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Robert Andrew Waugh

Associate Professor Emeritus of Medicine
Medicine, Cardiology
Duke Box 3032, Durham, NC 27710
8027 North Pavillion, 2400 Pratt Street, Durham, NC 27710

Selected Publications


Implementation of echocardiography core laboratory best practices: a case study of the PARTNER I trial.

Journal Article J Am Soc Echocardiogr · April 2013 BACKGROUND: Multicenter clinical trials use echocardiographic core laboratories to ensure expertise and consistency in the assessment of imaging eligibility criteria, as well as safety and efficacy end points. The aim of this study was to report the real-w ... Full text Link to item Cite

Linkages Between Facial Expressions of Anger and Transient Myocardial Ischemia in Men with Coronary Artery Disease

Journal Article · March 22, 2012 This chapter examines linkages between spontaneous facial expressions of emotion and ischemia and examines the relative contributions of hostility and anger to a coronary heart disease-relevant outcome. The dynamic linkages between facial expressions of an ... Full text Cite

Effects of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers in men and women with high blood pressure: the ENCORE study.

Journal Article Arch Intern Med · January 25, 2010 BACKGROUND: Although the DASH (Dietary Approaches to Stop Hypertension) diet has been shown to lower blood pressure (BP) in short-term feeding studies, it has not been shown to lower BP among free-living individuals, nor has it been shown to alter cardiova ... Full text Link to item Cite

Prognosis after change in left ventricular ejection fraction during mental stress testing in patients with stable coronary artery disease.

Journal Article Am J Cardiol · January 1, 2010 Previous studies of patients with stable coronary artery disease have demonstrated that decreases in the left ventricular ejection fraction (LVEF) during acute mental stress are predictive of adverse clinical outcomes. The aim of the present study was to e ... Full text Link to item Cite

Intima-media thickness and age of first depressive episode.

Journal Article Biol Psychol · March 2009 BACKGROUND: Late life depression, including patients with vascular depression, has been associated with higher levels of intima-media thickness (IMT). Although individuals with vascular depression tend to report a later onset of depression, the relationshi ... Full text Link to item Cite

Independent prognostic value of echocardiography and N-terminal pro-B-type natriuretic peptide in patients with heart failure.

Journal Article Am Heart J · December 2008 BACKGROUND: Echocardiographic indices of cardiac structure and function and natriuretic peptide levels are strong predictors of mortality in patients with heart failure. Whether cardiac ultrasound and natriuretic peptides provide independent prognostic inf ... Full text Link to item Cite

Relationship of depression to death or hospitalization in patients with heart failure.

Journal Article Arch Intern Med · February 26, 2007 BACKGROUND: Depression is widely recognized as a risk factor in patients with coronary heart disease. However, patients with heart failure (HF) have been less frequently studied, and the effect of depression on prognosis, independent of disease severity, i ... Full text Link to item Cite

Exercise and pharmacotherapy in the treatment of major depressive disorder.

Journal Article Psychosom Med · 2007 OBJECTIVE: To assess whether patients receiving aerobic exercise training performed either at home or in a supervised group setting achieve reductions in depression comparable to standard antidepressant medication (sertraline) and greater reductions in dep ... Full text Link to item Cite

Understanding prognostic benefits of exercise and antidepressant therapy for persons with depression and heart disease: the UPBEAT study--rationale, design, and methodological issues.

Journal Article Clin Trials · 2007 BACKGROUND: Depression is relatively common in patients with coronary heart disease (CHD) and is associated with worse prognosis. Recently there has been interest in evaluating the impact of treating depression on clinical outcomes. Anti-depressant medicat ... Full text Link to item Cite

Cerebrovascular risk factors, vascular disease, and neuropsychological outcomes in adults with major depression.

Journal Article Psychosom Med · 2007 OBJECTIVE: To investigate the relationship of cerebrovascular risk factors (CVRFs), endothelial function, carotid artery intima medial thickness (IMT), and neuropsychological performance in a sample of 198 middle-aged and older individuals with major depre ... Full text Link to item Cite

Changes in plasma volume associated with mental stress ischemia in patients with coronary artery disease.

Journal Article Int J Psychophysiol · August 2006 Psychological stress has been shown to trigger angina and myocardial ischemia in patients with coronary artery disease. However, the mechanisms by which stress may trigger cardiac events has yet to be fully elucidated. Twenty five patients underwent radion ... Full text Link to item Cite

Impaired endothelial function in coronary heart disease patients with depressive symptomatology.

Journal Article J Am Coll Cardiol · August 16, 2005 OBJECTIVES: The purpose of this study was to assess whether depressive symptomatology was associated with vascular endothelial dysfunction in patients with coronary heart disease (CHD). BACKGROUND: In patients with CHD, the presence of depression is associ ... Full text Link to item Cite

Effects of exercise and stress management training on markers of cardiovascular risk in patients with ischemic heart disease: a randomized controlled trial.

Journal Article JAMA · April 6, 2005 CONTEXT: Observational studies have shown that psychosocial factors are associated with increased risk for cardiovascular morbidity and mortality, but the effects of behavioral interventions on psychosocial and medical end points remain uncertain. OBJECTIV ... Full text Link to item Cite

Association between exercise capacity and left ventricular geometry in overweight patients with mild systemic hypertension.

Journal Article Am J Cardiol · November 15, 2004 The purpose of this study was to determine the relation between left ventricular (LV) geometry and exercise capacity in unmedicated, hypertensive patients. Analysis of the data revealed peak oxygen consumption (ml kg(-1) min(-1)) for concentric hypertrophy ... Full text Link to item Cite

Effects of spouse-assisted coping skills training and exercise training in patients with osteoarthritic knee pain: a randomized controlled study.

Journal Article Pain · August 2004 This study tested the separate and combined effects of spouse-assisted pain coping skills training (SA-CST) and exercise training (ET) in a sample of patients having persistent osteoarthritic knee pain. Seventy-two married osteoarthritis (OA) patients with ... Full text Link to item Cite

Effects of daily stress on autonomic cardiac control in patients with coronary artery disease.

Journal Article Am J Cardiol · May 15, 2004 Emotional stress has been implicated in the development and progression of coronary artery disease, with 1 proposed causal pathway being changes in cardiac autonomic tone. One hundred thirty-five patients with coronary artery disease underwent 48 hours of ... Full text Link to item Cite

Relationship between exercise systolic blood pressure and left ventricular geometry in overweight, mildly hypertensive patients.

Journal Article J Hypertens · February 2004 OBJECTIVE: To examine the association between the graded exercise systolic blood pressure (SBP) response and left ventricular (LV) geometric structure in patients with untreated mild hypertension. PARTICIPANTS: The study included 80 sedentary, overweight p ... Full text Link to item Cite

Ethnic differences in left ventricular structure: relations to hemodynamics and diurnal blood pressure variation.

Journal Article Am J Hypertens · January 2004 BACKGROUND: Previous studies have suggested that African Americans have a greater left ventricular relative wall thickness than whites with similar levels of blood pressure (BP), whereas other investigators have documented an attenuated nocturnal decline i ... Full text Link to item Cite

Effects of exercise and weight loss on cardiac risk factors associated with syndrome X.

Journal Article Arch Intern Med · September 8, 2003 BACKGROUND: Patients with high blood pressure (BP) often exhibit syndrome X, an aggregation of abnormalities in carbohydrate and lipoprotein metabolism associated with increased risk of coronary heart disease (CHD). The present study evaluated the effects ... Full text Link to item Cite

Depression and increased myocardial ischemic activity in patients with ischemic heart disease.

Journal Article Am Heart J · July 2003 BACKGROUND: Depression is relatively common in patients with ischemic heart disease (IHD) and is associated with increased risk of mortality and morbidity. However, the mechanisms by which depression adversely affects clinical outcomes of patients with IHD ... Full text Link to item Cite

Implementation of echocardiography core laboratory best practices: a case study of the PARTNER I trial.

Journal Article J Am Soc Echocardiogr · April 2013 BACKGROUND: Multicenter clinical trials use echocardiographic core laboratories to ensure expertise and consistency in the assessment of imaging eligibility criteria, as well as safety and efficacy end points. The aim of this study was to report the real-w ... Full text Link to item Cite

Linkages Between Facial Expressions of Anger and Transient Myocardial Ischemia in Men with Coronary Artery Disease

Journal Article · March 22, 2012 This chapter examines linkages between spontaneous facial expressions of emotion and ischemia and examines the relative contributions of hostility and anger to a coronary heart disease-relevant outcome. The dynamic linkages between facial expressions of an ... Full text Cite

Effects of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers in men and women with high blood pressure: the ENCORE study.

Journal Article Arch Intern Med · January 25, 2010 BACKGROUND: Although the DASH (Dietary Approaches to Stop Hypertension) diet has been shown to lower blood pressure (BP) in short-term feeding studies, it has not been shown to lower BP among free-living individuals, nor has it been shown to alter cardiova ... Full text Link to item Cite

Prognosis after change in left ventricular ejection fraction during mental stress testing in patients with stable coronary artery disease.

Journal Article Am J Cardiol · January 1, 2010 Previous studies of patients with stable coronary artery disease have demonstrated that decreases in the left ventricular ejection fraction (LVEF) during acute mental stress are predictive of adverse clinical outcomes. The aim of the present study was to e ... Full text Link to item Cite

Intima-media thickness and age of first depressive episode.

Journal Article Biol Psychol · March 2009 BACKGROUND: Late life depression, including patients with vascular depression, has been associated with higher levels of intima-media thickness (IMT). Although individuals with vascular depression tend to report a later onset of depression, the relationshi ... Full text Link to item Cite

Independent prognostic value of echocardiography and N-terminal pro-B-type natriuretic peptide in patients with heart failure.

Journal Article Am Heart J · December 2008 BACKGROUND: Echocardiographic indices of cardiac structure and function and natriuretic peptide levels are strong predictors of mortality in patients with heart failure. Whether cardiac ultrasound and natriuretic peptides provide independent prognostic inf ... Full text Link to item Cite

Relationship of depression to death or hospitalization in patients with heart failure.

Journal Article Arch Intern Med · February 26, 2007 BACKGROUND: Depression is widely recognized as a risk factor in patients with coronary heart disease. However, patients with heart failure (HF) have been less frequently studied, and the effect of depression on prognosis, independent of disease severity, i ... Full text Link to item Cite

Exercise and pharmacotherapy in the treatment of major depressive disorder.

Journal Article Psychosom Med · 2007 OBJECTIVE: To assess whether patients receiving aerobic exercise training performed either at home or in a supervised group setting achieve reductions in depression comparable to standard antidepressant medication (sertraline) and greater reductions in dep ... Full text Link to item Cite

Understanding prognostic benefits of exercise and antidepressant therapy for persons with depression and heart disease: the UPBEAT study--rationale, design, and methodological issues.

Journal Article Clin Trials · 2007 BACKGROUND: Depression is relatively common in patients with coronary heart disease (CHD) and is associated with worse prognosis. Recently there has been interest in evaluating the impact of treating depression on clinical outcomes. Anti-depressant medicat ... Full text Link to item Cite

Cerebrovascular risk factors, vascular disease, and neuropsychological outcomes in adults with major depression.

Journal Article Psychosom Med · 2007 OBJECTIVE: To investigate the relationship of cerebrovascular risk factors (CVRFs), endothelial function, carotid artery intima medial thickness (IMT), and neuropsychological performance in a sample of 198 middle-aged and older individuals with major depre ... Full text Link to item Cite

Changes in plasma volume associated with mental stress ischemia in patients with coronary artery disease.

Journal Article Int J Psychophysiol · August 2006 Psychological stress has been shown to trigger angina and myocardial ischemia in patients with coronary artery disease. However, the mechanisms by which stress may trigger cardiac events has yet to be fully elucidated. Twenty five patients underwent radion ... Full text Link to item Cite

Impaired endothelial function in coronary heart disease patients with depressive symptomatology.

Journal Article J Am Coll Cardiol · August 16, 2005 OBJECTIVES: The purpose of this study was to assess whether depressive symptomatology was associated with vascular endothelial dysfunction in patients with coronary heart disease (CHD). BACKGROUND: In patients with CHD, the presence of depression is associ ... Full text Link to item Cite

Effects of exercise and stress management training on markers of cardiovascular risk in patients with ischemic heart disease: a randomized controlled trial.

Journal Article JAMA · April 6, 2005 CONTEXT: Observational studies have shown that psychosocial factors are associated with increased risk for cardiovascular morbidity and mortality, but the effects of behavioral interventions on psychosocial and medical end points remain uncertain. OBJECTIV ... Full text Link to item Cite

Association between exercise capacity and left ventricular geometry in overweight patients with mild systemic hypertension.

Journal Article Am J Cardiol · November 15, 2004 The purpose of this study was to determine the relation between left ventricular (LV) geometry and exercise capacity in unmedicated, hypertensive patients. Analysis of the data revealed peak oxygen consumption (ml kg(-1) min(-1)) for concentric hypertrophy ... Full text Link to item Cite

Effects of spouse-assisted coping skills training and exercise training in patients with osteoarthritic knee pain: a randomized controlled study.

Journal Article Pain · August 2004 This study tested the separate and combined effects of spouse-assisted pain coping skills training (SA-CST) and exercise training (ET) in a sample of patients having persistent osteoarthritic knee pain. Seventy-two married osteoarthritis (OA) patients with ... Full text Link to item Cite

Effects of daily stress on autonomic cardiac control in patients with coronary artery disease.

Journal Article Am J Cardiol · May 15, 2004 Emotional stress has been implicated in the development and progression of coronary artery disease, with 1 proposed causal pathway being changes in cardiac autonomic tone. One hundred thirty-five patients with coronary artery disease underwent 48 hours of ... Full text Link to item Cite

Relationship between exercise systolic blood pressure and left ventricular geometry in overweight, mildly hypertensive patients.

Journal Article J Hypertens · February 2004 OBJECTIVE: To examine the association between the graded exercise systolic blood pressure (SBP) response and left ventricular (LV) geometric structure in patients with untreated mild hypertension. PARTICIPANTS: The study included 80 sedentary, overweight p ... Full text Link to item Cite

Ethnic differences in left ventricular structure: relations to hemodynamics and diurnal blood pressure variation.

Journal Article Am J Hypertens · January 2004 BACKGROUND: Previous studies have suggested that African Americans have a greater left ventricular relative wall thickness than whites with similar levels of blood pressure (BP), whereas other investigators have documented an attenuated nocturnal decline i ... Full text Link to item Cite

Effects of exercise and weight loss on cardiac risk factors associated with syndrome X.

Journal Article Arch Intern Med · September 8, 2003 BACKGROUND: Patients with high blood pressure (BP) often exhibit syndrome X, an aggregation of abnormalities in carbohydrate and lipoprotein metabolism associated with increased risk of coronary heart disease (CHD). The present study evaluated the effects ... Full text Link to item Cite

Depression and increased myocardial ischemic activity in patients with ischemic heart disease.

Journal Article Am Heart J · July 2003 BACKGROUND: Depression is relatively common in patients with ischemic heart disease (IHD) and is associated with increased risk of mortality and morbidity. However, the mechanisms by which depression adversely affects clinical outcomes of patients with IHD ... Full text Link to item Cite

Reduction of left ventricular hypertrophy after exercise and weight loss in overweight patients with mild hypertension.

Journal Article Arch Intern Med · June 24, 2002 BACKGROUND: Hypertrophy and concentric remodeling of the left ventricle are important manifestations of hypertension that are associated with increased morbidity and mortality. Although lifestyle interventions are efficacious in lowering blood pressure, ev ... Full text Link to item Cite

Changes in hemodynamics and left ventricular structure after menopause.

Journal Article Am J Cardiol · April 1, 2002 To evaluate the cardiovascular changes associated with menopause, we studied hemodynamics at rest, ambulatory blood pressure, and left ventricular structure in a biracial cohort of pre- and postmenopausal women of similar age, race, weight, and blood press ... Full text Link to item Cite

Usefulness of psychosocial treatment of mental stress-induced myocardial ischemia in men.

Journal Article Am J Cardiol · January 15, 2002 This study examined the effects of exercise and stress management training on clinical outcomes and medical expenditures over a 5-year follow-up period in 94 male patients with established coronary artery disease (CAD) and evidence of ambulatory or mental ... Full text Link to item Cite

Relationship of clinic, ambulatory, and laboratory stress blood pressure to left ventricular mass in overweight men and women with high blood pressure.

Journal Article Psychosom Med · 2002 OBJECTIVE: This study was designed to evaluate the relationship between left ventricular (LV) mass and blood pressure (BP) recorded in the following contexts: in the clinic, using standard auscultatory procedures, during a typical day using ambulatory BP m ... Full text Link to item Cite

Blunted nighttime blood pressure dipping in postmenopausal women.

Journal Article Am J Hypertens · August 2001 Blunting of the normal drop in blood pressure (BP) from day to night is emerging as a strong prognostic indicator of cardiovascular morbidity and mortality. This study evaluated the effects of natural menopause on BP dipping in African American and white w ... Full text Link to item Cite

Linkages between facial expressions of anger and transient myocardial ischemia in men with coronary artery disease.

Journal Article Emotion · June 2001 The authors examined whether facial expressions of emotion would predict changes in heart function. One hundred fifteen male patients with coronary artery disease underwent the Type A Structured Interview, during which time measures of transient myocardial ... Full text Link to item Cite

Effects of exercise training on cognitive functioning among depressed older men and women

Journal Article Journal of Aging and Physical Activity · January 1, 2001 The effects of a structured exercise program on the cognitive functioning of 84 clinically depressed middle-aged and older adults (mean age = 57 years) were examined. Participants were randomized to either 4 months of aerobic exercise (n = 42) or antidepre ... Full text Cite

Enhancing Recovery in Coronary Heart Disease (ENRICHD) study intervention: rationale and design.

Journal Article Psychosom Med · 2001 OBJECTIVE: Depression and low social support are risk factors for medical morbidity and mortality after acute MI. The ENRICHD study is a multicenter, randomized, controlled clinical trial of a cognitive-behavioral treatment for depression and low social su ... Link to item Cite

Effects of exercise and weight loss on mental stress-induced cardiovascular responses in individuals with high blood pressure.

Journal Article Hypertension · August 2000 The purpose of this study was to determine the effects of exercise and weight loss on cardiovascular responses during mental stress in mildly to moderately overweight patients with elevated blood pressure. Ninety-nine men and women with high normal or unme ... Full text Link to item Cite

Exercise and weight loss reduce blood pressure in men and women with mild hypertension: effects on cardiovascular, metabolic, and hemodynamic functioning.

Journal Article Arch Intern Med · July 10, 2000 BACKGROUND: Lifestyle modifications have been recommended as the initial treatment strategy for lowering high blood pressure (BP). However, evidence for the efficacy of exercise and weight loss in the management of high BP remains controversial. METHODS: O ... Full text Link to item Cite

Effects of exercise training on older patients with major depression.

Journal Article Arch Intern Med · October 25, 1999 BACKGROUND: Previous observational and interventional studies have suggested that regular physical exercise may be associated with reduced symptoms of depression. However, the extent to which exercise training may reduce depressive symptoms in older patien ... Full text Link to item Cite

Simulation technology for health care professional skills training and assessment.

Journal Article JAMA · September 1, 1999 Changes in medical practice that limit instruction time and patient availability, the expanding options for diagnosis and management, and advances in technology are contributing to greater use of simulation technology in medical education. Four areas of hi ... Full text Link to item Cite

Emotional responsivity and transient myocardial ischemia.

Journal Article J Consult Clin Psychol · August 1999 This study examined the relationship between "emotional responsivity" (i.e., individuals who exhibit relatively large variations of self-reported tension levels) and myocardial ischemia. One hundred thirty-six patients with coronary artery disease underwen ... Full text Link to item Cite

Implementation of a four-year multimedia computer curriculum in cardiology at six medical schools.

Journal Article Acad Med · February 1999 The pressures of a changing health care system are making inroads on the commitment and effort that both basic science and clinical faculty can give to medical education. A tool that has the potential to compensate for decreased faculty time and thereby to ... Full text Link to item Cite

Predicting peak oxygen uptake among older patients with chronic illness.

Journal Article J Cardiopulm Rehabil · 1999 PURPOSE: To compare three equations developed to predict VO2 among patients diagnosed with one of two chronic diseases: essential hypertension (HTN), and fibromyalgia (FM). The equations included the American College of Sports Medicine (ACSM) equation, the ... Full text Link to item Cite

Computers and evaluation of clinical competence [10] (multiple letters)

Journal Article Annals of Internal Medicine · 1999 Cite

Stress management and exercise training in cardiac patients with myocardial ischemia. Effects on prognosis and evaluation of mechanisms.

Journal Article Arch Intern Med · October 27, 1997 BACKGROUND: Previous studies have demonstrated that myocardial ischemia can be elicited by mental stress in the laboratory and during daily life and that ischemia induced by mental stress is associated with an increased risk for future cardiac events in pa ... Link to item Cite

Stability over time of circadian rhythm of variability of heart rate in patients with stable coronary artery disease.

Journal Article Am Heart J · September 1997 Reproducibility of circadian rhythm of variability in heart rate was studied in 40 patients with stable coronary artery disease who underwent 48-hour ambulatory electrocardiographic recordings at baseline (time 1) and after 4 months (time 2). The standard ... Full text Link to item Cite

Electrocardiographic differentiation of the ST-segment depression of acute myocardial injury due to the left circumflex artery occlusion from that of myocardial ischemia of nonocclusive etiologies.

Journal Article Am J Cardiol · August 15, 1997 Lead distributions of peak ST-segment depression were compared between patients undergoing left circumflex artery percutaneous transluminal coronary angioplasty and exercise tolerance test. Localization of peak ST-segment depression to leads V2 or V3 was 9 ... Full text Link to item Cite

Effects of mental stress on myocardial ischemia during daily life.

Journal Article JAMA · May 21, 1997 OBJECTIVE: To determine the relative risk of myocardial ischemia triggered by specific emotions during daily life. DESIGN AND SETTING: Relative risk was calculated by the recently developed case-crossover method, in which the frequency of a presumed trigge ... Link to item Cite

Mental stress--induced myocardial ischemia and cardiac events.

Journal Article JAMA · June 5, 1996 OBJECTIVE: To assess the clinical significance of mental stress-induced myocardial ischemia in patients with coronary artery disease (CAD). DESIGN AND SETTING: Cohort study in outpatients in a tertiary care teaching hospital assessed at baseline and follow ... Full text Link to item Cite

Bedside science reduces laboratory art.

Journal Article Circulation · November 1, 1995 Link to item Cite

Mental stress-induced ischemia in the laboratory and ambulatory ischemia during daily life. Association and hemodynamic features.

Journal Article Circulation · October 15, 1995 BACKGROUND: The purpose of this study was to determine the correspondence of mental stress-induced ischemia in the laboratory with ambulatory ischemia and to assess the relationship between hemodynamic responses to mental stress and the occurrence of ische ... Full text Link to item Cite

Relative importance of electrode placement over number of channels in transient myocardial ischemia detection by Holter monitoring.

Journal Article Am J Cardiol · August 15, 1995 To compare the efficacy of 3-channel ambulatory electrocardiographic monitoring (Holter monitoring) with 2-channel Holter monitoring in the detection of transient myocardial ischemia (TMI), channels CM2, CM5, and modified II were studied. Sixty patients wi ... Full text Link to item Cite

Accuracy and reliability of apical S3 gallop detection.

Journal Article J Gen Intern Med · August 1995 This study assessed physician performance in detecting the apical S3 gallop using a cardiology patient simulator. Six physicians (two cardiology fellows, two medicine residents, and two attending physicians) performed two sets of 24 cardiac examinations th ... Full text Link to item Cite

Does hypotension during dobutamine stress echocardiography correlate with anatomic or functional cardiac impairment?

Journal Article Am Heart J · June 1995 The development of hypotension during various exercise stress tests has been correlated with the presence of multivessel coronary artery disease and impaired left ventricular contractility. Hypotension may also occur during dobutamine stress echocardiograp ... Full text Link to item Cite

Do exercise and weight loss reduce blood pressure in patients with mild hypertension?

Journal Article N C Med J · February 1995 We conclude from our review that exercise and weight loss offer some promise as non-pharmacologic treatments for hypertension. Unfortunately, most available studies are methodologically unsound, and the mechanisms by which exercise lowers blood pressure ar ... Link to item Cite

Multimedia computer-assisted instruction in cardiology.

Journal Article Arch Intern Med · January 23, 1995 BACKGROUND: Medical education faces problems caused by increasing restraints on resources. A multicenter consortium combined simulation and multimedia computer-assisted instruction (MCAI) to develop unique interactive teaching programs that can address a n ... Link to item Cite

Association of physical fitness and transient myocardial ischemia in patients with coronary artery disease.

Journal Article J Cardiopulm Rehabil · 1995 PURPOSE: To examine the relationship between physical fitness and transient myocardial ischemia (TMI) in the laboratory and during daily life, in a sample of coronary patients with a recent positive exercise test. METHODS: 47 patients with coronary disease ... Full text Link to item Cite

The affordability and efficacy of MCAI [2]

Journal Article Archives of Internal Medicine · 1995 Cite

Value of transthoracic echocardiography in predicting embolic events in active infective endocarditis. Duke Endocarditis Service.

Journal Article Am J Cardiol · October 15, 1994 The purpose of this study was twofold: (1) to determine interobserver variability of echocardiographic characteristics of vegetations in patients with infective endocarditis, and (2) to assess the value of these vegetation characteristics in predicting emb ... Full text Link to item Cite

New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service.

Journal Article Am J Med · March 1994 PURPOSE: This study was designed to develop improved criteria for the diagnosis of infective endocarditis and to compare these criteria with currently accepted criteria in a large series of cases. PATIENTS AND METHODS: A total of 405 consecutive cases of s ... Full text Link to item Cite

TEE for infective endocarditis

Journal Article Choices in Cardiology · January 1, 1994 Transthoracic echocardiography (TTE) is an established diagnostic tool for patients with endocarditis, but transesophageal echocardiography (TEE) has emerged as a more sensitive method of identifying vegetations and detecting complications of endocarditis, ... Cite

Usefulness of dobutamine echocardiography for detecting restenosis after percutaneous transluminal coronary angioplasty.

Journal Article Am J Cardiol · December 1, 1993 To determine the usefulness of dobutamine stress echocardiography for detecting restenosis after percutaneous transluminal coronary angioplasty, the results of coronary arteriography and dobutamine stress echocardiography were compared in 103 patients 6 mo ... Full text Link to item Cite

Teaching cardiovascular examination skills: results from a randomized controlled trial.

Journal Article Am J Med · October 1993 PURPOSE: To evaluate the effectiveness of a teaching program designed to improve interns' cardiovascular examination skills. PARTICIPANTS: All 56 interns rotating on a mandatory 4-week inpatient cardiology service during 1 academic year (July 1989-June 199 ... Full text Link to item Cite

Relation of cardiovascular responses to mental stress and cardiac vagal activity in coronary artery disease.

Journal Article Am J Cardiol · September 1, 1993 Forty-six patients with documented coronary artery disease were studied to examine the relation of cardiovascular reactivity to mental stress and cardiac vagal activity. Cardiac vagal activity was measured by means of frequency-domain analysis of heart rat ... Full text Link to item Cite

Assessing housestaff diagnostic skills using a cardiology patient simulator.

Journal Article Ann Intern Med · November 1, 1992 OBJECTIVE: To assess the cardiovascular physical examination skills of internal medicine housestaff. DESIGN: Cross-sectional assessment of housestaff performance on three valvular abnormality simulations conducted on the cardiology patient simulator, "Harv ... Full text Link to item Cite

To excite a heart: a bird's view.

Journal Article Acta Physiol Scand Suppl · 1991 Ultrastructural investigations of avian cardiac muscle, including ratite hearts, have provided great insights into the mechanisms as to how excitation leads to contraction in the heart. The geometry of the conduction fibers of ratite hearts confirms earlie ... Link to item Cite

Cardiology patient simulator and computer-assisted instruction technologies in bedside teaching.

Journal Article Med Educ · November 1990 The design and uses of an innovative technology-based approach which addresses critical problems with bedside teaching during ward rounds in the current health care situation are described. A cardiology patient simulator (HARVEY) and an accompanying comput ... Full text Link to item Cite

Test of a cardiology patient simulator with students in fourth-year electives.

Journal Article J Med Educ · September 1987 A total of 208 fourth-year students at five medical schools participated in an evaluation of a cardiology patient simulator (CPS). One group (116 students) used the CPS during a fourth-year cardiology elective, while another group (92 students) completed a ... Full text Link to item Cite

The impact of echocardiographic results on treatment decisions for patients suspected of mitral valve prolapse.

Journal Article Med Care · July 1987 Although echocardiography is frequently ordered in ambulatory settings for patients suspected of mitral valve prolapse (MVP), its impact on their subsequent management is unknown. We studied the relationship between the results of echocardiography for outp ... Full text Link to item Cite

Mitral valve prolapse. Disease or illness?

Journal Article Arch Intern Med · June 1986 Mitral valve prolapse (MVP) is a common condition that is believed to be responsible for numerous symptoms and potentially serious complications. To determine whether symptoms and functional impairment are related to MVP itself, we studied 274 outpatients ... Link to item Cite

Predicting outcome in coronary disease. Statistical models versus expert clinicians.

Journal Article Am J Med · April 1986 To study the accuracy with which long-term prognosis can be predicted in patients with coronary artery disease, prognostic predictions from a data-based multivariable statistical model were compared with predictions from senior clinical cardiologists. Test ... Full text Link to item Cite

Interatrial shunting in atrial septal aneurysm.

Journal Article Am J Cardiol · February 1, 1986 Adequate contrast 2-dimensional (2-D) echocardiograms were recorded in 13 to 16 patients with typical 2-D findings of atrial septal aneurysm. Five patients were referred for detection of intracardiac source of emboli after embolic stroke and 11 were evalua ... Full text Link to item Cite

The application of official policy. Prophylaxis recommendations for patients with mitral valve prolapse.

Journal Article Med Care · October 1985 In 1977, the American Heart Association recommended that patients with mitral valve prolapse (MVP) and mitral insufficiency receive antibiotic prophylaxis prior to procedures that place them at risk for bacterial endocarditis. To study how clinicians confo ... Link to item Cite

Endocarditis and mitral valve prolapse: what is the "risk"?

Journal Article International Journal of Cardiology · 1984 Cite

Prognostic value of ventricular arrhythmias associated with treadmill exercise testing in patients studied with cardiac catheterization for suspected ischemic heart disease.

Journal Article J Am Coll Cardiol · December 1983 The prognostic information provided by ventricular arrhythmias associated with treadmill exercise testing was evaluated in 1,293 consecutive nonsurgically treated patients undergoing an exercise test within 6 weeks of cardiac catheterization. The 236 patie ... Full text Link to item Cite

Comparative stereology of mouse atria.

Journal Article Tissue Cell · 1981 The left and right atria of the mouse were compared to each other and to the mouse left ventricle using stereologic techniques. The volume fraction (Vv) and surface area per unit cell volume (Sv) of the interior junctional sarcoplasmic reticulum (IJSR), to ... Full text Link to item Cite

A cardiology patient simulator for continuing education of family physicians.

Journal Article Journal of Family Practice · 1981 "Harvey," the cardiology patient simulator (CPS), is the result of a new type of simulation technology that allows for repetitive practice of bedside cardiology skills and provides feedback to the learner. "Harvey" is able to realistically simulate an esse ... Cite

The effect of coronary bypass surgery on survival.

Journal Article Proceedings, the annual meeting of the Medical Section of the American Council of Life Insurance · 1981 Cite

Symposium: A multi-institutional research study on the use of simulation for teaching and evaluating patient examination skills.

Journal Article Annual Conference on Research in Medical Education. Conference on Research in Medical Education · 1980 Cite

Histoplasma capsulatum endocarditis

Journal Article American Heart Journal · 1980 Endocarditis is a rare manifestation of disseminated Histoplasma capsulatum infection. A 22-year-old man presented with a seven month history of fever, weight loss, and progressive aortic insufficiency. The diagnosis of H. capsulatum was suggested by a dia ... Cite

Ultrastructure of heart muscle.

Journal Article Environ Health Perspect · October 1978 The ultrastructure of cardiac muscle is described. In the course of the descriptions advantage has been taken of comparative anatomy, in order to elucidate the relationships between structure and function. Physiologic parameters are discussed in a comparat ... Full text Link to item Cite

Comparative stereology of the mouse and finch left ventricle.

Journal Article Tissue Cell · 1978 The volume fractions and surface per unit cell volume of some subcellular components of the left ventricles of the finch and mouse were quantitated by stereologic techniques. These species were chosen for study because they have similar heart rates but dif ... Full text Link to item Cite

Effect of phasic respiration on left ventricular dimension and performance in a normal population. An echocardiographic study

Journal Article Circulation · 1978 Echocardiographic examination of the left ventricle (LV) in 30 normal subjects, 5 to 47 years of age, was performed in order to analyze the effects of phasic respiration on LV dimensions and derived LV function. Peak expiratory and peak inspiratory LV dias ... Cite

Synthesis of ordinary and β-hydroxy fatty acids by heart mitochondria

Journal Article Archives of Biochemistry and Biophysics · 1972 The fatty acids (FA) synthesized from acetate by intact rabbit heart mitochondria were identified. These FA were mainly 12 to 16 carbons long. One-half were β-hydroxy FA, and mass spectrometric analysis after [1-13C)acetate incorporation showed them to be ... Full text Cite