Vijyendra Ramesh

Journal Article Elife · April 24, 2023 The functional maturation of neurons is a prolonged process that extends past the mitotic exit and is mediated by the chromatin-dependent orchestration of gene transcription programs. We find that expression of this maturation gene program in mouse cerebel ... Full text Link to item Cite

A reactive metabolite as an immune suppressant.

Journal Article Nature immunology · May 2020 Full text Cite

Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis.

Journal Article J Biol Chem · January 3, 2020 Aerobic glycolysis or the Warburg effect (WE) is characterized by increased glucose uptake and incomplete oxidation to lactate. Although the WE is ubiquitous, its biological role remains controversial, and whether glucose metabolism is functionally differe ... Full text Link to item Cite

Acetate Metabolism in Physiology, Cancer, and Beyond.

Journal Article Trends in cell biology · September 2019 Featured Publication Acetate and the related metabolism of acetyl-coenzyme A (acetyl-CoA) confer numerous metabolic functions, including energy production, lipid synthesis, and protein acetylation. Despite its importance as a nutrient for cellular metabolism, its source has be ... Full text Cite

Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells.

Journal Article Science advances · June 2019 Codeletions of gene loci containing tumor suppressors and neighboring metabolic enzymes present an attractive synthetic dependency in cancers. However, the impact that these genetic events have on metabolic processes, which are also dependent on nutrient a ... Full text Cite