Ng. “Combining levodopa and virtual reality-based therapy for rehabilitation of the upper limb after acute stroke: pilot study Part II.” Singapore Med J 58, no. 10 (October 2017): 610–17. https://doi.org/10.11622/smedj.2016111.
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  - Bhinge, Akshay, Seema C. Namboori, Xiaoyu Zhang, Antonius M. J. VanDongen, and Lawrence W. Stanton. “Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis.” Stem Cell Reports 8, no. 4 (April 11, 2017): 856–69. https://doi.org/10.1016/j.stemcr.2017.02.019.
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  - Leung, How-Wing, Gabriel Foo, Gokulakrishna Banumurthy, Xiaoran Chai, Sujoy Ghosh, Tora Mitra-Ganguli, and Antonius M. J. VanDongen. “The effect of Bacopa monnieri on gene expression levels in SH-SY5Y human neuroblastoma cells.” Plos One 12, no. 8 (2017): e0182984. https://doi.org/10.1371/journal.pone.0182984.
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  - Zhang, Xiaoyu, Han Ju, Trevor B. Penney, and Antonius M. J. VanDongen. “Familiarity Detection is an Intrinsic Property of Cortical Microcircuits with Bidirectional Synaptic Plasticity.” Eneuro 4, no. 3 (2017). https://doi.org/10.1523/ENEURO.0361-16.2017.
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  - Poon, Vivian Y., Minxia Gu, Fang Ji, Antonius M. VanDongen, and Marc Fivaz. “miR-27b shapes the presynaptic transcriptome and influences neurotransmission by silencing the polycomb group protein Bmi1.” Bmc Genomics 17, no. 1 (October 4, 2016): 777. https://doi.org/10.1186/s12864-016-3139-7.
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  - Lin, Lin, Jonathan Göke, Engin Cukuroglu, Mark R. Dranias, Antonius M. J. VanDongen, and Lawrence W. Stanton. “Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients.” Cell Rep 15, no. 11 (June 14, 2016): 2411–26. https://doi.org/10.1016/j.celrep.2016.05.022.
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  - Tie, Hieng Chiong, Divyanshu Mahajan, Bing Chen, Li Cheng, Antonius M. J. VanDongen, and Lei Lu. “A novel imaging method for quantitative Golgi localization reveals differential intra-Golgi trafficking of secretory cargoes.” Mol Biol Cell 27, no. 5 (March 1, 2016): 848–61. https://doi.org/10.1091/mbc.E15-09-0664.
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  - Ma, Dongliang, Su-In Yoon, Chih-Hao Yang, Guillaume Marcy, Na Zhao, Wan-Ying Leong, Vinu Ganapathy, et al. “Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital.” Neurotherapeutics 12, no. 2 (April 2015): 477–90. https://doi.org/10.1007/s13311-015-0343-0.
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  - Ju, Han, Mark R. Dranias, Gokulakrishna Banumurthy, and Antonius M. J. VanDongen. “Spatiotemporal memory is an intrinsic property of networks of dissociated cortical neurons.” J Neurosci 35, no. 9 (March 4, 2015): 4040–51. https://doi.org/10.1523/JNEUROSCI.3793-14.2015.
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  - Dranias, Mark R., M Brandon Westover, Sidney Cash, and Antonius M. J. VanDongen. “Stimulus information stored in lasting active and hidden network states is destroyed by network bursts.” Front Integr Neurosci 9 (2015): 14. https://doi.org/10.3389/fnint.2015.00014.
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  - Oey, Nicodemus E., How Wing Leung, Rajaram Ezhilarasan, Lei Zhou, Roger W. Beuerman, Hendrika M. A. VanDongen, and Antonius M. J. VanDongen. “A Neuronal Activity-Dependent Dual Function Chromatin-Modifying Complex Regulates Arc Expression.” Eneuro 2, no. 1 (2015). https://doi.org/10.1523/ENEURO.0020-14.2015.
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  - Zhao, Na, Dongliang Ma, Wan Ying Leong, Ju Han, Antonius VanDongen, Teng Chen, and Eyleen L. K. Goh. “The methyl-CpG-binding domain (MBD) is crucial for MeCP2's dysfunction-induced defects in adult newborn neurons.” Front Cell Neurosci 9 (2015): 158. https://doi.org/10.3389/fncel.2015.00158.
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  - Wee, Caroline L., Shaun Teo, Nicodemus E. Oey, Graham D. Wright, Hendrika M. A. VanDongen, and Antonius M. J. VanDongen. “Nuclear Arc Interacts with the Histone Acetyltransferase Tip60 to Modify H4K12 Acetylation(1,2,3).” Eneuro 1, no. 1 (2014). https://doi.org/10.1523/ENEURO.0019-14.2014.
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  - Ju, Han, Jian-Xin Xu, Edmund Chong, and Antonius M. J. VanDongen. “Effects of synaptic connectivity on liquid state machine performance.” Neural Netw 38 (February 2013): 39–51. https://doi.org/10.1016/j.neunet.2012.11.003.
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  - Dranias, Mark R., Han Ju, Ezhilarasan Rajaram, and Antonius M. J. VanDongen. “Short-term memory in networks of dissociated cortical neurons.” J Neurosci 33, no. 5 (January 30, 2013): 1940–53. https://doi.org/10.1523/JNEUROSCI.2718-12.2013.
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  - Fu, Y., L. K. Chin, T. Bourouina, A. Q. Liu, and A. M. J. VanDongen. “Erratum: Nuclear deformation during breast cancer cell transmigration (Lab on a Chip - Miniaturisation for Chemistry and Biology (2012) 12 DOI: 10.1039/c2lc40477j).” Lab on a Chip 12, no. 24 (December 21, 2012): 5283. https://doi.org/10.1039/c2lc90132c.
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  - Zhang, X., G. Foderaro, C. Henriquez, A. M. J. VanDongen, and S. Ferrari. “A Radial Basis Function Spike Model for Indirect Learning via Integrate-and-Fire Sampling and Reconstruction Techniques.” Advances in Artificial Neural Systems 2012 (October 10, 2012): 1–16. https://doi.org/10.1155/2012/713581.
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  - Fu, Yi, Lip Ket Chin, Tarik Bourouina, Ai Qin Liu, and Antonius M. J. VanDongen. “Nuclear deformation during breast cancer cell transmigration.” Lab Chip 12, no. 19 (October 7, 2012): 3774–78. https://doi.org/10.1039/c2lc40477j.
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  - Fu, Y., A. Vandongen, T. Bourouina, W. M. Tsang, M. Je, and A. Q. Liu. “A study of axonal protein trafficking in neuronal networks via the microfluidic platform.” Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Microtas 2012, January 1, 2012, 1072–74.
  - Fu, Y., A. Vandongen, T. Bourouina, W. M. Tsang, M. Je, and A. Q. Liu. “The significance of nuclear deformation for cancer cell transmigration.” Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Microtas 2012, January 1, 2012, 1561–63.
  - Fu, Yi, Lip Ket Chin, Tarik Bourouina, Ai Qun Liu, and Antonius M. J. VanDongen. “Nuclear deformation during breast cancer cell transmigration (vol 12, pg 3774, 2012).” Lab on a Chip 12, no. 24 (January 1, 2012): 5283–5283.
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  - Maheswaranathan, Niru, Silvia Ferrari, Antonius M. J. Vandongen, and Craig S. Henriquez. “Emergent bursting and synchrony in computer simulations of neuronal cultures.” Front Comput Neurosci 6 (2012): 15. https://doi.org/10.3389/fncom.2012.00015.
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  - Sharma, Reetu, Roopa Kothapalli, Antonius M. J. Van Dongen, and Kunchithapadam Swaminathan. “Chemoinformatic identification of novel inhibitors against Mycobacterium tuberculosis L-aspartate α-decarboxylase.” Plos One 7, no. 3 (2012): e33521. https://doi.org/10.1371/journal.pone.0033521.
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  - Han, N. L. R., H. M. A. Vandongen, and A. M. J. Vandongen. “Identification of a novel class of allosteric modulators of the NMDA receptor.” Singapore General Hospital Proceedings 18, no. 3 (December 1, 2009): 99–107.
  - Blanke, M. L., and A. M. VanDongen. “Erratum: The NR1 M3 domain mediates allosteric coupling in the N-methyl-D-aspartate receptor (Molecular Pharmacology (2008) 74 (454-465)).” Molecular Pharmacology 75, no. 1 (January 1, 2009): 255–57.
  - Ferrari, S., B. Mehta, G. Di Muro, A. M. J. VanDongen, and C. Henriquez. “Biologically realizable reward-modulated hebbian training for spiking neural networks.” Proceedings of the International Joint Conference on Neural Networks, November 24, 2008, 1780–86. https://doi.org/10.1109/IJCNN.2008.4634039.
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  - Blanke, Marie L., and Antonius M. J. VanDongen. “The NR1 M3 domain mediates allosteric coupling in the N-methyl-D-aspartate receptor.” Mol Pharmacol 74, no. 2 (August 2008): 454–65. https://doi.org/10.1124/mol.107.044115.
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  - Blanke, Marie L., and Antonius M. J. VanDongen. “Constitutive activation of the N-methyl-D-aspartate receptor via cleft-spanning disulfide bonds.” J Biol Chem 283, no. 31 (August 1, 2008): 21519–29. https://doi.org/10.1074/jbc.M709190200.
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  - Bloomer, Wendy A. C., Hendrika M. A. VanDongen, and Antonius M. J. VanDongen. “Arc/Arg3.1 translation is controlled by convergent N-methyl-D-aspartate and Gs-coupled receptor signaling pathways.” J Biol Chem 283, no. 1 (January 4, 2008): 582–92. https://doi.org/10.1074/jbc.M702451200.
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  - Bloomer, Wendy A. C., Hendrika M. A. VanDongen, and Antonius M. J. VanDongen. “Activity-regulated cytoskeleton-associated protein Arc/Arg3.1 binds to spectrin and associates with nuclear promyelocytic leukemia (PML) bodies.” Brain Res 1153 (June 11, 2007): 20–33. https://doi.org/10.1016/j.brainres.2007.03.079.
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  - Chapman, Mark L., Marie L. Blanke, Howard S. Krovetz, and Antonius M. J. VanDongen. “Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel.” Pflugers Arch 451, no. 6 (March 2006): 776–92. https://doi.org/10.1007/s00424-005-1515-2.
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  - Van de Ven, Thomas J., Hendrika M. A. VanDongen, and Antonius M. J. VanDongen. “The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density.” J Neurosci 25, no. 41 (October 12, 2005): 9488–96. https://doi.org/10.1523/JNEUROSCI.2450-05.2005.
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  - Chapman, Mark L., and Antonius M. J. VanDongen. “K channel subconductance levels result from heteromeric pore conformations.” J Gen Physiol 126, no. 2 (August 2005): 87–103. https://doi.org/10.1085/jgp.200509253.
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  - Grigston, Jeffrey C., Hendrika M. A. VanDongen, James O. McNamara, and Antonius M. J. VanDongen. “Translation of an integral membrane protein in distal dendrites of hippocampal neurons.” Eur J Neurosci 21, no. 6 (March 2005): 1457–68. https://doi.org/10.1111/j.1460-9568.2005.03999.x.
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  - Persaud-Sawin, Dixie-Ann, James O. McNamara, Svetlana Rylova, Antonius Vandongen, and Rose-Mary N. Boustany. “A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes.” Pediatr Res 56, no. 3 (September 2004): 449–63. https://doi.org/10.1203/01.PDR.0000136152.54638.95.
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  - McNamara, James O., Jeffrey C. Grigston, Hendrika M. A. VanDongen, and Antonius M. J. VanDongen. “Rapid dendritic transport of TGN38, a putative cargo receptor.” Brain Res Mol Brain Res 127, no. 1–2 (August 23, 2004): 68–78. https://doi.org/10.1016/j.molbrainres.2004.05.013.
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  - Kalbaugh, Trisha L., Hendrika M. A. VanDongen, and Antonius M. J. VanDongen. “Ligand-binding residues integrate affinity and efficacy in the NMDA receptor.” Mol Pharmacol 66, no. 2 (August 2004): 209–19. https://doi.org/10.1124/mol.66.2.209.
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  - Barnes, Anthony P., F Donelson Smith, Hendrika M. VanDongen, Antonius M. J. VanDongen, and Sharon L. Milgram. “The identification of a second actin-binding region in spinophilin/neurabin II.” Brain Res Mol Brain Res 124, no. 2 (May 19, 2004): 105–13. https://doi.org/10.1016/j.molbrainres.2003.12.020.
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  - VanDongen, Antonius M. J. “K channel gating by an affinity-switching selectivity filter.” Proc Natl Acad Sci U S A 101, no. 9 (March 2, 2004): 3248–52. https://doi.org/10.1073/pnas.0308743101.
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  - VanDongen, Antonius M. J. “Idealization and simulation of single ion channel data.” Methods Enzymol 383 (2004): 229–44. https://doi.org/10.1016/S0076-6879(04)83010-6.
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  - VanDongen, Antonius M. J., and Hendrika M. A. VanDongen. “Effects of mRNA untranslated regions on translational efficiency of NMDA receptor subunits.” Neurosignals 13, no. 4 (2004): 194–206. https://doi.org/10.1159/000077526.
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  - Persaud-Sawin, Dixie-Ann N. W., Antonius VanDongen, and Rose-Mary N. Boustany. “Motifs within the CLN3 protein: modulation of cell growth rates and apoptosis.” Hum Mol Genet 11, no. 18 (September 1, 2002): 2129–42. https://doi.org/10.1093/hmg/11.18.2129.
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  - Jones, Kevin S., Hendrika M. A. VanDongen, and Antonius M. J. VanDongen. “The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening.” J Neurosci 22, no. 6 (March 15, 2002): 2044–53. https://doi.org/10.1523/JNEUROSCI.22-06-02044.2002.
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  - Chapman, M. L., H. S. Krovetz, and A. M. VanDongen. “GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity.” J Physiol 530, no. Pt 1 (January 1, 2001): 21–33. https://doi.org/10.1111/j.1469-7793.2001.0021m.x.
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  - Courtney, K. D., M. Grove, H. Vandongen, A. Vandongen, A. S. LaMantia, and A. M. Pendergast. “Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system.” Mol Cell Neurosci 16, no. 3 (September 2000): 244–57. https://doi.org/10.1006/mcne.2000.0865.
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  - Wood, M. W., H. M. VanDongen, and A. M. VanDongen. “A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.” Brain Res Mol Brain Res 73, no. 1–2 (November 10, 1999): 189–92. https://doi.org/10.1016/s0169-328x(99)00247-8.
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  - VanDongen, H. M., and A. M. VanDongen. “Determination of membrane topology of glutamate receptors.” Methods Mol Biol 128 (1999): 155–66. https://doi.org/10.1385/1-59259-683-5:155.
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  - Wood, M. W., H. M. VanDongen, and A. M. VanDongen. “An alanine residue in the M3-M4 linker lines the glycine binding pocket of the N-methyl-D-aspartate receptor.” J Biol Chem 272, no. 6 (February 7, 1997): 3532–37. https://doi.org/10.1074/jbc.272.6.3532.
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  - Chapman, M. L., H. M. VanDongen, and A. M. VanDongen. “Activation-dependent subconductance levels in the drk1 K channel suggest a subunit basis for ion permeation and gating.” Biophys J 72, no. 2 Pt 1 (February 1997): 708–19. https://doi.org/10.1016/s0006-3495(97)78707-1.
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  - Krovetz, H. S., H. M. VanDongen, and A. M. VanDongen. “Atomic distance estimates from disulfides and high-affinity metal-binding sites in a K+ channel pore.” Biophys J 72, no. 1 (January 1997): 117–26. https://doi.org/10.1016/S0006-3495(97)78651-X.
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  - Wood, M. W., H. M. VanDongen, and A. M. VanDongen. “The 5'-untranslated region of the N-methyl-D-aspartate receptor NR2A subunit controls efficiency of translation.” J Biol Chem 271, no. 14 (April 5, 1996): 8115–20. https://doi.org/10.1074/jbc.271.14.8115.
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  - VanDongen, A. M. “A new algorithm for idealizing single ion channel data containing multiple unknown conductance levels.” Biophys J 70, no. 3 (March 1996): 1303–15. https://doi.org/10.1016/S0006-3495(96)79687-X.
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  - Wood, M. W., H. M. VanDongen, and A. M. VanDongen. “Structural conservation of ion conduction pathways in K channels and glutamate receptors.” Proc Natl Acad Sci U S A 92, no. 11 (May 23, 1995): 4882–86. https://doi.org/10.1073/pnas.92.11.4882.
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  - Taglialatela, M., G. E. Kirsch, A. M. VanDongen, J. A. Drewe, H. A. Hartmann, R. H. Joho, E. Stefani, and A. M. Brown. “Gating currents from a delayed rectifier K+ channel with altered pore structure and function.” Biophys J 62, no. 1 (April 1992): 34–36. https://doi.org/10.1016/S0006-3495(92)81770-8.
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  - Taglialatela, M., A. M. Vandongen, J. A. Drewe, R. H. Joho, A. M. Brown, and G. E. Kirsch. “Patterns of internal and external tetraethylammonium block in four homologous K+ channels.” Mol Pharmacol 40, no. 2 (August 1991): 299–307.
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  - Brown, A. M., A. Yatani, G. Kirsch, K. Okabe, A. M. VanDongen, and L. Birnbaumer. “Control of K+ channels by G proteins.” J Bioenerg Biomembr 23, no. 4 (August 1991): 499–507. https://doi.org/10.1007/BF00785808.
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  - Brown, A. M., A. Yatani, G. Kirsch, A. M. VanDongen, B. Schubert, J. Codina, and L. Birnbaumer. “Regulation of ionic channels by G proteins.” Adv Exp Med Biol 308 (1991): 119–34. https://doi.org/10.1007/978-1-4684-6015-5_10.
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  - VanDongen, A. M., G. C. Frech, J. A. Drewe, R. H. Joho, and A. M. Brown. “Alteration and restoration of K+ channel function by deletions at the N- and C-termini.” Neuron 5, no. 4 (October 1990): 433–43. https://doi.org/10.1016/0896-6273(90)90082-q.
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  - Van Erp, M. G., A. M. Van Dongen, and R. J. Van den Berg. “Voltage-dependent action of valproate on potassium channels in frog node of Ranvier.” Eur J Pharmacol 184, no. 1 (August 2, 1990): 151–61. https://doi.org/10.1016/0014-2999(90)90676-w.
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  - SCHUBERT, B., A. M. J. VANDONGEN, G. E. KIRSCH, and A. M. BROWN. “INHIBITION OF CARDIAC NA+ CURRENTS BY ISOPROTERENOL.” American Journal of Physiology 258, no. 4 (April 1, 1990): H977–82.
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  - Schubert, B., A. M. Vandongen, G. E. Kirsch, and A. M. Brown. “Inhibition of cardiac Na+ currents by isoproterenol.” Am J Physiol 258, no. 4 Pt 2 (April 1990): H977–82. https://doi.org/10.1152/ajpheart.1990.258.4.H977.
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  - Joho, R. H., J. R. Moorman, A. M. VanDongen, G. E. Kirsch, H. Silberberg, G. Schuster, and A. M. Brown. “Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes.” Brain Res Mol Brain Res 7, no. 2 (February 1990): 105–13. https://doi.org/10.1016/0169-328x(90)90087-t.
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  - Moorman, J. R., G. E. Kirsch, A. M. VanDongen, R. H. Joho, and A. M. Brown. “Fast and slow gating of sodium channels encoded by a single mRNA.” Neuron 4, no. 2 (February 1990): 243–52. https://doi.org/10.1016/0896-6273(90)90099-2.
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  - Birnbaumer, L., A. Yatani, A. M. VanDongen, R. Graf, J. Codina, K. Okabe, R. Mattera, and A. M. Brown. “G protein coupling of receptors to ionic channels and other effector systems.” Soc Gen Physiol Ser 45 (1990): 169–83.
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  - Birnbaumer, L., A. Yatani, A. M. VanDongen, R. Graf, J. Codina, K. Okabe, R. Mattera, and A. M. Brown. “G protein coupling of receptors to ionic channels and other effector systems.” Society of General Physiologists Series 45 (January 1, 1990): 169–83.
  - Brown, A. M., A. Yatani, A. M. VanDongen, G. E. Kirsch, J. Codina, and L. Birnbaumer. “Networking ionic channels by G proteins.” Soc Gen Physiol Ser 45 (1990): 1–9.
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  - Brown, A. M., A. Yatani, A. M. VanDongen, G. E. Kirsch, J. Codina, and L. Birnbaumer. “Networking ionic channels by G proteins.” Society of General Physiologists Series 45 (January 1, 1990): 1–9.
  - Birnbaumer, L., A. Yatani, A. M. VanDongen, R. Graf, J. Codina, K. Okabe, R. Mattera, and A. M. Brown. “G protein coupling of receptors to ionic channels and other effector systems.” Br J Clin Pharmacol 30 Suppl 1, no. Suppl 1 (1990): 13S-22S. https://doi.org/10.1111/j.1365-2125.1990.tb05463.x.
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  - Frech, G. C., A. M. VanDongen, G. Schuster, A. M. Brown, and R. H. Joho. “A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning.” Nature 340, no. 6235 (August 24, 1989): 642–45. https://doi.org/10.1038/340642a0.
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  - Schubert, B., A. M. VanDongen, G. E. Kirsch, and A. M. Brown. “Beta-adrenergic inhibition of cardiac sodium channels by dual G-protein pathways.” Science 245, no. 4917 (August 4, 1989): 516–19. https://doi.org/10.1126/science.2547248.
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  - Birnbaumer, L., A. M. VanDongen, J. Codina, A. Yatani, R. Mattera, R. Graf, and A. M. Brown. “Identification of G protein-gated and G protein-modulated ionic channels. Molecular basis for G protein action.” Soc Gen Physiol Ser 44 (1989): 17–54.
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  - VanDongen, A. M., J. Codina, J. Olate, R. Mattera, R. Joho, L. Birnbaumer, and A. M. Brown. “Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go.” Science 242, no. 4884 (December 9, 1988): 1433–37. https://doi.org/10.1126/science.3144040.
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  - Habets, A. M., A. M. Van Dongen, F. Van Huizen, and M. A. Corner. “Spontaneous neuronal firing patterns in fetal rat cortical networks during development in vitro: a quantitative analysis.” Exp Brain Res 69, no. 1 (1987): 43–52. https://doi.org/10.1007/BF00247027.
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  - VanDongen, A. M., M. G. VanErp, and R. A. Voskuyl. “Valproate reduces excitability by blockage of sodium and potassium conductance.” Epilepsia 27, no. 3 (1986): 177–82. https://doi.org/10.1111/j.1528-1157.1986.tb03525.x.
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  - Van Dongen, A. M. J., and F. Bretschneider. “Functioning of catfish electroreceptors: Bursting discharge pattern of Kryptopterus electroreceptors elicited by microelectrode impalement.” Comparative Biochemistry and Physiology Part A: Physiology 77, no. 4 (January 1, 1984): 647–50. https://doi.org/10.1016/0300-9629(84)90178-6.
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- Book Sections
  - Blanke, M. L., and A. M. J. VanDongen. “Activation mechanisms of the NMDA receptor.” In Biology of the NMDA Receptor, 283–312, 2008.
- Conference Papers
  - Fu, Y., A. M. J. Vandongen, T. Bourouina, W. T. Park, M. Y. Je, J. M. Tsai, D. L. Kwong, and A. Q. Liu. “A study of cancer cell metastasis using microfluidic transmigration device.” In Proceedings of the Ieee International Conference on Micro Electro Mechanical Systems (Mems), 773–76, 2012. https://doi.org/10.1109/MEMSYS.2012.6170300.
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  - Ju, H., J. X. Xu, and A. M. J. Vandongen. “Classification of musical styles using liquid state machines.” In Proceedings of the International Joint Conference on Neural Networks, 2010. https://doi.org/10.1109/IJCNN.2010.5596470.
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  - Blanke, Marie L., and Antonius M. J. VanDongen. “Allosteric coupling in the NMDA receptor; M3 activation leads to closure of the ligand-binding domain.” In Biophysical Journal, 452A-452A. BIOPHYSICAL SOCIETY, 2007.
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  - Zhang, H. T., J. Parker, Y. X. Li, A. M. J. VanDongen, and T. L. Creazzo. “Function of a two pore domain potassium channel (TASK-1) in developing chick heart.” In Biophysical Journal, 86:550A-550A. BIOPHYSICAL SOCIETY, 2004.
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  - Chapman, M. L., H. S. Krovetz, and A. M. J. VanDongen. “Identification of a K binding site important for K channel gating.” In Biophysical Journal, 76:A79–A79. BIOPHYSICAL SOCIETY, 1999.
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  - VanDongen, A. M. J., and M. L. Chapman. “K channel gating by a dynamic selectivity filter.” In Biophysical Journal, 76:A415–A415. BIOPHYSICAL SOCIETY, 1999.
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  - Chapman, M. L., and A. M. J. VanDongen. “Ion selectivity is determined by the interaction of internal and external potassium binding sites in Kv2.1.” In Biophysical Journal, 74:A126–A126. BIOPHYSICAL SOCIETY, 1998.
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  - VanDongen, A. M. J., and M. L. Chapman. “Functional and physical interactions between GYGD signature sequences in neighboring K channel subunits.” In Biophysical Journal, 74:A127–A127. BIOPHYSICAL SOCIETY, 1998.
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  - Chapman, M. L., H. M. A. VanDongen, and A. M. J. VanDongen. “Complementation of voltage sensor mutations by mutations in the pore of drk1.” In Biophysical Journal, 72:WAMH1–WAMH1. CELL PRESS, 1997.
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  - Krovetz, H. S., H. M. A. VanDongen, and A. M. J. VanDongen. “An external potassium binding site revealed in DRK1, a voltage-gated K channel.” In Biophysical Journal, 72:WAMH2–WAMH2. CELL PRESS, 1997.
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  - Chapman, M. L., H. M. A. VanDongen, and A. M. J. VanDongen. “Subunit basis for ion permeation and gating suggested by subconductance levels in K channels.” In Biophysical Journal, 70:TUAM8–TUAM8. CELL PRESS, 1996.
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  - Krovetz, H. S., H. M. A. VanDongen, and A. M. J. VanDongen. “Structural implications of novel metal binding sites introduced into a potassium channel pore.” In Biophysical Journal, 70:MP216–MP216. CELL PRESS, 1996.
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  - VANDONGEN, A. M. J. “TRANSIT - A NEW ALGORITHM FOR ANALYZING SINGLE ION CHANNEL DATA CONTAINING MULTIPLE CONDUCTANCE LEVELS.” In Faseb Journal, 6:A256–A256. FEDERATION AMER SOC EXP BIOL, 1992.
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  - MOORMAN, J. R., A. M. J. VANDONGEN, G. E. KIRSCH, H. SILBERBERG, G. SCHUSTER, A. M. BROWN, and R. H. JOHO. “GATING OF CLONED TYPE-III SODIUM-CHANNELS.” In Molecular Biology of the Cardiovascular System, edited by R. ROBERTS and M. D. SCHNEIDER, 131:215–22. WILEY-LISS, INC, 1990.
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  - VANDONGEN, A. M. J., and A. M. BROWN. “ION CHANNEL SUBCONDUCTANCE STATES - ANALYSIS AND STRUCTURE-FUNCTION IMPLICATIONS.” In Journal of General Physiology, 94:A33–34. ROCKEFELLER UNIV PRESS, 1989.
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  - BUISMAN, H. P., H. J. JONGSMA, A. M. J. VANDONGEN, W. P. M. VANMEERWIJK, and D. L. YPEY. “AN INTERACTIVE COMPUTER-MODEL FOR SIMULATION AND ANALYSIS OF STOCHASTIC-BEHAVIOR OF IONIC CHANNELS.” In Journal of Physiology London, 366:P9–P9. CAMBRIDGE UNIV PRESS, 1985.
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  - RIJNSBURGER, W. H., R. J. VANDENBERG, A. M. J. VANDONGEN, and C. A. A. VERSLUIJS. “AN EXTREMELY FAST VOLTAGE CLAMP FOR RANVIER NODES.” In Journal of Physiology London, 366:P3–P3. CAMBRIDGE UNIV PRESS, 1985.
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  - VANDONGEN, A. M. J., M. G. VANERP, and R. J. VANDENBERG. “BLOCKAGE OF SODIUM-CHANNELS BY THE ANTI-EPILEPTIC DRUG PHENYTOIN.” In Experientia, 40:1296–97. BIRKHAUSER VERLAG AG, 1984.
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