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Jan Victoria Scott

Associate Consulting Professor in the Department of Family Medicine and Community Health
Family Medicine and Community Health, Physician Assistant Program
Box 104780, Physician Assistant Program, Durham, NC 27710
800 South Duke Street, Durham, NC 27710

Selected Publications


Mucocele-like lesions of the breast - A radiological and clinicopathological analysis.

Journal Article Curr Probl Cancer · December 2021 INTRODUCTION: Mucocele-like lesions (MLL) of the breast are rare entities which are considered to harbor uncertain malignant potential. Current UK guidelines recommend vacuum assisted excision (VAE) of all such lesions regardless of whether they display ep ... Full text Link to item Cite

Reinventing the Wheel: One Program's Approach to Redesign of Didactic Courses.

Journal Article J Physician Assist Educ · December 2015 Curriculum and course redesign are expected and intentional efforts in health professions education. For physician assistant (PA) education, ongoing program self-assessment is a required accreditation standard and may guide deliberate changes within curric ... Link to item Cite

Breast self-examination: defining a cohort still in need.

Journal Article Am J Surg · October 2009 BACKGROUND: The value of breast self-examination (BSE) to detect early breast cancer is controversial. METHODS: Within an institutional review board-approved prospective study, 147 high-risk women were enrolled from 2004 to 2007. Yearly clinical examinatio ... Full text Link to item Cite

PROBLEMS IN TRANSITIONS OF CARE: A COURSE SESSION EXEMPLAR

Journal Article GERONTOLOGIST · October 1, 2009 Link to item Cite

Reproducibility of random periareolar fine needle aspiration in a multi-institutional Cancer and Leukemia Group B (CALGB) cross-sectional study.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2009 BACKGROUND: Random periareolar fine needle aspiration (RPFNA) is a research technique developed to assess short-term breast cancer risk in women at increased risk of breast cancer. Although there is increasing acceptance of RPFNA, neither the reproducibili ... Full text Link to item Cite

ESR1 promoter hypermethylation does not predict atypia in RPFNA nor persistent atypia after 12 months tamoxifen chemoprevention.

Journal Article Cancer Epidemiol Biomarkers Prev · August 2008 PURPOSE: Currently, we lack biomarkers to predict whether high-risk women with mammary atypia will respond to tamoxifen chemoprevention. EXPERIMENTAL DESIGN: Thirty-four women with cytologic mammary atypia from the Duke University High-Risk clinic were off ... Full text Link to item Cite

Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF.

Journal Article Clin Cancer Res · November 15, 2007 PURPOSE: p16(INK4a) has been appreciated as a key regulator of cell cycle progression and senescence. Cultured human mammary epithelial cells that lack p16(INK4a) activity have been shown to exhibit premalignant phenotypes, such as telomeric dysfunction, c ... Full text Link to item Cite

Atypia in random periareolar fine-needle aspiration affects the decision of women at high risk to take tamoxifen for breast cancer chemoprevention.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2007 Random periareolar fine-needle aspiration (RPFNA) is a research procedure designed to (a) evaluate short-term breast cancer risk in women at high risk for developing breast cancer, and (b) track response to chemoprevention. Of import, cellular atypia in br ... Full text Link to item Cite

Overweight and obese perimenopausal and postmenopausal women exhibit increased abnormal mammary epithelial cytology.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2007 High body mass index (BMI >or= 25 kg/m2) is associated with increased postmenopausal breast cancer incidence and mortality. However, few studies have explored associations between BMI and direct measures on target tissue. Epithelial cytology was assessed i ... Full text Link to item Cite

Hypermethylation of the breast cancer-associated gene 1 promoter does not predict cytologic atypia or correlate with surrogate end points of breast cancer risk.

Journal Article Cancer Epidemiol Biomarkers Prev · January 2007 Mutation of the breast cancer-associated gene 1 (BRCA1) plays an important role in familial breast cancer. Although hypermethylation of the BRCA1 promoter has been observed in sporadic breast cancer, its exact role in breast cancer initiation and associati ... Full text Link to item Cite

Retinoic acid receptor-beta2 promoter methylation in random periareolar fine needle aspiration.

Journal Article Cancer Epidemiol Biomarkers Prev · April 2005 Methylation of the retinoic acid receptor-beta2 (RARbeta2) P2 promoter is hypothesized to be an important mechanism for loss of RARbeta2 function during early mammary carcinogenesis. The frequency of RARbeta2 P2 methylation was tested in (a) 16 early stage ... Full text Link to item Cite

RARbeta P2 promoter methylation: Potential biomarker for use with breast Random Periareolar Fine Needle Aspiration in breast cancer risk assessment.

Journal Article J Clin Oncol · July 15, 2004 1014 Background: Methylation of RARbeta P2 promoter is hypothesized to be an important early event in mammary carcinogenesis. Random Periareolar Breast Fine Needle Aspiration (RPFNA) is a research technique developed to repeatedly sample mammary cells from ... Link to item Cite

Team Process Exercise: An Evaluative Admissions Tool

Journal Article The Journal of Physician Assistant Education · 2003 Full text Cite