Journal ArticleJ Am Soc Echocardiogr · April 2013
BACKGROUND: Multicenter clinical trials use echocardiographic core laboratories to ensure expertise and consistency in the assessment of imaging eligibility criteria, as well as safety and efficacy end points. The aim of this study was to report the real-w ...
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Journal Article · March 22, 2012
This chapter examines linkages between spontaneous facial expressions of emotion and ischemia and examines the relative contributions of hostility and anger to a coronary heart disease-relevant outcome. The dynamic linkages between facial expressions of an ...
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Journal ArticleArch Intern Med · January 25, 2010
BACKGROUND: Although the DASH (Dietary Approaches to Stop Hypertension) diet has been shown to lower blood pressure (BP) in short-term feeding studies, it has not been shown to lower BP among free-living individuals, nor has it been shown to alter cardiova ...
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Journal ArticleAm J Cardiol · January 1, 2010
Previous studies of patients with stable coronary artery disease have demonstrated that decreases in the left ventricular ejection fraction (LVEF) during acute mental stress are predictive of adverse clinical outcomes. The aim of the present study was to e ...
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Journal ArticleBiol Psychol · March 2009
BACKGROUND: Late life depression, including patients with vascular depression, has been associated with higher levels of intima-media thickness (IMT). Although individuals with vascular depression tend to report a later onset of depression, the relationshi ...
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Journal ArticleAm Heart J · December 2008
BACKGROUND: Echocardiographic indices of cardiac structure and function and natriuretic peptide levels are strong predictors of mortality in patients with heart failure. Whether cardiac ultrasound and natriuretic peptides provide independent prognostic inf ...
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Journal ArticleArch Intern Med · February 26, 2007
BACKGROUND: Depression is widely recognized as a risk factor in patients with coronary heart disease. However, patients with heart failure (HF) have been less frequently studied, and the effect of depression on prognosis, independent of disease severity, i ...
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Journal ArticlePsychosom Med · 2007
OBJECTIVE: To assess whether patients receiving aerobic exercise training performed either at home or in a supervised group setting achieve reductions in depression comparable to standard antidepressant medication (sertraline) and greater reductions in dep ...
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Journal ArticleClin Trials · 2007
BACKGROUND: Depression is relatively common in patients with coronary heart disease (CHD) and is associated with worse prognosis. Recently there has been interest in evaluating the impact of treating depression on clinical outcomes. Anti-depressant medicat ...
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Journal ArticlePsychosom Med · 2007
OBJECTIVE: To investigate the relationship of cerebrovascular risk factors (CVRFs), endothelial function, carotid artery intima medial thickness (IMT), and neuropsychological performance in a sample of 198 middle-aged and older individuals with major depre ...
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Journal ArticleInt J Psychophysiol · August 2006
Psychological stress has been shown to trigger angina and myocardial ischemia in patients with coronary artery disease. However, the mechanisms by which stress may trigger cardiac events has yet to be fully elucidated. Twenty five patients underwent radion ...
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Journal ArticleJ Am Coll Cardiol · August 16, 2005
OBJECTIVES: The purpose of this study was to assess whether depressive symptomatology was associated with vascular endothelial dysfunction in patients with coronary heart disease (CHD). BACKGROUND: In patients with CHD, the presence of depression is associ ...
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Journal ArticleJAMA · April 6, 2005
CONTEXT: Observational studies have shown that psychosocial factors are associated with increased risk for cardiovascular morbidity and mortality, but the effects of behavioral interventions on psychosocial and medical end points remain uncertain. OBJECTIV ...
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Journal ArticleAm J Cardiol · November 15, 2004
The purpose of this study was to determine the relation between left ventricular (LV) geometry and exercise capacity in unmedicated, hypertensive patients. Analysis of the data revealed peak oxygen consumption (ml kg(-1) min(-1)) for concentric hypertrophy ...
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Journal ArticlePain · August 2004
This study tested the separate and combined effects of spouse-assisted pain coping skills training (SA-CST) and exercise training (ET) in a sample of patients having persistent osteoarthritic knee pain. Seventy-two married osteoarthritis (OA) patients with ...
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Journal ArticleAm J Cardiol · May 15, 2004
Emotional stress has been implicated in the development and progression of coronary artery disease, with 1 proposed causal pathway being changes in cardiac autonomic tone. One hundred thirty-five patients with coronary artery disease underwent 48 hours of ...
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Journal ArticleJ Hypertens · February 2004
OBJECTIVE: To examine the association between the graded exercise systolic blood pressure (SBP) response and left ventricular (LV) geometric structure in patients with untreated mild hypertension. PARTICIPANTS: The study included 80 sedentary, overweight p ...
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Journal ArticleAm J Hypertens · January 2004
BACKGROUND: Previous studies have suggested that African Americans have a greater left ventricular relative wall thickness than whites with similar levels of blood pressure (BP), whereas other investigators have documented an attenuated nocturnal decline i ...
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Journal ArticleArch Intern Med · September 8, 2003
BACKGROUND: Patients with high blood pressure (BP) often exhibit syndrome X, an aggregation of abnormalities in carbohydrate and lipoprotein metabolism associated with increased risk of coronary heart disease (CHD). The present study evaluated the effects ...
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Journal ArticleAm Heart J · July 2003
BACKGROUND: Depression is relatively common in patients with ischemic heart disease (IHD) and is associated with increased risk of mortality and morbidity. However, the mechanisms by which depression adversely affects clinical outcomes of patients with IHD ...
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Journal ArticleJ Am Soc Echocardiogr · April 2013
BACKGROUND: Multicenter clinical trials use echocardiographic core laboratories to ensure expertise and consistency in the assessment of imaging eligibility criteria, as well as safety and efficacy end points. The aim of this study was to report the real-w ...
Full textLink to itemCite
Journal Article · March 22, 2012
This chapter examines linkages between spontaneous facial expressions of emotion and ischemia and examines the relative contributions of hostility and anger to a coronary heart disease-relevant outcome. The dynamic linkages between facial expressions of an ...
Full textCite
Journal ArticleArch Intern Med · January 25, 2010
BACKGROUND: Although the DASH (Dietary Approaches to Stop Hypertension) diet has been shown to lower blood pressure (BP) in short-term feeding studies, it has not been shown to lower BP among free-living individuals, nor has it been shown to alter cardiova ...
Full textLink to itemCite
Journal ArticleAm J Cardiol · January 1, 2010
Previous studies of patients with stable coronary artery disease have demonstrated that decreases in the left ventricular ejection fraction (LVEF) during acute mental stress are predictive of adverse clinical outcomes. The aim of the present study was to e ...
Full textLink to itemCite
Journal ArticleBiol Psychol · March 2009
BACKGROUND: Late life depression, including patients with vascular depression, has been associated with higher levels of intima-media thickness (IMT). Although individuals with vascular depression tend to report a later onset of depression, the relationshi ...
Full textLink to itemCite
Journal ArticleAm Heart J · December 2008
BACKGROUND: Echocardiographic indices of cardiac structure and function and natriuretic peptide levels are strong predictors of mortality in patients with heart failure. Whether cardiac ultrasound and natriuretic peptides provide independent prognostic inf ...
Full textLink to itemCite
Journal ArticleArch Intern Med · February 26, 2007
BACKGROUND: Depression is widely recognized as a risk factor in patients with coronary heart disease. However, patients with heart failure (HF) have been less frequently studied, and the effect of depression on prognosis, independent of disease severity, i ...
Full textLink to itemCite
Journal ArticlePsychosom Med · 2007
OBJECTIVE: To assess whether patients receiving aerobic exercise training performed either at home or in a supervised group setting achieve reductions in depression comparable to standard antidepressant medication (sertraline) and greater reductions in dep ...
Full textLink to itemCite
Journal ArticleClin Trials · 2007
BACKGROUND: Depression is relatively common in patients with coronary heart disease (CHD) and is associated with worse prognosis. Recently there has been interest in evaluating the impact of treating depression on clinical outcomes. Anti-depressant medicat ...
Full textLink to itemCite
Journal ArticlePsychosom Med · 2007
OBJECTIVE: To investigate the relationship of cerebrovascular risk factors (CVRFs), endothelial function, carotid artery intima medial thickness (IMT), and neuropsychological performance in a sample of 198 middle-aged and older individuals with major depre ...
Full textLink to itemCite
Journal ArticleInt J Psychophysiol · August 2006
Psychological stress has been shown to trigger angina and myocardial ischemia in patients with coronary artery disease. However, the mechanisms by which stress may trigger cardiac events has yet to be fully elucidated. Twenty five patients underwent radion ...
Full textLink to itemCite
Journal ArticleJ Am Coll Cardiol · August 16, 2005
OBJECTIVES: The purpose of this study was to assess whether depressive symptomatology was associated with vascular endothelial dysfunction in patients with coronary heart disease (CHD). BACKGROUND: In patients with CHD, the presence of depression is associ ...
Full textLink to itemCite
Journal ArticleJAMA · April 6, 2005
CONTEXT: Observational studies have shown that psychosocial factors are associated with increased risk for cardiovascular morbidity and mortality, but the effects of behavioral interventions on psychosocial and medical end points remain uncertain. OBJECTIV ...
Full textLink to itemCite
Journal ArticleAm J Cardiol · November 15, 2004
The purpose of this study was to determine the relation between left ventricular (LV) geometry and exercise capacity in unmedicated, hypertensive patients. Analysis of the data revealed peak oxygen consumption (ml kg(-1) min(-1)) for concentric hypertrophy ...
Full textLink to itemCite
Journal ArticlePain · August 2004
This study tested the separate and combined effects of spouse-assisted pain coping skills training (SA-CST) and exercise training (ET) in a sample of patients having persistent osteoarthritic knee pain. Seventy-two married osteoarthritis (OA) patients with ...
Full textLink to itemCite
Journal ArticleAm J Cardiol · May 15, 2004
Emotional stress has been implicated in the development and progression of coronary artery disease, with 1 proposed causal pathway being changes in cardiac autonomic tone. One hundred thirty-five patients with coronary artery disease underwent 48 hours of ...
Full textLink to itemCite
Journal ArticleJ Hypertens · February 2004
OBJECTIVE: To examine the association between the graded exercise systolic blood pressure (SBP) response and left ventricular (LV) geometric structure in patients with untreated mild hypertension. PARTICIPANTS: The study included 80 sedentary, overweight p ...
Full textLink to itemCite
Journal ArticleAm J Hypertens · January 2004
BACKGROUND: Previous studies have suggested that African Americans have a greater left ventricular relative wall thickness than whites with similar levels of blood pressure (BP), whereas other investigators have documented an attenuated nocturnal decline i ...
Full textLink to itemCite
Journal ArticleArch Intern Med · September 8, 2003
BACKGROUND: Patients with high blood pressure (BP) often exhibit syndrome X, an aggregation of abnormalities in carbohydrate and lipoprotein metabolism associated with increased risk of coronary heart disease (CHD). The present study evaluated the effects ...
Full textLink to itemCite
Journal ArticleAm Heart J · July 2003
BACKGROUND: Depression is relatively common in patients with ischemic heart disease (IHD) and is associated with increased risk of mortality and morbidity. However, the mechanisms by which depression adversely affects clinical outcomes of patients with IHD ...
Full textLink to itemCite
Journal ArticleArch Intern Med · June 24, 2002
BACKGROUND: Hypertrophy and concentric remodeling of the left ventricle are important manifestations of hypertension that are associated with increased morbidity and mortality. Although lifestyle interventions are efficacious in lowering blood pressure, ev ...
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Journal ArticleAm J Cardiol · April 1, 2002
To evaluate the cardiovascular changes associated with menopause, we studied hemodynamics at rest, ambulatory blood pressure, and left ventricular structure in a biracial cohort of pre- and postmenopausal women of similar age, race, weight, and blood press ...
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Journal ArticleAm J Cardiol · January 15, 2002
This study examined the effects of exercise and stress management training on clinical outcomes and medical expenditures over a 5-year follow-up period in 94 male patients with established coronary artery disease (CAD) and evidence of ambulatory or mental ...
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Journal ArticlePsychosom Med · 2002
OBJECTIVE: This study was designed to evaluate the relationship between left ventricular (LV) mass and blood pressure (BP) recorded in the following contexts: in the clinic, using standard auscultatory procedures, during a typical day using ambulatory BP m ...
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Journal ArticleAm J Hypertens · August 2001
Blunting of the normal drop in blood pressure (BP) from day to night is emerging as a strong prognostic indicator of cardiovascular morbidity and mortality. This study evaluated the effects of natural menopause on BP dipping in African American and white w ...
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Journal ArticleEmotion · June 2001
The authors examined whether facial expressions of emotion would predict changes in heart function. One hundred fifteen male patients with coronary artery disease underwent the Type A Structured Interview, during which time measures of transient myocardial ...
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Journal ArticleJournal of Aging and Physical Activity · January 1, 2001
The effects of a structured exercise program on the cognitive functioning of 84 clinically depressed middle-aged and older adults (mean age = 57 years) were examined. Participants were randomized to either 4 months of aerobic exercise (n = 42) or antidepre ...
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Journal ArticlePsychosom Med · 2001
OBJECTIVE: Depression and low social support are risk factors for medical morbidity and mortality after acute MI. The ENRICHD study is a multicenter, randomized, controlled clinical trial of a cognitive-behavioral treatment for depression and low social su ...
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Journal ArticleHypertension · August 2000
The purpose of this study was to determine the effects of exercise and weight loss on cardiovascular responses during mental stress in mildly to moderately overweight patients with elevated blood pressure. Ninety-nine men and women with high normal or unme ...
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Journal ArticleArch Intern Med · July 10, 2000
BACKGROUND: Lifestyle modifications have been recommended as the initial treatment strategy for lowering high blood pressure (BP). However, evidence for the efficacy of exercise and weight loss in the management of high BP remains controversial. METHODS: O ...
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Journal ArticleArch Intern Med · October 25, 1999
BACKGROUND: Previous observational and interventional studies have suggested that regular physical exercise may be associated with reduced symptoms of depression. However, the extent to which exercise training may reduce depressive symptoms in older patien ...
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Journal ArticleJAMA · September 1, 1999
Changes in medical practice that limit instruction time and patient availability, the expanding options for diagnosis and management, and advances in technology are contributing to greater use of simulation technology in medical education. Four areas of hi ...
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Journal ArticleJ Consult Clin Psychol · August 1999
This study examined the relationship between "emotional responsivity" (i.e., individuals who exhibit relatively large variations of self-reported tension levels) and myocardial ischemia. One hundred thirty-six patients with coronary artery disease underwen ...
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Journal ArticleAcad Med · February 1999
The pressures of a changing health care system are making inroads on the commitment and effort that both basic science and clinical faculty can give to medical education. A tool that has the potential to compensate for decreased faculty time and thereby to ...
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Journal ArticleJ Cardiopulm Rehabil · 1999
PURPOSE: To compare three equations developed to predict VO2 among patients diagnosed with one of two chronic diseases: essential hypertension (HTN), and fibromyalgia (FM). The equations included the American College of Sports Medicine (ACSM) equation, the ...
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Journal ArticleArch Intern Med · October 27, 1997
BACKGROUND: Previous studies have demonstrated that myocardial ischemia can be elicited by mental stress in the laboratory and during daily life and that ischemia induced by mental stress is associated with an increased risk for future cardiac events in pa ...
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Journal ArticleAm Heart J · September 1997
Reproducibility of circadian rhythm of variability in heart rate was studied in 40 patients with stable coronary artery disease who underwent 48-hour ambulatory electrocardiographic recordings at baseline (time 1) and after 4 months (time 2). The standard ...
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Journal ArticleAm J Cardiol · August 15, 1997
Lead distributions of peak ST-segment depression were compared between patients undergoing left circumflex artery percutaneous transluminal coronary angioplasty and exercise tolerance test. Localization of peak ST-segment depression to leads V2 or V3 was 9 ...
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Journal ArticleJAMA · May 21, 1997
OBJECTIVE: To determine the relative risk of myocardial ischemia triggered by specific emotions during daily life. DESIGN AND SETTING: Relative risk was calculated by the recently developed case-crossover method, in which the frequency of a presumed trigge ...
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Journal ArticleJAMA · June 5, 1996
OBJECTIVE: To assess the clinical significance of mental stress-induced myocardial ischemia in patients with coronary artery disease (CAD). DESIGN AND SETTING: Cohort study in outpatients in a tertiary care teaching hospital assessed at baseline and follow ...
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Journal ArticleCirculation · October 15, 1995
BACKGROUND: The purpose of this study was to determine the correspondence of mental stress-induced ischemia in the laboratory with ambulatory ischemia and to assess the relationship between hemodynamic responses to mental stress and the occurrence of ische ...
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Journal ArticleAm J Cardiol · August 15, 1995
To compare the efficacy of 3-channel ambulatory electrocardiographic monitoring (Holter monitoring) with 2-channel Holter monitoring in the detection of transient myocardial ischemia (TMI), channels CM2, CM5, and modified II were studied. Sixty patients wi ...
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Journal ArticleJ Gen Intern Med · August 1995
This study assessed physician performance in detecting the apical S3 gallop using a cardiology patient simulator. Six physicians (two cardiology fellows, two medicine residents, and two attending physicians) performed two sets of 24 cardiac examinations th ...
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Journal ArticleAm Heart J · June 1995
The development of hypotension during various exercise stress tests has been correlated with the presence of multivessel coronary artery disease and impaired left ventricular contractility. Hypotension may also occur during dobutamine stress echocardiograp ...
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Journal ArticleN C Med J · February 1995
We conclude from our review that exercise and weight loss offer some promise as non-pharmacologic treatments for hypertension. Unfortunately, most available studies are methodologically unsound, and the mechanisms by which exercise lowers blood pressure ar ...
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Journal ArticleArch Intern Med · January 23, 1995
BACKGROUND: Medical education faces problems caused by increasing restraints on resources. A multicenter consortium combined simulation and multimedia computer-assisted instruction (MCAI) to develop unique interactive teaching programs that can address a n ...
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Journal ArticleJ Cardiopulm Rehabil · 1995
PURPOSE: To examine the relationship between physical fitness and transient myocardial ischemia (TMI) in the laboratory and during daily life, in a sample of coronary patients with a recent positive exercise test. METHODS: 47 patients with coronary disease ...
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Journal ArticleAm J Cardiol · October 15, 1994
The purpose of this study was twofold: (1) to determine interobserver variability of echocardiographic characteristics of vegetations in patients with infective endocarditis, and (2) to assess the value of these vegetation characteristics in predicting emb ...
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Journal ArticleAm J Med · March 1994
PURPOSE: This study was designed to develop improved criteria for the diagnosis of infective endocarditis and to compare these criteria with currently accepted criteria in a large series of cases. PATIENTS AND METHODS: A total of 405 consecutive cases of s ...
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Journal ArticleChoices in Cardiology · January 1, 1994
Transthoracic echocardiography (TTE) is an established diagnostic tool for patients with endocarditis, but transesophageal echocardiography (TEE) has emerged as a more sensitive method of identifying vegetations and detecting complications of endocarditis, ...
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Journal ArticleAm J Cardiol · December 1, 1993
To determine the usefulness of dobutamine stress echocardiography for detecting restenosis after percutaneous transluminal coronary angioplasty, the results of coronary arteriography and dobutamine stress echocardiography were compared in 103 patients 6 mo ...
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Journal ArticleAm J Med · October 1993
PURPOSE: To evaluate the effectiveness of a teaching program designed to improve interns' cardiovascular examination skills. PARTICIPANTS: All 56 interns rotating on a mandatory 4-week inpatient cardiology service during 1 academic year (July 1989-June 199 ...
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Journal ArticleAm J Cardiol · September 1, 1993
Forty-six patients with documented coronary artery disease were studied to examine the relation of cardiovascular reactivity to mental stress and cardiac vagal activity. Cardiac vagal activity was measured by means of frequency-domain analysis of heart rat ...
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Journal ArticleAnn Intern Med · November 1, 1992
OBJECTIVE: To assess the cardiovascular physical examination skills of internal medicine housestaff. DESIGN: Cross-sectional assessment of housestaff performance on three valvular abnormality simulations conducted on the cardiology patient simulator, "Harv ...
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Journal ArticleActa Physiol Scand Suppl · 1991
Ultrastructural investigations of avian cardiac muscle, including ratite hearts, have provided great insights into the mechanisms as to how excitation leads to contraction in the heart. The geometry of the conduction fibers of ratite hearts confirms earlie ...
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Journal ArticleMed Educ · November 1990
The design and uses of an innovative technology-based approach which addresses critical problems with bedside teaching during ward rounds in the current health care situation are described. A cardiology patient simulator (HARVEY) and an accompanying comput ...
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Journal ArticleJ Med Educ · September 1987
A total of 208 fourth-year students at five medical schools participated in an evaluation of a cardiology patient simulator (CPS). One group (116 students) used the CPS during a fourth-year cardiology elective, while another group (92 students) completed a ...
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Journal ArticleMed Care · July 1987
Although echocardiography is frequently ordered in ambulatory settings for patients suspected of mitral valve prolapse (MVP), its impact on their subsequent management is unknown. We studied the relationship between the results of echocardiography for outp ...
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Journal ArticleArch Intern Med · June 1986
Mitral valve prolapse (MVP) is a common condition that is believed to be responsible for numerous symptoms and potentially serious complications. To determine whether symptoms and functional impairment are related to MVP itself, we studied 274 outpatients ...
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Journal ArticleAm J Med · April 1986
To study the accuracy with which long-term prognosis can be predicted in patients with coronary artery disease, prognostic predictions from a data-based multivariable statistical model were compared with predictions from senior clinical cardiologists. Test ...
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Journal ArticleAm J Cardiol · February 1, 1986
Adequate contrast 2-dimensional (2-D) echocardiograms were recorded in 13 to 16 patients with typical 2-D findings of atrial septal aneurysm. Five patients were referred for detection of intracardiac source of emboli after embolic stroke and 11 were evalua ...
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Journal ArticleMed Care · October 1985
In 1977, the American Heart Association recommended that patients with mitral valve prolapse (MVP) and mitral insufficiency receive antibiotic prophylaxis prior to procedures that place them at risk for bacterial endocarditis. To study how clinicians confo ...
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Journal ArticleJ Am Coll Cardiol · December 1983
The prognostic information provided by ventricular arrhythmias associated with treadmill exercise testing was evaluated in 1,293 consecutive nonsurgically treated patients undergoing an exercise test within 6 weeks of cardiac catheterization. The 236 patie ...
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Journal ArticleTissue Cell · 1981
The left and right atria of the mouse were compared to each other and to the mouse left ventricle using stereologic techniques. The volume fraction (Vv) and surface area per unit cell volume (Sv) of the interior junctional sarcoplasmic reticulum (IJSR), to ...
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Journal ArticleJournal of Family Practice · 1981
"Harvey," the cardiology patient simulator (CPS), is the result of a new type of simulation technology that allows for repetitive practice of bedside cardiology skills and provides feedback to the learner. "Harvey" is able to realistically simulate an esse ...
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Journal ArticleAmerican Heart Journal · 1980
Endocarditis is a rare manifestation of disseminated Histoplasma capsulatum infection. A 22-year-old man presented with a seven month history of fever, weight loss, and progressive aortic insufficiency. The diagnosis of H. capsulatum was suggested by a dia ...
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Journal ArticleEnviron Health Perspect · October 1978
The ultrastructure of cardiac muscle is described. In the course of the descriptions advantage has been taken of comparative anatomy, in order to elucidate the relationships between structure and function. Physiologic parameters are discussed in a comparat ...
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Journal ArticleTissue Cell · 1978
The volume fractions and surface per unit cell volume of some subcellular components of the left ventricles of the finch and mouse were quantitated by stereologic techniques. These species were chosen for study because they have similar heart rates but dif ...
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Journal ArticleCirculation · 1978
Echocardiographic examination of the left ventricle (LV) in 30 normal subjects, 5 to 47 years of age, was performed in order to analyze the effects of phasic respiration on LV dimensions and derived LV function. Peak expiratory and peak inspiratory LV dias ...
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Journal ArticleArchives of Biochemistry and Biophysics · 1972
The fatty acids (FA) synthesized from acetate by intact rabbit heart mitochondria were identified. These FA were mainly 12 to 16 carbons long. One-half were β-hydroxy FA, and mass spectrometric analysis after [1-13C)acetate incorporation showed them to be ...
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