The significance of nuclear deformation for cancer cell transmigration
Publication
, Journal Article
Fu, Y; Vandongen, A; Bourouina, T; Tsang, WM; Je, M; Liu, AQ
Published in: Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences Microtas 2012
January 1, 2012
In this paper, we present a microfluidic platform for the study of cancer cell transmigration and anti-cancer drug screening. The device consists of an array of microchannels with dimensions close to the capillaries on the cellular barriers, while a thin glass coverslip is used as the substrate to enable high resolution imaging of cell dynamics during cancer cell transmigration. We have investigated the transmigration of highly metastatic human breast cancer cells, MDA-MB-231, after their cell nucleus are fluorescently labeled. The results show that 1) the cell nucleus deformed drastically during the transmigration process, and 2) an anti-cancer drug targeting the cell nucleus significantly inhibited transmigration.
Duke Scholars
Published In
Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences Microtas 2012
Publication Date
January 1, 2012
Start / End Page
1561 / 1563
Citation
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MLA
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Fu, Y., Vandongen, A., Bourouina, T., Tsang, W. M., Je, M., & Liu, A. Q. (2012). The significance of nuclear deformation for cancer cell transmigration. Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences Microtas 2012, 1561–1563.
Fu, Y., A. Vandongen, T. Bourouina, W. M. Tsang, M. Je, and A. Q. Liu. “The significance of nuclear deformation for cancer cell transmigration.” Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences Microtas 2012, January 1, 2012, 1561–63.
Fu Y, Vandongen A, Bourouina T, Tsang WM, Je M, Liu AQ. The significance of nuclear deformation for cancer cell transmigration. Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences Microtas 2012. 2012 Jan 1;1561–3.
Fu, Y., et al. “The significance of nuclear deformation for cancer cell transmigration.” Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences Microtas 2012, Jan. 2012, pp. 1561–63.
Fu Y, Vandongen A, Bourouina T, Tsang WM, Je M, Liu AQ. The significance of nuclear deformation for cancer cell transmigration. Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences Microtas 2012. 2012 Jan 1;1561–1563.
Published In
Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences Microtas 2012
Publication Date
January 1, 2012
Start / End Page
1561 / 1563