Scholars@Duke
Wanda Cook Lakey

Wanda Cook Lakey

Associate Professor of Medicine
Medicine, Endocrinology, Metabolism, and Nutrition
wanda.lakey@duke.edu
Duke Box 3633, Duke University Medical Center, Durham, NC 27710
Orange Zone 375, Durham, NC 27710

Selected Publications

Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.

Journal Article N Engl J Med · September 28, 2017 BACKGROUND: The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. METHODS: We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, ... Full text Open Access Link to item Cite

Recent Clinical Trials in Osteoporosis: A Firm Foundation or Falling Short?

Journal Article PLoS One · 2016 The global burden of osteoporotic fractures is associated with significant morbidity, mortality, and healthcare costs. We examined the ClinicalTrials.gov database to determine whether recently registered clinical trials addressed prevention and treatment i ... Full text Open Access Link to item Cite

Statin intolerance in a referral lipid clinic.

Journal Article J Clin Lipidol · 2016 BACKGROUND: Statins effectively prevent atherosclerotic cardiovascular disease, but rates of statin discontinuation after adverse events are high. OBJECTIVE: Describe the range and relative frequencies of adverse events potentially attributable to statins ... Full text Link to item Cite

Statin intolerance: more questions than answers.

Journal Article Expert Rev Clin Pharmacol · January 2014 The dramatic effectiveness of statins in improving the course of atherosclerotic cardiovascular disease tends to overshadow questions of statin intolerance. Thus after more than 25 years of clinical statin use, intolerance remains a poorly understood, frus ... Full text Link to item Cite

Are current clinical trials in diabetes addressing important issues in diabetes care?

Journal Article Diabetologia · June 2013 AIMS/HYPOTHESIS: Clinical trials assessing interventions for treating and preventing diabetes mellitus and its complications are needed to inform evidence-based practice. To examine whether current studies adequately address these needs, we conducted a des ... Full text Link to item Cite

Short communication: from wasting to obesity: initial antiretroviral therapy and weight gain in HIV-infected persons.

Journal Article AIDS Res Hum Retroviruses · March 2013 Data on weight gain and the progression to overweight/obesity in HIV-infected persons during initial combination antiretroviral therapy (cART) are limited, and comparisons to the general population are inconclusive. Weight and body mass index (BMI) changes ... Full text Link to item Cite

Adverse reactions of Achilles tendon xanthomas in three hypercholesterolemic patients after treatment intensification with niacin and bile acid sequestrants.

Journal Article J Clin Lipidol · 2013 Multiple cholesterol-reducing therapies have been shown to induce the regression of tendon xanthoma in patients with familial hypercholesterolemia. We present 3 cases of adverse reactions in Achilles tendon xanthomas after the addition of niacin and bile a ... Full text Link to item Cite

Osteoporosis in lung transplant candidates compared to matched healthy controls.

Journal Article Clin Transplant · 2011 PURPOSE: Advanced lung disease increases the risk for diminished bone mineral density (BMD). The prevalence and severity of osteoporosis in lung transplant candidates is unclear. METHODS: We retrospectively evaluated BMD of subjects screened for lung trans ... Full text Link to item Cite

Lipid changes associated with antiretroviral therapy: results differ by reporting approach.

Journal Article Curr HIV Res · September 2009 In order to evaluate consistency and comparability of lipid reporting in antiretroviral treatment (ART) studies, 25 ART trials cited in the Department of Health and Human Services Guidelines were analyzed. Changes in lipids from a separate clinical cohort ... Full text Link to item Cite