Scholars@Duke
Wei Chen

Wei Chen

Assistant Professor of Pathology
Pathology

Selected Publications

Margin clearance and post-procedure ablation decrease recurrence risk in endoscopic mucosal resections for Barrett's-related neoplasia.

Journal Article Histopathology · December 2025 AIMS: Endoscopic mucosal resection (EMR) is widely used for treating Barrett's-related oesophageal dysplasia and low-stage carcinoma. Disease can recur after this procedure. We analysed a large cohort of EMR specimens to assess clinical and histopathologic ... Full text Link to item Cite

Keratin-positive giant cell-rich tumor with HMGA::NCOR2 fusion in a 4-year-old.

Journal Article Skeletal Radiol · November 8, 2025 Epiphyseal and metaphyseal bone lesions in pediatric patients are uncommon, and lesions that cross an open physis are even rarer. The differential diagnosis for such lesions consists of infection, giant cell tumor, and chondroblastoma. We describe a 4-year ... Full text Link to item Cite

Vascular outflow obstruction changes and low prevalence of advanced fibrosis characterize the liver pathology in orthotopic heart transplant recipients.

Journal Article Am J Clin Pathol · October 4, 2025 OBJECTIVE: The number of orthotopic heart transplants (OHTs) performed each year continues to increase, as does the post-transplant survival rate. Little is known, however, about the morphologic changes in the liver after the patient has undergone an OHT. ... Full text Link to item Cite

Diffuse expression of p16 in pancreatic neuroendocrine tumors (PanNETs) and the association of morphology variants.

Journal Article Am J Clin Pathol · May 17, 2025 OBJECTIVE: Distinguishing grade 3 pancreatic neuroendocrine tumors (PanNETs) from neuroendocrine carcinomas (PanNECs) is sometimes challenging. Recently, a diffuse p16-positive pattern was reported in PanNECs but not in grade 3 PanNETs, suggesting that p16 ... Full text Link to item Cite

Vascular flow alteration is a dominant pattern of liver pathology in patients with orthotopic lung transplants: a retrospective observational study.

Journal Article Histopathology · May 2025 AIMS: The number of orthotopic lung transplants (OLT) has skyrocketed since the 1960s, generating an ever-increasing cohort of post-OLT patients. Many challenges exist in the post-OLT timeframe, including donor graft dysfunction, infection, malignancy, and ... Full text Link to item Cite

The utility of the mHAI scoring system in pediatric autoimmune hepatitis diagnosis and its association with treatment response.

Journal Article Ann Diagn Pathol · December 2024 Autoimmune hepatitis (AIH) is a chronic inflammatory autoimmune disease with either acute or chronic presentation. Previous scoring systems have primarily focused on chronic hepatitis, but none have been validated in an acute setting of pediatric patients. ... Full text Link to item Cite

Is Social Media Here to Stay?: Survey Results Indicate Increasing Pathologist Interest and Engagement Over Time.

Journal Article Arch Pathol Lab Med · October 1, 2024 CONTEXT.—: Social media has become widely adopted by pathologists and other physicians for professional purposes. While engagement has likely increased over time, there remain few concrete data regarding attitudes toward its use. OBJECTIVE.—: To assess pat ... Full text Link to item Cite

A Case of Immune Checkpoint Inhibitor-Induced Duodenitis.

Journal Article ACG Case Rep J · October 2024 Immune checkpoint inhibitors improve patient survival in multiple cancers, but immune-related adverse events, including new immunologic conditions arising during therapy, pose a significant challenge. Gastrointestinal immune-related adverse events, althoug ... Full text Link to item Cite

Venous Invasion in Pancreatic Neuroendocrine Tumors Is Independently Associated With Disease-free Survival and Overall Survival.

Journal Article The American journal of surgical pathology · June 2023 In this study, we evaluated venous invasion and its association with survival in patients with resected pancreatic neuroendocrine tumor (PanNET). Surgical Pathology Archives were searched for pancreatectomies performed for PanNET between October 1, 2005, a ... Full text Cite

Cytomorphologic observations on the sclerosing variant of well-differentiated pancreatic neuroendocrine tumors: Towards making specific diagnoses early.

Journal Article Diagn Cytopathol · May 12, 2023 BACKGROUND: The recently described sclerosing variant of pancreatic neuroendocrine tumor (spNET) shows prominent stromal fibrosis and decreased tumor cellularity in surgical pathology specimens. Although prognostic data are currently ambivalent, some studi ... Full text Link to item Cite

High Frequency of HES1 Loss in Colorectal Adenocarcinomas with RAS/BRAF Mutations

Journal Article Journal of Clinical and Translational Pathology · December 1, 2022 Background and objectives: Hes1 is the downstream target of the canonical Notch-signaling pathway, which plays an essential role in maintaining intestinal proliferative crypts and regulating enterocyte differentiation. Loss of Hes1 expression is frequently ... Full text Cite

Florid Foreign Body-type Giant Cell Response to Keratin Is Associated With Improved Overall Survival in Patients Receiving Preoperative Therapy for Esophageal Squamous Cell Carcinoma.

Journal Article Am J Surg Pathol · December 1, 2021 Featured Publication While most resection specimens from patients with neoadjuvantly treated esophageal squamous cell carcinoma show therapy-related changes in the form of inflammation and fibrosis, others harbor a florid foreign body-type giant cell response to keratin debris ... Full text Link to item Cite

Combined histopathological risk score using TP53 protein expression, CD8+ T cell density and intratumoral budding is an independent predictor of neoadjuvant therapy response in rectal adenocarcinoma.

Journal Article Histopathology · November 2021 Featured Publication AIMS: Neoadjuvant therapy is the recommended treatment for locally advanced rectal adenocarcinoma; however, there remains significant variability in response to therapy. Tumour protein 53 (TP53) has been associated with therapy response and prognosis with ... Full text Link to item Cite

NKX3.1 immunoreactivity is not identified in mesenchymal chondrosarcoma: a 25-case cohort study.

Journal Article Histopathology · January 2021 AIMS: Mesenchymal chondrosarcoma (MC) is characterised typically by a bimorphic microscopic appearance of islands of a well-differentiated cartilaginous component, admixed with a primitive small cell component, which commonly expresses CD99 and NKX2.2. Giv ... Full text Link to item Cite

Peritumoral/vascular expression of PSMA as a diagnostic marker in hepatic lesions.

Journal Article Diagn Pathol · July 23, 2020 BACKGROUND: The differential diagnosis between primary cholangiocarcinoma and metastatic pancreatobiliary adenocarcinoma is histologically challenging due to lack of distinct morphological features and reliable molecular markers. Prostate-specific membrane ... Full text Link to item Cite

Hairy Cell Leukemia, Hairy Cell Leukemia Variant, and Splenic Diffuse Red Pulp Small B-Cell Lymphoma.

Chapter · April 29, 2020 This book provides a comprehensive and up-to-date overview of the pathologic features of common benign and malignant hematopoietic disorders in spleen and liver for practicing pathologists, hematopathologists and clinicians. ... Cite

The Role of Chronic Inflammation in Prostate Carcinogenesis: A Follow-Up Study

Journal Article annals of urologic oncology · June 30, 2019 Purpose To investigate the role of chronic inflammation in prostatic carcinogenesis with an emphasis on cancers of grade group 2 or above. Methods The presence/absence and extent of chronic inflammation and other relevant pathological findings were ... Full text Cite

Absolute immature platelet counts in the setting of suspected heparin-induced thrombocytopenia may predict anti-PF4-heparin immunoassay testing results.

Journal Article Transfus Apher Sci · August 2018 BACKGROUND: Heparin-induced-thrombocytopenia (HIT) is a disease mediated by antibodies to platelet factor 4 (PF4)-heparin complexes. Immature platelet fraction (%-IPF) and absolute immature platelet count (A-IPC) measure newly-released platelets into circu ... Full text Link to item Cite

Renal angiofibroma: A case report

Journal Article Human Pathology: Case Reports · June 2018 Full text Cite

Comparison of long-term effectiveness and complications of radiofrequency ablation with hepatectomy for small hepatocellular carcinoma.

Journal Article J Gastroenterol Hepatol · January 2014 BACKGROUND AND AIM: To determine and compare the adverse events and long-term effectiveness for patients with small hepatocellular carcinoma (HCC) (≤ 3 cm) treated by percutaneous radiofrequency ablation (RFA) or hepatectomy. METHODS: Small HCC from 120 pa ... Full text Link to item Cite

Tumor angiogenesis phenotyping by nanoparticle-facilitated magnetic resonance and near-infrared fluorescence molecular imaging.

Journal Article Neoplasia · October 2012 One of the challenges of tailored antiangiogenic therapy is the ability to adequately monitor the angiogenic activity of a malignancy in response to treatment. The α(v)β(3) integrin, highly overexpressed on newly formed tumor vessels, has been successfully ... Full text Link to item Cite

Adeno-associated virus serotype 8 ApoA-I gene transfer reduces progression of atherosclerosis in ApoE-KO mice: comparison of intramuscular and intravenous administration.

Journal Article J Cardiovasc Pharmacol · March 2011 Apolipoprotein A-I (ApoA-I)/high-density lipoprotein (HDL)-raising treatments are effective antiatherosclerotic strategies. We have compared the antiatherogenic effects of human ApoA-I (hApoA-I) overexpression by intraportal and intramuscular gene transfer ... Full text Link to item Cite

Nanoparticles as magnetic resonance imaging contrast agents for vascular and cardiac diseases.

Journal Article Wiley Interdiscip Rev Nanomed Nanobiotechnol · 2011 Advances in nanoparticle contrast agents for molecular imaging have made magnetic resonance imaging a promising modality for noninvasive visualization and assessment of vascular and cardiac disease processes. This review provides a description of the vario ... Full text Link to item Cite

Detection of clonal lymphoid receptor gene rearrangements in langerhans cell histiocytosis.

Journal Article Am J Surg Pathol · July 2010 Langerhans cell histiocytosis (LCH), also known as histiocytosis X, is a rare human disorder characterized by an abnormal accumulation and/or clonal proliferation of Langerhans cells (LCs) in various body organs. The cellular origin of LCs has been a subje ... Full text Link to item Cite

C/EBPA gene mutation and C/EBPA promoter hypermethylation in acute myeloid leukemia with normal cytogenetics.

Journal Article Am J Hematol · June 2010 In the current study, we investigated C/EBPA gene mutations and promoter hypermethylation in a series of 53 patients with CN-AML. In addition, we also analyzed two other frequent mutations (FLT3/ITD and NPM1) in these patients and correlated them with C/EB ... Full text Link to item Cite

ALK-negative anaplastic large cell lymphoma with extensive peripheral blood and bone marrow involvements manifested as "leukemic phase".

Journal Article Leuk Res · April 2010 CD30-positive anaplastic large cell lymphoma (ALCL) is a distinctive malignant large cell lymphoma of T-cell lineage, often presenting in lymph node or extranodal sites. ALCL cases with extensive bone marrow and peripheral blood involvement manifested as " ... Full text Link to item Cite

Therapy-related acute lymphoblastic leukemia without 11q23 abnormality: report of six cases and a literature review.

Journal Article Am J Clin Pathol · January 2010 Therapy-related acute lymphoblastic leukemia (t-ALL) is a rare secondary leukemia following chemotherapy and/or radiotherapy for primary malignancies. Chromosomal 11q23 abnormality, frequently detected in therapy-related acute myeloid leukemia, is the most ... Full text Link to item Cite

C/Ebpa Gene Mutation and C/Ebpa Promoter Hypermethylation in Acute Myeloid Leukemia with Normal Cytogenetics.

Conference Blood · November 20, 2009 AbstractAbstract 1570Poster Board I-594Acute myeloid leukemia with normal cytogenetics (CN-AML) represents approximately 40-50% of de novo AM ... Full text Cite

Safe and sustained overexpression of functional apolipoprotein A-I/high-density lipoprotein in apolipoprotein A-I-null mice by muscular adeno-associated viral serotype 8 vector gene transfer.

Journal Article J Cardiovasc Pharmacol · November 2009 High levels of high-density lipoprotein (HDL) have protective effects against atherosclerosis and cardiovascular diseases. The postulated mechanism of action for these benefits is an enhanced reverse cholesterol transport. Apolipoprotein A-I (ApoA-I) is th ... Full text Link to item Cite

HDL as a contrast agent for medical imaging.

Journal Article Clin Lipidol · August 2009 Contrast-enhanced MRI of atherosclerosis can provide valuable additional information on a patient's disease state. As a result of the interactions of HDL with atherosclerotic plaque and the flexibility of its reconstitution, it is a versatile candidate for ... Full text Link to item Cite

t(11;14) Plasma cell disorder presents as a true nonsecretory, nonproducer multiple myeloma.

Journal Article Clin Lymphoma Myeloma · June 2009 We describe an extremely rare case of so-called nonsecretory, nonproducer myeloma in an 80-year-old man who presented with weight loss and anemia. The patient's serum protein electrophoresis was negative for M protein spike, and quantitation of his immunog ... Full text Link to item Cite

High frequency of clonal immunoglobulin receptor gene rearrangements in sporadic histiocytic/dendritic cell sarcomas.

Journal Article Am J Surg Pathol · June 2009 Featured Publication The diagnosis of histiocytic/dendritic cell (H/DC) sarcomas is currently based on morphology and the presence of immunophenotypic features of H/DC differentiation. The issue whether clonal immunoglobulin receptor gene rearrangements are present in H/DC sar ... Full text Link to item Cite

High-relaxivity gadolinium-modified high-density lipoproteins as magnetic resonance imaging contrast agents.

Journal Article J Phys Chem B · May 7, 2009 There is an ongoing desire to produce high-relaxivity, Gd-based magnetic resonance imaging (MRI) contrast agents. These may allow for lower doses to be used, which is especially important in view of the current safety concerns surrounding Gd in patients. H ... Full text Link to item Cite

Complete absence of KSHV/HHV-8 in posttransplant lymphoproliferative disorders: an immunohistochemical and molecular study of 52 cases.

Journal Article Am J Clin Pathol · May 2009 Posttransplant lymphoproliferative disorders (PTLDs), a heterogeneous group of monoclonal or polyclonal lesions, occur in immunosuppressed patients after solid organ or bone marrow transplantation. Although most PTLDs are Epstein-Barr virus (EBV)+ and seem ... Full text Link to item Cite

Short-chain fatty acids induce colonic mucosal injury in rats with various postnatal ages.

Journal Article Pediatr Res · February 2005 Short chain fatty acids (SCFAs) may play a role in the pathogenesis of neonatal necrotizing enterocolitis. To evaluate the injurious effect of SCFAs on the colonic mucosa of rats at various postnatal developmental stages, we studied a total of 170 newborn ... Full text Link to item Cite

Monsel's artifact in gynecologic biopsies: A simple remedy

Journal Article Journal of Histotechnology · January 1, 2005 Occasional cervical biopsies and endocervical curettage specimens show a dark-brown artifactual discoloration that may compromise diagnostic evaluation. In this work, we sought to identify the cause of this artifact and find a remedy. Positive and negative ... Full text Cite

Vitamin B-6 requirement and status assessment of young women fed a high-protein diet with various levels of vitamin B-6.

Journal Article Am J Clin Nutr · February 1998 The vitamin B-6 requirement of young women consuming a constant high-protein diet (1.55 g/kg body wt) and the effect of various ratios of vitamin B-6 to protein on this requirement were studied. Eight women were fed a lactoovovegetarian basal diet containi ... Full text Link to item Cite