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Antonius M. J. VanDongen

Antonius M. J. VanDongen

Associate Professor of Pharmacology and Cancer Biology
Pharmacology & Cancer Biology
antonius.vandongen@duke.edu
308 Research Drive LSRC C334, DUMC 3813, Durham, NC 27710
1 Kingswear Avenue, Singapore, SG, SG 557183

Selected Publications

A Proteome-Wide Effect of PHF8 Knockdown on Cortical Neurons Shows Downregulation of Parkinson's Disease-Associated Protein Alpha-Synuclein and Its Interactors.

Journal Article Biomedicines · February 8, 2023 Synaptic dysfunction may underlie the pathophysiology of Parkinson's disease (PD), a presently incurable condition characterized by motor and cognitive symptoms. Here, we used quantitative proteomics to study the role of PHD Finger Protein 8 (PHF8), a hist ... Full text Link to item Cite

Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer's Disease.

Journal Article Biomedicines · August 11, 2022 The immediate early gene Arc is a master regulator of synaptic function and a critical determinant of memory consolidation. Here, we show that Arc interacts with dynamic chromatin and closely associates with histone markers for active enhancers and transcr ... Full text Link to item Cite

Selective increase of correlated activity in Arc-positive neurons after chemically induced long-term potentiation in cultured hippocampal neurons.

Journal Article eNeuro · November 12, 2021 The activity-dependent expression of immediate-early genes (IEGs) has been utilised to label memory traces. However, their roles in engram specification are incompletely understood. Outstanding questions remain as to whether expression of IEGs can interpla ... Full text Link to item Cite

Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimer's Disease.

Journal Article ACS Biomater Sci Eng · January 11, 2021 Advances in the development of three-dimensional (3D) brain organoids maintained in vitro have provided excellent opportunities to study brain development and neurodegenerative disorders, including Alzheimer's disease (AD). However, there remains a need to ... Full text Link to item Cite

Familiarity Detection and Memory Consolidation in Cortical Assemblies.

Journal Article eNeuro · 2020 Humans have a large capacity of recognition memory (Dudai, 1997), a fundamental property of higher-order brain functions such as abstraction and generalization (Vogt and Magnussen, 2007). Familiarity is the first step towards recognition memory. We have pr ... Full text Link to item Cite

Whole Brain White Matter Microstructure and Upper Limb Function: Longitudinal Changes in Fractional Anisotropy and Axial Diffusivity in Post-Stroke Patients.

Journal Article J Cent Nerv Syst Dis · 2019 BACKGROUND: Diffusion tensor imaging (DTI) magnetic resonance imaging (MRI) measuring fractional anisotropy (FA) and axial diffusivity (AD) may be a useful biomarker for monitoring changes in white matter after stroke, but its associations with upper-limb ... Full text Open Access Link to item Cite

Combining levodopa and virtual reality-based therapy for rehabilitation of the upper limb after acute stroke: pilot study Part II.

Journal Article Singapore Med J · October 2017 INTRODUCTION: This study aimed to evaluate the safety and efficacy of a combination of levodopa and virtual reality (VR)-based therapy for the enhancement of upper limb recovery following acute stroke. METHODS: This was a pilot single-blinded case series o ... Full text Link to item Cite

Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis.

Journal Article Stem Cell Reports · April 11, 2017 Although mutations in several genes with diverse functions have been known to cause amyotrophic lateral sclerosis (ALS), it is unknown to what extent causal mutations impinge on common pathways that drive motor neuron (MN)-specific neurodegeneration. In th ... Full text Link to item Cite

Familiarity Detection is an Intrinsic Property of Cortical Microcircuits with Bidirectional Synaptic Plasticity.

Journal Article eNeuro · 2017 Humans instantly recognize a previously seen face as "familiar." To deepen our understanding of familiarity-novelty detection, we simulated biologically plausible neural network models of generic cortical microcircuits consisting of spiking neurons with ra ... Full text Link to item Cite

The effect of Bacopa monnieri on gene expression levels in SH-SY5Y human neuroblastoma cells.

Journal Article PLoS One · 2017 Bacopa monnieri is a plant used as a nootropic in Ayurveda, a 5000-year-old system of traditional Indian medicine. Although both animal and clinical studies supported its role as a memory enhancer, the molecular and cellular mechanism underlying Bacopa's n ... Full text Link to item Cite

miR-27b shapes the presynaptic transcriptome and influences neurotransmission by silencing the polycomb group protein Bmi1.

Journal Article BMC Genomics · October 4, 2016 BACKGROUND: MicroRNAs (miRNAs) are short non-coding RNAs that are emerging as important post-transcriptional regulators of neuronal and synaptic development. The precise impact of miRNAs on presynaptic function and neurotransmission remains, however, poorl ... Full text Link to item Cite

Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients.

Journal Article Cell Rep · June 14, 2016 The fact that Parkinson's disease (PD) can arise from numerous genetic mutations suggests a unifying molecular pathology underlying the various genetic backgrounds. To address this hypothesis, we took an integrated approach utilizing in vitro disease model ... Full text Link to item Cite

A novel imaging method for quantitative Golgi localization reveals differential intra-Golgi trafficking of secretory cargoes.

Journal Article Mol Biol Cell · March 1, 2016 Cellular functions of the Golgi are determined by the unique distribution of its resident proteins. Currently, electron microscopy is required for the localization of a Golgi protein at the sub-Golgi level. We developed a quantitative sub-Golgi localizatio ... Full text Link to item Cite

Rescue of Methyl-CpG Binding Protein 2 Dysfunction-induced Defects in Newborn Neurons by Pentobarbital.

Journal Article Neurotherapeutics · April 2015 Rett syndrome is a neurodevelopmental disorder that usually arises from mutations or deletions in methyl-CpG binding protein 2 (MeCP2), a transcriptional regulator that affects neuronal development and maturation without causing cell loss. Here, we show th ... Full text Link to item Cite

Spatiotemporal memory is an intrinsic property of networks of dissociated cortical neurons.

Journal Article J Neurosci · March 4, 2015 The ability to process complex spatiotemporal information is a fundamental process underlying the behavior of all higher organisms. However, how the brain processes information in the temporal domain remains incompletely understood. We have explored the sp ... Full text Link to item Cite

The methyl-CpG-binding domain (MBD) is crucial for MeCP2's dysfunction-induced defects in adult newborn neurons.

Journal Article Frontiers in cellular neuroscience · January 2015 Mutations in the human X-linked gene MECP2 are responsible for most Rett syndrome (RTT) cases, predominantly within its methyl-CpG-binding domain (MBD). To examine the role of MBD in the pathogenesis of RTT, we generated two MeCP2 mutant constructs, one wi ... Full text Cite

Stimulus information stored in lasting active and hidden network states is destroyed by network bursts.

Journal Article Front Integr Neurosci · 2015 In both humans and animals brief synchronizing bursts of epileptiform activity known as interictal epileptiform discharges (IEDs) can, even in the absence of overt seizures, cause transient cognitive impairments (TCI) that include problems with perception ... Full text Link to item Cite

A Neuronal Activity-Dependent Dual Function Chromatin-Modifying Complex Regulates Arc Expression.

Journal Article eNeuro · 2015 Chromatin modification is an important epigenetic mechanism underlying neuroplasticity. Histone methylation and acetylation have both been shown to modulate gene expression, but the machinery responsible for mediating these changes in neurons has remained ... Full text Open Access Link to item Cite

Nuclear Arc Interacts with the Histone Acetyltransferase Tip60 to Modify H4K12 Acetylation(1,2,3).

Journal Article eNeuro · 2014 Arc is an immediate-early gene whose genetic ablation selectively abrogates long-term memory, indicating a critical role in memory consolidation. Although Arc protein is found at synapses, it also localizes to the neuronal nucleus, where its function is le ... Full text Open Access Link to item Cite

Effects of synaptic connectivity on liquid state machine performance.

Journal Article Neural Netw · February 2013 The Liquid State Machine (LSM) is a biologically plausible computational neural network model for real-time computing on time-varying inputs, whose structure and function were inspired by the properties of neocortical columns in the central nervous system ... Full text Link to item Cite

Short-term memory in networks of dissociated cortical neurons.

Journal Article J Neurosci · January 30, 2013 Short-term memory refers to the ability to store small amounts of stimulus-specific information for a short period of time. It is supported by both fading and hidden memory processes. Fading memory relies on recurrent activity patterns in a neuronal networ ... Full text Link to item Cite

A Radial Basis Function Spike Model for Indirect Learning via Integrate-and-Fire Sampling and Reconstruction Techniques

Journal Article Advances in Artificial Neural Systems · October 10, 2012 This paper presents a deterministic and adaptive spike model derived from radial basis functions and a leaky integrate-and-fire sampler developed for training spiking neural networks without direct weight manipulation. Several algorithms have been ... Full text Cite

Nuclear deformation during breast cancer cell transmigration.

Journal Article Lab Chip · October 7, 2012 Metastasis is the main cause of cancer mortality. During this process, cancer cells dislodge from a primary tumor, enter the circulation and form secondary tumors in distal organs. It is poorly understood how these cells manage to cross the tight syncytium ... Full text Link to item Cite

A study of cancer cell metastasis using microfluidic transmigration device

Conference Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems MEMS · May 7, 2012 Metastasis of cancer cell was studied using microfluidic device. Migration of cells in the microchannel array mimics their transmigration in tissue capillaries during in vivo metastasis. Details of the morphological changes were recorded through high resol ... Full text Cite

A study of axonal protein trafficking in neuronal networks via the microfluidic platform

Journal Article Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences Microtas 2012 · January 1, 2012 This paper reports a microfluidic platform for culturing neuronal networks and the study of axonal protein trafficking. The device consists of cultural microchambers connected by microchannel array. Molecular biological methods were used to express fluores ... Cite

The significance of nuclear deformation for cancer cell transmigration

Journal Article Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences Microtas 2012 · January 1, 2012 In this paper, we present a microfluidic platform for the study of cancer cell transmigration and anti-cancer drug screening. The device consists of an array of microchannels with dimensions close to the capillaries on the cellular barriers, while a thin g ... Cite

Emergent bursting and synchrony in computer simulations of neuronal cultures.

Journal Article Front Comput Neurosci · 2012 Experimental studies of neuronal cultures have revealed a wide variety of spiking network activity ranging from sparse, asynchronous firing to distinct, network-wide synchronous bursting. However, the functional mechanisms driving these observed firing pat ... Full text Link to item Cite

Chemoinformatic identification of novel inhibitors against Mycobacterium tuberculosis L-aspartate α-decarboxylase.

Journal Article PLoS One · 2012 L-aspartate α-decarboxylase (ADC) belongs to a class of pyruvoyl dependent enzymes and catalyzes the conversion of aspartate to β-alanine in the pantothenate pathway, which is critical for the growth of several micro-organisms, including Mycobacterium tube ... Full text Link to item Cite

Classification of musical styles using liquid state machines

Conference Proceedings of the International Joint Conference on Neural Networks · January 1, 2010 Music Information Retrieval (MIR) is an interdisciplinary field that facilitates indexing and content-based organization of music databases. Music classification and clustering is one of the major topics in MIR. Music can be defined as 'organized sound'. T ... Full text Cite

Identification of a novel class of allosteric modulators of the NMDA receptor

Journal Article Singapore General Hospital Proceedings · December 1, 2009 Introduction: N-methyl-D-aspartate (NMDA) receptors are glutamate-gated ion channels that play key roles in processes underlying learning and memory. NMDA receptor dysfunction is thought to contribute to virtually every major neurological disorder, includi ... Cite

Biologically realizable reward-modulated hebbian training for spiking neural networks

Journal Article Proceedings of the International Joint Conference on Neural Networks · November 24, 2008 Spiking neural networks have been shown capable of simulating sigmoidal artificial neural networks providing promising evidence that they too are universal function approximators. Spiking neural networks offer several advantages over sigmoidal networks, be ... Full text Cite

The NR1 M3 domain mediates allosteric coupling in the N-methyl-D-aspartate receptor.

Journal Article Mol Pharmacol · August 2008 N-Methyl-D-aspartate (NMDA) receptors play a critical role in both development of the central nervous system and adult neuroplasticity. However, although the NMDA receptor presents a valuable therapeutic target, the relationship between its structure and f ... Full text Link to item Cite

Constitutive activation of the N-methyl-D-aspartate receptor via cleft-spanning disulfide bonds.

Journal Article J Biol Chem · August 1, 2008 Although the N-methyl-D-aspartate (NMDA) receptor plays a critical role in the central nervous system, many questions remain regarding the relationship between its structure and functional properties. In particular, the involvement of ligand-binding domain ... Full text Link to item Cite

Arc/Arg3.1 translation is controlled by convergent N-methyl-D-aspartate and Gs-coupled receptor signaling pathways.

Journal Article J Biol Chem · January 4, 2008 Arc/Arg3.1 is an immediate early gene whose expression is necessary for the late-phase of long-term potentiation (LTP) and memory consolidation. Whereas pathways regulating Arc transcription have been extensively investigated, less is known about the role ... Full text Open Access Link to item Cite

Biology of the NMDA receptor

Book · January 1, 2008 The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhyt ... Cite

Activation mechanisms of the NMDA receptor

Chapter · January 1, 2008 NMDA receptors (NMDARs) are glutamate-gated cation channels with high calcium permeability that play important roles in many aspects of the biology of higher organisms. They are critical for the development of the central nervous system (CNS), generation o ... Full text Cite

Preface

Book · January 1, 2008 Cite

Activity-regulated cytoskeleton-associated protein Arc/Arg3.1 binds to spectrin and associates with nuclear promyelocytic leukemia (PML) bodies.

Journal Article Brain Res · June 11, 2007 Activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) is an immediate early gene, whose expression in the central nervous system is induced by specific patterns of synaptic activity. Arc is required for the late-phase of long-term potentiation (L ... Full text Link to item Cite

Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel.

Journal Article Pflugers Arch · March 2006 K+ channels achieve exquisite ion selectivity without jeopardizing efficient permeation by employing multiple, interacting K+-binding sites. Introduction ofa cadmium (Cd2+)-binding site in the external vestibule of Kv2.1 (drk1), allowed us to functionally ... Full text Open Access Link to item Cite

The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density.

Journal Article J Neurosci · October 12, 2005 Featured Publication Abnormalities in dendritic spines have long been associated with cognitive dysfunction and neurodevelopmental delay, whereas rapid changes in spine shape underlie synaptic plasticity. The key regulators of cytoskeletal reorganization in dendrites and spine ... Full text Link to item Cite

K channel subconductance levels result from heteromeric pore conformations.

Journal Article J Gen Physiol · August 2005 Featured Publication Voltage-gated K channels assemble from four identical subunits symmetrically arranged around a central permeation pathway. Each subunit harbors a voltage-sensing domain. The sigmoidal nature of the activation kinetics suggests that multiple sensors need to ... Full text Link to item Cite

Translation of an integral membrane protein in distal dendrites of hippocampal neurons.

Journal Article Eur J Neurosci · March 2005 Maintenance of synaptic plasticity requires protein translation. Because changes in synaptic strength are regulated at the level of individual synapses, a mechanism is required for newly translated proteins to specifically and persistently modify only a su ... Full text Link to item Cite

A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes.

Journal Article Pediatr Res · September 2004 Juvenile neuronal ceroid lipofuscinosis (JNCL) is due to mutations in the CLN3 gene. We previously determined that CLN3 protein harbors a highly conserved motif, VYFAE, necessary for its impact on cell growth and apoptosis. Using molecular modeling we demo ... Full text Link to item Cite

Rapid dendritic transport of TGN38, a putative cargo receptor.

Journal Article Brain Res Mol Brain Res · August 23, 2004 Protein transport to and from the postsynaptic plasma membrane is thought to be of central importance for synaptic plasticity. However, the molecular details of such processes are poorly understood. One mechanism by which membrane and secretory proteins ma ... Full text Link to item Cite

Ligand-binding residues integrate affinity and efficacy in the NMDA receptor.

Journal Article Mol Pharmacol · August 2004 Featured Publication The interaction of an agonist with its receptor can be characterized by two fundamental properties, affinity and efficacy. Affinity defines how tightly the agonist associates with its receptor, and efficacy measures the ability of the bound ligand to activ ... Full text Link to item Cite

The identification of a second actin-binding region in spinophilin/neurabin II.

Journal Article Brain Res Mol Brain Res · May 19, 2004 Spinophilin/neurabin II is an actin-associated scaffolding protein enriched in the dendritic spines of neurons. Previously, the actin-binding domain (ABD) of spinophilin was localized to a domain between amino acids (aa) 1 and 154. In a mass spectrometry s ... Full text Link to item Cite

K channel gating by an affinity-switching selectivity filter.

Journal Article Proc Natl Acad Sci U S A · March 2, 2004 Featured Publication A universal property of ion channels is their ability to alternate stochastically between two permeation states, open and closed. This behavior is thought to be controlled by a steric "gate", a structure that physically impedes ion flow in the closed state ... Full text Link to item Cite

Effects of mRNA untranslated regions on translational efficiency of NMDA receptor subunits.

Journal Article Neurosignals · 2004 Because NMDA receptors play critical roles in both neuronal survival and plasticity, their expression levels need to be carefully controlled. The number of functional NMDA receptors is temporally and spatially regulated at a hierarchy of levels, from gene ... Full text Link to item Cite

Motifs within the CLN3 protein: modulation of cell growth rates and apoptosis.

Journal Article Hum Mol Genet · September 1, 2002 Juvenile Batten disease (JNCL) is an autosomal recessive disease that results from mutations in the CLN3 gene. The wild-type CLN3 gene coding sequence has 15 exons, and the translated protein consists of 438 amino acids. The most commonly observed mutation ... Full text Link to item Cite

The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening.

Journal Article J Neurosci · March 15, 2002 Featured Publication Ion channels alternate stochastically between two functional states, open and closed. This gating behavior is controlled by membrane potential or by the binding of neurotransmitters in voltage- and ligand-gated channels, respectively. Although much progres ... Full text Link to item Cite

GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity.

Journal Article J Physiol · January 1, 2001 Featured Publication Cells maintain a negative resting membrane potential through the constitutive activity of background K+ channels. A novel multigene family of such K+ channels has recently been identified. A unique characteristic of these K+ channels is the presence of two ... Full text Link to item Cite

Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system.

Journal Article Mol Cell Neurosci · September 2000 Abl-interactor (Abi) proteins are targets of Abl-family nonreceptor tyrosine kinases and are required for Rac-dependent cytoskeletal reorganization in response to growth factor stimulation. We asked if the expression, phosphorylation, and cellular localiza ... Full text Link to item Cite

A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy.

Journal Article Brain Res Mol Brain Res · November 10, 1999 Alanine 714 of the NMDA receptor NR1 subunit resides in the glycine binding pocket. The Ala714Leu mutation substantially shifts glycine affinity, but here no effect on antagonism by DCK is detected. Ala714Leu is also found to limit the efficacy of a partia ... Full text Link to item Cite

K channel gating by a dynamic selectivity filter.

Conference BIOPHYSICAL JOURNAL · January 1, 1999 Link to item Cite

An alanine residue in the M3-M4 linker lines the glycine binding pocket of the N-methyl-D-aspartate receptor.

Journal Article J Biol Chem · February 7, 1997 Featured Publication While attempting to map a central region in the M3-M4 linker of the N-methyl-D-aspartate receptor NR1 subunit, we found that mutation of a single position, Ala-714, greatly reduced the apparent affinity for glycine. Proximal N-glycosylation localized this ... Full text Link to item Cite

Activation-dependent subconductance levels in the drk1 K channel suggest a subunit basis for ion permeation and gating.

Journal Article Biophys J · February 1997 Featured Publication Ion permeation and channel opening are two fundamental properties of ion channels, the molecular bases of which are poorly understood. Channels can exist in two permeability states, open and closed. The relative amount of time a channel spends in the open ... Full text Link to item Cite

Atomic distance estimates from disulfides and high-affinity metal-binding sites in a K+ channel pore.

Journal Article Biophys J · January 1997 The pore of potassium channels is lined by four identical, highly conserved hairpin loops, symmetrically arranged around a central permeation pathway. Introduction of cysteines into the external mouth of the drk1 K channel pore resulted in the formation of ... Full text Link to item Cite

The 5'-untranslated region of the N-methyl-D-aspartate receptor NR2A subunit controls efficiency of translation.

Journal Article J Biol Chem · April 5, 1996 Featured Publication The N-methyl-D-aspartate (NMDA) receptor plays a central role in such phenomena as long term potentiation and excitotoxicity. This importance in defining both function and viability suggests that neurons must carefully control their expression of NMDA rece ... Full text Link to item Cite

A new algorithm for idealizing single ion channel data containing multiple unknown conductance levels.

Journal Article Biophys J · March 1996 A new algorithm is presented for idealizing single channel data containing any number of conductance levels. The number of levels and their amplitudes do not have to be known a priori. No assumption has to be made about the behavior of the channel, other t ... Full text Link to item Cite

Structural conservation of ion conduction pathways in K channels and glutamate receptors.

Journal Article Proc Natl Acad Sci U S A · May 23, 1995 Featured Publication Single channel recordings demonstrate that ion channels switch stochastically between an open and a closed pore conformation. In search of a structural explanation for this universal open/close behavior, we have uncovered a striking degree of amino acid ho ... Full text Link to item Cite

Patterns of internal and external tetraethylammonium block in four homologous K+ channels.

Journal Article Mol Pharmacol · August 1991 Tetraethylammonium (TEA) is a small ion that is thought to block open K+ channels by binding either to an internal or to an external site. For this reason, it has been used to probe the ion conduction pathway or pore of K+ channel mutants and a K+ channel ... Link to item Cite

Control of K+ channels by G proteins.

Journal Article J Bioenerg Biomembr · August 1991 Heterotrimeric G3 proteins are though to couple receptors to ionic channels via cytoplasmic mediators such as cGMP in the case of retinal rods, cAMP in the case of olfactory cells, and the cAMP cascade in the case of cardiac myocytes. G protein-mediated se ... Full text Link to item Cite

Alteration and restoration of K+ channel function by deletions at the N- and C-termini.

Journal Article Neuron · October 1990 Voltage-dependent ion channels are thought to consist of a highly conserved repeated core of six transmembrane segments, flanked by more variable cytoplasmic domains. Significant functional differences exist among related types of K+ channels. These differ ... Full text Link to item Cite

Voltage-dependent action of valproate on potassium channels in frog node of Ranvier.

Journal Article Eur J Pharmacol · August 2, 1990 The influence of the anti-epileptic drug, valproate, on K conductance (gK) was investigated in voltage-clamped Ranvier nodes of Xenopus laevis. A double pulse method was used in order to eliminate the effect of accumulation of potassium ions in the perinod ... Full text Link to item Cite

Inhibition of cardiac Na+ currents by isoproterenol.

Journal Article Am J Physiol · April 1990 The mechanism by which the beta-adrenergic agonist isoproterenol (ISO) modulates voltage-dependent cardiac Na+ currents (INa) was studied in single ventricular myocytes of neonatal rat using the gigaseal patch-clamp technique. ISO inhibited INa reversibly, ... Full text Link to item Cite

INHIBITION OF CARDIAC NA+ CURRENTS BY ISOPROTERENOL

Journal Article AMERICAN JOURNAL OF PHYSIOLOGY · April 1, 1990 Link to item Cite

Fast and slow gating of sodium channels encoded by a single mRNA.

Journal Article Neuron · February 1990 We investigated the kinetics of rat brain type III Na+ currents expressed in Xenopus oocytes. We found distinct patterns of fast and slow gating. Fast gating was characterized by bursts of longer openings. Traces with slow gating occurred in runs with life ... Full text Link to item Cite

Toxin and kinetic profile of rat brain type III sodium channels expressed in Xenopus oocytes.

Journal Article Brain Res Mol Brain Res · February 1990 Sodium (Na+) channels are members of a multigene family and are responsible for generation and propagation of the action potential in excitable cells. We have assembled, in a transcription-competent vector, a full-length cDNA clone encoding the rat brain t ... Full text Link to item Cite

Networking ionic channels by G proteins.

Journal Article Soc Gen Physiol Ser · 1990 Link to item Cite

G protein coupling of receptors to ionic channels and other effector systems.

Journal Article Br J Clin Pharmacol · 1990 1. Four questions raised by previous studies that had shown activation of K+ channels by alpha subunits of the type 3 Gi protein are addressed in the present communication: a) are K+ channels specific for one Gi? b) are there more ionic channels under dire ... Full text Link to item Cite

GATING OF CLONED TYPE-III SODIUM-CHANNELS

Conference MOLECULAR BIOLOGY OF THE CARDIOVASCULAR SYSTEM · January 1, 1990 Link to item Cite

Networking ionic channels by G proteins.

Journal Article Society of General Physiologists Series · January 1, 1990 Cite

G protein coupling of receptors to ionic channels and other effector systems.

Journal Article Society of General Physiologists series · January 1, 1990 Cite

A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning.

Journal Article Nature · August 24, 1989 Voltage-activated potassium channels play an important part in the control of excitability in nerve and muscle. Different K+ channels are involved in establishing the resting potential, determining the duration of action potentials, modulation of transmitt ... Full text Link to item Cite

Beta-adrenergic inhibition of cardiac sodium channels by dual G-protein pathways.

Journal Article Science · August 4, 1989 The signaling pathways by which beta-adrenergic agonists modulate voltage-dependent cardiac sodium currents are unknown, although it is likely that adenosine 3'5'-monophosphate (cAMP) is involved. Single-channel and whole-cell sodium currents were measured ... Full text Link to item Cite

Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go.

Journal Article Science · December 9, 1988 Potassium channels in neurons are linked by guanine nucleotide binding (G) proteins to numerous neurotransmitter receptors. The ability of Go, the predominant G protein in the brain, to stimulate potassium channels was tested in cell-free membrane patches ... Full text Link to item Cite

Spontaneous neuronal firing patterns in fetal rat cortical networks during development in vitro: a quantitative analysis.

Journal Article Exp Brain Res · 1987 The development of spontaneous bioelectric activity (SBA) was studied in dissociated occipital cortex cultures prepared from 19 day old rat fetuses. All cultures, recorded one per diem from 5 to 33 days in vitro (div), showed SBA. Computer analysis of 76 e ... Full text Link to item Cite

Valproate reduces excitability by blockage of sodium and potassium conductance.

Journal Article Epilepsia · 1986 Effects of the antiepileptic drug valproate on sodium and potassium currents in the nodal membrane of peripheral nerve fibers of Xenopus laevis were determined by voltage- and current-clamp experiments. Under voltage-clamp conditions, a reduction of both s ... Full text Link to item Cite

AN EXTREMELY FAST VOLTAGE CLAMP FOR RANVIER NODES

Conference JOURNAL OF PHYSIOLOGY-LONDON · January 1, 1985 Link to item Cite

Functioning of catfish electroreceptors: Bursting discharge pattern of Kryptopterus electroreceptors elicited by microelectrode impalement

Journal Article Comparative Biochemistry and Physiology Part A Physiology · January 1, 1984 1. I. The time course of the spontaneous discharge of Kryptopterus ampullary electroreceptors may change from regular to bursting upon impalement by a glass microelectrode. 2. 2. The burst duration is very constant relative to the interburst interval, duri ... Full text Cite