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Spatiotemporal memory is an intrinsic property of networks of dissociated cortical neurons.

Publication ,  Journal Article
Ju, H; Dranias, MR; Banumurthy, G; VanDongen, AMJ
Published in: J Neurosci
March 4, 2015

The ability to process complex spatiotemporal information is a fundamental process underlying the behavior of all higher organisms. However, how the brain processes information in the temporal domain remains incompletely understood. We have explored the spatiotemporal information-processing capability of networks formed from dissociated rat E18 cortical neurons growing in culture. By combining optogenetics with microelectrode array recording, we show that these randomly organized cortical microcircuits are able to process complex spatiotemporal information, allowing the identification of a large number of temporal sequences and classification of musical styles. These experiments uncovered spatiotemporal memory processes lasting several seconds. Neural network simulations indicated that both short-term synaptic plasticity and recurrent connections are required for the emergence of this capability. Interestingly, NMDA receptor function is not a requisite for these short-term spatiotemporal memory processes. Indeed, blocking the NMDA receptor with the antagonist APV significantly improved the temporal processing ability of the networks, by reducing spontaneously occurring network bursts. These highly synchronized events have disastrous effects on spatiotemporal information processing, by transiently erasing short-term memory. These results show that the ability to process and integrate complex spatiotemporal information is an intrinsic property of generic cortical networks that does not require specifically designed circuits.

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Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

March 4, 2015

Volume

35

Issue

9

Start / End Page

4040 / 4051

Location

United States

Related Subject Headings

  • Time Perception
  • Space Perception
  • Receptors, N-Methyl-D-Aspartate
  • Optogenetics
  • Neurons
  • Neurology & Neurosurgery
  • Nerve Net
  • Music
  • Microelectrodes
  • Humans
 

Citation

APA
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ICMJE
MLA
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Ju, H., Dranias, M. R., Banumurthy, G., & VanDongen, A. M. J. (2015). Spatiotemporal memory is an intrinsic property of networks of dissociated cortical neurons. J Neurosci, 35(9), 4040–4051. https://doi.org/10.1523/JNEUROSCI.3793-14.2015
Ju, Han, Mark R. Dranias, Gokulakrishna Banumurthy, and Antonius M. J. VanDongen. “Spatiotemporal memory is an intrinsic property of networks of dissociated cortical neurons.J Neurosci 35, no. 9 (March 4, 2015): 4040–51. https://doi.org/10.1523/JNEUROSCI.3793-14.2015.
Ju H, Dranias MR, Banumurthy G, VanDongen AMJ. Spatiotemporal memory is an intrinsic property of networks of dissociated cortical neurons. J Neurosci. 2015 Mar 4;35(9):4040–51.
Ju, Han, et al. “Spatiotemporal memory is an intrinsic property of networks of dissociated cortical neurons.J Neurosci, vol. 35, no. 9, Mar. 2015, pp. 4040–51. Pubmed, doi:10.1523/JNEUROSCI.3793-14.2015.
Ju H, Dranias MR, Banumurthy G, VanDongen AMJ. Spatiotemporal memory is an intrinsic property of networks of dissociated cortical neurons. J Neurosci. 2015 Mar 4;35(9):4040–4051.

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

March 4, 2015

Volume

35

Issue

9

Start / End Page

4040 / 4051

Location

United States

Related Subject Headings

  • Time Perception
  • Space Perception
  • Receptors, N-Methyl-D-Aspartate
  • Optogenetics
  • Neurons
  • Neurology & Neurosurgery
  • Nerve Net
  • Music
  • Microelectrodes
  • Humans