William Erle Kraus

Richard and Pat Johnson University Distinguished Professor

Medicine, Cardiology

william.kraus@duke.edu

Duke Box 104775, Room 51-201, Durham, NC 27710

300 N. Duke Street, Carmichael Building 51-201, Durham, NC 27701

More About This Person

At a Glance

Credentials
1. Education
2. Training & Certifications

Academic Experience
1. Current Appointments & Affiliations
2. Previous Appointments & Affiliations

Expertise

Research
1. Selected Grants

Publications
1. Selected Publications

Artistic Works / Events

Teaching
1. Recent Courses

Advising & Mentoring

Recognition
1. In the News

Professional Activities

Selected Grants

Endocrinology and Metabolism Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029

The Effect of Exercise on T Cell Aging in Rheumatoid Arthritis

ResearchCo-Mentor · Awarded by National Institutes of Health · 2024 - 2029

Stress Reactivity and Low Back Pain in Older Adults: Influences on Disability (ReLOAD)

Clinical TrialCo-Mentor · Awarded by National Institute on Aging · 2022 - 2027

Age-Related Clonal Hematopoiesis of Indeterminate Potential (CHIP) in Exercise Responsiveness

ResearchCo-Mentor · Awarded by National Institutes of Health · 2024 - 2026

Legacy Effects of CALERIE, a 2-year Calorie Restriction Intervention, on Hallmarks of Healthspan and Aging

ResearchCo Investigator · Awarded by Tufts Medical Center · 2022 - 2026

A precision health approach to target exercise interventions for short- and long-term cardiometabolic health benefits

ResearchMentor · Awarded by American Heart Association · 2023 - 2026

ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2021 - 2026

Extracellular Vesicle Analyses to Develop Aging and Resilience Biomarkers

ResearchCo Investigator · Awarded by National Institute on Aging · 2021 - 2025

Molecular Transducers of Physical Activity and Health: NC Consortium Clinical Site

ResearchPrincipal Investigator · Awarded by National Institute of Arthritis and Musculoskeletal and Skin Diseases · 2016 - 2025

Behavior and Physiology in Aging

Inst. Training Prgm or CMEMentor · Awarded by National Institute on Aging · 2015 - 2025

COPD Pulmonary Rehab GEMSSTAR Award

ResearchCo-Mentor · Awarded by National Institutes of Health · 2023 - 2025

Investigating the effects of aerobic and resistance training in vivo on skeletal muscle metabolism in vitro in primary human muscle cells (MoTrMyo)

ResearchCollaborator · Awarded by Florida Hospital · 2019 - 2025

Skeletal Muscle Molecular Drug Targets for Exercise-induced Cardiometabolic Health

ResearchPrincipal Investigator · Awarded by National Heart, Lung, and Blood Institute · 2021 - 2025

Molecular Basis of Exercise-induced Changes in HDL Function

ResearchCollaborator · Awarded by University of South Carolina · 2019 - 2025

Exercise-induced Legacy Health Benefits on Cardiometabolic Risk Factors in Aging Adults with Prediabetes

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2024

Effects of Blueberry Extract on Physical Activity, Vascular Function and Cognition in Sedentary Older Adults

Clinical TrialPrincipal Investigator · Awarded by U.S. Highbush Blueberry Council · 2019 - 2024

Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative (PRIME Collaborative)

ResearchInvestigator · Awarded by National Institutes of Health · 2017 - 2024

Wearable Biosensors to Monitor Cardiorespiratory Fitness in Patients with Heart Failure

FellowshipCo-Mentor · Awarded by American Heart Association · 2023 - 2024

Accelerated Metabolic Aging in Rheumatoid Arthritis Immune cells and Skeletal Muscle: A Pilot Study

ResearchSignificant Contributor · Awarded by National Institutes of Health · 2020 - 2024

Epigenetic Mechanisms Promoting Longevity

ResearchInvestigator · Awarded by National Institutes of Health · 2018 - 2024

Postdoctoral Training in Genomic Medicine Research

Inst. Training Prgm or CMECo-Mentor · Awarded by National Institutes of Health · 2017 - 2023

Multidisciplinary Heart and Vascular Diseases

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2023

Weight loss and exercise to improve rheumatoid arthritis cardiovascular risk

ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2023

The AMPK/ULK1/p27Kip1 axis regulates autophagy and cell survival in aged satellite cells

ResearchMentor · Awarded by National Institutes of Health · 2017 - 2023

Congestion Phenotypes and Splanchnic Nerve Modulation in Chronic Heart Failure

Clinical TrialCo-Mentor · Awarded by National Institutes of Health · 2020 - 2022

Exercise and Pharmacotherapy for Anxiety in Cardiac Patients

ResearchCo Investigator · Awarded by National Institutes of Health · 2015 - 2022

Systemic Inflammation in Microphysiological Models of Muscle and Vascular Disease

ResearchCo Investigator · Awarded by National Institutes of Health · 2017 - 2022

Analysis of NMR lipoprotein and metabolite data of plasma obtained from CATHGEN and STRRIDE study participants

ResearchPrincipal Investigator · Awarded by Liposcience Inc. · 2017 - 2022

Exercise training to promote improved immune resilience in adults with chronic lymphocytic leukemia - a randomized control trial

Clinical TrialMentor · Awarded by American Society of Hematology · 2020 - 2021

The Effect of Exercise Type, Dose, and Intensity on Plasma Amyloid Beta and Tau in Healthy Adults

ResearchMentor · Awarded by Dementia Alliance of North Carolina · 2019 - 2021

Facility and Web-based Approaches to Lifestyle Change in Resistant Hypertension

ResearchCo Investigator · Awarded by National Institutes of Health · 2014 - 2021

Biomarkers of Caloric Restriction in Humans: the CALERIE Biorepository

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2021

GSK Parexel

Clinical TrialPrincipal Investigator · Awarded by GlaxoSmithKline · 2018 - 2019

Develoment of Behavior-Based Circadian Rhythm Index in a PAD Rehabilitation Population Pilot Project

Clinical TrialPrincipal Investigator · Awarded by University of Alabama at Birmingham · 2017 - 2019

Effects of Ranolazine plus Exercise on Stable Angina and Daily Physical Activity

Clinical TrialPrincipal Investigator · Awarded by Gilead Sciences, Inc. · 2013 - 2018

Epigenetic Mechanisms Promoting Longevity

ResearchCollaborating Investigator · Awarded by National Institutes of Health · 2017 - 2018

Circulatory system and integrated muscle tissue for drug and tissue toxicity

ResearchCo Investigator · Awarded by National Institutes of Health · 2012 - 2018

Lifestyle, CVD Risk and Cognitive Impairment

ResearchCo Investigator · Awarded by National Institutes of Health · 2011 - 2018

Determine the methylation profile of DNA samples II

ResearchPrincipal Investigator · Awarded by Environmental Protection Agency · 2017 - 2017

Air Quality by Genomics Interactions in a Cardiovascular Disease Cohort

ResearchPrincipal Investigator · Awarded by Health Effects Institute · 2014 - 2017

Determine the Methylation Profile of DNA Samples

ResearchPrincipal Investigator · Awarded by Environmental Protection Agency · 2016 - 2017

Effects of Chondroitin Sulfate and Chrondroitin Sulfate/Glucosamine on Muscle Immune Signaling and Function in TNF-alpha Stimulated Three Dimensional Muscle Cultures

ResearchCo Investigator · Awarded by Bioiberica, S.A. · 2016 - 2017

Stress Management and Biomarkers of Risk in Cardiac Rehabilitation

ResearchCo Investigator · Awarded by National Institutes of Health · 2009 - 2016

A mHealth Strategy for Long-Term Care in Cardiac Rehabilitation Patients

Clinical TrialPrincipal Investigator · Awarded by Vida Health · 2014 - 2016

A Pilot Study in Healthy Male Volunteers to Evaluate a Skeletal-muscle Microbiopsy Technique

Clinical TrialPrincipal Investigator · Awarded by GlaxoSmithKline · 2013 - 2016

Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVD

ResearchCo Investigator · Awarded by National Institutes of Health · 2009 - 2016

Bioiberica "Pre-Pilot Mobile App for OA"

Clinical TrialClinical Research Facilitator · Awarded by Bioiberica, S.A. · 2014 - 2015

Mechanisms of Insulin Resistance in Rheumatoid Arthritis

ResearchMentor · Awarded by National Institutes of Health · 2008 - 2015

Behavior And Physiology In Aging

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1999 - 2015

Exercise Dose-Response Effects in Prediabetes:Responses and Mechanisms

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2015

Dietary Nitrate to Augment Exercise Training Benefits in DM+PAD

ResearchConsultant · Awarded by National Institutes of Health · 2013 - 2015

CALERIE

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2014

CALERIE Non-competing Extension with Funds

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2014

Increased Plasma Nitrite, Tissue Oxygenation and Functional Changes in PAD

ResearchConsultant · Awarded by National Institutes of Health · 2012 - 2014

Aerobic Training During or After Adjuvant Therapy: A Randomized Trial

ResearchCo Investigator · Awarded by National Institutes of Health · 2012 - 2014

Randomized Trial of Optimal Type of Aerobic Training in Breast Cancer

ResearchCo Investigator · Awarded by National Institutes of Health · 2010 - 2014

Phase III Trial of Exercise Training in Postsurgical Lung Cancer

ResearchInvestigator · Awarded by National Institutes of Health · 2009 - 2014

Multiwavelength Optical Emitter for Biomedical Diagnostics

Clinical TrialPrincipal Investigator · Awarded by Valencell, INC · 2011 - 2013

Analyses and reports of Cathgen database

ResearchPrincipal Investigator · Awarded by Environmental Protection Agency · 2012 - 2013

Mechanisms of Insulin Resistance in Rheumatoid Arthritis

ResearchMentor · Awarded by National Institutes of Health · 2008 - 2013

The Role of Ankyrin-B Mutations in Premature Senescence

ResearchCollaborator · Awarded by National Institutes of Health · 2011 - 2013

Peripheral endothelial and muscle cell pathology in cardiovascular disease

ResearchCollaborator · Awarded by National Institutes of Health · 2010 - 2013

MicroRNA Mediation of Stretch-Induced Myoblast Function for Engineered Tissues

ResearchCo Investigator · Awarded by National Institutes of Health · 2009 - 2013

Mechanisms linking the adipogenic phenotype of aging muscle to insulin resistance

ResearchCo Investigator · Awarded by National Institutes of Health · 2006 - 2012

Genetic modifiers of dilated cardiomyopathy in adult Drosophila

ResearchCollaborator · Awarded by National Institutes of Health · 2007 - 2012

Genetic Mediators of Metabolic Cardiovascular Disease Risk

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2012

Candidate Genes and Longitudinal Disability Phenotypes

ResearchCo-Mentor · Awarded by National Institutes of Health · 2006 - 2012

Survival and Age Biases in Gene Associations with Coronary Disease

ResearchMentor · Awarded by National Institutes of Health · 2009 - 2011

HF Action Supplement

Clinical TrialCommunications Project Manager · Awarded by National Institutes of Health · 2002 - 2010

A CHF Trial Investigating Outcomes of Exercise Training

ResearchCo Investigator · Awarded by National Institutes of Health · 2002 - 2010

Advanced Haplotype Analyses in Coronary Artery Disease

ResearchMentor · Awarded by National Institutes of Health · 2004 - 2010

Peripheral Effects of Exercise on Cardiovascular Health

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2009

Systems Biology of Angiogenesis

ResearchInvestigator · Awarded by National Institutes of Health · 2006 - 2009

Changes in Functional Status Across Therapy for Primary Gilioma

ResearchConsultant · Awarded by National Cancer Institute · 2006 - 2009

CALERIE

Clinical TrialCo Investigator · Awarded by National Institutes of Health · 2002 - 2009

Training in Biomolecular and Tissue Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2003 - 2009

Skeletal Muscle Plasticity Following LVAD Support

ResearchInvestigator · Awarded by National Institutes of Health · 2006 - 2009

GENECARD: Gene identification in Early-Onset CAD

ResearchCo Investigator · Awarded by National Institutes of Health · 2003 - 2009

Comparative Approach to Genomics of Complex Traits

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2008

Angiogenesis and Mechanisms of Exercise Training in PAD

ResearchCo Investigator · Awarded by National Institutes of Health · 2003 - 2008

Duke Site Agreement for HF-ACTION trial

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2007

Insulin Resistance and Polycystic Ovary Syndrome

ResearchAdvisor · Awarded by National Institutes of Health · 2002 - 2007

Modifier Genes in Heart Failure

ResearchCo Investigator · Awarded by National Institutes of Health · 2001 - 2007

Promoting Health in Prostate and Breast Cancer Survivors

ResearchCo Investigator · Awarded by National Institutes of Health · 2001 - 2006

Mentored Clinical Research Scholar Program

ResearchMentor · Awarded by National Institutes of Health · 2002 - 2006

Stress & Myocardial Ischemia: Mechanisms & Treatment

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1998 - 2006

STRENGTH: Survivor Training for Enhancing Total Health

ResearchCo Investigator · Awarded by National Institutes of Health · 2001 - 2005

Differentiation and maintenance of skeletal and cardiac muscle in simulated microgravity

ResearchPrincipal Investigator · Awarded by National Aeronautics and Space Administration · 1999 - 2003

Peripheral Effects Of Exercise On Cardiovascular Health

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2003

Differentiation And Maintenance Of Skeletal And Cardiac Mu

ResearchPrincipal Investigator · Awarded by National Aeronautics and Space Administration · 1999 - 2002

Graduate Student Research Proposal for Amy Collinsworth (Cytoskeletal Contributions to Changes in Elasticity of Mammalian Myocytes After Cyclic Mechanical Loading)

FellowshipCo-Principal Investigator · Awarded by National Aeronautics and Space Administration · 1999 - 2001