Vasudevarao PENUGURTI

Journal Article Nat Cell Biol · May 2025 MPC1 and MPC2 are two well-known components of the mitochondrial pyruvate carrier (MPC) complex maintaining MPC activity to transport pyruvate into mitochondria for tricarboxylic acid (TCA) cycle entry in mammalian cells. It is currently unknown whether th ... Full text Open Access Link to item Cite

Potential role of Hematopoietic PBX-Interacting Protein (HPIP) in trophoblast fusion and invasion: Implications in pre-eclampsia pathogenesis.

Journal Article Cellular signalling · April 2025 Pre-eclampsia is a known hypertensive disorder of pregnancy. While abnormal placentation and poor trophoblast invasion into maternal endometrium during blastocyst implantation are primary causes of pre-eclampsia, the underlying mechanisms remain elusive. H ... Full text Cite

IMPA1-derived inositol maintains stemness in castration-resistant prostate cancer via IMPDH2 activation.

Journal Article J Exp Med · November 4, 2024 Acquisition of prostate cancer stem cells (PCSCs) manifested during androgen ablation therapy (ABT) contributes to castration-resistant prostate cancer (CRPC). However, little is known about the specific metabolites critically orchestrating this process. H ... Full text Link to item Cite

AMPK: The energy sensor at the crossroads of aging and cancer.

Journal Article Seminars in cancer biology · November 2024 AMP-activated protein kinase (AMPK) is a protein kinase that plays versatile roles in response to a variety of physiological stresses, including glucose deprivation, hypoxia, and ischemia. As a kinase with pleiotropic functions, it plays a complex role in ... Full text Cite

HPIP and RUFY3 are noncanonical guanine nucleotide exchange factors of Rab5 to regulate endocytosis-coupled focal adhesion turnover.

Journal Article The Journal of biological chemistry · November 2023 While the role of endocytosis in focal adhesion turnover-coupled cell migration has been established in addition to its conventional role in cellular functions, the molecular regulators and precise molecular mechanisms that underlie this process remain lar ... Full text Open Access Cite

Deregulated transcription factors in cancer cell metabolisms and reprogramming.

Journal Article Semin Cancer Biol · November 2022 Metabolic reprogramming is an important cancer hallmark that plays a key role in cancer malignancies and therapy resistance. Cancer cells reprogram the metabolic pathways to generate not only energy and building blocks but also produce numerous key signali ... Full text Link to item Cite

AMPK: An odyssey of a metabolic regulator, a tumor suppressor, and now a contextual oncogene.

Journal Article Biochimica et biophysica acta. Reviews on cancer · September 2022 Metabolic reprogramming is a unique but complex biochemical adaptation that allows solid tumors to tolerate various stresses that challenge cancer cells for survival. Under conditions of metabolic stress, mammalian cells employ adenosine monophosphate (AMP ... Full text Open Access Cite

Hematopoietic PBX-interacting protein is a novel regulator of mammary epithelial cell differentiation.

Journal Article The FEBS journal · March 2022 Hematopoietic PBX-interacting protein (HPIP, also known as PBXIP1) is an estrogen receptor (ER) interacting protein that regulates estrogen-mediated breast cancer cell proliferation and tumorigenesis. However, its functional significance in the context of ... Full text Cite

A reciprocal feedback loop between HIF-1α and HPIP controls phenotypic plasticity in breast cancer cells.

Journal Article Cancer letters · February 2022 While phenotypic plasticity is a critical factor contributing to tumor heterogeneity, molecular mechanisms underlying this process are largely unknown. Here we report that breast cancer cells display phenotypic diversity in response to hypoxia or normoxia ... Full text Cite

In vitro studies of B2O3–SiO2–Na2O–CaO–ZnO bioactive glass system

Journal Article Journal of Non-Crystalline Solids · December 2021 Full text Cite

HPIP protooncogene differentially regulates metabolic adaptation and cell fate in breast cancer cells under glucose stress via AMPK and RNF2 dependent pathways.

Journal Article Cancer letters · October 2021 While cancer cells rewire metabolic pathways to sustain growth and survival under metabolic stress in solid tumors, the molecular mechanisms underlying these processes remain largely unknown. In this study, cancer cells switched from survival to death duri ... Full text Cite

Zirconia-containing wollastonite ceramics derived from biowaste resources for bone tissue engineering.

Journal Article Biomedical materials (Bristol, England) · August 2020 Zirconia-containing wollastonite (CaSiO3) ceramics with partial substitution of zirconia (1, 3 and 5 mol%) were prepared using eggshells and rice husk ash as source materials for calcium oxide and silica, respectively, through a sol-gel techniqu ... Full text Cite

A comparative study on in vitro behavior of calcium silicate ceramics synthesized from biowaste resources

Journal Article Journal of the American Ceramic Society · February 1, 2020 Calcium silicate ceramics have received significant attention for biomedical applications for their excellent bioactivity and osteoconduction properties. Sol-gel process is extensively used for the fabrication of calcium silicates. In sol-gel process, calc ... Full text Cite

Alpinoid c analog inhibits angiogenesis and induces apoptosis in COLO205 cell line.

Journal Article Chemico-biological interactions · August 2019 Diarylheptanoids display an array of biological and pharmacological properties. We previously reported the synthesis of a diarylheptanoid Alpinoid c and a series of its derivatives, evaluated their cytotoxicity against various human cancer cells. We found ... Full text Cite

Synthesis of Novel Diaziridinyl Quinone Isoxazole Hybrids and Evaluation of Their Anti-Cancer Activity as Potential Tubulin-Targeting Agents.

Journal Article Drug research · July 2019 Two series of diaziridinyl quinone isoxazole derivatives were prepared and evaluated for their cytotoxic activity against MCF7, HeLa, BT549, A549 and HEK293 cell lines and interaction with tubulin. Compounds (6A-M: ) showed promising activity against all t ... Full text Cite

Hematopoietic PBX-interacting protein is a substrate and an inhibitor of the APC/C-Cdc20 complex and regulates mitosis by stabilizing cyclin B1.

Journal Article The Journal of biological chemistry · June 2019 Proper cell division relies on the coordinated regulation between a structural component, the mitotic spindle, and a regulatory component, anaphase-promoting complex/cyclosome (APC/C). Hematopoietic PBX-interacting protein (HPIP) is a microtubule-associate ... Full text Cite

In vitro evaluation of niobia added soda lime borosilicate bioactive glasses

Journal Article Journal of Alloys and Compounds · October 5, 2018 In the present study, systematic and detailed investigations have been reported, in terms of bioactivity, cytocompatibility and mechanical hardness of a synthetic material that is proposed as a bone implant material in in-vitro conditions. The objective of ... Full text Cite

Bio-inspired synthesis of a hierarchical self-assembled zinc phosphate nanostructure in the presence of cowpea mosaic virus: in vitro cell cycle, proliferation and prospects for tissue regeneration.

Journal Article Biomedical materials (Bristol, England) · December 2017 Self-assembly is an important auto-organization process used in designing structural biomaterials which have the potential capability to heal tissues after traumatic injury. Although various materials having the ability to heal after injury are available, ... Full text Cite

MTA1 expression in human cancers - Clinical and pharmacological significance.

Journal Article Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · November 2017 Remarkably, majority of the cancer deaths are due to metastasis, not because of primary tumors. Metastasis is one of the important hallmarks of cancer. During metastasis invasion of primary tumor cells from the site of origin to a new organ occurs. Metasta ... Full text Cite

Cytocompatibility studies of titania-doped calcium borosilicate bioactive glasses in-vitro.

Journal Article Materials science & engineering. C, Materials for biological applications · August 2017 The present study aims to elucidate the applications of Titania (TiO2) doped calcium borosilicate glass as a biocompatible material in regenerative orthopedic applications. In this context, we have examined the bioactivity of various concentrati ... Full text Cite

HPIP promotes epithelial-mesenchymal transition and cisplatin resistance in ovarian cancer cells through PI3K/AKT pathway activation.

Journal Article Cellular oncology (Dordrecht, Netherlands) · April 2017 PurposeHematopoietic PBX interacting protein (HPIP), a scaffold protein, is known to regulate the proliferation, migration and invasion in different cancer cell types. The aim of this study was to assess the role of HPIP in ovarian cancer cell mig ... Full text Cite