Vidhya Karivedu

Journal Article Cancer Res Commun · June 1, 2025 PURPOSE: Recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) portends a poor prognosis. DNA pathway repair mutations in HNSCC are associated with higher tumor mutational burden rates and immune checkpoint inhibitor response. PARP inhibit ... Full text Link to item Cite

Comparative analysis of the tumor microbiome, molecular profiles, and immune cell abundances by HPV status in mucosal head and neck cancers and their impact on survival.

Journal Article Cancer Biol Ther · December 31, 2024 Head and Neck Squamous Cell Carcinoma (HNSCC) comprises a diverse group of tumors with variable treatment response and prognosis. The tumor microenvironment (TME), which includes microbiome and immune cells, can impact outcomes. Here, we sought to relate t ... Full text Link to item Cite

Association between Tumor Microbiome and Hypoxia across Anatomic Subsites of Head and Neck Cancers.

Journal Article Int J Mol Sci · December 8, 2022 Purpose/Objective(s): Microbiome has been shown to affect tumorigenesis by promoting inflammation. However, the association between the upper aerodigestive microbiome and head and neck squamous cell carcinoma (HNSCC) is not well established. Hypoxia is a m ... Full text Link to item Cite

Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition.

Journal Article J Immunother Cancer · November 2022 BACKGROUND: Metformin slows tumor growth and progression in vitro, and in combination with chemoradiotherapy, resulted in high overall survival in patients with head and neck cancer squamous cell carcinoma (HNSCC) in our phase 1 clinical trial (NCT02325401 ... Full text Link to item Cite

Update of a prognostic survival model in head and neck squamous cell carcinoma patients treated with immune checkpoint inhibitors using an expansion cohort.

Journal Article BMC Cancer · July 14, 2022 BACKGROUND: Immune checkpoint inhibitors (ICI) treatment in recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) offers new therapeutic venues. We have previously developed a predictive survival model in this patient population based on ... Full text Link to item Cite

COVID-19 vaccination and breakthrough infections in patients with cancer.

Journal Article Ann Oncol · March 2022 BACKGROUND: Vaccination is an important preventive health measure to protect against symptomatic and severe COVID-19. Impaired immunity secondary to an underlying malignancy or recent receipt of antineoplastic systemic therapies can result in less robust a ... Full text Link to item Cite

Multi-Institutional Study Validates Safety of Intraoperative Cesium-131 Brachytherapy for Treatment of Recurrent Head and Neck Cancer

Journal Article Frontiers in Oncology · November 26, 2021 Introduction: Surgery is the primary treatment for resectable, non-metastatic recurrent head and neck squamous cell carcinoma (HNSCC). We explore the safety and oncologic benefit of intraoperative Cesium-131 (Cs-131) brachytherapy combined with salvage loc ... Full text Cite

Managing Recurrent Metastatic Head and Neck Cancer.

Journal Article Hematol Oncol Clin North Am · October 2021 Head and neck squamous cell carcinoma (HNSCC) treatment is often associated with high morbidity especially in the recurrent and/or metastatic (R/M) setting, limiting effective treatment options. Local disease control is important. Therefore, local therapie ... Full text Link to item Cite

Weekly vs. 3-weekly paclitaxel, carboplatin, and cetuximab (pcc) in recurrent/metastatic head and neck cancer

Journal Article Molecular and Clinical Oncology · January 1, 2021 The combination of paclitaxel, carboplatin and cetuximab (PCC) is efficacious in patients with recur-rent/metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN). The current study assessed the incidence of grade 3/4 (G3/4) toxicity for patie ... Full text Cite

Treatment Outcomes of Head and Neck Cancer Patients in the Elderly Receiving Different Chemoradiation Combinations: A Single-Center Experience.

Journal Article Oncol Res Treat · 2021 OBJECTIVES: This study aimed to assess the effect of definitive or adjuvant concurrent chemoradiation (CRT) among elderly patients with locally advanced head and neck squamous cell carcinoma (LA HNSCC). MATERIALS AND METHODS: We retrospectively analyzed 15 ... Full text Link to item Cite

A predictive survival model for patients with head and neck squamous cell carcinoma treated with immune check point inhibitors.

Journal Article Oral Oncol · November 2020 BACKGROUND: ICIs have expanded treatment options for HNSCC. A minority of the patients respond to these expensive treatments. PATIENTS AND METHODS: This is a single institutional retrospective review on 121 unresectable or metastatic HNSCC patients treated ... Full text Link to item Cite

Identification of clinical and socioeconomic predictors of adjuvant therapy after trans-oral robotic surgery in patients with oropharyngeal squamous cell carcinoma

Journal Article Cancers · September 1, 2020 Trans-oral robotic surgery (TORS) has emerged as an important surgical treatment option in the management of human papillomavirus (HPV)-positive and-negative oropharynx cancer. However, treatment selection is paramount to ensure that patients will not requ ... Full text Cite

Role of Positron Emission Tomography Imaging in Metabolically Active Renal Cell Carcinoma.

Journal Article Curr Urol Rep · August 29, 2019 PURPOSE OF REVIEW: The clinical role of fluorine-18 fluoro-2-deoxyglucose (FDG)-positron emission tomography (PET) in renal cell carcinoma (RCC) is still evolving. Use of FDG PET in RCC is currently not a standard investigation in the diagnosis and staging ... Full text Link to item Cite

Salvage treatment for radio-recurrent prostate cancer: a review of literature with focus on recent advancements in image-guided focal salvage therapies.

Journal Article Int Urol Nephrol · July 2019 Biochemical recurrence of prostate cancer occurs in 25-33% of patients who undergo radiation therapy (RT). Unfortunately, greater than 90% of patients with radiation recurrence undergo androgen deprivation therapy (ADT), despite the detrimental side effect ... Full text Link to item Cite

A review of optimal prostate biopsy: indications and techniques

Journal Article Therapeutic Advances in Urology · January 1, 2019 Prostate biopsy is the gold standard diagnostic technique for the detection of prostate cancer. Patient selection for prostate biopsy is complex and is influenced by emerging use of prebiopsy imaging. The introduction of the magnetic resonance imaging (MRI ... Full text Cite

High-risk pathological features at the time of salvage surgery predict poor survival after definitive therapy in patients with head and neck squamous cell carcinoma.

Journal Article Oral Oncol · January 2019 OBJECTIVES: Salvage surgical resection is the preferred treatment for head and neck squamous cell carcinoma (HNSCC) patients who develop locally recurrent disease after failing primary therapy. However, salvage surgical resection is not always feasible, an ... Full text Link to item Cite

Systemic therapy for brain metastases.

Chapter · 2018 Central nervous system metastases cause grave morbidity in patients with advanced malignancies. Lung cancer, breast cancer, and melanoma are the three most common causes of brain metastases. Although the exact incidence of brain metastases is unclear, ther ... Full text Link to item Cite

Longitudinal experience with WHO Grade III (anaplastic) meningiomas at a single institution.

Journal Article J Neurooncol · February 2017 To retrospectively analyze and assess the outcomes and prognostic factors in patients with anaplastic meningioma (AM) (WHO Grade III). Clinical data and outcome [overall (OS) and progression-free (PFS) survival] from 18 patients with Grade III meningioma ( ... Full text Link to item Cite