Scholars@Duke
William Erle Kraus

William Erle Kraus

Richard and Pat Johnson University Distinguished Professor
Medicine, Cardiology
william.kraus@duke.edu
Duke Box 104775, Room 51-201, Durham, NC 27710
300 N. Duke Street, Carmichael Building 51-201, Durham, NC 27701

Selected Publications

A Computational Pipeline for Identifying Gene Regulatory Networks: A Case Study of Response to Exercise.

Journal Article Methods in molecular biology (Clifton, N.J.) · January 2025 Gene regulatory networks are foundational in the control of virtually all biological processes. These networks orchestrate a myriad of cell functions ranging from metabolic rate to the response to a drug or other intervention. The data required to accurate ... Full text Cite

The CALERIE Genomic Data Resource.

Journal Article Nat Aging · December 13, 2024 Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from the CALERIE randomized, controlled trial of long-term CR in healthy, nonobese humans broadly supports a similar pattern of effects in humans. To ... Full text Link to item Cite

Decline in Isotope Dilution Space Ratio Above Age 60 Could Affect Energy Estimates Using the Doubly Labeled Water Method.

Journal Article J Nutr · December 2024 BACKGROUND: Doubly labeled water is gold standard for measuring total energy expenditure (TEE). Measurements using the method are sensitive to the isotope dilution space ratio (DSR). Accuracy and precision of the method might be improved if we could identi ... Full text Link to item Cite

Barriers and Predictors of Long-Term Physical Activity Maintenance: The STRRIDE i Reunion Cohort

Journal Article Translational Journal of the American College of Sports Medicine · November 26, 2024 Introduction This study aimed to identify barriers and predictors of self-reported physical activity (PA) maintenance 10 yr following the Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE I) randomized trial among young ol ... Full text Cite

Association Between Lipoprotein(a) and Obstructive Coronary Artery Disease and High-Risk Plaque: Insights From the PROMISE Trial.

Journal Article Am J Cardiol · November 15, 2024 The role of lipoprotein (a) (Lp[a]) in the development of obstructive coronary artery disease (CAD) and high-risk plaque (HRP) in primary prevention patients with stable chest pain is unknown. We sought to evaluate the relation of Lp(a), independent of low ... Full text Link to item Cite

Cardiovascular Disease Pathogenicity Predictor (CVD-PP): A Tissue-Specific In Silico Tool for Discriminating Pathogenicity of Variants of Unknown Significance in Cardiovascular Disease Genes.

Journal Article Circ Genom Precis Med · October 29, 2024 BACKGROUND: Interpretation of variants of uncertain significance (VUSs) remains a challenge in the care of patients with inherited cardiovascular diseases (CVDs); 56% of variants within CVD risk genes are VUS, and machine learning algorithms trained upon l ... Full text Link to item Cite

Predicting physical activity by the personality styles of the five-factor model.

Journal Article Health Psychol · October 2024 OBJECTIVE: Low neuroticism, high extraversion, and high conscientiousness are related to physical activity (PA). We tested whether the small size and heterogeneity of these relationships result because personality traits influence one another as well as be ... Full text Link to item Cite

Sex-Specific Skeletal Muscle Gene Expression Responses to Exercise Reveal Novel Direct Mediators of Insulin Sensitivity Change.

Journal Article medRxiv · September 8, 2024 BACKGROUND: Understanding the causal pathways, systems, and mechanisms through which exercise impacts human health is complex. This study explores molecular signaling related to whole-body insulin sensitivity (Si) by examining changes in skeletal muscle ge ... Full text Link to item Cite

Molecular Transducers of Physical Activity Consortium (MoTrPAC): human studies design and protocol.

Journal Article J Appl Physiol (1985) · September 1, 2024 Physical activity, including structured exercise, is associated with favorable health-related chronic disease outcomes. Although there is evidence of various molecular pathways that affect these responses, a comprehensive molecular map of these molecular r ... Full text Link to item Cite

Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC).

Journal Article Function (Oxf) · July 11, 2024 While regular physical activity is a cornerstone of health, wellness, and vitality, the impact of endurance exercise training on molecular signaling within and across tissues remains to be delineated. The Molecular Transducers of Physical Activity Consorti ... Full text Link to item Cite

The mitochondrial multi-omic response to exercise training across rat tissues.

Journal Article Cell Metab · June 4, 2024 Mitochondria have diverse functions critical to whole-body metabolic homeostasis. Endurance training alters mitochondrial activity, but systematic characterization of these adaptations is lacking. Here, the Molecular Transducers of Physical Activity Consor ... Full text Link to item Cite

Effect of long-term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis.

Journal Article Aging Cell · June 2024 Caloric restriction (CR) modifies lifespan and aging biology in animal models. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE™) 2 trial tested translation of these findings to humans. CALERIE™ randomized healthy, no ... Full text Link to item Cite

Lipoprotein subclasses are associated with Hepatic steatosis: insights from the prospective multicenter imaging study for the evaluation of chest pain (PROMISE) clinical trial.

Journal Article Am J Prev Cardiol · June 2024 OBJECTIVES: To determine the relationship between lipoprotein particle size/number with hepatic steatosis (HS), given its association with traditional lipoproteins and coronary atherosclerosis. METHODS: Individuals with available CT data and blood samples ... Full text Link to item Cite

Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue.

Journal Article Nat Metab · May 2024 Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape is not fully established. Utilizing an integrativ ... Full text Link to item Cite

Implementation of Exercise Management Services Among Sports Medicine Physicians in the United States.

Journal Article Clin J Sport Med · May 1, 2024 OBJECTIVE: Assessment of physical activity and exercise prescription has been widely supported by many organizations, yet provision of such services remains limited in the United States. We sought to uncover why such services have not been widely adopted. ... Full text Link to item Cite

Temporal dynamics of the multi-omic response to endurance exercise training.

Journal Article Nature · May 2024 Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood1-3. Here, the Molecular Transducers of Physical Activity Consortium4 profiled the temporal transcriptome, proteome, metabo ... Full text Link to item Cite

The impact of exercise on gene regulation in association with complex trait genetics.

Journal Article Nat Commun · May 1, 2024 Endurance exercise training is known to reduce risk for a range of complex diseases. However, the molecular basis of this effect has been challenging to study and largely restricted to analyses of either few or easily biopsied tissues. Extensive transcript ... Full text Link to item Cite

Associations among NMR-measured inflammatory and metabolic biomarkers and accelerated aging in cardiac catheterization patients.

Journal Article Aging (Albany NY) · April 23, 2024 Research into aging has grown substantially with the creation of molecular biomarkers of biological age that can be used to determine age acceleration. Concurrently, nuclear magnetic resonance (NMR) assessment of biomarkers of inflammation and metabolism p ... Full text Link to item Cite

Genome-Wide Genetic Analysis of Dropout in a Controlled Exercise Intervention in Sedentary Adults With Overweight or Obesity and Cardiometabolic Disease.

Journal Article Ann Behav Med · April 11, 2024 BACKGROUND: Despite the benefits of exercise, many individuals are unable or unwilling to adopt an exercise intervention. PURPOSE: The purpose of this analysis was to identify putative genetic variants associated with dropout from exercise training interve ... Full text Open Access Link to item Cite

Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-RKT.

Journal Article Cell Rep · March 26, 2024 An intriguing effect of short-term caloric restriction (CR) is the expansion of certain stem cell populations, including muscle stem cells (satellite cells), which facilitate an accelerated regenerative program after injury. Here, we utilized the MetRSL274 ... Full text Link to item Cite

Physical activity and sleep changes among children during the COVID-19 pandemic.

Journal Article NPJ Digit Med · March 16, 2024 Daily routines, including in-person school and extracurricular activities, are important for maintaining healthy physical activity and sleep habits in children. The COVID-19 pandemic significantly disrupted daily routines as in-person school and activities ... Full text Link to item Cite

Inaccurately Reported Statin Use Affects the Assessing of Lipid Profile Measures and Their Association with Coronary Artery Disease Risk.

Journal Article Clin Chem · March 2, 2024 BACKGROUND: Lipid profiling is central for coronary artery disease (CAD) risk assessment. Nonadherence or unreported use of lipid-lowering drugs, particularly statins, can significantly complicate the association between lipid profile measures and CAD clin ... Full text Link to item Cite

Effect of Remotely Supervised Weight Loss and Exercise Training Versus Lifestyle Counseling on Cardiovascular Risk and Clinical Outcomes in Older Adults With Rheumatoid Arthritis: A Randomized Controlled Trial.

Journal Article ACR Open Rheumatol · March 2024 OBJECTIVE: To compare a remotely supervised weight loss and exercise intervention to lifestyle counseling for effects on cardiovascular disease risk, disease activity, and patient-reported outcomes in older patients with rheumatoid arthritis (RA) and overw ... Full text Link to item Cite

Effects of Lifestyle Modification on Psychosocial Function in Patients With Resistant Hypertension: SECONDARY OUTCOMES FROM THE TRIUMPH RANDOMIZED CLINICAL TRIAL.

Journal Article J Cardiopulm Rehabil Prev · January 1, 2024 PURPOSE: In a secondary analysis of the TRIUMPH clinical trial, psychological outcomes in patients with resistant hypertension (RH) receiving a diet and exercise intervention delivered in a cardiac rehabilitation setting were compared with those receiving ... Full text Link to item Cite

The Science of Precision Prevention: Research Opportunities and Clinical Applications to Reduce Cardiovascular Health Disparities.

Journal Article JACC Adv · January 2024 Precision prevention embraces personalized prevention but includes broader factors such as social determinants of health to improve cardiovascular health. The quality, quantity, precision, and diversity of data relatable to individuals and communities cont ... Full text Link to item Cite

Anti-CMV IgG Seropositivity is Associated with Plasma Biomarker Evidence of Amyloid-β Accumulation.

Journal Article J Alzheimers Dis · 2024 BACKGROUND: Some human studies have identified infection with cytomegalovirus (CMV), a member of the alpha herpesvirus family, as a risk factor for Alzheimer's disease and related dementias (ADRD). To our knowledge, no studies have evaluated associations o ... Full text Link to item Cite

Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study.

Journal Article Aging Cell · December 2023 The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by postponement of disease, preservation of function, and increased stress resistance. Whether CR elicits the same physiological and molecular responses in humans rema ... Full text Link to item Cite

Genome-Wide Association Study of Beta-Blocker Survival Benefit in Black and White Patients with Heart Failure with Reduced Ejection Fraction.

Journal Article Genes (Basel) · October 28, 2023 In patients with heart failure with reduced ejection fraction (HFrEF), individual responses to beta-blockers vary. Candidate gene pharmacogenetic studies yielded significant but inconsistent results, and they may have missed important associations. Our obj ... Full text Link to item Cite

Greater male variability in daily energy expenditure develops through puberty.

Journal Article Biol Lett · September 2023 There is considerably greater variation in metabolic rates between men than between women, in terms of basal, activity and total (daily) energy expenditure (EE). One possible explanation is that EE is associated with male sexual characteristics (which are ... Full text Link to item Cite

Creatine and creatinine quantified using nuclear magnetic resonance: A method validation study and clinical associations between circulating creatine and fatigue in kidney transplant recipients.

Journal Article Clin Chim Acta · August 1, 2023 BACKGROUND: A potential contributor to fatigue in kidney transplant recipients (KTR) may be impaired creatine homeostasis. We developed and validated a high-throughput NMR assay allowing for simultaneous measurement of circulating creatine and creatinine, ... Full text Link to item Cite

Clinical Predictors of Adherence to Exercise Training Among Individuals With Heart Failure: THE HF-ACTION STUDY.

Journal Article J Cardiopulm Rehabil Prev · May 1, 2023 PURPOSE: Suboptimal adherence is a major limitation to achieving the benefits of exercise interventions, and our ability to predict and improve adherence is limited. The purpose of this analysis was to identify baseline clinical and demographic characteris ... Full text Open Access Link to item Cite

Remotely Supervised Weight Loss and Exercise Training to Improve Rheumatoid Arthritis Cardiovascular Risk: Rationale and Design of the Supervised Weight Loss Plus Exercise Training-Rheumatoid Arthritis Trial.

Journal Article ACR Open Rheumatol · May 2023 Patients with rheumatoid arthritis (RA) remain at an increased risk for cardiovascular disease (CVD) and mortality. RA CVD results from a combination of traditional risk factors and RA-related systemic inflammation. One hypothetical means of improving over ... Full text Open Access Link to item Cite

Confirmation of Statin and Fibrate Use from Small-Volume Archived Plasma Samples by High-Throughput LC-MS/MS Method.

Journal Article Int J Mol Sci · April 27, 2023 Designing studies for lipid-metabolism-related biomarker discovery is challenging because of the high prevalence of various statin and fibrate usage for lipid-lowering therapies. When the statin and fibrate use is determined based on self-reports, patient ... Full text Link to item Cite

Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure.

Journal Article Nat Metab · April 2023 Obesity is caused by a prolonged positive energy balance1,2. Whether reduced energy expenditure stemming from reduced activity levels contributes is debated3,4. Here we show that in both sexes, total energy expenditure (TEE) adjusted for body composition a ... Full text Link to item Cite

An antiplatelet response gene expression signature is associated with bleeding.

Journal Article Cardiovasc Res · March 31, 2023 AIMS: Gene expression biosignatures may hold promise to individualize antiplatelet therapy in conjunction with current guidelines and risk scores. The Aspirin Response Signature (ARS) score is comprised of a weighted sum of correlated, pro-thrombotic gene ... Full text Link to item Cite

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.

Journal Article Nat Aging · March 2023 The geroscience hypothesis proposes that therapy to slow or reverse molecular changes that occur with aging can delay or prevent multiple chronic diseases and extend healthy lifespan1-3. Caloric restriction (CR), defined as lessening caloric intake without ... Full text Link to item Cite

Abstract P358: Racial Differences in Determinants and Timing of Dropout From an Exercise Intervention: The STRRIDE Trials

Conference Circulation · February 28, 2023 Introduction: Most adults recognize the positive health benefits of being physically active and maintaining a healthy weight, yet inactivity and obesity rates continue to rise. This disconnect is even ... Full text Cite

Effect of behavioral weight-loss program on biomarkers of cardiometabolic disease risk: Heart Health Study randomized trial.

Journal Article Obesity (Silver Spring) · February 2023 OBJECTIVE: This study aimed to determine whether novel biomarkers of cardiometabolic health improve in response to a 12-month behavioral weight-loss intervention and to compare benefits of diet alone with diet plus physical activity for these biomarkers. M ... Full text Open Access Link to item Cite

Multimarkers of metabolic malnutrition and inflammation and their association with mortality risk in cardiac catheterisation patients: a prospective, longitudinal, observational, cohort study.

Journal Article Lancet Healthy Longev · February 2023 BACKGROUND: Complex and incompletely understood metabolic dysfunction associated with inflammation and protein-energy wasting contribute to the increased mortality risk of older patients and those with chronic organ diseases affected by cachexia, sarcopeni ... Full text Link to item Cite

A New Era in Cardiac Rehabilitation Delivery: Research Gaps, Questions, Strategies, and Priorities.

Journal Article Circulation · January 17, 2023 Cardiac rehabilitation (CR) is a guideline-recommended, multidisciplinary program of exercise training, risk factor management, and psychosocial counseling for people with cardiovascular disease (CVD) that is beneficial but underused and with substantial d ... Full text Link to item Cite

Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis.

Journal Article Circulation · January 10, 2023 BACKGROUND: Taking fewer than the widely promoted "10 000 steps per day" has recently been associated with lower risk of all-cause mortality. The relationship of steps and cardiovascular disease (CVD) risk remains poorly described. A meta-analysis examinin ... Full text Link to item Cite

Lipoprotein Subclasses Associated With High-Risk Coronary Atherosclerotic Plaque: Insights From the PROMISE Clinical Trial.

Journal Article J Am Heart Assoc · January 3, 2023 BACKGROUND More than half of major adverse cardiovascular events (MACE) occur in the absence of obstructive coronary artery disease and are often attributed to the rupture of high-risk coronary atherosclerotic plaque (HRP). Blood-based biomarkers that asso ... Full text Link to item Cite

Tryptophan Metabolism and Neurodegeneration: Longitudinal Associations of Kynurenine Pathway Metabolites with Cognitive Performance and Plasma Alzheimer's Disease and Related Dementias Biomarkers in the Duke Physical Performance Across the LifeSpan Study.

Journal Article J Alzheimers Dis · 2023 BACKGROUND: The kynurenine pathway (KP) comprises a family of tryptophan-derived metabolites that some studies have reported are associated with poorer cognitive performance and an increased risk of Alzheimer's disease and related dementias (ADRD). OBJECTI ... Full text Open Access Link to item Cite

Inflammation moderates the effects of lifestyle modification on neurocognition among individuals with resistant hypertension.

Journal Article J Clin Hypertens (Greenwich) · January 2023 Individuals with resistant hypertension (RH) have the greatest risk of cerebrovascular disease and cognitive impairment among individuals with hypertension. Elevated levels of pro-inflammatory cytokines may represent a critical yet unexamined factor influe ... Full text Link to item Cite

Sleep Quality, Metabolic Function, Physical Activity, and Neurocognition Among Individuals with Resistant Hypertension.

Journal Article J Alzheimers Dis · 2023 BACKGROUND: Resistant hypertension (RH) is a major risk factor for stroke, cognitive decline, and dementia. Sleep quality is increasingly suggested to play an important role linking RH to cognitive outcomes, although the mechanisms linking sleep quality to ... Full text Link to item Cite

Demographic, Clinical, and Psychosocial Predictors of Exercise Adherence: The STRRIDE Trials.

Journal Article Transl J Am Coll Sports Med · 2023 PURPOSE: To identify baseline demographic, clinical, and psychosocial predictors of exercise intervention adherence in the Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) trials. METHODS: A total of 947 adults with dysl ... Full text Open Access Link to item Cite

Race and sex differences in dropout from the STRRIDE trials.

Journal Article Front Sports Act Living · 2023 PURPOSE: To determine if race and sex differences exist in determinants and timing of dropout among individuals enrolled in an exercise and/or caloric restriction intervention. METHODS: A total of 947 adults with dyslipidemia (STRRIDE I, STRRIDE AT/RT) or ... Full text Open Access Link to item Cite

Effects of exercise amount and intensity versus a combined exercise and lifestyle intervention on metabolic syndrome in adults with prediabetes: a STRRIDE-PD randomized trial.

Journal Article Front Physiol · 2023 The purpose of this secondary analysis was to determine what portion of the effects of a Diabetes Prevention Program-like intervention on metabolic syndrome (MetS) could be achieved with exercise alone, as well as to determine the relative importance of ex ... Full text Open Access Link to item Cite

Nightshift imposes irregular lifestyle behaviors in police academy trainees.

Journal Article Sleep Adv · 2023 STUDY OBJECTIVE: Shiftwork increases risk for numerous chronic diseases, which is hypothesized to be linked to disruption of circadian timing of lifestyle behaviors. However, empirical data on timing of lifestyle behaviors in real-world shift workers are l ... Full text Open Access Link to item Cite

Environment-induced epigenetic modifications as therapeutic targets for prevention and treatment

Chapter · January 1, 2023 Epigenetics holds great promise within the clinical and health fields both for its ability to impact health outcomes and for its ability to be a record of the exposures an individual receives. While the role of epigenetics in environmental health is still ... Full text Cite

Epigenome-wide Association Study Analysis of Calorie Restriction in Humans, CALERIETM Trial Analysis.

Journal Article J Gerontol A Biol Sci Med Sci · December 29, 2022 Calorie restriction (CR) increases healthy life span and is accompanied by slowing or reversal of aging-associated DNA methylation (DNAm) changes in animal models. In the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIETM ... Full text Link to item Cite

The association of accelerated epigenetic age with all-cause mortality in cardiac catheterization patients as mediated by vascular and cardiometabolic outcomes.

Journal Article Clin Epigenetics · December 3, 2022 BACKGROUND: Epigenetic age is a DNA methylation-based biomarker of aging that is accurate across the lifespan and a range of cell types. The difference between epigenetic age and chronological age, termed age acceleration (AA), is a strong predictor of lif ... Full text Open Access Link to item Cite

Patient-reported and Clinical Outcomes Among Patients Hospitalized for Heart Failure With Reduced Versus Preserved Ejection Fraction.

Journal Article J Card Fail · December 2022 BACKGROUND: Differences between patients hospitalized for heart failure with reduced ejection fraction (HFrEF) vs HF with preserved EF (HFpEF) are not well-characterized, particularly as pertains to in-hospital decongestion and longitudinal patient-reporte ... Full text Link to item Cite

Interindividual Differences in Trainability and Moderators of Cardiorespiratory Fitness, Waist Circumference, and Body Mass Responses: A Large-Scale Individual Participant Data Meta-analysis.

Journal Article Sports Med · December 2022 Although many studies have assumed variability reflects variance caused by exercise training, few studies have examined whether interindividual differences in trainability are present following exercise training. The present individual participant data (IP ... Full text Link to item Cite

Human skeletal muscle nitrate and nitrite in individuals with peripheral arterial disease: Effect of inorganic nitrate supplementation and exercise.

Journal Article Physiol Rep · December 2022 Skeletal muscle may act as a reservoir for N-oxides following inorganic nitrate supplementation. This idea is most intriguing in individuals with peripheral artery disease (PAD) who are unable to endogenously upregulate nitric oxide. This study analyzed pl ... Full text Link to item Cite

Variation in human water turnover associated with environmental and lifestyle factors.

Journal Article Science · November 25, 2022 Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determ ... Full text Link to item Cite

Protein biomarkers of cardiac remodeling and inflammation associated with HFpEF and incident events.

Journal Article Sci Rep · November 22, 2022 There is increasing evidence that HFpEF is a heterogeneous clinical entity and distinct molecular pathways may contribute to pathophysiology. Leveraging unbiased proteomics to identify novel biomarkers, this study seeks to understand the underlying molecul ... Full text Link to item Cite

Exposures to low-levels of fine particulate matter are associated with acute changes in heart rate variability, cardiac repolarization, and circulating blood lipids in coronary artery disease patients.

Journal Article Environ Res · November 2022 Exposure to air pollution is a major risk factor for cardiovascular disease, disease risk factors, and mortality. Specifically, particulate matter (PM), and to some extent ozone, are contributors to these effects. In addition, exposures to these pollutants ... Full text Link to item Cite

Causal analysis identifies small HDL particles and physical activity as key determinants of longevity of older adults.

Journal Article EBioMedicine · November 2022 BACKGROUND: The hard endpoint of death is one of the most significant outcomes in both clinical practice and research settings. Our goal was to discover direct causes of longevity from medically accessible data. METHODS: Using a framework that combines loc ... Full text Link to item Cite

Health coaching and genetic risk testing in primary care: Randomized controlled trial.

Journal Article Health Psychol · October 2022 OBJECTIVE: Accessible interventions are needed to prevent coronary heart disease (CHD) and Type 2 diabetes (T2D). This prospective, randomized, controlled trial evaluated remote health coaching (HC), genetic risk testing (GRT), or both added to standardize ... Full text Link to item Cite

Variability in energy expenditure is much greater in males than females.

Journal Article J Hum Evol · October 2022 In mammals, trait variation is often reported to be greater among males than females. However, to date, mainly only morphological traits have been studied. Energy expenditure represents the metabolic costs of multiple physical, physiological, and behaviora ... Full text Link to item Cite

Prevalence and Phenotypic Burden of Monogenic Arrhythmias Using Integration of Electronic Health Records With Genetics.

Journal Article Circulation. Genomic and precision medicine · October 2022 BackgroundInherited primary arrhythmia syndromes and arrhythmogenic cardiomyopathies can lead to sudden cardiac arrest in otherwise healthy individuals. The burden and expression of these diseases in a real-world, well-phenotyped cardiovascular po ... Full text Cite

Exercise and Escitalopram in the Treatment of Anxiety in Patients with Coronary Heart Disease: One Year Follow-Up of the UNWIND Randomized Clinical Trial.

Journal Article J Cardiovasc Dev Dis · September 22, 2022 Anxiety is common among patients with coronary heart disease (CHD) and is associated with a worse prognosis. UNWIND was a 12-week randomized clinical trial comparing exercise and escitalopram to placebo on measures of anxiety, depression, and CHD biomarker ... Full text Link to item Cite

Longer term benefits of exercise and escitalopram in the treatment of anxiety in patients with coronary heart disease: Six month follow-up of the UNWIND randomized clinical trial.

Journal Article Am Heart J · September 2022 BACKGROUND: Anxiety is a common comorbidity in patients with coronary heart disease (CHD) and is associated with worse prognosis. However, effective treatment for anxiety in CHD patients is uncertain. The UNWIND randomized clinical trial showed that 12-wee ... Full text Link to item Cite

Titration of medical therapy and clinical outcomes among patients with heart failure with reduced ejection fraction: Findings from the HF-ACTION trial.

Journal Article Am Heart J · September 2022 BACKGROUND: Clinical guidelines recommend titration of angiotensin converting enzyme inhibitors (ACEi) and beta-blockers among patients with heart failure with reduced ejection fraction (HFrEF) to maximally tolerated doses. Patient characteristics associat ... Full text Link to item Cite

Human total, basal and activity energy expenditures are independent of ambient environmental temperature.

Journal Article iScience · August 19, 2022 Lower ambient temperature (Ta) requires greater energy expenditure to sustain body temperature. However, effects of Ta on human energetics may be buffered by environmental modification and behavioral compensation. We used the IAEA DLW database for adults i ... Full text Link to item Cite

Using Machine Learning to Identify Organ System Specific Limitations to Exercise via Cardiopulmonary Exercise Testing.

Journal Article IEEE J Biomed Health Inform · August 2022 Cardiopulmonary Exer cise Testing (CPET) is a unique physiologic medical test used to evaluate human response to progressive maximal exercise stress. Depending on the degree and type of deviation from the normal physiologic response, CPET can help identify ... Full text Open Access Link to item Cite

Differential Effects of Amount, Intensity, and Mode of Exercise Training on Insulin Sensitivity and Glucose Homeostasis: A Narrative Review.

Journal Article Sports Med Open · July 14, 2022 As type 2 diabetes remains a leading cause of morbidity and mortality, identifying the most appropriate preventive treatment early in the development of disease is an important public health matter. In general, lifestyle interventions incorporating exercis ... Full text Link to item Cite

Frailty Status Modifies the Efficacy of Exercise Training Among Patients With Chronic Heart Failure and Reduced Ejection Fraction: An Analysis From the HF-ACTION Trial.

Journal Article Circulation · July 12, 2022 BACKGROUND: Supervised aerobic exercise training (ET) is recommended for stable outpatients with heart failure (HF) with reduced ejection fraction (HFrEF). Frailty, a syndrome characterized by increased vulnerability and decreased physiologic reserve, is c ... Full text Link to item Cite

Lifestyle modification and cognitive function among individuals with resistant hypertension: cognitive outcomes from the TRIUMPH trial.

Journal Article J Hypertens · July 1, 2022 BACKGROUND: Resistant hypertension is associated with increased risk of cognitive decline, stroke, and dementia. Lifestyle modification has been suggested to improve cognitive function through its salutary effects on vascular function. METHODS: Participant ... Full text Link to item Cite

Challenges in defining successful adherence to calorie restriction goals in humans: Results from CALERIE™ 2.

Journal Article Exp Gerontol · June 1, 2022 BACKGROUND: The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE™) phase 2 trial tested the effects of two years of 25% calorie restriction (CR) on aging in humans. CALERIE 2 was one of the first studies to use a graph of ... Full text Link to item Cite

Field-Based Assessments of Behavioral Patterns During Shiftwork in Police Academy Trainees Using Wearable Technology.

Journal Article J Biol Rhythms · June 2022 Circadian misalignment, as occurs in shiftwork, is associated with numerous negative health outcomes. Here, we sought to improve data labeling accuracy from wearable technology using a novel data pre-processing algorithm in 27 police trainees during shiftw ... Full text Open Access Link to item Cite

Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness.

Journal Article Sci Rep · May 6, 2022 Rheumatoid arthritis (RA) T cells drive autoimmune features via metabolic reprogramming that reduces oxidative metabolism. Exercise training improves cardiorespiratory fitness (i.e., systemic oxidative metabolism) and thus may impact RA T cell oxidative me ... Full text Open Access Link to item Cite

ACSM-AMSSM Call to Action: Adapting Preparticipation Cardiovascular Screening to the COVID-19 Pandemic.

Journal Article Curr Sports Med Rep · May 1, 2022 Preparticipation cardiovascular screening, designed to identify cardiovascular pathology responsible for sudden unexpected death, is recommended by all major professional medical organizations overseeing the clinical care of competitive athletes. Data from ... Full text Link to item Cite

Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease.

Journal Article American heart journal plus : cardiology research and practice · May 2022 BackgroundIschemic coronary heart disease (IHD) is the leading cause of death worldwide. Genetic variation is presumed to be a major factor underlying sex differences for IHD events, including mortality. The purpose of this study was to identify s ... Full text Cite

Impact of a Novel Training Approach on Hemodynamic and Vascular Profiles in Older Adults.

Journal Article J Aging Phys Act · April 1, 2022 Exercise training beneficially moderates the effects of vascular aging. This study compared the efficacy of Peripheral Remodeling through Intermittent Muscular Exercise (PRIME), a novel training regimen, versus aerobic training on hemodynamic profiles in p ... Full text Link to item Cite

Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts.

Journal Article Lancet Public Health · March 2022 BACKGROUND: Although 10 000 steps per day is widely promoted to have health benefits, there is little evidence to support this recommendation. We aimed to determine the association between number of steps per day and stepping rate with all-cause mortality. ... Full text Link to item Cite

Abstract P080: Health-related Quality Of Life Predictors Of Exercise Intervention Dropout

Conference Circulation · March 2022 Introduction: Though many individuals know the health benefits of participating in exercise, few report sufficient activity to meet the US 2018 Physical Activity Guidelines. Current research assessing ... Full text Cite

Tissue engineered skeletal muscle model of rheumatoid arthritis using human primary skeletal muscle cells.

Journal Article J Tissue Eng Regen Med · February 2022 Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily targeting the joints. Autoreactive immune cells involved in RA affect other tissues, including skeletal muscle. Patients with RA experience diminished physical function, limited mobility ... Full text Link to item Cite

A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease.

Journal Article Elife · January 17, 2022 Insulin resistance (IR) contributes to the pathophysiology of diabetes, dementia, viral infection, and cardiovascular disease. Drug repurposing (DR) may identify treatments for IR; however, barriers include uncertainty whether in vitro transcriptomic assay ... Full text Link to item Cite

Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition.

Journal Article Nat Commun · January 10, 2022 Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measureme ... Full text Link to item Cite

Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial.

Journal Article EClinicalMedicine · January 2022 BACKGROUND: For many cardiovascular risk factors there is no lower limit to which further reduction will result in decreased disease risk; this includes values within ranges considered normal for healthy adults. This seems to be true for new emerging metab ... Full text Link to item Cite

Associations between neighborhood socioeconomic cluster and hypertension, diabetes, myocardial infarction, and coronary artery disease within a cohort of cardiac catheterization patients.

Journal Article Am Heart J · January 2022 BACKGROUND: Neighborhood-level socioeconomic status (SES) is associated with health outcomes, including cardiovascular disease and diabetes, but these associations are rarely studied across large, diverse populations. METHODS: We used Ward's Hierarchical c ... Full text Link to item Cite

Amount and intensity effects of exercise training alone versus a combined diet and exercise lifestyle intervention on health-related quality of life in the STRRIDE-PD randomized trial.

Journal Article BMJ Open Diabetes Res Care · January 2022 INTRODUCTION: To determine the relative contributions of various amounts and intensities of exercise alone to a combined lifestyle intervention on health-related quality of life (HrQoL) measures. RESEARCH DESIGN AND METHODS: Participants (n=162) were seden ... Full text Link to item Cite

Cerebrovascular Function, Vascular Risk, and Lifestyle Patterns in Resistant Hypertension.

Journal Article J Alzheimers Dis · 2022 BACKGROUND: Impaired cerebrovascular reactivity (CVR) and blunted cerebral hemodynamic recruitment are thought to be important mechanisms linking hypertension to cerebrovascular and cognitive outcomes. Few studies have examined cardiovascular or dietary co ... Full text Link to item Cite

Determinants of Dropout from and Variation in Adherence to an Exercise Intervention: The STRRIDE Randomized Trials.

Journal Article Transl J Am Coll Sports Med · 2022 PURPOSE: This study aimed to characterize the timing and self-reported determinants of exercise dropout among sedentary adults with overweight or obesity. We also sought to explore variations in adherence among individuals who completed a 6- to 8-month str ... Full text Open Access Link to item Cite

Evaluating Variation In Weight Change To An Exercise Intervention: The Strride Trials

Conference MEDICINE & SCIENCE IN SPORTS & EXERCISE · 2022 Cite

Effects Of Six Months Of Aerobic Exercise On Mir Expression In Skeletal Muscle

Conference MEDICINE & SCIENCE IN SPORTS & EXERCISE · 2022 Cite

Increasing physical activity in Cancer Survivors through a Text-messaging Exercise motivation Program (ICanSTEP).

Journal Article Support Care Cancer · December 2021 PURPOSE: Cancer survivors are often sedentary. Self-monitoring may promote physical activity through self-activation. We conducted a pilot trial to evaluate whether wearable activity tracker with personalized text message feedback would increase physical a ... Full text Link to item Cite

Physical activity and fat-free mass during growth and in later life.

Journal Article Am J Clin Nutr · November 8, 2021 BACKGROUND: Physical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass. OBJECTIVES: A study is presented of the association between FFM and physical activit ... Full text Link to item Cite

A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.

Journal Article J Am Geriatr Soc · November 2021 BACKGROUND: Older adults with similar health conditions often experience widely divergent outcomes following health stressors. Variable recovery after a health stressor may be due in part to differences in biological mechanisms at the molecular, cellular, ... Full text Link to item Cite

Effect of Exercise, Escitalopram, or Placebo on Anxiety in Patients With Coronary Heart Disease: The Understanding the Benefits of Exercise and Escitalopram in Anxious Patients With Coronary Heart Disease (UNWIND) Randomized Clinical Trial.

Journal Article JAMA Psychiatry · November 1, 2021 IMPORTANCE: Anxiety is common among patients with coronary heart disease (CHD) and is associated with worse health outcomes; however, effective treatment for anxiety in patients with CHD is uncertain. OBJECTIVE: To determine whether exercise and escitalopr ... Full text Link to item Cite

Association between the FTO rs9939609 single nucleotide polymorphism and dietary adherence during a 2-year caloric restriction intervention: Exploratory analyses from CALERIE™ phase 2.

Journal Article Exp Gerontol · November 2021 Caloric restriction (CR) improves markers of aging in humans; but it is not known if the fat mass and obesity-associated gene (FTO) rs9939609 single nucleotide polymorphism (SNP), which is associated with appetite and energy intake, influences adherence to ... Full text Link to item Cite

Energy compensation and adiposity in humans.

Journal Article Curr Biol · October 25, 2021 Understanding the impacts of activity on energy balance is crucial. Increasing levels of activity may bring diminishing returns in energy expenditure because of compensatory responses in non-activity energy expenditures.1-3 This suggestion has profound imp ... Full text Link to item Cite

Greater Pain Severity Is Associated with Worse Outcomes in Patients with Heart Failure.

Journal Article J Cardiovasc Transl Res · October 2021 We examined the relationship between pain severity and outcomes in patients with heart failure with reduced ejection fraction (HFrEF) in the HF-ACTION randomized controlled trial. Trends of health-related quality of life (HRQoL) measures grouped by patient ... Full text Link to item Cite

Effects of Lifestyle Modification on Patients With Resistant Hypertension: Results of the TRIUMPH Randomized Clinical Trial.

Journal Article Circulation · October 2021 BackgroundAlthough lifestyle modifications generally are effective in lowering blood pressure (BP) among patients with unmedicated hypertension and in those treated with 1 or 2 antihypertensive agents, the value of exercise and diet for lowering B ... Full text Cite

Making Cardiopulmonary Exercise Testing Interpretable for Clinicians.

Journal Article Curr Sports Med Rep · October 1, 2021 Cardiopulmonary exercise testing (CPET) is a dynamic clinical tool for determining the cause for a person's exercise limitation. CPET provides clinicians with fundamental knowledge of the coupling of external to internal respiration (oxygen and carbon diox ... Full text Link to item Cite

Weight-Related Behaviors of Children with Obesity during the COVID-19 Pandemic.

Journal Article Child Obes · September 2021 Background: During the coronavirus disease 2019 (COVID-19) pandemic, children and families have had to adapt their daily lives. The purpose of this study was to describe changes in the weight-related behaviors of children with obesity after the onset of th ... Full text Link to item Cite

Early Identification of Patients at Risk for Incident Heart Failure With Preserved Ejection Fraction: Novel Approach to Echocardiographic Trends.

Journal Article J Card Fail · September 2021 BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) continues to increase in prevalence with a 50% mortality rate within 3 years of diagnosis, but lacking effective evidence-based therapies. Specific echocardiographic markers are not typical ... Full text Link to item Cite

Best Practices for Meta-Reviews in Physical Activity and Health Research: Insights From the Physical Activity Guidelines for Americans Advisory Committee Scientific Report.

Journal Article J Phys Act Health · September 1, 2021 BACKGROUND: Systematic reviews (SRs) and meta-analyses (MAs) have proliferated with a concomitant increase in reviews of SRs/MAs or "meta-reviews" (MRs). As uncovered by the 2018 US Physical Activity Guidelines Advisory Committee (PAGAC), there is a paucit ... Full text Link to item Cite

Daily energy expenditure through the human life course.

Journal Article Science · August 13, 2021 Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditur ... Full text Link to item Cite

Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy.

Journal Article Cardiovasc Diabetol · August 3, 2021 BACKGROUND: Whether differences in circulating long chain acylcarnitines (LCAC) are seen in heart failure (HF) patients with and without diabetes mellitus (DM), and whether these biomarkers report on exercise capacity and clinical outcomes, remains unknown ... Full text Link to item Cite

Exploring Differences in Cardiorespiratory Fitness Response Rates Across Varying Doses of Exercise Training: A Retrospective Analysis of Eight Randomized Controlled Trials.

Journal Article Sports Med · August 2021 OBJECTIVE: This study tested the hypothesis that greater mean changes in cardiorespiratory fitness (CRF), in either the absence or presence of reduced interindividual variability, explain larger CRF response rates following higher doses of exercise trainin ... Full text Link to item Cite

Physical Activity as a Critical Component of First-Line Treatment for Elevated Blood Pressure or Cholesterol: Who, What, and How?: A Scientific Statement From the American Heart Association.

Journal Article Hypertension (Dallas, Tex. : 1979) · August 2021 Current guidelines published by the American Heart Association and the American College of Cardiology broadly recommend lifestyle approaches to prevent and treat elevated blood pressure and cholesterol. For patients with mildly or moderately elevated blood ... Full text Cite

Increasing the Availability of Automated External Defibrillators at Sporting Events: A Call to Action from the American College of Sports Medicine.

Journal Article Curr Sports Med Rep · August 1, 2021 Given that most sudden cardiac arrests (SCAs) occur outside of a medical facility, often in association with exercise and sporting events, and given that early cardiopulmonary resuscitation (CPR) plus defibrillation is the strongest predictor of survival f ... Full text Link to item Cite

SARS-CoV-2 Cardiac Involvement in Young Competitive Athletes.

Journal Article Circulation · July 27, 2021 BACKGROUND: Cardiac involvement among hospitalized patients with severe coronavirus disease 2019 (COVID-19) is common and associated with adverse outcomes. This study aimed to determine the prevalence and clinical implications of COVID-19 cardiac involveme ... Full text Link to item Cite

Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis.

Journal Article Arthritis Res Ther · July 10, 2021 BACKGROUND: Exercise training, including high-intensity interval training (HIIT), improves rheumatoid arthritis (RA) inflammatory disease activity via unclear mechanisms. Because exercise requires skeletal muscle, skeletal muscle molecular pathways may con ... Full text Link to item Cite

Effects of Acute Exercise on Anxiety Ratings in Patients With Coronary Heart Disease and Elevated Anxiety.

Journal Article J Cardiopulm Rehabil Prev · July 1, 2021 PURPOSE: To explore individual differences in state anxiety following a single, acute bout of aerobic exercise among anxious patients with diagnosed coronary heart disease (CHD). METHODS: One hundred eighteen CHD patients with elevated symptoms of anxiety ... Full text Link to item Cite

Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity.

Journal Article Science (New York, N.Y.) · July 2021 Large-scale human exome sequencing can identify rare protein-coding variants with a large impact on complex traits such as body adiposity. We sequenced the exomes of 645,626 individuals from the United Kingdom, the United States, and Mexico and estimated a ... Full text Cite

Evaluation of PM2.5 air pollution sources and cardiovascular health.

Journal Article Environ Epidemiol · June 2021 Long-term air pollution exposure, notably fine particulate matter, is a global contributor to morbidity and mortality and a known risk factor for coronary artery disease (CAD) and myocardial infarctions (MI). Knowledge of impacts related to source-apportio ... Full text Link to item Cite

Cardiopulmonary Exercise Testing in the Coronavirus Disease - 2019 Era: Safety and Protocol Considerations.

Journal Article Curr Sports Med Rep · May 1, 2021 Cardiopulmonary exercise testing (CPX) is a valuable tool in both clinical practice and research settings. Therefore, it is advantageous for human performance laboratories to continue operating during the coronavirus disease 2019 (COVID-19) pandemic. All i ... Full text Link to item Cite

Association between short-term exposure to ambient fine particulate matter and myocardial injury in the CATHGEN cohort.

Journal Article Environ Pollut · April 15, 2021 Exposure to fine particulate matter (PM2.5) has been associated with a higher risk for coronary events. Elevated circulating cardiac troponins (cTn) are suggestive of myocardial injury in both ischemic and non-ischemic conditions. However, little is known ... Full text Link to item Cite

Effect of 2 years of calorie restriction on liver biomarkers: results from the CALERIE phase 2 randomized controlled trial.

Journal Article Eur J Nutr · April 2021 PURPOSE: Calorie restriction (CR) is an effective treatment for obesity-related liver and metabolic disease. However, CR studies in individuals without obesity are needed to see if CR could delay disease onset. Liver biomarkers indicate hepatic health and ... Full text Link to item Cite

Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci.

Journal Article Genome medicine · April 2021 BackgroundDNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African Americans. The causes for this are poor ... Full text Open Access Cite

Beta-blocker and ACE-inhibitor dosing as a function of body surface area: From the HF-ACTION trial.

Journal Article Am Heart J · March 2021 Recognizing that body surface area (BSA) is a commonly used metric to inform medication dosing across fields of medicine, it is possible that patients with heart failure with reduced ejection fraction (HFrEF) with higher BSA may be more likely to tolerate ... Full text Link to item Cite

Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis.

Journal Article J Appl Physiol (1985) · March 1, 2021 Rheumatoid arthritis (RA) is a systemic inflammatory arthritis impacting primarily joints and cardiac and skeletal muscle. RA's distinct impact on cardiac and skeletal muscle tissue is suggested by studies showing that new RA pharmacologic agents strongly ... Full text Link to item Cite

Genome-wide analysis identifies novel susceptibility loci for myocardial infarction.

Journal Article Eur Heart J · March 1, 2021 AIMS: While most patients with myocardial infarction (MI) have underlying coronary atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought to address the hypothesis that some of the genetic factors which establish atheros ... Full text Open Access Link to item Cite

A standard calculation methodology for human doubly labeled water studies.

Journal Article Cell Rep Med · February 16, 2021 The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adu ... Full text Link to item Cite

Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2.

Journal Article Nutr Rev · January 1, 2021 Caloric restriction (CR) is a strategy that attenuates aging in multiple nonhuman species. The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trials are part of a research program aiming to test the effects of CR on ag ... Full text Link to item Cite

A Role for Exercise to Counter Skeletal Muscle Clock Disruption.

Journal Article Exerc Sport Sci Rev · January 2021 Disruption of the skeletal muscle circadian clock leads to a preferential shift toward lipid oxidation while reducing carbohydrate oxidation. These effects are apparent at the whole-body level, including glucose intolerance, increased energy expenditure, a ... Full text Link to item Cite

Effects of Amount, Intensity, and Mode of Exercise Training on Insulin Resistance and Type 2 Diabetes Risk in the STRRIDE Randomized Trials.

Journal Article Front Physiol · 2021 BACKGROUND: Lipoprotein Insulin Resistance Index (LP-IR) and Diabetes Risk Index are novel spectroscopic multimarkers of insulin resistance and type 2 diabetes risk. As the Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE ... Full text Link to item Cite

Aerobic Versus Resistance Training Effects on Ventricular-Arterial Coupling and Vascular Function in the STRRIDE-AT/RT Trial.

Journal Article Front Cardiovasc Med · 2021 Background: The goal was studying the differential effects of aerobic training (AT) vs. resistance training (RT) on cardiac and peripheral arterial capacity on cardiopulmonary (CP) and peripheral vascular (PV) function in sedentary and obese adults. Method ... Full text Link to item Cite

Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions.

Journal Article PLoS One · 2021 Obesity is an epidemic internationally. While weight loss interventions are efficacious, they are compounded by heterogeneity with regards to clinically relevant metabolic responses. Thus, we sought to identify metabolic biomarkers that are associated with ... Full text Link to item Cite

Genome-Wide Variants Associated With Longitudinal Survival Outcomes Among Individuals With Coronary Artery Disease.

Journal Article Front Genet · 2021 OBJECTIVE: Coronary artery disease (CAD) is an age-associated condition that greatly increases the risk of mortality. The purpose of this study was to identify gene variants associated with all-cause mortality among individuals with clinically phenotyped C ... Full text Link to item Cite

Corrigendum: Genome-Wide Variants Associated With Longitudinal Survival Outcomes Among Individuals With Coronary Artery Disease.

Journal Article Front Genet · 2021 [This corrects the article DOI: 10.3389/fgene.2021.661497.]. ... Full text Link to item Cite

Branched-Chain Amino Acid Catabolism and Cardiopulmonary Function Following Acute Maximal Exercise Testing in Adolescents.

Journal Article Front Cardiovasc Med · 2021 Background: To provide energy for cardiopulmonary function and maintenance of blood glucose, acute aerobic exercise induces lipolysis, fatty acid oxidation (FAO), glycolysis, and glycogenolysis/gluconeogenesis. These adaptations are mediated by increases i ... Full text Link to item Cite

A Simplified And Intuitive Visualization For Cardiopulmonary Exercise Testing Data

Conference MEDICINE AND SCIENCE IN SPORTS AND EXERCISE · 2021 Cite

The Relation of Accelerometer-Measured Physical Activity and Serum Uric Acid Using the National Health and Nutrition Survey (NHANES) 2003-2004.

Journal Article Front Sports Act Living · 2021 Objective: Gout is a crystal-induced inflammatory arthritis caused by elevated uric acid. Physical activity has the potential to reduce serum uric acid (SUA), thus improving the disease burden of gout. In this study, we examined the association of objectiv ... Full text Open Access Link to item Cite

Novel plasma biomarkers improve discrimination of metabolic health independent of weight.

Journal Article Sci Rep · December 7, 2020 We sought to determine if novel plasma biomarkers improve traditionally defined metabolic health (MH) in predicting risk of cardiovascular disease (CVD) events irrespective of weight. Poor MH was defined in CATHGEN biorepository participants (n > 9300), a ... Full text Link to item Cite

Accelerated epigenetic age as a biomarker of cardiovascular sensitivity to traffic-related air pollution.

Journal Article Aging (Albany NY) · December 7, 2020 BACKGROUND: Accelerated epigenetic age has been proposed as a biomarker of increased aging, which may indicate disruptions in cellular and organ system homeostasis and thus contribute to sensitivity to environmental exposures. METHODS: Using 497 participan ... Full text Open Access Link to item Cite

Polygenic Score for β-Blocker Survival Benefit in European Ancestry Patients With Reduced Ejection Fraction Heart Failure.

Journal Article Circ Heart Fail · December 2020 BACKGROUND: β-Blockers (BBs) are mainstay therapy for heart failure with reduced ejection fraction. However, individual patient responses to BB vary, which may be partially due to genetic variation. The goal of this study was to derive and validate the fir ... Full text Link to item Cite

GlycA measured by NMR spectroscopy is associated with disease activity and cardiovascular disease risk in chronic inflammatory diseases.

Journal Article Am J Prev Cardiol · December 2020 GlycA is a biomarker of systemic inflammation, quantifying both the protein concentrations and glycosylation states of several acute phase proteins. GlycA has been shown to be associated with both subclinical atherosclerosis and with cardiovascular disease ... Full text Link to item Cite

Metabolic and physiological effects of high intensity interval training in patients with knee osteoarthritis: A pilot and feasibility study.

Journal Article Osteoarthr Cartil Open · December 2020 OBJECTIVE: To examine the feasibility of a 6-week high intensity interval training (HIIT) program in patients with symptomatic knee osteoarthritis (OA). A secondary aim was to evaluate the change in whole-body metabolism. DESIGN: In a single-arm interventi ... Full text Link to item Cite

Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.

Journal Article Cell Rep · November 10, 2020 Glycine levels are inversely associated with branched-chain amino acids (BCAAs) and cardiometabolic disease phenotypes, but biochemical mechanisms that explain these relationships remain uncharted. Metabolites and genes related to BCAA metabolism and nitro ... Full text Link to item Cite

Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants.

Journal Article Transl Psychiatry · October 20, 2020 In prior work, we identified a novel gene-by-stress association of EBF1's common variation (SNP rs4704963) with obesity (i.e., hip, waist) in Whites, which was further strengthened through multiple replications using our synthetic stress measure. We now ex ... Full text Open Access Link to item Cite

Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease.

Journal Article Vasc Med · October 2020 Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities, causing claudication and exercise intolerance. Exercise intolerance may result from reduced skeletal muscle capillary density and impaired muscle oxygen deliv ... Full text Link to item Cite

Built Environment Approaches to Increase Physical Activity: A Science Advisory From the American Heart Association.

Journal Article Circulation · September 15, 2020 Engaging in regular physical activity is one of the most important things people can do to improve their cardiovascular health; however, population levels of physical activity remain low in the United States. Effective population-based approaches implement ... Full text Link to item Cite

New Equations for Predicting Maximum Oxygen Uptake in Patients With Heart Failure.

Journal Article Am J Cardiol · August 1, 2020 We obtained directly measured maximal oxygen uptake (VO2 max) by open-circuit spirometry in 1,453 patients with chronic heart failure (HF) who completed a treadmill test (n = 1,453) or cycle ergometry (n = 1,838), as participants in The Fitness Registry an ... Full text Link to item Cite

Mapping and characterization of structural variation in 17,795 human genomes.

Journal Article Nature · July 2020 A key goal of whole-genome sequencing for studies of human genetics is to interrogate all forms of variation, including single-nucleotide variants, small insertion or deletion (indel) variants and structural variants. However, tools and resources for the s ... Full text Cite

Rationale and design of "Hearts & Parks": study protocol for a pragmatic randomized clinical trial of an integrated clinic-community intervention to treat pediatric obesity.

Journal Article BMC Pediatr · June 26, 2020 BACKGROUND: The prevalence of child and adolescent obesity and severe obesity continues to increase despite decades of policy and research aimed at prevention. Obesity strongly predicts cardiovascular and metabolic disease risk; both begin in childhood. Ch ... Full text Link to item Cite

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise.

Journal Article Cell · June 25, 2020 Exercise provides a robust physiological stimulus that evokes cross-talk among multiple tissues that when repeated regularly (i.e., training) improves physiological capacity, benefits numerous organ systems, and decreases the risk for premature mortality. ... Full text Link to item Cite

Systematic review of the prospective association of daily step counts with risk of mortality, cardiovascular disease, and dysglycemia.

Journal Article Int J Behav Nutr Phys Act · June 20, 2020 BACKGROUND: Daily step counts is an intuitive metric that has demonstrated success in motivating physical activity in adults and may hold potential for future public health physical activity recommendations. This review seeks to clarify the pattern of the ... Full text Link to item Cite

Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm.

Journal Article Elife · May 5, 2020 Biological aging is the gradual, progressive decline in system integrity that occurs with advancing chronological age, causing morbidity and disability. Measurements of the pace of aging are needed as surrogate endpoints in trials of therapies designed to ... Full text Open Access Link to item Cite

Response.

Journal Article Med Sci Sports Exerc · April 2020 Full text Link to item Cite

Abstract P177: Effects of Gender, Race, and Glucose Tolerance on Lipoprotein Insulin Resistance Index Responses to Exercise Training

Conference Circulation · March 3, 2020 Introduction: Lipoprotein Insulin Resistance Index (LP-IR) is a novel spectroscopic multimarker linked to future diabetes risk. We recently assessed changes in LP-IR across the three STRRIDE trials, w ... Full text Cite

Abstract P481: Early Recognition of Heart Failure With Preserved Ejection Fraction (HFpEF): Ventricular Elastance as a Predictive Marker for Prevention and Treatment

Conference Circulation · March 3, 2020 Introduction: Heart failure with preserved ejection fraction (HFpEF) is the most common type of heart failure, carries a 50% mortality rate within 3 years of diagnosis with evidence to support early l ... Full text Cite

Abstract P461: Genome-wide Analysis in Sedentary Adults of Non-completion of a Controlled Exercise Intervention

Conference Circulation · March 3, 2020 A wide range of health benefits of exercise have been documented in clinical lifestyle medicine. However, many individuals fail to complete or maintain an exercise program. We hypothesized that this behavior has biological underpinning ... Full text Cite

Longer Term Effects of Diet and Exercise on Neurocognition: 1-Year Follow-up of the ENLIGHTEN Trial.

Journal Article J Am Geriatr Soc · March 2020 OBJECTIVES: To evaluate the longer term changes in executive functioning among participants with cardiovascular disease (CVD) risk factors and cognitive impairments with no dementia (CIND) randomized to a diet and exercise intervention. DESIGN: A 2 (Exerci ... Full text Link to item Cite

Healthy Aging and Cardiovascular Function: Invasive Hemodynamics During Rest and Exercise in 104 Healthy Volunteers.

Journal Article JACC Heart Fail · February 2020 OBJECTIVES: The aim of this study was to evaluate the association between age and invasive cardiovascular hemodynamics during upright exercise among healthy adults. BACKGROUND: The marked age-related decline in maximal exercise oxygen uptake (peak VO2) may ... Full text Link to item Cite

Rejuvenation of Neutrophil Functions in Association With Reduced Diabetes Risk Following Ten Weeks of Low-Volume High Intensity Interval Walking in Older Adults With Prediabetes - A Pilot Study.

Journal Article Front Immunol · 2020 Neutrophil dysfunction is a common feature of aging, and is associated with the pathogenesis of many age-related diseases, including type 2 diabetes mellitus (T2DM). Although exercise training improves metabolic health, decreases risk of T2DM, and is assoc ... Full text Link to item Cite

Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.

Journal Article J Alzheimers Dis · 2020 BACKGROUND: Previous studies have demonstrated that aerobic exercise (AE) and the Dietary Approaches to Stop Hypertension (DASH) diet can improve neurocognition. However, the mechanisms by which lifestyle improves neurocognition have not been widely studie ... Full text Link to item Cite

Utilizing A Clinical Research Registry As A Recruitment Tool For Exercise Trials

Conference MEDICINE & SCIENCE IN SPORTS & EXERCISE · 2020 Cite

Distribution Of Cardiorespiratory Fitness Among Children In The Hearts And Parks Study

Conference MEDICINE & SCIENCE IN SPORTS & EXERCISE · 2020 Cite

Aerobic, Resistance, and Combination Training on Health-Related Quality of Life: The STRRIDE-AT/RT Randomized Trial.

Journal Article Front Sports Act Living · 2020 Purpose: The main purpose of this study was to determine the differential effects of aerobic training (AT), resistance training (RT), and a combination of aerobic and resistance training (AT/RT) on changes in self-rated HrQoL measures, including the Short- ... Full text Link to item Cite

Systolic Blood Pressure and Socioeconomic Status in a large multi-study population.

Journal Article SSM Popul Health · December 2019 The present study used harmonized data from eight studies (N = 28,891) to examine the association between socioeconomic status (SES) and resting systolic blood pressure (SBP). The study replicates and extends our prior work on this topic by examining poten ... Full text Open Access Link to item Cite

Impact of Age on Comorbidities and Outcomes in Heart Failure With Reduced Ejection Fraction.

Journal Article JACC Heart Fail · December 2019 OBJECTIVES: This study sought to determine whether age modifies the impact of key comorbidities on clinical outcomes for patients with heart failure with reduced ejection fraction (HFrEF). BACKGROUND: Comorbidities impact outcomes in HFrEF. However, the ef ... Full text Link to item Cite

Epigenome-Wide Association Study for All-Cause Mortality in a Cardiovascular Cohort Identifies Differential Methylation in Castor Zinc Finger 1 (CASZ1).

Journal Article J Am Heart Assoc · November 5, 2019 Background DNA methylation is implicated in many chronic diseases and may contribute to mortality. Therefore, we conducted an epigenome-wide association study (EWAS) for all-cause mortality with whole-transcriptome data in a cardiovascular cohort (CATHGEN ... Full text Link to item Cite

Plasma lactate as a marker of metabolic health: Implications of elevated lactate for impairment of aerobic metabolism in the metabolic syndrome.

Journal Article Surgery · November 2019 BACKGROUND: Fasting lactate is elevated in metabolic diseases and could possibly be predictive of the risk of developing the metabolic syndrome. METHODS: Plasma samples were analyzed for fasting lactate to compare lean subjects, nondiabetic subjects with s ... Full text Link to item Cite

Short-Term Changes in Cardiorespiratory Fitness in Response to Exercise Training and the Association with Long-Term Cardiorespiratory Fitness Decline: The STRRIDE Reunion Study.

Journal Article J Am Heart Assoc · October 15, 2019 Background Substantial heterogeneity exists in the cardiorespiratory fitness (CRF) change in response to exercise training, and its long-term prognostic implication is not well understood. We evaluated the association between the short-term supervised trai ... Full text Link to item Cite

Effects of Exercise Training With and Without Ranolazine on Peak Oxygen Consumption, Daily Physical Activity, and Quality of Life in Patients With Chronic Stable Angina Pectoris.

Journal Article Am J Cardiol · September 1, 2019 Ranolazine reduces angina frequency and increases exercise capacity. We hypothesized that exercise training with ranolazine would allow subjects to train at greater intensities, resulting in greater improvements in exercise capacity, physical activity, and ... Full text Link to item Cite

2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial.

Journal Article Lancet Diabetes Endocrinol · September 2019 BACKGROUND: For several cardiometabolic risk factors, values considered within normal range are associated with an increased risk of cardiovascular morbidity and mortality. We aimed to investigate the short-term and long-term effects of calorie restriction ... Full text Link to item Cite

A statistical and biological response to an informatics appraisal of healthy aging gene signatures.

Journal Article Genome Biol · August 2, 2019 Jacob and Speed did not identify even a single example of a '150-gene-set' that was statistically significant at classifying Alzheimer's disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below. ... Full text Link to item Cite

Longevity-related molecular pathways are subject to midlife "switch" in humans.

Journal Article Aging Cell · August 2019 Emerging evidence indicates that molecular aging may follow nonlinear or discontinuous trajectories. Whether this occurs in human neuromuscular tissue, particularly for the noncoding transcriptome, and independent of metabolic and aerobic capacities, is un ... Full text Link to item Cite

Modeling the Effect of TNF-α upon Drug-Induced Toxicity in Human, Tissue-Engineered Myobundles.

Journal Article Ann Biomed Eng · July 2019 A number of significant muscle diseases, such as cachexia, sarcopenia, systemic chronic inflammation, along with inflammatory myopathies share TNF-α-dominated inflammation in their pathogenesis. In addition, inflammatory episodes may increase susceptibilit ... Full text Link to item Cite

Effects of Physical Activity in Knee and Hip Osteoarthritis: A Systematic Umbrella Review.

Journal Article Med Sci Sports Exerc · June 2019 INTRODUCTION: We conducted a systematic umbrella review to evaluate the literature relating to effects of physical activity on pain, physical function, health-related quality of life, comorbid conditions and osteoarthritis (OA) structural disease progressi ... Full text Link to item Cite

High-Intensity Interval Training for Cardiometabolic Disease Prevention.

Journal Article Med Sci Sports Exerc · June 2019 PURPOSE: The 2018 Physical Activity Guidelines Advisory Committee systematically searched existing literature reviews to assess the relationship between high-intensity interval training (HIIT) and reduction in cardiometabolic disease risk. METHODS: Duplica ... Full text Link to item Cite

Physical Activity, All-Cause and Cardiovascular Mortality, and Cardiovascular Disease.

Journal Article Med Sci Sports Exerc · June 2019 PURPOSE: Conduct a systematic umbrella review to evaluate the relationship of physical activity (PA) with all-cause mortality, cardiovascular mortality, and incident cardiovascular disease (CVD); to evaluate the shape of the dose-response relationships; an ... Full text Link to item Cite

Physical Activity to Prevent and Treat Hypertension: A Systematic Review.

Journal Article Med Sci Sports Exerc · June 2019 PURPOSE: This systematic umbrella review examines and updates the evidence on the relationship between physical activity (PA) and blood pressure (BP) presented in the 2008 Physical Activity Guidelines Advisory Committee Scientific Report. METHODS: We perfo ... Full text Link to item Cite

Daily Step Counts for Measuring Physical Activity Exposure and Its Relation to Health.

Journal Article Med Sci Sports Exerc · June 2019 PURPOSE: A systematic primary literature review was conducted to evaluate the relationship of physical activity-as measured by daily step counts-with all-cause mortality, cardiovascular disease mortality, incident cardiovascular disease, and type 2 diabete ... Full text Link to item Cite

Association between Bout Duration of Physical Activity and Health: Systematic Review.

Journal Article Med Sci Sports Exerc · June 2019 PURPOSE: This study aimed to conduct a systematic literature review to determine whether physical activity episodes of <10 min in duration have health-related benefits or, alternatively, if the benefits are only realized when the duration of physical activ ... Full text Link to item Cite

Trends in cardiorespiratory fitness: The evolution of exercise treadmill testing at a single Academic Medical Center from 1970 to 2012.

Journal Article Am Heart J · April 2019 OBJECTIVE: To identify temporal trends in the use of exercise treadmill testing (ETT) and cardiorespiratory fitness (CRF) estimated by ETT in metabolic equivalents (METs). PATIENTS AND METHODS: We compiled an ETT database of all available treadmill tests-i ... Full text Link to item Cite

Abstract MP59: The Differential Effects of Amount and Intensity of Aerobic Exercise Training on MVX, a Novel Mortality Risk Multimarker

Conference Circulation · March 5, 2019 Introduction: Metabolic Vulnerability Index (MVX) is a novel spectroscopic multimarker of mortality risk. MVX reflects components of nutrition and systemic inflammation status and is hypothesized to e ... Full text Cite

Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood.

Journal Article J Gerontol A Biol Sci Med Sci · February 15, 2019 Aging is characterized by deleterious immune and metabolic changes, but the onset of these changes is unknown. We measured immune and metabolic biomarkers in adults beginning at age 30. To our knowledge, this is the first study to evaluate these biomarkers ... Full text Open Access Link to item Cite

Disentangling the genetics of lean mass.

Journal Article Am J Clin Nutr · February 1, 2019 BACKGROUND: Lean body mass (LM) plays an important role in mobility and metabolic function. We previously identified five loci associated with LM adjusted for fat mass in kilograms. Such an adjustment may reduce the power to identify genetic signals having ... Full text Link to item Cite

Neighborhood sociodemographic effects on the associations between long-term PM2.5 exposure and cardiovascular outcomes and diabetes.

Journal Article Environ Epidemiol · February 2019 INTRODUCTION: Exposure to PM2.5 air pollution and neighborhood-level sociodemographic characteristics are associated with cardiovascular disease and possibly diabetes. However, the joint effect of sociodemographics and PM2.5 on these outcomes is uncertain. ... Full text Link to item Cite

High-Density Lipoprotein Particle Subfractions in Heart Failure With Preserved or Reduced Ejection Fraction.

Journal Article J Am Coll Cardiol · January 22, 2019 BACKGROUND: Circulating high-density lipoprotein particle (HDL-P) subfractions impact atherogenesis, inflammation, and endothelial function, all of which are implicated in the pathobiology of heart failure (HF). OBJECTIVES: The authors sought to identify k ... Full text Link to item Cite

Lifestyle and neurocognition in older adults with cognitive impairments: A randomized trial.

Journal Article Neurology · January 15, 2019 OBJECTIVE: To determine the independent and additive effects of aerobic exercise (AE) and the Dietary Approaches to Stop Hypertension (DASH) diet on executive functioning in adults with cognitive impairments with no dementia (CIND) and risk factors for car ... Full text Link to item Cite

Relationship between changing patient-reported outcomes and subsequent clinical events in patients with chronic heart failure: insights from HF-ACTION.

Journal Article Eur J Heart Fail · January 2019 AIMS: A 5-point change in the Kansas City Cardiomyopathy Questionnaire (KCCQ) is commonly considered to be a clinically significant difference in health status in patients with heart failure. We evaluated how the magnitude of change relates to subsequent c ... Full text Link to item Cite

Association of long-term PM2.5 exposure with traditional and novel lipid measures related to cardiovascular disease risk.

Journal Article Environ Int · January 2019 BACKGROUND: Fine particulate matter (PM2.5) exposure is associated with increased morbidity and mortality, particularly for cardiovascular disease. The association between long-term exposure to PM2.5 and measures of lipoprotein subfractions remains unclear ... Full text Link to item Cite

Evaluating DNA methylation age on the Illumina MethylationEPIC Bead Chip.

Journal Article PLoS One · 2019 DNA methylation age (DNAm age) has become a widely utilized epigenetic biomarker for the aging process. The Horvath method for determining DNAm age is perhaps the most widely utilized and validated DNA methylation age assessment measure. Horvath DNAm age i ... Full text Link to item Cite

Ten-Year Legacy Effects of Three Eight-Month Exercise Training Programs on Cardiometabolic Health Parameters.

Journal Article Front Physiol · 2019 Background: STRRIDE (Studies Targeting Risk Reduction Interventions through Defined Exercise) was an eight-month exercise study conducted from 1998-2003. Subjects were randomized to control or one of three exercise groups differing in intensity and amount. ... Full text Link to item Cite

Plasma MicroRNAs in Established Rheumatoid Arthritis Relate to Adiposity and Altered Plasma and Skeletal Muscle Cytokine and Metabolic Profiles.

Journal Article Front Immunol · 2019 Background: MicroRNAs have been implicated in the pathogenesis of rheumatoid arthritis (RA), obesity, and altered metabolism. Although RA is associated with both obesity and altered metabolism, expression of RA-related microRNA in the setting of these card ... Full text Link to item Cite

Association Between Insulin Resistance, Plasma Leptin, and Neurocognition in Vascular Cognitive Impairment.

Journal Article J Alzheimers Dis · 2019 BACKGROUND: Greater body weight has been associated impairments in neurocognition and greater dementia risk, although the mechanisms linking weight and neurocognition have yet to be adequately delineated. OBJECTIVE: To examine metabolic mechanisms underlyi ... Full text Link to item Cite

Thyroid Hormone Status Regulates Skeletal Muscle Response to Chronic Motor Nerve Stimulation.

Journal Article Front Physiol · 2019 Although both exercise and thyroid hormone (TH) status can cause cellular and metabolic changes in skeletal muscle, the impact of TH status on exercise-associated changes is not well understood. Here, we examined the effects of TH status on muscle fiber ty ... Full text Link to item Cite

Impact on cardiometabolic risk of a weight loss intervention with higher protein from lean red meat: Combined results of 2 randomized controlled trials in obese middle-aged and older adults.

Journal Article J Clin Lipidol · 2019 BACKGROUND: The recognized benefits of a higher protein diet on muscle mass and strength in older adults are tempered by concerns of the potentially negative cardiometabolic impact of dietary sources of animal protein. OBJECTIVE: The aim of this study was ... Full text Link to item Cite

Evaluating Individual Level Responses to Exercise for Health Outcomes in Overweight or Obese Adults.

Journal Article Front Physiol · 2019 BACKGROUND: Understanding group responses to a given exercise exposure is becoming better developed; however, understanding of individual responses to specific exercise exposures is significantly underdeveloped and must advance before personalized exercise ... Full text Link to item Cite

Effect of high-intensity interval training on muscle remodeling in rheumatoid arthritis compared to prediabetes.

Journal Article Arthritis Res Ther · December 27, 2018 BACKGROUND: Sarcopenic obesity, associated with greater risk of cardiovascular disease (CVD) and mortality in rheumatoid arthritis (RA), may be related to dysregulated muscle remodeling. To determine whether exercise training could improve remodeling, we m ... Full text Open Access Link to item Cite

The Scientific Foundation for the Physical Activity Guidelines for Americans, 2nd Edition.

Journal Article J Phys Act Health · December 17, 2018 BACKGROUND: The 2018 Physical Activity Guidelines Advisory Committee Scientific Report provides the evidence base for the Physical Activity Guidelines for Americans, 2nd Edition. METHODS: The 2018 Physical Activity Guidelines Advisory Committee addressed 3 ... Full text Link to item Cite

Influence of Baseline Physical Activity Level on Exercise Training Response and Clinical Outcomes in Heart Failure: The HF-ACTION Trial.

Journal Article JACC Heart Fail · December 2018 OBJECTIVES: This study sought to evaluate the influence of baseline physical activity (PA) on responses to aerobic exercise training and clinical events in outpatients with chronic systolic heart failure (HF) from the multicenter HF-ACTION (Exercise Traini ... Full text Link to item Cite

Loop diuretic adjustments in patients with chronic heart failure: Insights from HF-ACTION.

Journal Article Am Heart J · November 2018 BACKGROUND: The relationship between diuretic use or change in diuretic use and outcomes in chronic heart failure (HF) remains poorly defined. We evaluated the association between diuretic use and changes in health status, exercise capacity, and clinical e ... Full text Link to item Cite

Short-term effects of fine particulate matter and ozone on the cardiac conduction system in patients undergoing cardiac catheterization.

Journal Article Part Fibre Toxicol · October 11, 2018 BACKGROUND: Air pollution-induced changes in cardiac electrophysiological properties could be a pathway linking air pollution and cardiovascular events. The evidence of air pollution effects on the cardiac conduction system is incomplete yet. We investigat ... Full text Link to item Cite

Effects of regular endurance exercise on GlycA: Combined analysis of 14 exercise interventions.

Journal Article Atherosclerosis · October 2018 BACKGROUND AND AIMS: GlycA is a relatively new biomarker for inflammation as well as cardiometabolic disease risk. However, the effect of exercise on GlycA is largely unknown. Therefore, the purpose of this study was to examine the effects of regular exerc ... Full text Link to item Cite

A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease.

Journal Article Nucleic Acids Res · September 6, 2018 Genome-wide association studies (GWAS), relying on hundreds of thousands of individuals, have revealed >200 genomic loci linked to metabolic disease (MD). Loss of insulin sensitivity (IS) is a key component of MD and we hypothesized that discovery of a rob ... Full text Link to item Cite

Correction of Biochemical Abnormalities and Improved Muscle Function in a Phase I/II Clinical Trial of Clenbuterol in Pompe Disease.

Journal Article Mol Ther · September 5, 2018 This 52-week, phase I/II double-blind, randomized, placebo-controlled study investigated the novel use of clenbuterol in late-onset Pompe disease (LOPD) stably treated with ERT. Eleven of thirteen participants completed the study. No serious adverse events ... Full text Link to item Cite

Multi-ethnic comparisons of diabetes in heart failure with reduced ejection fraction: insights from the HF-ACTION trial and the ASIAN-HF registry.

Journal Article Eur J Heart Fail · September 2018 AIM: To describe differences in patient characteristics and outcomes by ethnicity in patients with diabetes mellitus (DM) and heart failure (HF) with reduced ejection fraction (HFrEF, ejection fraction ≤35%) in a multi-ethnic cohort. METHODS AND RESULTS: P ... Full text Link to item Cite

Effects of a 12-Week mHealth Program on FunctionalCapacity and Physical Activity in Patients With PeripheralArtery Disease.

Journal Article Am J Cardiol · September 1, 2018 Supervised exercise is beneficial for peripheral artery disease (PAD) patients limited by intermittent claudication (IC). However, supervised exercise for PAD remains widely underutilized. Mobile health (mHealth) provides an intermediate solution between s ... Full text Link to item Cite

Genome-Wide Association Study Links Receptor Tyrosine Kinase Inhibitor Sprouty 2 to Thrombocytopenia after Coronary Artery Bypass Surgery.

Conference Thromb Haemost · September 2018 INTRODUCTION:  Thrombocytopenia after cardiac surgery independently predicts stroke, acute kidney injury and death. To understand the underlying risks and mechanisms, we analysed genetic variations associated with thrombocytopenia in patients undergoing co ... Full text Link to item Cite

Pilot randomized trial of a couple-based physical activity videoconference intervention for sedentary cancer survivors.

Journal Article Health Psychol · September 2018 OBJECTIVE: Including partners in interventions to increase physical activity (PA) could promote better adherence and longer-term effects. In preparation for a future large-scale randomized controlled trial (RCT), this randomized pilot trial tested the acce ... Full text Link to item Cite

Beet the Best?

Journal Article Circ Res · August 31, 2018 RATIONALE: A primary goal of therapy for patients with peripheral artery disease (PAD) and intermittent claudication is increased ambulatory function. Supervised exercise rehabilitation was recently shown to confer superior walking benefits to pharmacologi ... Full text Link to item Cite

The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells.

Journal Article Stem Cell Reports · August 14, 2018 Skeletal muscle stem cell (MuSC) function declines with age and contributes to impaired muscle regeneration in older individuals. Acting through AMPK/p27Kip1, we have identified a pathway regulating the balance between autophagy, apoptosis, and senescence ... Full text Link to item Cite

Developing a synthetic psychosocial stress measure and harmonizing CVD-risk data: a way forward to GxE meta- and mega-analyses.

Journal Article BMC Res Notes · July 24, 2018 OBJECTIVES: Among many challenges in cardiovascular disease (CVD) risk prediction are interactions of genes with stress, race, and/or sex and developing robust estimates of these interactions. Improved power with larger sample size contributed by the accum ... Full text Link to item Cite

Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults.

Journal Article J Am Geriatr Soc · July 2018 OBJECTIVES: To determine whether combinations of inflammatory markers are related to physical function. DESIGN AND SUBJECTS: secondary analysis of baseline of three observational studies of community-dwelling older adults MEASUREMENTS: The baseline data fr ... Full text Open Access Link to item Cite

Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study.

Journal Article Arthritis Res Ther · June 14, 2018 BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease in which adults have significant joint issues leading to poor health. Poor health is compounded by many factors, including exercise avoidance and increased risk of opportunistic infect ... Full text Open Access Link to item Cite

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

Journal Article Nat Commun · June 13, 2018 Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve glucose homeostasis and decreas ... Full text Link to item Cite

Relations of established aging biomarkers (IL-6, D-dimer, s-VCAM) to glomerular filtration rate and mortality in community-dwelling elderly adults.

Journal Article Clin Kidney J · June 2018 BACKGROUND: Biomarkers improving risk prediction for elderly populations with chronic kidney disease (CKD), an independent predictor of mortality, could be particularly useful. We previously observed that interleukin-6 (IL-6), D-dimer and soluble vascular ... Full text Link to item Cite

PRIME: A Novel Low-Mass, High-Repetition Approach to Improve Function in Older Adults.

Journal Article Med Sci Sports Exerc · May 2018 INTRODUCTION: The ability to maintain functional independence in a rapidly aging population results in an increased life expectancy without corresponding increases in health care costs. The accelerated decline in V˙O2peak after the age of 65 yr is primaril ... Full text Link to item Cite

Prevalent digoxin use and subsequent risk of death or hospitalization in ambulatory heart failure patients with a reduced ejection fraction-Findings from the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) randomized controlled trial.

Journal Article Am Heart J · May 2018 BACKGROUND: Despite more than 200 years of clinical experience and a pivotal trial, recently published research has called into question the safety and efficacy of digoxin therapy in heart failure (HF). METHODS: HF-ACTION (ClinicalTrials.gov Number: NCT000 ... Full text Link to item Cite

Effects of a 12-week mHealth program on peak VO2 and physical activity patterns after completing cardiac rehabilitation: A randomized controlled trial.

Journal Article Am Heart J · May 2018 BACKGROUND: Site-based cardiac rehabilitation (CR) provides supervised exercise, education and motivation for patients. Graduates of CR have improved exercise tolerance. However, when participation in CR ceases, adherence to regular physical activity often ... Full text Link to item Cite

Volume of Light Versus Moderate-to-Vigorous Physical Activity: Similar Benefits for All-Cause Mortality?

Journal Article J Am Heart Assoc · April 2, 2018 BACKGROUND: It is unclear whether the greater benefits of moderate-to-vigorous physical activity (PA) over light PA are attributed to the higher-intensity PA or simply the greater volume of PA accumulated per unit time for moderate-to-vigorous PA. We exami ... Full text Link to item Cite

Effects of Increasing Exercise Intensity and Dose on Multiple Measures of HDL (High-Density Lipoprotein) Function.

Journal Article Arterioscler Thromb Vasc Biol · April 2018 OBJECTIVE: Measures of HDL (high-density lipoprotein) function are associated with cardiovascular disease. However, the effects of regular exercise on these measures is largely unknown. Thus, we examined the effects of different doses of exercise on 3 meas ... Full text Link to item Cite

Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial.

Journal Article Aging Cell · April 2018 Calorie restriction (CR) without malnutrition slows aging in animal models. Oxidative stress reduction was proposed to mediate CR effects. CR effect on urinary F2-isoprostanes, validated oxidative stress markers, was assessed in CALERIE, a two-year randomi ... Full text Link to item Cite

Volume of light versus moderate-to-vigorous physical activity: Similar benefits for all-cause mortality?

Journal Article Journal of the American Heart Association · April 1, 2018 Background--It is unclear whether the greater benefits of moderate-to-vigorous physical activity (PA) over light PA are attributed to the higher-intensity PA or simply the greater volume of PA accumulated per unit time for moderate-to-vigorous PA. We exami ... Full text Cite

Moderate-to-Vigorous Physical Activity and All-Cause Mortality: Do Bouts Matter?

Journal Article J Am Heart Assoc · March 22, 2018 BACKGROUND: The 2008 Physical Activity Guidelines for Americans recommends that adults accumulate moderate-to-vigorous physical activity (MVPA) in bouts of ≥10 minutes for substantial health benefits. To what extent the same amount of MVPA accumulated in b ... Full text Link to item Cite

A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans.

Journal Article J Pers Med · February 26, 2018 Idiopathic dilated cardiomyopathy (IDC) is the most common form of non-ischemic chronic heart failure. Despite the higher prevalence of IDC in African Americans, the genetics of IDC have been relatively understudied in this ethnic group. We performed a gen ... Full text Link to item Cite

Associations Between Residential Proximity to Traffic and Vascular Disease in a Cardiac Catheterization Cohort.

Journal Article Arterioscler Thromb Vasc Biol · January 2018 OBJECTIVE: Exposure to mobile source emissions is nearly ubiquitous in developed nations and is associated with multiple adverse health outcomes. There is an ongoing need to understand the specificity of traffic exposure associations with vascular outcomes ... Full text Link to item Cite

Personalized Lifestyle Medicine

Chapter · January 1, 2018 Lifestyle medicine is the application of exercise, nutrition, and other lifestyle habits to maintain and improve human health. It is becoming clear that the typical elements of pharmacologic medicine apply to lifestyle medicine. These include the following ... Full text Cite

Effects of aerobic training with and without weight loss on insulin sensitivity and lipids.

Journal Article PLoS One · 2018 PURPOSE: The purpose of this study is to evaluate the effect of exercise training with modest or greater weight loss (≥3%) or not (<3%) on insulin sensitivity, lipoprotein concentrations, and lipoprotein particle size in overweight and obese participants. ... Full text Link to item Cite

Genetic Variation in Acid Ceramidase Predicts Non-completion of an Exercise Intervention.

Journal Article Front Physiol · 2018 Genetic variation is associated with a number of lifestyle behaviours; it may be associated with adherence and individual responses to exercise training. We tested single nucleotide polymorphisms (SNPs) in the acid ceramidase gene (ASAH1) for association w ... Full text Link to item Cite

Relationship between baseline physical activity assessed by pedometer count and new-onset diabetes in the NAVIGATOR trial.

Journal Article BMJ Open Diabetes Res Care · 2018 OBJECTIVE: Physical activity is related to clinical outcomes, even after adjusting for body mass, but is rarely assessed in randomized clinical trials. RESEARCH DESIGN AND METHODS: We conducted an observational analysis of data from the Nateglinide and Val ... Full text Link to item Cite

Lack of Association of a Functional Polymorphism in the Serotonin Receptor Gene With Body Mass Index and Depressive Symptoms in a Large Meta-Analysis of Population Based Studies.

Journal Article Front Genet · 2018 The serotonin receptor 5-HTR2C is thought to be involved in the function of multiple brain structures. Consequently, the HTR2C gene has been studied extensively with respect to its association with a variety of phenotypes. One coding variant in the HTR2C g ... Full text Open Access Link to item Cite

Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis.

Journal Article J Gerontol A Biol Sci Med Sci · December 12, 2017 Biological aging measures have been proposed as proxies for extension of healthy life span in trials of geroprotective therapies that aim to slow aging. Several methods to measure biological aging show promise but it is not known if these methods are sensi ... Full text Open Access Link to item Cite

Exercise training as treatment of nonalcoholic fatty liver disease

Journal Article Journal of Functional Morphology and Kinesiology · December 1, 2017 Nonalcoholic Fatty Liver Disease (NAFLD) is a growing health epidemic in developed countries with increased prevalence in obese and diabetic populations. Exercise is an established and essential component of lifestyle modification for NAFLD disease managem ... Full text Cite

Ozone exposure is associated with acute changes in inflammation, fibrinolysis, and endothelial cell function in coronary artery disease patients.

Journal Article Environ Health · November 21, 2017 BACKGROUND: Air pollution is a major risk factor for cardiovascular disease, of which ozone is a major contributor. Several studies have found associations between ozone and cardiovascular morbidity, but the results have been inconclusive. We investigated ... Full text Link to item Cite

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Journal Article Nat Commun · November 7, 2017 A correction to this article has been published and is linked from the HTML version of this article. ... Full text Open Access Link to item Cite

Fine particulate matter and cardiovascular disease: Comparison of assessment methods for long-term exposure.

Journal Article Environ Res · November 2017 BACKGROUND: Adverse cardiovascular events have been linked with PM2.5 exposure obtained primarily from air quality monitors, which rarely co-locate with participant residences. Modeled PM2.5 predictions at finer resolution may more accurately predict resid ... Full text Link to item Cite

Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength.

Journal Article Med Sci Sports Exerc · November 2017 PURPOSE: Calorie restriction (CR) improves health span and delays age-related diseases in many species. The multicenter Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) study was the first randomized controlled trial of ... Full text Link to item Cite

Combined Dietary Nitrate and Exercise Intervention in Peripheral Artery Disease: Protocol Rationale and Design.

Journal Article JMIR Res Protoc · October 3, 2017 BACKGROUND: Peripheral artery disease (PAD) is caused by atherosclerotic occlusions in the legs. It affects approximately 8-12 million people in the United States alone, one-third of whom suffer from intermittent claudication (IC), defined as ischemic leg ... Full text Link to item Cite

Utility of Growth Differentiation Factor-15, A Marker of Oxidative Stress and Inflammation, in Chronic Heart Failure: Insights From the HF-ACTION Study.

Journal Article JACC Heart Fail · October 2017 OBJECTIVES: This study sought to determine the relationship between growth differentiation factor (GDF)-15 and clinical outcomes in ambulatory patients with heart failure and reduced ejection fraction (HFrEF). BACKGROUND: The prognostic utility of GDF-15, ... Full text Link to item Cite

Rheumatoid arthritis complicates noninvasive whole blood gene expression testing for coronary artery disease.

Journal Article Am Heart J · October 2017 BACKGROUND: Our objective was to evaluate an age- and sex-specific gene expression score (ASGES) previously validated to detect obstructive coronary artery disease (CAD) in patients with rheumatoid arthritis (RA). METHODS: We evaluated 20 pairs of nondiabe ... Full text Link to item Cite

Multinational and multiethnic variations in health-related quality of life in patients with chronic heart failure.

Journal Article Am Heart J · September 2017 BACKGROUND: Assessing health-related quality of life (HRQoL) in patients with heart failure (HF) is an important goal of clinical care and HF research. We sought to investigate ethnic differences in perceived HRQoL and its association with mortality among ... Full text Link to item Cite

Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan.

Journal Article Aging Cell · August 2017 Therapies to extend healthspan are poised to move from laboratory animal models to human clinical trials. Translation from mouse to human will entail challenges, among them the multifactorial heterogeneity of human aging. To inform clinical trials about th ... Full text Link to item Cite

Sildenafil Treatment in Heart Failure With Preserved Ejection Fraction: Targeted Metabolomic Profiling in the RELAX Trial.

Journal Article JAMA Cardiol · August 1, 2017 IMPORTANCE: Phosphodiesterase-5 inhibition with sildenafil compared with a placebo had no effect on the exercise capacity or clinical status of patients with heart failure with preserved ejection fraction (HFpEF) in the PhosphodiesteRasE-5 Inhibition to Im ... Full text Link to item Cite

Atherogenic Lipoprotein Determinants of Cardiovascular Disease and Residual Risk Among Individuals With Low Low-Density Lipoprotein Cholesterol.

Journal Article J Am Heart Assoc · July 21, 2017 BACKGROUND: Levels of LDL (low-density lipoprotein) cholesterol in the population are declining, and increasing attention is being focused on residual lipid-related pathways of atherosclerotic cardiovascular disease risk beyond LDL cholesterol. Among indiv ... Full text Link to item Cite

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.

Journal Article N Engl J Med · July 20, 2017 BACKGROUND: Loss-of-function variants in the angiopoietin-like 3 gene (ANGPTL3) have been associated with decreased plasma levels of triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol. It is not known w ... Full text Link to item Cite

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Journal Article Nat Commun · July 19, 2017 Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) ... Full text Link to item Cite

A novel approach for measuring residential socioeconomic factors associated with cardiovascular and metabolic health.

Journal Article J Expo Sci Environ Epidemiol · May 2017 Individual-level characteristics, including socioeconomic status, have been associated with poor metabolic and cardiovascular health; however, residential area-level characteristics may also independently contribute to health status. In the current study, ... Full text Link to item Cite

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.

Journal Article J Am Coll Cardiol · April 25, 2017 BACKGROUND: Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). Whether ANGPTL3 deficiency reduces ris ... Full text Link to item Cite

Exercise Training in Patients With Chronic Heart Failure and Atrial Fibrillation.

Journal Article J Am Coll Cardiol · April 4, 2017 BACKGROUND: The safety and efficacy of aerobic exercise in heart failure (HF) patients with atrial fibrillation (AF) has not been well evaluated. OBJECTIVES: This study examined whether outcomes with exercise training in HF vary according to AF status. MET ... Full text Link to item Cite

Physical Performance Across the Adult Life Span: Correlates With Age and Physical Activity.

Journal Article J Gerontol A Biol Sci Med Sci · April 1, 2017 BACKGROUND: A number of large-scale population studies have provided valuable information about physical performance in aged individuals; however, there is little information about trajectories of function and associations with age across the adult life sp ... Full text Link to item Cite

Aerobic exercise training and general health status in ambulatory heart failure patients with a reduced ejection fraction-Findings from the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION)trial.

Journal Article Am Heart J · April 2017 BACKGROUND: Although aerobic exercise improves quality of life as assessed by a disease-specific instrument in ambulatory HF patients with a reduced ejection fraction (EF), the impact of an exercise intervention on general health status has not been previo ... Full text Link to item Cite

Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans.

Journal Article Am J Clin Nutr · April 2017 Background: Calorie restriction (CR) retards aging and increases longevity in many animal models. However, it is unclear whether CR can be implemented in humans without adverse effects on body composition.Objective: We evaluated the effect of a 2-y CR regi ... Full text Link to item Cite

Human, Tissue-Engineered, Skeletal Muscle Myobundles to Measure Oxygen Uptake and Assess Mitochondrial Toxicity.

Journal Article Tissue Eng Part C Methods · April 2017 Mitochondrial dysfunction is responsible for the toxicity of a number of drugs. Current isolated mitochondria or cellular monoculture mitochondrial respiration measurement systems lack physiological relevance. Using a tissue engineering rather than cell- o ... Full text Link to item Cite

Plasma acylcarnitines are associated with pulmonary hypertension.

Journal Article Pulm Circ · March 2017 Quantifying metabolic derangements in pulmonary hypertension (PH) by plasma metabolomics could identify biomarkers useful for diagnosis and treatment. The objective of this paper is to test the hypotheses that circulating metabolites are differentially exp ... Full text Link to item Cite

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.

Journal Article J Am Coll Cardiol · February 21, 2017 BACKGROUND: Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or traits. OBJECTIVES: This study sought ... Full text Link to item Cite

Does a lack of physical activity explain the rheumatoid arthritis lipid profile?

Journal Article Lipids Health Dis · February 10, 2017 BACKGROUND: In rheumatoid arthritis (RA), cardiovascular risk is associated with paradoxical reductions in total cholesterol, low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C). Concentrations of small LDL (LDL-P) ... Full text Link to item Cite

An age- and sex-specific gene expression score is associated with revascularization and coronary artery disease: Insights from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial.

Journal Article Am Heart J · February 2017 BACKGROUND: Identifying predictors of coronary artery disease (CAD)-related procedures and events remains a priority. METHODS: We measured an age- and sex-specific gene expression score (ASGES) previously validated to detect obstructive CAD (oCAD) in sympt ... Full text Link to item Cite

Apolipoprotein L1 Genetic Variants Are Associated with Chronic Kidney Disease but Not with Cardiovascular Disease in a Population Referred for Cardiac Catheterization.

Journal Article Cardiorenal Med · February 2017 BACKGROUND: While the association between APOL1 genetic variants and chronic kidney disease (CKD) has been established, their association with cardiovascular disease (CVD) is unclear. This study sought to understand CKD and cardiovascular risk conferred by ... Full text Link to item Cite

Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability.

Journal Article Arthritis Res Ther · January 23, 2017 BACKGROUND: To identify molecular alterations in skeletal muscle in rheumatoid arthritis (RA) that may contribute to ongoing disability in RA. METHODS: Persons with seropositive or erosive RA (n = 51) and control subjects matched for age, gender, race, bod ... Full text Open Access Link to item Cite

A Novel Protein Glycan-Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality.

Journal Article Clin Chem · January 2017 BACKGROUND: Evidence suggests that systemic inflammation may adversely impact HDL function. In this study we sought to evaluate the independent and incremental predictive performance of GlycA-a novel serum inflammatory biomarker that is an aggregate measur ... Full text Link to item Cite

Socioeconomic and partner status in chronic heart failure: Relationship to exercise capacity, quality of life, and clinical outcomes.

Journal Article Am Heart J · January 2017 BACKGROUND: Prognosis in patients with heart failure (HF) is commonly assessed based on clinical characteristics. The association between partner status and socioeconomic status (SES) and outcomes in chronic HF requires further study. METHODS: We performed ... Full text Link to item Cite

A genome-wide trans-ethnic interaction study links the PIGR-FCAMR locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic.

Journal Article PLoS One · 2017 Air pollution is a worldwide contributor to cardiovascular disease mortality and morbidity. Traffic-related air pollution is a widespread environmental exposure and is associated with multiple cardiovascular outcomes such as coronary atherosclerosis, perip ... Full text Link to item Cite

Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment.

Journal Article Psychosom Med · 2017 OBJECTIVE: The aim of the study was to determine the relationship of lifestyle factors and neurocognitive functioning in older adults with vascular risk factors and cognitive impairment, no dementia (CIND). METHODS: One hundred sixty adults (M [SD] = 65.4 ... Full text Link to item Cite

Association of the Composite Inflammatory Biomarker GlycA, with Exercise-Induced Changes in Body Habitus in Men and Women with Prediabetes.

Journal Article Oxid Med Cell Longev · 2017 GlycA is a new composite measure of systemic inflammation and a predictor of many inflammatory diseases. GlycA is the nuclear magnetic resonance spectroscopy-derived signal arising from glucosamine residues on acute-phase proteins. This study aimed to eval ... Full text Open Access Link to item Cite

A Practical and Time-Efficient High-Intensity Interval Training Program Modifies Cardio-Metabolic Risk Factors in Adults with Risk Factors for Type II Diabetes.

Journal Article Front Endocrinol (Lausanne) · 2017 INTRODUCTION: Regular physical activity (PA) can reduce the risk of developing type 2 diabetes, but adherence to time-orientated (150 min week-1 or more) PA guidelines is very poor. A practical and time-efficient PA regime that was equally efficacious at c ... Full text Link to item Cite

NMR Lipoprotein Profiling Identifies HDL Subclasses Associated With Obstructive CAD: Insights From the PROMISE Clinical Trial

Conference · 2017 Introduction: In patients at high CV risk, the molar sum of concentrations of small and medium HDL subclasses (HMSP) has significant protective associations with CV outcomes, and outperforms HDL cholesterol for risk prediction. The association of HMSP with ... Cite

A Multi-Marker Approach for Risk Stratification in Patients With Chronic Heart Failure: Insights From the HF-ACTION Trial

Conference · 2017 Introduction: It is unclear whether multi-marker approaches improve risk stratification among patients with heart failure (HF). We evaluated the prognostic utility of a multi-marker approach with biomarkers of HF status; Growth-differentiation factor-15 (G ... Cite

Application of the Marginal Structural Model to Account for Suboptimal Adherence in a Randomized Controlled Trial.

Journal Article Contemp Clin Trials Commun · December 15, 2016 BACKGROUND: There is considerable interest in adjusting for suboptimal adherence in randomized controlled trials. A per-protocol analysis, for example removes individuals who fail to achieve a minimal level of adherence. One can also reassign non-adherers ... Full text Link to item Cite

Associations among plasma metabolite levels and short-term exposure to PM2.5 and ozone in a cardiac catheterization cohort.

Journal Article Environ Int · December 2016 RATIONALE: Exposure to ambient particulate matter (PM) and ozone has been associated with cardiovascular disease (CVD). However, the mechanisms linking PM and ozone exposure to CVD remain poorly understood. OBJECTIVE: This study explored associations betwe ... Full text Link to item Cite

The Effect of Vigorous- Versus Moderate-Intensity Aerobic Exercise on Insulin Action.

Journal Article Curr Cardiol Rep · December 2016 Due to the beneficial effects on a wide range of modern medical conditions, most professional societies recommend regular aerobic exercise as part of a healthy lifestyle. Many of the exercise-related health benefits exhibit a dose-response relationship: Up ... Full text Link to item Cite

Pyruvate Dehydrogenase Phosphatase Regulatory Gene Expression Correlates with Exercise Training Insulin Sensitivity Changes.

Journal Article Med Sci Sports Exerc · December 2016 PURPOSE: Whole body insulin sensitivity (Si) typically improves after aerobic exercise training; however, individual responses can be highly variable. The purpose of this study was to use global gene expression to identify skeletal muscle genes that correl ... Full text Link to item Cite

Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.

Journal Article J Gerontol A Biol Sci Med Sci · November 2016 BACKGROUND: Older age and obesity are associated with metabolic dysregulation; the mechanism by which these factors impact metabolism across the lifespan is important, but relatively unknown. We evaluated a panel of amino acids (AAs) and acylcarnitines (AC ... Full text Link to item Cite

Short-term effects of air temperature on plasma metabolite concentrations in patients undergoing cardiac catheterization.

Journal Article Environ Res · November 2016 BACKGROUND: Epidemiological studies have shown associations between air temperature and cardiovascular health outcomes. Metabolic dysregulation might also play a role in the development of cardiovascular disease. OBJECTIVES: To investigate short-term tempe ... Full text Link to item Cite

Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION).

Journal Article Am J Cardiol · October 15, 2016 Angina pectoris (AP) is associated with worse outcomes in heart failure (HF). We investigated the association of AP with health-related quality of life (HRQoL), exercise capacity, and clinical outcomes and its interaction with exercise training in an HF po ... Full text Link to item Cite

Effects of exercise training alone vs a combined exercise and nutritional lifestyle intervention on glucose homeostasis in prediabetic individuals: a randomised controlled trial.

Journal Article Diabetologia · October 2016 AIMS/HYPOTHESIS: Although the Diabetes Prevention Program (DPP) established lifestyle changes (diet, exercise and weight loss) as the 'gold standard' preventive therapy for diabetes, the relative contribution of exercise alone to the overall utility of the ... Full text Link to item Cite

Statins and Exercise Training Response in Heart Failure Patients: Insights From HF-ACTION.

Journal Article JACC Heart Fail · August 2016 OBJECTIVES: The aim of this study was to assess for a treatment interaction between statin use and exercise training (ET) response. BACKGROUND: Recent data suggest that statins may attenuate ET response, but limited data exist in patients with heart failur ... Full text Link to item Cite

Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure.

Journal Article J Am Heart Assoc · July 29, 2016 BACKGROUND: Metabolic impairment is an important contributor to heart failure (HF) pathogenesis and progression. Dysregulated metabolic pathways remain poorly characterized in patients with HF and preserved ejection fraction (HFpEF). We sought to determine ... Full text Open Access Link to item Cite

PDPR Gene Expression Correlates with Exercise-Training Insulin Sensitivity Changes.

Journal Article Med Sci Sports Exerc · July 18, 2016 PURPOSE: Whole body insulin sensitivity (Si) typically improves following aerobic exercise training; however, individual responses can be highly variable. The purpose of this study was to use global gene expression to identify skeletal muscle genes that co ... Full text Link to item Cite

Response to Exercise Training and Outcomes in Patients With Heart Failure and Diabetes Mellitus: Insights From the HF-ACTION Trial.

Journal Article J Card Fail · July 2016 BACKGROUND: In HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training), exercise training improved functional capacity in heart failure with reduced ejection fraction (HFrEF). Previous studies have suggested that diabetes ... Full text Link to item Cite

In reply

Journal Article JAMA - Journal of the American Medical Association · June 21, 2016 Full text Cite

Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease.

Journal Article N Engl J Med · June 2, 2016 BACKGROUND: Several sequence variants are known to have effects on serum levels of non-high-density lipoprotein (HDL) cholesterol that alter the risk of coronary artery disease. METHODS: We sequenced the genomes of 2636 Icelanders and found variants that w ... Full text Link to item Cite

Treatment of anxiety in patients with coronary heart disease: Rationale and design of the UNderstanding the benefits of exercise and escitalopram in anxious patients WIth coroNary heart Disease (UNWIND) randomized clinical trial.

Journal Article Am Heart J · June 2016 BACKGROUND: Anxiety is highly prevalent among patients with coronary heart disease (CHD), and there is growing evidence that high levels of anxiety are associated with worse prognosis. However, few studies have evaluated the efficacy of treating anxiety in ... Full text Link to item Cite

Metabolic Dysfunction in Heart Failure: Diagnostic, Prognostic, and Pathophysiologic Insights From Metabolomic Profiling.

Journal Article Curr Heart Fail Rep · June 2016 Metabolic impairment is an intrinsic component of heart failure (HF) pathophysiology. Although initially conceived as a myocardial defect, metabolic dysfunction is now recognized as a systemic process with complex interplay between the myocardium and perip ... Full text Link to item Cite

Safety of two-year caloric restriction in non-obese healthy individuals.

Journal Article Oncotarget · April 12, 2016 BACKGROUND: The extent to which sustained caloric restriction (CR) in healthy non-obese adults is safe has not been previously investigated. OBJECTIVE: Assess the safety and tolerability of sustained two-year CR intervention in healthy, non-obese adults. D ... Full text Link to item Cite

A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls.

Journal Article Arthritis Res Ther · April 12, 2016 BACKGROUND: RA and CVD both have inflammation as part of the underlying biology. Our objective was to explore the relationships of GlycA, a measure of glycosylated acute phase proteins, with inflammation and cardiometabolic risk in RA, and explore whether ... Full text Open Access Link to item Cite

Enhancing Cardiac Rehabilitation With Stress Management Training: A Randomized, Clinical Efficacy Trial.

Journal Article Circulation · April 5, 2016 BACKGROUND: Cardiac rehabilitation (CR) is the standard of care for patients with coronary heart disease. Despite considerable epidemiological evidence that high stress is associated with worse health outcomes, stress management training (SMT) is not inclu ... Full text Link to item Cite

Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues.

Journal Article Tissue Eng Part A · April 2016 To utilize three-dimensional (3D) engineered human skeletal muscle tissue for translational studies and in vitro studies of drug toxicity, there is a need to promote differentiation and functional behavior. In this study, we identified conditions to promot ... Full text Link to item Cite

Association of standard clinical and laboratory variables with red blood cell distribution width.

Journal Article Am Heart J · April 2016 BACKGROUND: Red blood cell distribution width (RDW) strongly predicts clinical outcomes among patients with coronary disease and heart failure. The factors underpinning this association are unknown. METHODS: In 6,447 individuals enrolled in the Measurement ... Full text Link to item Cite

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.

Journal Article N Engl J Med · March 24, 2016 BACKGROUND: The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. METHODS: Through DNA genotyping, we tested 54,003 coding-sequence variants covering 13,715 h ... Full text Link to item Cite

High-density lipoprotein subclass measurements improve mortality risk prediction, discrimination and reclassification in a cardiac catheterization cohort.

Journal Article Atherosclerosis · March 2016 BACKGROUND AND AIMS: Recent failures of HDL cholesterol (HDL-C)-raising therapies to prevent cardiovascular disease (CVD) events have tempered the interest in the role of HDL-C in clinical risk assessment. Emerging data suggest that the atheroprotective pr ... Full text Link to item Cite

Variables Measured During Cardiopulmonary Exercise Testing as Predictors of Mortality in Chronic Systolic Heart Failure.

Journal Article J Am Coll Cardiol · February 23, 2016 BACKGROUND: Data from a cardiopulmonary exercise (CPX) test are used to determine prognosis in patients with chronic heart failure (HF). However, few published studies have simultaneously compared the relative prognostic strength of multiple CPX variables. ... Full text Link to item Cite

A Novel Analytic Technique to Measure Associations Between Circulating Biomarkers and Physical Performance Across the Adult Life Span.

Journal Article J Gerontol A Biol Sci Med Sci · February 2016 Understanding associations between circulating biomarkers and physical performance across the adult life span could aid in better describing mechanistic pathways leading to disability. We hypothesized that high concentrations of circulating biomarkers woul ... Full text Link to item Cite

Association between satellite-based estimates of long-term PM2.5 exposure and coronary artery disease.

Journal Article Environ Res · February 2016 BACKGROUND: Epidemiological studies have identified associations between long-term PM2.5 exposure and cardiovascular events, though most have relied on concentrations from central-site air quality monitors. METHODS: We utilized a cohort of 5679 patients wh ... Full text Link to item Cite

Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support.

Journal Article J Am Coll Cardiol · January 26, 2016 BACKGROUND: Heart failure (HF) is characterized by perturbations in energy homeostasis and metabolism. The reversibility and prognostic value of circulating markers associated with these changes remain unclear. OBJECTIVES: This study sought to describe the ... Full text Link to item Cite

Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.

Journal Article JAMA · January 5, 2016 IMPORTANCE: More than 80% of patients with heart failure with preserved ejection fraction (HFPEF), the most common form of heart failure among older persons, are overweight or obese. Exercise intolerance is the primary symptom of chronic HFPEF and a major ... Full text Link to item Cite

Adverse Cardiovascular Response to Aerobic Exercise Training: Is This a Concern?

Journal Article Med Sci Sports Exerc · January 2016 PURPOSE: Aerobic exercise training in sedentary individuals improves physical fitness and various cardiovascular (CV) biomarkers. Nevertheless, there has been controversy as to whether exercise training may adversely affect some biomarkers in a small segme ... Full text Link to item Cite

Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease.

Journal Article PLoS One · 2016 There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes, potentially by increasing susceptibility to these exposures. However, genome-scale investigations of these ... Full text Link to item Cite

Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship.

Journal Article PLoS One · 2016 Survival bias may unduly impact genetic association with complex diseases; gene-specific survival effects may further complicate such investigations. Coronary artery disease (CAD) is a complex phenotype for which little is understood about gene-specific su ... Full text Link to item Cite

Deaths in triathletes: immersion pulmonary oedema as a possible cause.

Journal Article BMJ Open Sport Exerc Med · 2016 BACKGROUND/AIM: To address the question as to whether immersion pulmonary oedema (IPO) may be a common cause of death in triathlons, markers of swimming-induced pulmonary oedema (SIPO) susceptibility were sought in triathletes' postmortem examinations. MET ... Full text Open Access Link to item Cite

The effects of exercise on the lipoprotein subclass profile: A meta-analysis of 10 interventions.

Journal Article Atherosclerosis · December 2015 OBJECTIVE: The goal was to examine lipoprotein subclass responses to regular exercise as measured in 10 exercise interventions derived from six cohorts. METHODS: Nuclear magnetic resonance spectroscopy was used to quantify average particle size, total and ... Full text Link to item Cite

A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience.

Journal Article J Cardiovasc Transl Res · November 2015 The CATHeterization GENetics (CATHGEN) biorepository was assembled in four phases. First, project start-up began in 2000. Second, between 2001 and 2010, we collected clinical data and biological samples from 9334 individuals undergoing cardiac catheterizat ... Full text Link to item Cite

Lifestyle modification for resistant hypertension: The TRIUMPH randomized clinical trial.

Journal Article Am Heart J · November 2015 BACKGROUND: Resistant hypertension (RH) is a growing health burden in this country affecting as many as 1 in 5 adults being treated for hypertension. Resistant hypertension is associated with increased risk of adverse cardiovascular disease (CVD) events an ... Full text Link to item Cite

Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis.

Journal Article PLoS Genet · November 2015 Levels of certain circulating short-chain dicarboxylacylcarnitine (SCDA), long-chain dicarboxylacylcarnitine (LCDA) and medium chain acylcarnitine (MCA) metabolites are heritable and predict cardiovascular disease (CVD) events. Little is known about the bi ... Full text Open Access Link to item Cite

Incorporation of pharmacogenetic testing into medication therapy management.

Journal Article Pharmacogenomics · November 2015 AIM: To assess feasibility and patient satisfaction with a pharmacist-delivered medication therapy management (MTM) plus pharmacogenetic (PGx) testing service. METHODS: Thirty patients from a cardiology outpatient clinic were enrolled to attend two MTM ses ... Full text Link to item Cite

Psychosocial Factors, Exercise Adherence, and Outcomes in Heart Failure Patients: Insights From Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION).

Journal Article Circ Heart Fail · November 2015 BACKGROUND: Psychosocial factors may influence adherence with exercise training for heart failure (HF) patients. We aimed to describe the association between social support and barriers to participation with exercise adherence and clinical outcomes. METHOD ... Full text Link to item Cite

Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients.

Journal Article Environ Health Perspect · October 2015 BACKGROUND: The relationship between traffic-related air pollution (TRAP) and risk factors for cardiovascular disease needs to be better understood in order to address the adverse impact of air pollution on human health. OBJECTIVE: We examined associations ... Full text Link to item Cite

Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.

Journal Article Kidney Int · October 2015 Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since prior studies have supported a genetic basis for postoperative AKI, we conducted a genome-wide association study (GWAS) for AKI following coronary bypass graft (CABG) sur ... Full text Open Access Link to item Cite

Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans.

Journal Article Diabetologia · October 2015 AIMS/HYPOTHESES: Obesity is associated with decreased insulin sensitivity (IS) and elevated plasma branched-chain amino acids (BCAAs). The purpose of this study was to investigate the relationship between BCAA metabolism and IS in overweight (OW) individua ... Full text Link to item Cite

A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status.

Journal Article Genome Biol · September 7, 2015 BACKGROUND: Diagnostics of the human ageing process may help predict future healthcare needs or guide preventative measures for tackling diseases of older age. We take a transcriptomics approach to build the first reproducible multi-tissue RNA expression s ... Full text Link to item Cite

A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity.

Journal Article J Gerontol A Biol Sci Med Sci · September 2015 BACKGROUND: Caloric restriction (CR), energy intake reduced below ad libitum (AL) intake, increases life span in many species. The implications for humans can be clarified by randomized controlled trials of CR. METHODS: To determine CR's feasibility, safet ... Full text Link to item Cite

Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene.

Journal Article Genet Epidemiol · September 2015 Chronic psychosocial stress adversely affects health and is associated with the development of disease [Williams, 2008]. Systematic epidemiological and genetic studies are needed to uncover genetic variants that interact with stress to modify metabolic res ... Full text Link to item Cite

Genome-wide association study of new-onset atrial fibrillation after coronary artery bypass grafting surgery.

Journal Article Am Heart J · September 2015 BACKGROUND: Postoperative atrial fibrillation (AF) is a potentially life-threatening complication after coronary artery bypass graft (CABG) surgery. Genetic predisposition may predict risk for developing postoperative AF. METHODS: Study subjects underwent ... Full text Link to item Cite

Epigenetic profiling identifies novel genes for ascending aortic aneurysm formation with bicuspid aortic valves.

Journal Article Heart Surg Forum · August 30, 2015 BACKGROUND:   Bicuspid aortic valves predispose to ascending aortic aneurysms, but the mechanisms underlying this aortopathy remain incompletely characterized.  We sought to identify epigenetic pathways predisposing to aneurysm formation in bicuspid patien ... Full text Link to item Cite

Prospective relationships between body weight and physical activity: an observational analysis from the NAVIGATOR study.

Journal Article BMJ Open · August 14, 2015 OBJECTIVES: While bidirectional relationships exist between body weight and physical activity, direction of causality remains uncertain and previous studies have been limited by self-reported activity or weight and small sample size. We investigated the pr ... Full text Link to item Cite

Physical activity as a determinant of fasting and 2-h post-challenge glucose: a prospective cohort analysis of the NAVIGATOR trial.

Journal Article Diabet Med · August 2015 AIM: To investigate whether previous physical activity levels are associated with blood glucose levels in individuals with impaired glucose tolerance in the context of an international pharmaceutical trial. METHODS: Data were analysed from the NAVIGATOR tr ... Full text Link to item Cite

Incremental and independent value of cardiopulmonary exercise test measures and the Seattle Heart Failure Model for prediction of risk in patients with heart failure.

Journal Article J Heart Lung Transplant · August 2015 BACKGROUND: Multivariable risk scores and exercise measures are well-validated risk prediction methods. Combining information from a functional evaluation and a risk model may improve accuracy of risk predictions. We analyzed whether adding exercise measur ... Full text Link to item Cite

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits.

Journal Article Cell Metab · July 7, 2015 The beneficial effects of physical activity (PA) are well documented, yet the mechanisms by which PA prevents disease and improves health outcomes are poorly understood. To identify major gaps in knowledge and potential strategies for catalyzing progress i ... Full text Link to item Cite

Evaluation of the Incremental Prognostic Utility of Increasingly Complex Testing in Chronic Heart Failure.

Journal Article Circ Heart Fail · July 2015 BACKGROUND: Current heart failure (HF) risk prediction models do not consider how individual patient assessments occur in incremental steps; furthermore, each additional diagnostic evaluation may add cost, complexity, and potential morbidity. METHODS AND R ... Full text Link to item Cite

The effects of aerobic, resistance, and combination training on insulin sensitivity and secretion in overweight adults from STRRIDE AT/RT: a randomized trial.

Journal Article J Appl Physiol (1985) · June 15, 2015 Most health organizations recommend a combination of aerobic training (AT) and resistance training (RT), yet few studies have compared their acute (within 24 h of the last exercise bout) and sustained (after 14 days of no exercise training) effects alone a ... Full text Link to item Cite

Physiology of sedentary behavior and its relationship to health outcomes.

Journal Article Med Sci Sports Exerc · June 2015 PURPOSE: This article reports on the findings and recommendations of the "Physiology of Sedentary Behavior and Its Relationship to Health Outcomes" group, a part of a larger workshop entitled Sedentary Behavior: Identifying Research Priorities sponsored by ... Full text Link to item Cite

Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene.

Journal Article Eur J Hum Genet · June 2015 We performed gene-environment interaction genome-wide association analysis (G × E GWAS) to identify SNPs whose effects on metabolic traits are modified by chronic psychosocial stress in the Multi-Ethnic Study of Atherosclerosis (MESA). In Whites, the G × E ... Full text Open Access Link to item Cite

Prognostic significance of depression in blacks with heart failure: insights from Heart Failure: a Controlled Trial Investigating Outcomes of Exercise Training.

Journal Article Circ Heart Fail · May 2015 BACKGROUND: Although studies have shown that depression is associated with worse outcomes in patients with heart failure, most studies have been in white patients. The impact of depression on outcomes in blacks with heart failure has not been studied. METH ... Full text Link to item Cite

Authorship in a multicenter clinical trial: The Heart Failure-A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) Authorship and Publication (HAP) scoring system results.

Journal Article Am Heart J · April 2015 BACKGROUND: Few guidelines exist regarding authorship on manuscripts resulting from large multicenter trials. The HF-ACTION investigators devised a system to address assignment of authorship on trial publications and tested the outcomes in the course of co ... Full text Link to item Cite

Genetic variants associated with vein graft stenosis after coronary artery bypass grafting.

Journal Article Heart Surg Forum · February 27, 2015 BACKGROUND: Vein graft stenosis after coronary artery bypass grafting (CABG) is common. Identifying genes associated with vein graft stenosis after CABG could reveal novel mechanisms of disease and discriminate patients at risk for graft failure. We hypoth ... Full text Link to item Cite

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.

Journal Article Nature · February 5, 2015 Myocardial infarction (MI), a leading cause of death around the world, displays a complex pattern of inheritance. When MI occurs early in life, genetic inheritance is a major component to risk. Previously, rare mutations in low-density lipoprotein (LDL) ge ... Full text Link to item Cite

Simultaneous consideration of multiple candidate protein biomarkers for long-term risk for cardiovascular events.

Journal Article Circ Cardiovasc Genet · February 2015 BACKGROUND: Although individual protein biomarkers are associated with cardiovascular risk, rarely have multiple proteins been considered simultaneously to identify which set of proteins best predicts risk. METHODS AND RESULTS: In a nested case-control stu ... Full text Link to item Cite

Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs.

Journal Article Elife · January 9, 2015 Existing in vitro models of human skeletal muscle cannot recapitulate the organization and function of native muscle, limiting their use in physiological and pharmacological studies. Here, we demonstrate engineering of electrically and chemically responsiv ... Full text Open Access Link to item Cite

Exercise training and pacing status in patients with heart failure: results from HF-ACTION.

Journal Article J Card Fail · January 2015 BACKGROUND: We sought to determine if outcomes with exercise training in heart failure (HF) vary according to ventricular pacing type. METHODS AND RESULTS: Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) randomized ... Full text Link to item Cite

Self-efficacy for exercise, more than disease-related factors, is associated with objectively assessed exercise time and sedentary behaviour in rheumatoid arthritis.

Journal Article Scand J Rheumatol · 2015 OBJECTIVES: Until recently, reports of physical activity in rheumatoid arthritis (RA) were limited to self-report methods and/or leisure-time physical activity. Our objectives were to assess, determine correlates of, and compare to well-matched controls bo ... Full text Link to item Cite

SLCO1B1 genetic variants, long-term low-density lipoprotein cholesterol levels and clinical events in patients following cardiac catheterization.

Journal Article Pharmacogenomics · 2015 AIM: SLCO1B1 variants are associated with intermediate outcomes that may increase risk of death/myocardial infarction (MI) in statin-treated patients. PATIENTS & METHODS: In high-risk Caucasians undergoing cardiac catheterization, we tested the association ... Full text Link to item Cite

The ACTN3 R577X Polymorphism Is Associated with Cardiometabolic Fitness in Healthy Young Adults.

Journal Article PLoS One · 2015 Homozygosity for a premature stop codon (X) in the ACTN3 "sprinter" gene is common in humans despite the fact that it reduces muscle size, strength and power. Because of the close relationship between skeletal muscle function and cardiometabolic health we ... Full text Link to item Cite

Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction.

Journal Article PLoS One · 2015 BACKGROUND: Influenza infection is associated with myocardial infarction (MI), suggesting that respiratory viral infection may induce biologic pathways that contribute to MI. We tested the hypotheses that 1) a validated blood gene expression signature of r ... Full text Open Access Link to item Cite

Preventive cardiology: Counseling older at-risk adults on nutrition

Chapter · January 1, 2015 Preventive cardiology brings a detailed understanding of the interplay between known and emerging risk factors to the long-term treatment of cardiac patients particularly targeting cardiometabolic risk factors. In essence, it translates a growing scientifi ... Full text Cite

Change in levels of physical activity after diagnosis of type 2 diabetes: an observational analysis from the NAVIGATOR study.

Journal Article Diabetes Obes Metab · December 2014 Increased physical activity is known to be beneficial in people with type 2 diabetes mellitus (T2DM), but it is not known whether individuals change their activity levels after T2DM diagnosis. The present Nateglinide and Valsartan in Impaired Glucose Toler ... Full text Link to item Cite

Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness.

Journal Article Diabetologia · November 2014 AIMS/HYPOTHESIS: Targeted metabolomic and transcriptomic approaches were used to evaluate the relationship between skeletal muscle metabolite signatures, gene expression profiles and clinical outcomes in response to various exercise training interventions. ... Full text Link to item Cite

Pilot study: incorporation of pharmacogenetic testing in medication therapy management services.

Journal Article Pharmacogenomics · November 2014 Aim: To describe the rationale and design of a pilot study evaluating the integration of pharmacogenetic (PGx) testing into pharmacist-delivered medication therapy management (MTM). Study rationale: Clinical delivery approaches of PGx testing involving pha ... Full text Link to item Cite

Biological and Analytical Stability of a Peripheral Blood Gene Expression Score for Obstructive Coronary Artery Disease in the PREDICT and COMPASS Studies

Journal Article Journal of Cardiovascular Translational Research · October 4, 2014 A gene expression score (GES) for obstructive coronary artery disease (CAD) has been validated in two multicenter studies. Receiver-operating characteristics (ROC) analysis of the GES on an expanded Personalized Risk Evaluation and Diagnosis in the Coronar ... Full text Cite

Adipose depots, not disease-related factors, account for skeletal muscle insulin sensitivity in established and treated rheumatoid arthritis.

Journal Article J Rheumatol · October 2014 OBJECTIVE: In prior reports, individuals with rheumatoid arthritis (RA) exhibited increased insulin resistance. However, those studies were limited by either suboptimal assessment methods for insulin sensitivity or a failure to account for important determ ... Full text Link to item Cite

G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving β-blockers.

Other Circ Cardiovasc Genet · October 2014 BACKGROUND: We hypothesized that genetic variations in the adrenergic signaling pathway and cytochrome P450 2D6 enzyme are associated with new-onset atrial fibrillation (AF) in patients who underwent coronary artery bypass grafting and were treated with pe ... Full text Link to item Cite

Biological and analytical stability of a peripheral blood gene expression score for obstructive coronary artery disease in the PREDICT and COMPASS studies.

Journal Article J Cardiovasc Transl Res · October 2014 A gene expression score (GES) for obstructive coronary artery disease (CAD) has been validated in two multicenter studies. Receiver-operating characteristics (ROC) analysis of the GES on an expanded Personalized Risk Evaluation and Diagnosis in the Coronar ... Full text Link to item Cite

Safety and efficacy of aerobic training in patients with cancer who have heart failure: an analysis of the HF-ACTION randomized trial.

Journal Article J Clin Oncol · August 10, 2014 PURPOSE: To investigate the efficacy and safety of aerobic training (AT) in patients with cancer with medically stable heart failure (HF). PATIENTS AND METHODS: A retrospective analysis of 90 patients with cancer who have HF and who were randomly assigned ... Full text Link to item Cite

Biomarkers of myocardial stress and fibrosis as predictors of mode of death in patients with chronic heart failure.

Journal Article JACC Heart Fail · June 2014 OBJECTIVES: The aim of this study was to determine whether biomarkers of myocardial stress and fibrosis improve prediction of the mode of death in patients with chronic heart failure. BACKGROUND: The 2 most common modes of death in patients with chronic he ... Full text Link to item Cite

The doubly labeled water method produces highly reproducible longitudinal results in nutrition studies.

Journal Article J Nutr · May 2014 The doubly labeled water (DLW) method is considered the reference method for the measurement of energy expenditure under free-living conditions. However, the reproducibility of the DLW method in longitudinal studies is not well documented. This study was d ... Full text Link to item Cite

Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction.

Journal Article Am J Physiol Heart Circ Physiol · May 2014 Heart failure (HF) with preserved ejection fraction (HFPEF) is the most common form of HF in older persons. The primary chronic symptom in HFPEF is severe exercise intolerance, and its pathophysiology is poorly understood. To determine whether skeletal mus ... Full text Link to item Cite

Impact of baseline physical activity and diet behavior on metabolic syndrome in a pharmaceutical trial: results from NAVIGATOR.

Journal Article Metabolism · April 2014 OBJECTIVE: The cardiometabolic risk cluster metabolic syndrome (MS) includes ≥3 of elevated fasting glucose, hypertension, elevated triglycerides, reduced high-density lipoprotein cholesterol (HDL-c), and increased waist circumference. Each can be affected ... Full text Link to item Cite

Genetically guided statin therapy on statin perceptions, adherence, and cholesterol lowering: a pilot implementation study in primary care patients.

Journal Article J Pers Med · March 27, 2014 Statin adherence is often limited by side effects. The SLCO1B1*5 variant is a risk factor for statin side effects and exhibits statin-specific effects: highest with simvastatin/atorvastatin and lowest with pravastatin/rosuvastatin. The effects of SLCO1B1*5 ... Full text Link to item Cite

Association between change in daily ambulatory activity and cardiovascular events in people with impaired glucose tolerance (NAVIGATOR trial): a cohort analysis.

Journal Article Lancet · March 22, 2014 BACKGROUND: The extent to which change in physical activity can modify the risk of cardiovascular disease in individuals at high cardiovascular risk is uncertain. We investigated whether baseline and change in objectively-assessed ambulatory activity is as ... Full text Link to item Cite

Conditions that promote primary human skeletal myoblast culture and muscle differentiation in vitro.

Journal Article Am J Physiol Cell Physiol · February 15, 2014 Conditions under which skeletal myoblasts are cultured in vitro are critical to growth and differentiation of these cells into mature skeletal myofibers. We examined several culture conditions that promoted human skeletal myoblast (HSkM) culture and examin ... Full text Link to item Cite

Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.

Journal Article Am J Hum Genet · February 6, 2014 Low-frequency coding DNA sequence variants in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) lower plasma low-density lipoprotein cholesterol (LDL-C), protect against risk of coronary heart disease (CHD), and have prompted the development o ... Full text Link to item Cite

The effects of exercise on cardiovascular biomarkers in patients with chronic heart failure.

Journal Article Am Heart J · February 2014 BACKGROUND: Exercise training is recommended for chronic heart failure (HF) patients to improve functional status and reduce risk of adverse outcomes. Elevated plasma levels of amino-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity C-re ... Full text Link to item Cite

Are there negative responders to exercise training among heart failure patients?

Journal Article Med Sci Sports Exerc · February 2014 PURPOSE: Aerobic exercise training has been used in patients with stable heart failure (HF) to reduce the risk of clinical events. However, due to patient heterogeneity, some patients may experience a decrease in functional capacity due to such training. T ... Full text Link to item Cite

Energy requirements in nonobese men and women: results from CALERIE.

Journal Article Am J Clin Nutr · January 2014 BACKGROUND: The energy intake necessary to maintain weight and body composition is called the energy requirement for weight maintenance and can be determined by using the doubly labeled water (DLW) method. OBJECTIVE: The objective was to determine the ener ... Full text Link to item Cite

Relationship between galectin-3 levels and mineralocorticoid receptor antagonist use in heart failure: analysis from HF-ACTION.

Journal Article J Card Fail · January 2014 BACKGROUND: Galectin-3 (Gal-3) is a marker of myocardial fibrosis, and elevated levels are associated with adverse outcomes. Mineralocorticoid receptor antagonists (MRAs) modulate cardiac fibrosis in heart failure (HF) patients and have been shown to impro ... Full text Link to item Cite

Psychosocial benefits of cardiac rehabilitation among women compared with men.

Journal Article J Cardiopulm Rehabil Prev · 2014 PURPOSE: Cardiac rehabilitation (CR) has been shown to reduce cardiac risk and improve the psychosocial functioning of participants. This study examines gender differences on several psychosocial indicators across the course of CR. METHODS: Patients (N = 3 ... Full text Link to item Cite

Diabetes status differentiates endothelial function and plasma nitrite response to exercise stress in peripheral arterial disease following supervised training.

Journal Article J Diabetes Complications · 2014 AIMS: To determine if type 2 diabetes mellitus (T2D) differentiates endothelial function and plasma nitrite response (a marker of nitric oxide bioavailability) during exercise in peripheral arterial disease (PAD) subjects prior to and following 3 months su ... Full text Link to item Cite

Validation of the association between a branched chain amino acid metabolite profile and extremes of coronary artery disease in patients referred for cardiac catheterization.

Journal Article Atherosclerosis · January 2014 OBJECTIVE: To validate independent associations between branched-chain amino acids (BCAA) and other metabolites with coronary artery disease (CAD). METHODS: We conducted mass-spectrometry-based profiling of 63 metabolites in fasting plasma from 1983 sequen ... Full text Link to item Cite

Human and mouse skeletal muscle stem cells: convergent and divergent mechanisms of myogenesis.

Journal Article PLoS One · 2014 Satellite cells are the chief contributor to skeletal muscle growth and regeneration. The study of mouse satellite cells has accelerated in recent years due to technical advancements in the isolation of these cells. The study of human satellite cells has l ... Full text Link to item Cite

Earbud-based sensor for the assessment of energy expenditure, HR, and VO2max.

Journal Article Med Sci Sports Exerc · 2014 INTRODUCTION/PURPOSE: The goal of this program was to determine the feasibility of a novel noninvasive, highly miniaturized optomechanical earbud sensor for accurately estimating total energy expenditure (TEE) and maximum oxygen consumption (VO2max). The o ... Full text Link to item Cite

The relationship between the blood pressure responses to exercise following training and detraining periods.

Journal Article PLoS One · 2014 BACKGROUND: Exercise training lowers blood pressure (BP), while BP increases and returns to pre-training values with detraining. Yet, there is considerable variability in these BP responses. We examined the relationship between the BP responses after 6 mon ... Full text Link to item Cite

A putatively functional polymorphism in the HTR2C gene is associated with depressive symptoms in white females reporting significant life stress.

Journal Article PLoS One · 2014 Psychosocial stress is well known to be positively associated with subsequent depressive symptoms. Cortisol response to stress may be one of a number of biological mechanisms that links psychological stress to depressive symptoms, although the precise caus ... Full text Open Access Link to item Cite

Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis.

Journal Article Hum Mol Genet · December 20, 2013 Smooth muscle cell (SMC) proliferation is a hallmark of vascular injury and disease. Global hypomethylation occurs during SMC proliferation in culture and in vivo during neointimal formation. Regardless of the programmed or stochastic nature of hypomethyla ... Full text Link to item Cite

Angiogenesis in peripheral artery disease: An emerging therapy targeting skeletal muscle

Journal Article · December 1, 2013 Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities causing claudication, exercise intolerance and a decreased quality of life. Despite the fact that stenosis of conduit vessels are largely responsible for PAD d ... Cite

Gene-smoking interactions in multiple Rho-GTPase pathway genes in an early-onset coronary artery disease cohort.

Journal Article Hum Genet · December 2013 We performed a gene-smoking interaction analysis using families from an early-onset coronary artery disease cohort (GENECARD). This analysis was focused on validating and expanding results from previous studies implicating single nucleotide polymorphisms ( ... Full text Link to item Cite

Soluble ST2 in ambulatory patients with heart failure: Association with functional capacity and long-term outcomes.

Journal Article Circ Heart Fail · November 2013 BACKGROUND: ST2 is involved in cardioprotective signaling in the myocardium and has been identified as a potentially promising biomarker in heart failure (HF). We evaluated ST2 levels and their association with functional capacity and long-term clinical ou ... Full text Link to item Cite

Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events.

Journal Article J Am Coll Cardiol · October 1, 2013 OBJECTIVES: The aim of this study was to develop ribonucleic acid (RNA) profiles that could serve as novel biomarkers for the response to aspirin. BACKGROUND: Aspirin reduces death and myocardial infarction (MI), suggesting that aspirin interacts with biol ... Full text Link to item Cite

Unlocking the barriers to improved functional capacity in the elderly: rationale and design for the "Fit for Life trial".

Journal Article Contemp Clin Trials · September 2013 Advancing age is associated with an increase in physical impairment, functional limitations, disability, and loss of independence. Regular physical activity conveys health benefits, but the yield on physical function in the elderly, is less clear. Current ... Full text Link to item Cite

Race, exercise training, and outcomes in chronic heart failure: findings from Heart Failure - a Controlled Trial Investigating Outcomes in Exercise TraiNing (HF-ACTION).

Journal Article Am Heart J · September 2013 BACKGROUND: The strength of race as an independent predictor of long-term outcomes in a contemporary chronic heart failure (HF) population and its association with exercise training response have not been well established. We aimed to investigate the assoc ... Full text Link to item Cite

Use of the Corus® CAD Gene Expression Test for Assessment of Obstructive Coronary Artery Disease Likelihood in Symptomatic Non-Diabetic Patients.

Journal Article PLoS Curr · August 26, 2013 The determination of the underlying etiology of symptoms suggestive of obstructive coronary artery disease (CAD, ≥50% stenosis in a major coronary artery) is a common clinical challenge in both primary care and cardiology clinics. Usual care in low to medi ... Full text Link to item Cite

Association between resting heart rate, chronotropic index, and long-term outcomes in patients with heart failure receiving β-blocker therapy: data from the HF-ACTION trial.

Journal Article Eur Heart J · August 2013 AIMS: The aim of this study was to assess the association between resting heart rate (HR), chronotropic index (CI), and clinical outcomes in optimally treated chronic heart failure (HF) patients on β-blocker therapy. METHODS AND RESULTS: We performed a sub ... Full text Link to item Cite

Trajectory classes of body mass index in a representative elderly community sample.

Journal Article J Gerontol A Biol Sci Med Sci · June 2013 BACKGROUND: It is unclear whether distinct weight-related trajectory classes, differing in course, demographics, and health characteristics, exist in the elderly population. METHODS: Data came from the 10-year (1986-1996) Duke Established Populations for E ... Full text Link to item Cite

Health coaching and genomics-potential avenues to elicit behavior change in those at risk for chronic disease: protocol for personalized medicine effectiveness study in air force primary care.

Journal Article Glob Adv Health Med · May 2013 BACKGROUND: Type 2 diabetes (T2D) and coronary heart disease (CHD) are prevalent chronic diseases from which military personnel are not exempt. While many genetic markers for these diseases have been identified, the clinical utility of genetic risk testing ... Full text Link to item Cite

Oxygen Uptake Efficiency Slope (oues): Maximal Vs. Submaximal Calculation Methods

Conference MEDICINE AND SCIENCE IN SPORTS AND EXERCISE · May 1, 2013 Link to item Cite

Cancer-specific concerns and physical activity among recently diagnosed breast and prostate cancer survivors.

Journal Article Integr Cancer Ther · May 2013 BACKGROUND: Cancer treatment -related side effects may have a negative impact on quality of life among cancer survivors and may limit participation in physical activity (PA). HYPOTHESIS: Cancer-specific concerns will be reduced throughout a 10-month diet a ... Full text Link to item Cite

Exercise training and implantable cardioverter-defibrillator shocks in patients with heart failure: results from HF-ACTION (Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing).

Journal Article JACC Heart Fail · April 2013 OBJECTIVES: The purpose of this study was to determine whether exercise training is associated with an increased risk of implantable cardioverter-defibrillator (ICD) therapy in patients with heart failure (HF). BACKGROUND: Few data are available regarding ... Full text Link to item Cite

Association between adrenergic receptor genotypes and beta-blocker dose in heart failure patients: analysis from the HF-ACTION DNA substudy.

Journal Article Eur J Heart Fail · March 2013 AIMS: Beta-blockers reduce morbidity and mortality in chronic heart failure (HF) patients with reduced ejection fraction. However, there is heterogeneity in the response to these drugs, perhaps due to genetic variations in the β1-adrenergic receptor (ADRβ1 ... Full text Link to item Cite

Clinical characteristics, response to exercise training, and outcomes in patients with heart failure and chronic obstructive pulmonary disease: findings from Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION).

Journal Article Am Heart J · February 2013 BACKGROUND: The aim of this study was to investigate the clinical characteristics, exercise training response, β-blocker selectivity, and outcomes in patients with heart failure (HF) and chronic obstructive pulmonary disease (COPD). METHODS: We performed a ... Full text Link to item Cite

Alglucosidase alfa enzyme replacement therapy as a therapeutic approach for glycogen storage disease type III.

Journal Article Mol Genet Metab · February 2013 We investigated the feasibility of using recombinant human acid-α glucosidase (rhGAA, Alglucosidase alfa), an FDA approved therapy for Pompe disease, as a treatment approach for glycogen storage disease type III (GSD III). An in vitro disease model was est ... Full text Open Access Link to item Cite

Moderate-intensity aerobic training program improves insulin sensitivity and inflammatory markers in a pilot study of morbidly obese minority teens.

Journal Article Pediatr Exerc Sci · February 2013 UNLABELLED: We initiated a pilot study to investigate the effects of 8 wks of aerobic exercise training (ET) on insulin sensitivity and inflammatory markers in obese and insulin-resistant minority adolescents. Eleven morbidly obese (BMI 41.4 ± 1.8 kg/m2) m ... Full text Link to item Cite

Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing.

Journal Article Stem Cell Res Ther · 2013 Microphysiological systems provide a tool to simulate normal and pathological function of organs for prolonged periods. These systems must incorporate the key functions of the individual organs and enable interactions among the corresponding microphysiolog ... Full text Link to item Cite

Can lifestyle modification improve neurocognition? Rationale and design of the ENLIGHTEN clinical trial.

Journal Article Contemp Clin Trials · January 2013 BACKGROUND: Risk factors for cardiovascular disease (CVD) not only increase the risk for clinical CVD events, but also are associated with a cascade of neurophysiologic and neuroanatomic changes that increase the risk of cognitive impairment and dementia. ... Full text Link to item Cite

Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.

Journal Article PLoS One · 2013 Given the importance of cardiovascular disease (CVD) to public health and the demonstrated heritability of both disease status and its related risk factors, identifying the genetic variation underlying these susceptibilities is a critical step in understan ... Full text Open Access Link to item Cite

Caloric restriction: implications for human cardiometabolic health.

Journal Article J Cardiopulm Rehabil Prev · 2013 PURPOSE: While the impact of caloric restriction on human health is not fully understood, there is strong evidence to support further studies of its influence on cardiovascular health. The purpose of this review was to update the state of the science by ex ... Full text Link to item Cite

The genetic basis for survivorship in coronary artery disease.

Journal Article Front Genet · 2013 Survivorship is a trait characterized by endurance and virility in the face of hardship. It is largely considered a psychosocial attribute developed during fatal conditions, rather than a biological trait for robustness in the context of complex, age-depen ... Full text Link to item Cite

Effects of aerobic and/or resistance training on body mass and fat mass in overweight or obese adults.

Journal Article J Appl Physiol (1985) · December 15, 2012 Recent guidelines on exercise for weight loss and weight maintenance include resistance training as part of the exercise prescription. Yet few studies have compared the effects of similar amounts of aerobic and resistance training on body mass and fat mass ... Full text Link to item Cite

A whole blood gene expression-based signature for smoking status.

Journal Article BMC Med Genomics · December 3, 2012 BACKGROUND: Smoking is the leading cause of preventable death worldwide and has been shown to increase the risk of multiple diseases including coronary artery disease (CAD). We sought to identify genes whose levels of expression in whole blood correlate wi ... Full text Link to item Cite

Race, Exercise Training and Outcomes in Chronic Heart Failure

Journal Article CIRCULATION · November 20, 2012 Link to item Cite

Relation between volume of exercise and clinical outcomes in patients with heart failure.

Journal Article J Am Coll Cardiol · November 6, 2012 OBJECTIVES: This study determined whether greater volumes of exercise were associated with greater reductions in clinical events. BACKGROUND: The HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) trial showed that am ... Full text Link to item Cite

In-hospital resource use and medical costs in the last year of life by mode of death (from the HF-ACTION randomized controlled trial).

Journal Article Am J Cardiol · October 15, 2012 Patterns of medical resource use near the end of life may differ across modes of death. The aim of this study was to characterize patterns of inpatient resource use and direct costs for patients with heart failure (HF) who died of sudden cardiac death (SCD ... Full text Link to item Cite

Aerobic and resistance training effects on energy intake: the STRRIDE-AT/RT study.

Journal Article Med Sci Sports Exerc · October 2012 PURPOSE: Our study characterizes food and energy intake responses to long-term aerobic training (AT) and resistance training (RT) during a controlled 8-month trial. METHODS: In the STRRIDE-AT/RT trial, overweight/obese sedentary dyslipidemic men and women ... Full text Link to item Cite

Statins, exercise, and skeletal muscle.

Journal Article Exerc Sport Sci Rev · October 2012 Full text Link to item Cite

Why do individuals not lose more weight from an exercise intervention at a defined dose? An energy balance analysis.

Journal Article Obes Rev · October 2012 Weight loss resulting from an exercise intervention tends to be lower than predicted. Modest weight loss can arise from an increase in energy intake, physiological reductions in resting energy expenditure, an increase in lean tissue or a decrease in non-ex ... Full text Link to item Cite

Population approaches to improve diet, physical activity, and smoking habits: a scientific statement from the American Heart Association.

Journal Article Circulation · September 18, 2012 BACKGROUND: Poor lifestyle behaviors, including suboptimal diet, physical inactivity, and tobacco use, are leading causes of preventable diseases globally. Although even modest population shifts in risk substantially alter health outcomes, the optimal popu ... Full text Link to item Cite

A gender-specific blood-based gene expression score for assessing obstructive coronary artery disease in nondiabetic patients: results of the Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) trial.

Journal Article Am Heart J · September 2012 BACKGROUND: Currently available noninvasive tests to risk stratify patients for obstructive coronary disease result in many unnecessary cardiac catheterizations, especially in women. We sought to compare the diagnostic accuracy of presenting symptoms, noni ... Full text Link to item Cite

Modest increase in peak VO2 is related to better clinical outcomes in chronic heart failure patients: results from heart failure and a controlled trial to investigate outcomes of exercise training.

Journal Article Circ Heart Fail · September 1, 2012 BACKGROUND: The prognostic ability of a single measurement of peak oxygen uptake (VO(2)) is well established in patients with chronic heart failure. The relation between a change in peak VO(2) and clinical outcomes is not well defined. METHODS AND RESULTS: ... Full text Link to item Cite

Obesity, insulin resistance, and skeletal muscle nitric oxide synthase.

Journal Article J Appl Physiol (1985) · September 1, 2012 The molecular mechanisms responsible for impaired insulin action have yet to be fully identified. Rodent models demonstrate a strong relationship between insulin resistance and an elevation in skeletal muscle inducible nitric oxide synthase (iNOS) expressi ... Full text Link to item Cite

Effects of exercise training on depressive symptoms in patients with chronic heart failure: the HF-ACTION randomized trial.

Journal Article JAMA · August 1, 2012 CONTEXT: Depression is common in patients with cardiac disease, especially in patients with heart failure, and is associated with increased risk of adverse health outcomes. Some evidence suggests that aerobic exercise may reduce depressive symptoms, but to ... Full text Link to item Cite

Relationship of beta-blocker dose with outcomes in ambulatory heart failure patients with systolic dysfunction: results from the HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) trial.

Journal Article J Am Coll Cardiol · July 17, 2012 OBJECTIVES: This study sought to examine the association between baseline beta-blocker (BB) dose and outcomes in the HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) trial. BACKGROUND: Beta-blockers reduce morbidity ... Full text Link to item Cite

Exercise effects on lipids in persons with varying dietary patterns-does diet matter if they exercise? Responses in Studies of a Targeted Risk Reduction Intervention through Defined Exercise I.

Journal Article Am Heart J · July 2012 BACKGROUND: The standard clinical approach for reducing cardiovascular disease risk due to dyslipidemia is to prescribe changes in diet and physical activity. The purpose of the current study was to determine if, across a range of dietary patterns, there w ... Full text Link to item Cite

Conference Scene: Is personalized medicine ready for prime time?

Journal Article Per Med · July 2012 This article provides a meeting report from the Duke Center for Personalized Medicine 2012 Symposium, which took place in Durham, NC, USA, on 29 March 2012. The event titled 'At the Interface of Clinical Research and Clinical Medicine', focused on many of ... Full text Link to item Cite

Whole blood gene expression testing for coronary artery disease in nondiabetic patients: major adverse cardiovascular events and interventions in the PREDICT trial.

Journal Article J Cardiovasc Transl Res · June 2012 The majority of first-time angiography patients are without obstructive coronary artery disease (CAD). A blood gene expression score (GES) for obstructive CAD likelihood was validated in the PREDICT study, but its relation to major adverse cardiovascular e ... Full text Link to item Cite

Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility.

Journal Article Cell Metab · May 2, 2012 The concept of "metabolic inflexibility" was first introduced to describe the failure of insulin-resistant human subjects to appropriately adjust mitochondrial fuel selection in response to nutritional cues. This phenomenon has since gained increasing reco ... Full text Link to item Cite

Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease.

Journal Article Am Heart J · May 2012 BACKGROUND: Cardiovascular risk models remain incomplete. Small-molecule metabolites may reflect underlying disease and, as such, serve as novel biomarkers of cardiovascular risk. METHODS: We studied 2,023 consecutive patients undergoing cardiac catheteriz ... Full text Link to item Cite

Functional Outcomes of Exercise Progression Models in the Elderly

Journal Article MEDICINE AND SCIENCE IN SPORTS AND EXERCISE · May 1, 2012 Link to item Cite

Changes in Peripheral and Central Blood Pressure following Regional Specific Exercise

Journal Article MEDICINE AND SCIENCE IN SPORTS AND EXERCISE · May 1, 2012 Link to item Cite

The Relation Between The Blodd Pressure Response To Exercise During Training And Detraining Periods

Journal Article MEDICINE AND SCIENCE IN SPORTS AND EXERCISE · May 1, 2012 Link to item Cite

Metabolic profiles predict adverse events after coronary artery bypass grafting.

Journal Article J Thorac Cardiovasc Surg · April 2012 OBJECTIVE: Clinical models incompletely predict the outcomes after coronary artery bypass grafting. Novel molecular technologies can identify biomarkers to improve risk stratification. We examined whether metabolic profiles can predict adverse events in pa ... Full text Link to item Cite

Alteration in angiogenic and anti-angiogenic forms of vascular endothelial growth factor-A in skeletal muscle of patients with intermittent claudication following exercise training.

Journal Article Vasc Med · April 2012 The aims of this study were twofold: (1) to identify whether peripheral artery disease (PAD) patients had increased muscle concentration of angiogenic VEGF-A, anti-angiogenic VEGF₁₆₅b or VEGF receptor 1 (VEGF-R1) when compared with control subjects, and (2 ... Full text Link to item Cite

A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.

Journal Article Circ Cardiovasc Genet · April 1, 2012 BACKGROUND: Recent genome-wide association studies (GWAS) have identified several novel loci that reproducibly associate with coronary artery disease (CAD) and/or myocardial infarction risk. However, known common CAD risk variants explain only 10% of the p ... Full text Link to item Cite

Exercise dose response in muscle.

Journal Article Int J Sports Med · March 2012 Exercise increases peak VO2 partially through muscle adaptations. However, understanding muscle adaptations related to exercise dose is incomplete. This study investigated exercise training dose on capillaries per fiber and capillaries per area; and citrat ... Full text Link to item Cite

Fine mapping of a linkage peak with integration of lipid traits identifies novel coronary artery disease genes on chromosome 5.

Journal Article BMC Genet · February 27, 2012 BACKGROUND: Coronary artery disease (CAD), and one of its intermediate risk factors, dyslipidemia, possess a demonstrable genetic component, although the genetic architecture is incompletely defined. We previously reported a linkage peak on chromosome 5q31 ... Full text Link to item Cite

Approaches for quantifying energy intake and %calorie restriction during calorie restriction interventions in humans: the multicenter CALERIE study.

Journal Article Am J Physiol Endocrinol Metab · February 15, 2012 Calorie restriction (CR) is a component of most weight loss interventions and a potential strategy to slow aging. Accurate determination of energy intake and %CR is critical when interpreting the results of CR interventions; this is most accurately achieve ... Full text Link to item Cite

Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.

Journal Article PLoS One · 2012 OBJECTIVES: To determine if caloric restriction (CR) would cause changes in plasma metabolic intermediates in response to a mixed meal, suggestive of changes in the capacity to adapt fuel oxidation to fuel availability or metabolic flexibility, and to dete ... Full text Open Access Link to item Cite

Factors related to morbidity and mortality in patients with chronic heart failure with systolic dysfunction: the HF-ACTION predictive risk score model.

Journal Article Circ Heart Fail · January 2012 BACKGROUND: We aimed to develop a multivariable statistical model for risk stratification in patients with chronic heart failure with systolic dysfunction, using patient data that are routinely collected and easily obtained at the time of initial presentat ... Full text Link to item Cite

Critical appraisal of four IL-6 immunoassays.

Journal Article PLoS One · 2012 BACKGROUND: Interleukin-6 (IL-6) contributes to numerous inflammatory, metabolic, and physiologic pathways of disease. We evaluated four IL-6 immunoassays in order to identify a reliable assay for studies of metabolic and physical function. Serial plasma s ... Full text Open Access Link to item Cite

Adverse metabolic response to regular exercise: is it a rare or common occurrence?

Journal Article PLoS One · 2012 BACKGROUND: Individuals differ in the response to regular exercise. Whether there are people who experience adverse changes in cardiovascular and diabetes risk factors has never been addressed. METHODOLOGY/PRINCIPAL FINDINGS: An adverse response is defined ... Full text Link to item Cite

Extant health behaviors and uptake of standardized vs tailored health messages among cancer survivors enrolled in the FRESH START trial: a comparison of fighting-spirits vs fatalists.

Journal Article Psychooncology · January 2012 OBJECTIVE: Cancer coping styles have been associated with several cancer-related outcomes. We examined whether baseline lifestyle behaviors differed between cancer survivors with fatalistic vs fighting-spirit coping styles, and whether there was differenti ... Full text Link to item Cite

Relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults.

Journal Article J Gerontol A Biol Sci Med Sci · December 2011 BACKGROUND: We wished to determine if a marker of endothelial dysfunction/activation soluble vascular cell adhesion molecule (s-VCAM)-was related to functional status and mortality in community-dwelling older adults independent of the known effects of mark ... Full text Link to item Cite

Effect of heparin administration on metabolomic profiles in samples obtained during cardiac catheterization.

Journal Article Circ Cardiovasc Genet · December 2011 BACKGROUND: Metabolic profiling holds promise for early detection of coronary artery disease and assessing risk for ischemic events. Heparin is frequently administered (1) to treat acute coronary syndromes; and (2) during routine cardiac catheterization pr ... Full text Link to item Cite

Exercise among breast and prostate cancer survivors--what are their barriers?

Journal Article J Cancer Surviv · December 2011 INTRODUCTION: Despite proven benefits of regular physical activity, estimates indicate that few cancer survivors meet physical activity guidelines. The purpose of this paper is to identify and compare exercise barriers among cancer survivors, both cross-se ... Full text Link to item Cite

Exercise in Heart Failure

Journal Article · December 1, 2011 Full text Cite

Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population.

Journal Article Clin Chim Acta · November 20, 2011 BACKGROUND: Red cell distribution width (RDW) is associated with morbidity and mortality in coronary artery disease (CAD), but the connection of RDW with chronic inflammation is equivocal. METHODS: In 1,489 patients with CAD and 8.4-15.2 years of follow-up ... Full text Link to item Cite

Angiogenesis in skeletal muscle precede improvements in peak oxygen uptake in peripheral artery disease patients.

Journal Article Arterioscler Thromb Vasc Biol · November 2011 OBJECTIVE: Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities, causing claudication and exercise intolerance. The mechanism(s) by which exercise training improves functional capacity is not understood. This stu ... Full text Link to item Cite

Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT.

Journal Article Am J Physiol Endocrinol Metab · November 2011 While the benefits of exercise are clear, many unresolved issues surround the optimal exercise prescription. Many organizations recommend aerobic training (AT) and resistance training (RT), yet few studies have compared their effects alone or in combinatio ... Full text Link to item Cite

Metabolic deterioration of the sedentary control group in clinical trials.

Journal Article J Appl Physiol (1985) · October 2011 Randomized clinical trials of exercise training regimens in sedentary individuals have provided a mechanistic understanding of the long-term health benefits and consequences of physical activity and inactivity. The sedentary control periods from these tria ... Full text Link to item Cite

Comparison of aerobic versus resistance exercise training effects on metabolic syndrome (from the Studies of a Targeted Risk Reduction Intervention Through Defined Exercise - STRRIDE-AT/RT).

Journal Article Am J Cardiol · September 15, 2011 Aerobic training (AT) improves the metabolic syndrome (MS) and its component risk factors; however, to our knowledge, no randomized clinical studies have addressed whether resistance training (RT) improves the MS when performed alone or combined with AT. S ... Full text Link to item Cite

Effects of an 8-month exercise training program on off-exercise physical activity.

Journal Article Med Sci Sports Exerc · September 2011 PURPOSE: An active lifestyle is widely recognized as having a beneficial effect on cardiovascular health. However, no clear consensus exists as to whether exercise training increases overall physical activity energy expenditure (PAEE) or whether individual ... Full text Link to item Cite

Effect of peripheral arterial disease on functional and clinical outcomes in patients with heart failure (from HF-ACTION).

Journal Article Am J Cardiol · August 1, 2011 Patients with peripheral arterial disease (PAD) have lower functional capacity and worse clinical outcomes than age- and gender-matched patients. Few data exist on the relation of PAD to functional and clinical outcomes in patients with heart failure (HF). ... Full text Link to item Cite

Resource Use and Medical Costs by Cause of Death in HF-ACTION

Journal Article Journal of Cardiac Failure · August 2011 Full text Cite

Relationship between leg muscle capillary density and peak hyperemic blood flow with endurance capacity in peripheral artery disease.

Journal Article J Appl Physiol (1985) · July 2011 The aim of this study was to determine if skeletal muscle capillary density is lower in patients with peripheral artery disease (PAD) and if capillary density relates to functional limitations. PAD patients with intermittent claudication (IC) have a decrea ... Full text Link to item Cite

Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system.

Journal Article Diabetes · July 2011 OBJECTIVE: Adipocyte infiltration of the musculoskeletal system is well recognized as a hallmark of aging, obesity, and type 2 diabetes. Intermuscular adipocytes might serve as a benign storage site for surplus lipid or play a role in disrupting energy hom ... Full text Link to item Cite

Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease.

Journal Article Hum Genet · June 2011 Tenascin-C (TNC) is an extracellular matrix protein implicated in biological processes important for atherosclerotic plaque development and progression, including smooth muscle cell migration and proliferation. Previously, we observed differential expressi ... Full text Link to item Cite

Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.

Journal Article J Appl Physiol (1985) · June 2011 Peripheral arterial disease (PAD) results in a failure to adequately supply blood and oxygen (O(2)) to working tissues and presents as claudication pain during walking. Nitric oxide (NO) bioavailability is essential for vascular health and function. Plasma ... Full text Link to item Cite

Relationship of technetium-99m tetrofosmin-gated rest single-photon emission computed tomography myocardial perfusion imaging to death and hospitalization in heart failure patients: results from the nuclear ancillary study of the HF-ACTION trial.

Journal Article Am Heart J · June 2011 BACKGROUND: We hypothesized that the severity of resting perfusion abnormalities assessed by the summed rest score (SRS) would be associated with a higher rate of adverse outcomes in patients with heart failure (HF) and reduced left ventricular (LV) ejecti ... Full text Link to item Cite

The 1p13.3 LDL (C)-associated locus shows large effect sizes in young populations.

Journal Article Pediatr Res · June 2011 Genome-wide association studies (GWASs) have identified polymorphic loci associated with coronary artery disease (CAD) risk factors (i.e. serum lipids) in adult populations (42-69 y). We hypothesized that younger populations would show a greater relative g ... Full text Link to item Cite

Increased Plasma Nitrite Enhances Exercise Performance in PAD:-A Nitric Oxide Effect?

Journal Article Medicine & Science in Sports & Exercise · May 2011 Full text Cite

Plasma acylcarnitines are associated with physical performance in elderly men.

Journal Article J Gerontol A Biol Sci Med Sci · May 2011 BACKGROUND: Metabolic profiling might provide insight into the biologic underpinnings of disability in older adults. METHODS: A targeted mass spectrometry-based platform was used to identify and quantify 45 plasma acylcarnitines in 77 older men with a mean ... Full text Link to item Cite

Genomic predictors of the maximal O₂ uptake response to standardized exercise training programs.

Journal Article J Appl Physiol (1985) · May 2011 Low cardiorespiratory fitness is a powerful predictor of morbidity and cardiovascular mortality. In 473 sedentary adults, all whites, from 99 families of the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family Study, the heritability of ... Full text Link to item Cite

Effect of calorie restriction on the free-living physical activity levels of nonobese humans: results of three randomized trials.

Journal Article J Appl Physiol (1985) · April 2011 The objective of this study was to evaluate the influence of calorie restriction (CR) on free-living physical activity levels among humans. Data were from three CALERIE phase I site-specific protocols. Participants were nonobese (body mass index = 23.5-29. ... Full text Link to item Cite

Development of adherence metrics for caloric restriction interventions.

Journal Article Clin Trials · April 2011 BACKGROUND: objective measures are needed to quantify dietary adherence during caloric restriction (CR) while participants are freeliving. One method to monitor adherence is to compare observed weight loss to the expected weight loss during a prescribed le ... Full text Link to item Cite

Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients.

Journal Article BMC Med Genomics · March 28, 2011 BACKGROUND: Alterations in gene expression in peripheral blood cells have been shown to be sensitive to the presence and extent of coronary artery disease (CAD). A non-invasive blood test that could reliably assess obstructive CAD likelihood would have dia ... Full text Open Access Link to item Cite

A common variant in the CDKN2B gene on chromosome 9p21 protects against coronary artery disease in Americans of African ancestry.

Journal Article J Hum Genet · March 2011 A 58 kb region on chromosome 9p21.3 has consistently shown strong association with coronary artery disease (CAD) in multiple genome-wide association studies in populations of European and East Asian ancestry. In this study, we sought to further characteriz ... Full text Link to item Cite

Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women.

Journal Article J Clin Endocrinol Metab · February 2011 OBJECTIVES: The objective of the study was to evaluate whether serum concentrations of metabolic intermediates are related to adiposity and insulin sensitivity (Si) in overweight healthy subjects and compare changes in metabolic intermediates with similar ... Full text Link to item Cite

AKT1 polymorphisms are associated with risk for metabolic syndrome.

Journal Article Hum Genet · February 2011 Converging lines of evidence suggest that AKT1 is a major mediator of the responses to insulin,insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. We hypothesized that ... Full text Link to item Cite

Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity.

Journal Article Diabetes Care · January 2011 OBJECTIVE: To understand relationships between exercise training-mediated improvements in insulin sensitivity (S(I)) and changes in circulating concentrations of metabolic intermediates, hormones, and inflammatory mediators. RESEARCH DESIGN AND METHODS: Ta ... Full text Open Access Link to item Cite

Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy.

Journal Article J Gerontol A Biol Sci Med Sci · January 2011 BACKGROUND: In a robust and consistent manner, sustained caloric restriction (CR) has been shown to retard the aging process in a variety of animal species. Nonhuman primate studies suggest that CR may have similar effects in longer-lived species. The CALE ... Full text Link to item Cite

Effect of microRNA modulation on bioartificial muscle function.

Journal Article Tissue Eng Part A · December 2010 Cellular therapies have recently employed the use of small RNA molecules, particularly microRNAs (miRNAs), to regulate various cellular processes that may be altered in disease states. In this study, we examined the effect of transient muscle-specific miRN ... Full text Open Access Link to item Cite

Exercise in Heart Failure

Chapter · November 11, 2010 Full text Cite

Myostatin decreases with aerobic exercise and associates with insulin resistance.

Journal Article Med Sci Sports Exerc · November 2010 PURPOSE: There is mounting evidence that skeletal muscle produces and secretes biologically active proteins or "myokines" that facilitate metabolic cross talk between organ systems. The increased expression of myostatin, a secreted anabolic inhibitor of mu ... Full text Link to item Cite

Rationale and design of the Exercise Intensity Trial (EXCITE): A randomized trial comparing the effects of moderate versus moderate to high-intensity aerobic training in women with operable breast cancer.

Journal Article BMC Cancer · October 6, 2010 BACKGROUND: The Exercise Intensity Trial (EXcITe) is a randomized trial to compare the efficacy of supervised moderate-intensity aerobic training to moderate to high-intensity aerobic training, relative to attention control, on aerobic capacity, physiologi ... Full text Open Access Link to item Cite

Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients.

Journal Article Ann Intern Med · October 5, 2010 BACKGROUND: Diagnosing obstructive coronary artery disease (CAD) in at-risk patients can be challenging and typically requires both noninvasive imaging methods and coronary angiography, the gold standard. Previous studies have suggested that peripheral blo ... Full text Link to item Cite

Accuracy of self-reported height and weight in a community-based sample of older African Americans and whites.

Journal Article J Gerontol A Biol Sci Med Sci · October 2010 BACKGROUND: To ascertain accuracy of self-reported height, weight (and hence body mass index) in African American and white women and men older than 70 years of age. METHOD: The sample consisted of cognitively intact participants at the third in-person wav ... Full text Link to item Cite

Reclassification of cardiovascular risk using integrated clinical and molecular biosignatures: Design of and rationale for the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Horizon 1 Cardiovascular Disease Study.

Journal Article Am Heart J · September 2010 BACKGROUND: Clinical predictive models leave gaps in our ability to stratify cardiovascular risk. High-throughput molecular profiling promises to improve risk classification. METHODS: Horizon 1 of the Measurement to Understand the Reclassification of Disea ... Full text Link to item Cite

Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies.

Journal Article Hum Mol Genet · July 15, 2010 Aging is believed to be among the most important contributors to atherosclerosis, through mechanisms that remain largely obscure. Serum levels of tumor necrosis factor (TNF) rise with aging and have been correlated with the incidence of myocardial infarcti ... Full text Open Access Link to item Cite

ACTN3 Genotype Effects on Skeletal Muscle Gene Expression

Conference Medicine & Science in Sports & Exercise · May 2010 Full text Cite

The 1p13.3 LDL-Associated Locus Shows Large Effect Sizes in Young Populations

Conference Medicine & Science in Sports & Exercise · May 2010 Full text Cite

The lung cancer exercise training study: a randomized trial of aerobic training, resistance training, or both in postsurgical lung cancer patients: rationale and design.

Journal Article BMC Cancer · April 21, 2010 BACKGROUND: The Lung Cancer Exercise Training Study (LUNGEVITY) is a randomized trial to investigate the efficacy of different types of exercise training on cardiorespiratory fitness (VO2peak), patient-reported outcomes, and the organ components that gover ... Full text Open Access Link to item Cite

Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events.

Journal Article Circ Cardiovasc Genet · April 2010 BACKGROUND: Molecular tools may provide insight into cardiovascular risk. We assessed whether metabolites discriminate coronary artery disease (CAD) and predict risk of cardiovascular events. METHODS AND RESULTS: We performed mass-spectrometry-based profil ... Full text Open Access Link to item Cite

Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family.

Journal Article Arthritis Rheum · March 2010 OBJECTIVE: The genetic contributions to the multifactorial disorder osteoarthritis (OA) have been increasingly recognized. The goal of the current study was to use OA-related biomarkers of severity and disease burden as quantitative traits to identify gene ... Full text Link to item Cite

Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma.

Journal Article Cancer · February 1, 2010 BACKGROUND: The study was undertaken to evaluate cardiorespiratory fitness, skeletal muscle function, and body composition of patients with newly diagnosed and untreated, postsurgical primary malignant glioma. METHODS: By using a cross-sectional design, pa ... Full text Link to item Cite

The 2008 Physical Activity Guidelines for Americans: Implications for Clinical and Public Health Practice

Journal Article American Journal of Lifestyle Medicine · January 1, 2010 The US government released its first formal recommendations on physical activity, the Physical Activity Guidelines for Americans, in 2008. By issuing the guidelines, the government has established increased physical activity as a major societal health targ ... Full text Cite

Enhancing standard cardiac rehabilitation with stress management training: background, methods, and design for the enhanced study.

Journal Article J Cardiopulm Rehabil Prev · 2010 PURPOSE: Enhancing Standard Cardiac Rehabilitation with Stress Management Training in Patients with Heart Disease (ENHANCED) is a randomized clinical trial funded by the National Heart Lung and Blood Institute to evaluate the effects of stress management t ... Full text Link to item Cite

Changes in functional performance measures in adults undergoing chemoradiation for primary malignant glioma: a feasibility study.

Journal Article Oncologist · 2010 PURPOSE: To investigate the feasibility of longitudinal assessment of functional performance measures in newly diagnosed postsurgical malignant glioma patients. METHODS: Patients with histologically confirmed, clinically stable, postsurgical, and previousl ... Full text Link to item Cite

Exercise training, lipid regulation, and insulin action: a tangled web of cause and effect.

Journal Article Obesity (Silver Spring) · December 2009 Lipids are a strong mediator of coronary artery disease and cardiovascular risk. Although the effects of exercise to improve high-density lipoprotein (HDL) cholesterol and serum triglycerides (TGs) have been known for some time, the effects of different am ... Full text Link to item Cite

Exercise, abdominal obesity, skeletal muscle, and metabolic risk: evidence for a dose response.

Journal Article Obesity (Silver Spring) · December 2009 The obese are at increased risk for cardiovascular disease and type 2 diabetes. However, some who are obese have no metabolic abnormalities. So, it is not adipose tissue per se, but perhaps where it is located that is important for determining metabolic co ... Full text Link to item Cite

Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking.

Journal Article Ann Hum Genet · November 2009 The CATHGEN study reported associations of chromosome 3q13-21 genes (KALRN, MYLK, CDGAP, and GATA2) with early-onset coronary artery disease (CAD). This study attempted to independently validate those associations. Eleven single nucleotide polymorphisms (S ... Full text Link to item Cite

Rationale and design of the Duke Electrophysiology Genetic and Genomic Studies (EPGEN) biorepository.

Journal Article Am Heart J · November 2009 BACKGROUND: Disturbances in cardiac rhythm can lead to significant morbidity and mortality. Many arrhythmias are known to have a heritable component, but the degree to which genetic variation contributes to disease risk and morbidity is poorly understood. ... Full text Link to item Cite

Effects of exercise training intensity on pancreatic beta-cell function.

Journal Article Diabetes Care · October 2009 OBJECTIVE: Insulin resistance and beta-cell dysfunction both are important contributors to the pathogenesis of type 2 diabetes. Exercise training improves insulin sensitivity, but its effects on beta-cell function are less well studied. RESEARCH DESIGN AND ... Full text Link to item Cite

Myocardial perfusion, function, and dyssynchrony in patients with heart failure: baseline results from the single-photon emission computed tomography imaging ancillary study of the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION) Trial.

Journal Article Am Heart J · October 2009 BACKGROUND: There are currently limited data on the relationships between resting perfusion abnormalities, left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) functional class, and exercise capacity as defined by peak VO(2) and 6-m ... Full text Link to item Cite

N-terminal pro-brain natriuretic peptide and exercise capacity in chronic heart failure: data from the Heart Failure and a Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) study.

Journal Article Am Heart J · October 2009 OBJECTIVES: To examine the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) and exercise capacity in a large contemporary cohort of patients with chronic heart failure. BACKGROUND: Natriuretic peptides such as NT-proBNP are importa ... Full text Link to item Cite

Relationship of age and exercise performance in patients with heart failure: the HF-ACTION study.

Journal Article Am Heart J · October 2009 BACKGROUND: More than three fourths of patients with heart failure (HF) are 65 years and older, and older age is associated with worse symptoms and prognoses than is younger age. Reduced exercise capacity is a chief HF complaint and indicates poorer progno ... Full text Link to item Cite

Safety of symptom-limited cardiopulmonary exercise testing in patients with chronic heart failure due to severe left ventricular systolic dysfunction.

Journal Article Am Heart J · October 2009 BACKGROUND: To assess the safety of symptom-limited exercise testing in patients with New York Heart Association class II-IV heart failure symptoms due to left ventricular systolic dysfunction, we investigated the frequency of all-cause fatal and nonfatal ... Full text Link to item Cite

Method for establishing authorship in a multicenter clinical trial.

Journal Article Ann Intern Med · September 15, 2009 With the emergence of large multicenter trials over the past 20 years, the numbers of investigators involved and publications resulting from each study have grown exponentially. An efficient, fair, and effective way to establish authorship on study-related ... Full text Link to item Cite

Gene expression patterns in peripheral blood correlate with the extent of coronary artery disease.

Journal Article PLoS One · September 14, 2009 Systemic and local inflammation plays a prominent role in the pathogenesis of atherosclerotic coronary artery disease, but the relationship of whole blood gene expression changes with coronary disease remains unclear. We have investigated whether gene expr ... Full text Link to item Cite

Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women.

Journal Article Diabetes Care · September 2009 OBJECTIVE: To determine whether circulating metabolic intermediates are related to insulin resistance and beta-cell dysfunction in individuals at risk for type 2 diabetes. RESEARCH DESIGN AND METHODS: In 73 sedentary, overweight to obese, dyslipidemic indi ... Full text Link to item Cite

Effects of exercise training amount on physical activity energy expenditure.

Journal Article Med Sci Sports Exerc · August 2009 INTRODUCTION: We examined the effects of three exercise training interventions on total physical activity energy expenditure (PAEE) or nonexercise PAEE in a randomized controlled trial where sedentary, overweight, and obese men and women were assigned to i ... Full text Link to item Cite

Comparing the 7-day physical activity recall with a triaxial accelerometer for measuring time in exercise.

Journal Article Med Sci Sports Exerc · June 2009 PURPOSE: The primary study aim was to evaluate associations of estimated weekly minutes of moderate-to-vigorous-intensity exercise from self-reports of the telephone-administered 7-Day Physical Activity Recall (7-Day PAR) with data captured by the RT3 tria ... Full text Link to item Cite

Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial.

Journal Article JAMA · April 8, 2009 CONTEXT: Findings from previous studies of the effects of exercise training on patient-reported health status have been inconsistent. OBJECTIVE: To test the effects of exercise training on health status among patients with heart failure. DESIGN, SETTING, A ... Full text Link to item Cite

Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial.

Journal Article JAMA · April 8, 2009 CONTEXT: Guidelines recommend that exercise training be considered for medically stable outpatients with heart failure. Previous studies have not had adequate statistical power to measure the effects of exercise training on clinical outcomes. OBJECTIVE: To ... Full text Link to item Cite

A sex-specific relationship between capillary density and anaerobic threshold.

Journal Article J Appl Physiol (1985) · April 2009 Although both capillary density and peak oxygen consumption (Vo(2)) improve with exercise training, it is difficult to find a relationship between these two measures. It has been suggested that peak Vo(2) may be more related to central hemodynamics than to ... Full text Link to item Cite

Effect of exercise intensity and volume on persistence of insulin sensitivity during training cessation.

Journal Article J Appl Physiol (1985) · April 2009 The purpose of this study was to determine whether exercise prescriptions differing in volume or intensity also differ in their ability to retain insulin sensitivity during an ensuing period of training cessation. Sedentary, overweight/obese subjects were ... Full text Link to item Cite

A Multivariable Model From HF-ACTION Predicting Peak VO2 in a Heart Failure Population

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 10, 2009 Link to item Cite

Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.

Journal Article Hum Genet · March 2009 Leukotrienes are arachidonic acid derivatives long known for their inflammatory properties and their involvement with a number of human diseases, most particularly asthma. Recently, leukotriene-based inflammation has also been shown to play an important ro ... Full text Link to item Cite

Effects of exercise on lipoprotein particles in women with polycystic ovary syndrome.

Journal Article Med Sci Sports Exerc · March 2009 PURPOSE: Women with polycystic ovary syndrome (PCOS) commonly have insulin resistance. Insulin resistance is associated with marked abnormalities of lipoprotein size and subclass particle concentration. The purpose of this study was to examine the effects ... Full text Link to item Cite

Sex-specific alterations in mRNA level of key lipid metabolism enzymes in skeletal muscle of overweight and obese subjects following endurance exercise.

Journal Article Physiol Genomics · February 2, 2009 Endurance exercise (EE) leads to beneficial alterations in skeletal muscle lipid metabolism in overweight and obese individuals; however, the mechanisms of these improvements are poorly understood. The primary goal of the current investigation was to test ... Full text Link to item Cite

High heritability of metabolomic profiles in families burdened with premature cardiovascular disease.

Journal Article Mol Syst Biol · 2009 Integration of genetic and metabolic profiling holds promise for providing insight into human disease. Coronary artery disease (CAD) is strongly heritable, but the heritability of metabolomic profiles has not been evaluated in humans. We performed quantita ... Full text Link to item Cite

Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis.

Journal Article PLoS Genet · January 2009 Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). We have previously identified genetic linkage to familial CAD in the genomic region of NPY. We performed follow-up genetic, biostatistical, and functional analysis of NPY in ... Full text Open Access Link to item Cite

Safety and feasibility of aerobic training on cardiopulmonary function and quality of life in postsurgical nonsmall cell lung cancer patients: a pilot study.

Journal Article Cancer · December 15, 2008 BACKGROUND: A feasibility study examining the effects of supervised aerobic exercise training on cardiopulmonary and quality of life (QOL) endpoints among postsurgical nonsmall cell lung cancer (NSCLC) patients was conducted. METHODS: Using a single-group ... Full text Link to item Cite

ALOX5AP variants are associated with in-stent restenosis after percutaneous coronary intervention.

Journal Article Atherosclerosis · November 2008 BACKGROUND: Use of drug-eluting stents (DES) has reduced in-stent restenosis after percutaneous coronary intervention (PCI); however, DES are associated with late stent thrombosis. There is no accurate way to predict in-stent restenosis, although risk fact ... Full text Link to item Cite

Cancer survivors' health worries and associations with lifestyle practices.

Journal Article J Health Psychol · November 2008 This study examined among recently diagnosed breast and prostate cancer survivors (N = 678) associations between worry about a future diagnosis of heart disease or cancer and hypothetical and actual adherence to exercise and dietary guidelines. Greater wor ... Full text Link to item Cite

Change in self-efficacy partially mediates the effects of the FRESH START intervention on cancer survivors' dietary outcomes.

Journal Article Psychooncology · October 2008 OBJECTIVE: This study examined change in self-efficacy as a mediator of the effects of a mailed print intervention on the dietary and exercise practices of newly diagnosed breast and prostate cancer survivors. METHOD: A total of 543 breast and prostate can ... Full text Link to item Cite

Correlation of peripheral-blood gene expression with the extent of coronary artery stenosis.

Journal Article Circ Cardiovasc Genet · October 2008 BACKGROUND: The molecular pathophysiology of coronary artery disease (CAD) includes cytokine release and a localized inflammatory response within the vessel wall. The extent to which CAD and its severity is reflected by gene expression in circulating cells ... Full text Link to item Cite

Reproducibility of peak oxygen uptake and other cardiopulmonary exercise testing parameters in patients with heart failure (from the Heart Failure and A Controlled Trial Investigating Outcomes of exercise traiNing).

Journal Article Am J Cardiol · September 15, 2008 Peak oxygen uptake (pVo2) is an important parameter in assessing the functional capacity and prognosis of patients with heart failure. In heart failure trials, change in pVo2 was often used to assess the effectiveness of an intervention. However, the withi ... Full text Link to item Cite

Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol.

Journal Article J Am Coll Cardiol · August 19, 2008 OBJECTIVES: This study investigated the role of adrenergic receptor genetics on transplant-free survival in heart failure (HF). BACKGROUND: Discordant results exist for genetic associations between adrenergic receptor alleles and end points of beta-blocker ... Full text Link to item Cite

Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women.

Journal Article Aging Clin Exp Res · August 2008 BACKGROUND AND AIMS: There are no data showing whether or not age-related declines in physical function are related to in vitro properties of human skeletal muscle. The purpose of this study was to determine whether physical function is independently assoc ... Full text Link to item Cite

Relationships between exercise-induced reductions in thigh intermuscular adipose tissue, changes in lipoprotein particle size, and visceral adiposity.

Journal Article Am J Physiol Endocrinol Metab · August 2008 Small LDL and HDL particle size are characteristic of a proatherogenic lipoprotein profile. Aerobic exercise increases these particle sizes. Although visceral adipose tissue (VAT) has been strongly linked with dyslipidemia, the importance of intermuscular ... Full text Link to item Cite

Impact of hormone replacement therapy on exercise training-induced improvements in insulin action in sedentary overweight adults.

Journal Article Metabolism · July 2008 Exercise training (ET) and hormone replacement therapy (HRT) are both recognized influences on insulin action, but the influence of HRT on responses to ET has not been examined. To determine if HRT use provided additive benefits for the response of insulin ... Full text Link to item Cite

Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease.

Journal Article Ann Hum Genet · July 2008 Previous association mapping on chromosome 3q13-21 detected evidence for association at the limbic system-associated membrane protein (LSAMP) gene in individuals with late-onset coronary artery disease (CAD). LSAMP has never been implicated in the pathogen ... Full text Link to item Cite

Differences in baseline characteristics and outcomes at 1- and 2-year follow-up of cancer survivors accrued via self-referral versus cancer registry in the FRESH START Diet and exercise trial.

Journal Article Cancer Epidemiol Biomarkers Prev · May 2008 Participant accrual to research studies is a challenge; oftentimes, advertisements are used to supplement cases ascertained through clinic caseloads and cancer registries. It is unknown, however, if cases ascertained through these two sources differ. In th ... Full text Link to item Cite

Chronic heart failure and exercise intolerance: the hemodynamic paradox.

Journal Article Curr Cardiol Rev · May 2008 Heart failure represents a major source of morbidity and mortality in industrialized nations. As the leading hospital discharge diagnosis in the United States in patients over the age of 65, it is also associated with substantial economic costs. While the ... Full text Link to item Cite

Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets.

Journal Article Hum Mol Genet · May 1, 2008 Platelet-activating factor acetylhydrolase (PLA2G7) is a potent pro- and anti-inflammatory molecule that has been implicated in multiple inflammatory disease processes, including cardiovascular disease. The goal of this study was to investigate the genetic ... Full text Link to item Cite

Genetic and functional association of FAM5C with myocardial infarction.

Journal Article BMC Med Genet · April 22, 2008 BACKGROUND: We previously identified a 40 Mb region of linkage on chromosome 1q in our early onset coronary artery disease (CAD) genome-wide linkage scan (GENECARD) with modest evidence for linkage (n = 420, LOD 0.95). When the data are stratified by acute ... Full text Link to item Cite

Relationships between adipose tissue and cytokine responses to a randomized controlled exercise training intervention.

Journal Article Metabolism · April 2008 Adipose-derived cytokines play a prominent role in mediating the metabolic consequences of obesity and excess body fat. Given this, we hypothesized that alterations in adipose tissue stores incurred with exercise training would be reflected in changes in s ... Full text Link to item Cite

Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy.

Journal Article Clin Breast Cancer · February 2008 PURPOSE: Patients with breast cancer on adjuvant chemotherapy can experience weight gain and concurrent losses in muscle mass. Exercise interventions can prevent these changes, but time and travel pose barriers to participation. The Survivor Training for E ... Full text Link to item Cite

Exercise training amount and intensity effects on metabolic syndrome (from Studies of a Targeted Risk Reduction Intervention through Defined Exercise).

Journal Article Am J Cardiol · December 15, 2007 Although exercise improves individual risk factors for metabolic syndrome (MS), there is little research on the effect of exercise on MS as a whole. The objective of this study was to determine how much exercise is recommended to decrease the prevalence of ... Full text Link to item Cite

Dietary carbohydrate intake and high-sensitivity C-reactive protein in at-risk women and men.

Journal Article Am Heart J · November 2007 BACKGROUND: The quality and quantity of dietary carbohydrate intake, measured as dietary glycemic load (GL), are associated with a number of cardiovascular disease (CVD) risk factors and, in healthy young women, are related to increased high-sensitivity C- ... Full text Link to item Cite

Increased levels of apoptosis in gastrocnemius skeletal muscle in patients with peripheral arterial disease.

Journal Article Vasc Med · November 2007 Intermittent claudication (IC) is the major clinical manifestation of peripheral arterial disease (PAD). Apoptosis has been linked to skeletal muscle pathophysiology in other chronic diseases such as congestive heart failure. This study tested the hypothes ... Full text Link to item Cite

Inactivity, exercise training and detraining, and plasma lipoproteins. STRRIDE: a randomized, controlled study of exercise intensity and amount.

Journal Article J Appl Physiol (1985) · August 2007 Exercise has beneficial effects on lipoproteins. Little is known about how long the effects persist with detraining or whether the duration of benefit is effected by training intensity or amount. Sedentary, overweight subjects (n = 240) were randomized to ... Full text Link to item Cite

Main outcomes of the FRESH START trial: a sequentially tailored, diet and exercise mailed print intervention among breast and prostate cancer survivors.

Journal Article J Clin Oncol · July 1, 2007 PURPOSE: Cancer survivors are at increased risk for cardiovascular disease, diabetes, osteoporosis, and second primary tumors. Healthful lifestyle practices may improve the health and well-being of survivors. The FRESH START trial tested the efficacy of se ... Full text Link to item Cite

Effect of exercise training on ventricular function, dyssynchrony, resting myocardial perfusion, and clinical outcomes in patients with heart failure: a nuclear ancillary study of Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION); design and rationale.

Journal Article Am Heart J · July 2007 BACKGROUND: Technetium Tc 99m gated single photon emission computed tomography (SPECT) has become the cornerstone of noninvasive risk stratification in patients with ischemic heart disease, but its role in patients with heart failure is not as well establi ... Full text Link to item Cite

Morphology and ultrastructure of differentiating three-dimensional mammalian skeletal muscle in a collagen gel.

Journal Article Muscle Nerve · July 2007 Because previous studies of three-dimensional skeletal muscle cultures have shown limited differentiation, the goal of this study was to establish conditions that would produce mature sarcomeres in a mammalian-derived skeletal muscle construct. We evaluate ... Full text Link to item Cite

Effect of cyclic stretch on beta1D-integrin expression and activation of FAK and RhoA.

Journal Article Am J Physiol Cell Physiol · June 2007 Integrins play a pivotal role in proliferation, differentiation, and survival in skeletal and cardiac myocytes. The beta(1D)-isoform of the beta(1)-integrin is specifically expressed in striated skeletal muscle. However, little is known about the role and ... Full text Link to item Cite

Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease.

Journal Article Am J Hum Genet · April 2007 A susceptibility locus for coronary artery disease (CAD) has been mapped to chromosome 3q13-21 in a linkage study of early-onset CAD. We completed an association-mapping study across the 1-LOD-unit-down supporting interval, using two independent white case ... Full text Link to item Cite

Minimal versus umbilical waist circumference measures as indicators of cardiovascular disease risk.

Journal Article Obesity (Silver Spring) · March 2007 OBJECTIVE: Measures of central obesity are strongly correlated with cardiovascular disease (CVD) risk. Although waist circumference (WC) is a commonly used measure of central obesity, there is no standard measurement location. We examined two WC locations ... Full text Link to item Cite

Heart failure and a controlled trial investigating outcomes of exercise training (HF-ACTION): design and rationale.

Journal Article Am Heart J · February 2007 BACKGROUND: Although there are limited clinical data to support the use of exercise training as a means to reduce mortality and morbidity in patients with heart failure, current guidelines state that exercise is beneficial. TRIAL DESIGN: The objective of t ... Full text Link to item Cite

Introduction

Chapter · 2007 Full text Cite

Modest exercise prevents the progressive disease associated with physical inactivity.

Journal Article Exerc Sport Sci Rev · January 2007 Activity levels continue to decline as technology continues to engineer movement out of our environment. We summarize the findings from Studies Targeting Risk Reduction Interventions through Defined Exercise (STRRIDE) emphasizing the high cost of even shor ... Full text Link to item Cite

Serum lipids in the GENECARD study of coronary artery disease identify quantitative trait loci and phenotypic subsets on chromosomes 3q and 5q.

Journal Article Ann Hum Genet · November 2006 Coronary artery disease (CAD) and dyslipidemia have strong genetic components. Heterogeneity complicates evaluating genetics of complex diseases such as CAD; incorporating disease-related phenotypes may help reduce heterogeneity. We hypothesized that incor ... Full text Link to item Cite

Response of high-sensitivity C-reactive protein to exercise training in an at-risk population.

Journal Article Am Heart J · October 2006 Featured Publication BACKGROUND: High-sensitivity C-reactive protein (hsCRP) is promoted as an independent predictor of atherosclerotic risk. In addition, cardiorespiratory fitness is inversely related to hsCRP in single-sex cross-sectional analyses. Our objective was to deter ... Full text Link to item Cite

Total nitrogen oxide following exercise testing reflects endothelial function and discriminates health status.

Journal Article Free Radic Biol Med · September 1, 2006 Nitric oxide (NO) bioavailability is important in vascular health, but unsuitable as a clinical measure due to biological oxidation. Total nitrogen oxides (NO(x)) are stable but background nitrate levels make it difficult to detect disease-based variation. ... Full text Link to item Cite

GATA2 is associated with familial early-onset coronary artery disease.

Journal Article PLoS Genet · August 25, 2006 Featured Publication The transcription factor GATA2 plays an essential role in the establishment and maintenance of adult hematopoiesis. It is expressed in hematopoietic stem cells, as well as the cells that make up the aortic vasculature, namely aortic endothelial cells and s ... Full text Link to item Cite

GATA2 is associated with familial early-onset coronary artery disease.

Journal Article PLoS genetics · August 25, 2006 The transcription factor GATA2 plays an essential role in the establishment and maintenance of adult hematopoiesis. It is expressed in hematopoietic stem cells, as well as the cells that make up the aortic vasculature, namely aortic endothelial cells and s ... Full text Cite

Obesity and physical activity: a review.

Journal Article Am Heart J · March 2006 Obesity has become a problem of epidemic proportions in the U.S., with nearly two thirds of American adults being either overweight or obese. Current data suggest that this trend remains on the rise and threatens many of the gains that have been made in th ... Full text Link to item Cite

The teachable moment following cancer diagnosis: the FRESH START trial.

Journal Article American Journal of Oncology Review · January 2006 no abstract available ... Cite

Effects of exercise training amount and intensity on peak oxygen consumption in middle-age men and women at risk for cardiovascular disease.

Journal Article Chest · October 2005 Featured Publication STUDY OBJECTIVES: Although increasing aerobic fitness by exercise training is advocated as part of a healthy lifestyle, studies examining the different effects of intensity and amount on peak consumption (V(O2)) remain sparse. DESIGN: This randomized contr ... Full text Link to item Cite

Inactivity, exercise, and visceral fat. STRRIDE: a randomized, controlled study of exercise intensity and amount.

Journal Article J Appl Physiol (1985) · October 2005 Featured Publication Despite the importance of randomized, dose-response studies for proper evaluation of effective clinical interventions, there have been no dose-response studies on the effects of exercise amount on abdominal obesity, a major risk factor for metabolic syndro ... Full text Link to item Cite

Where does fitness fit in?

Journal Article N Engl J Med · August 4, 2005 Full text Link to item Cite

Exercise and health: Can biotechnology confer similar Benefits?

Journal Article PLoS Medicine · May 18, 2005 Summary and Conclusions Long the province of physiologists who have contributed valuable insights in past decades, exercise science more recently has attracted the attention of molecular biologists, who have recognized the biological interest and medical i ... Full text Cite

Exercise and health: can biotechnology confer similar benefits?

Journal Article PLoS Med · March 2005 Education and public policies are largely failing to encourage people to exercise. Could our knowledge of exercise biology lead to pharmaceutical treaments that could confer the same benefits as exercise? ... Full text Link to item Cite

Metabolic syndrome: Recognition, etiology, and physical fitness as a component

Chapter · January 1, 2005 The general concept of the metabolic syndrome, which describes a clustering of metabolic abnormalities associated with increased risk of cardiovascular disease, diabetes, and hypertension, has been recognized for many years.1-4 Despite a definition of synd ... Cite

Exercise training increases electron and substrate shuttling proteins in muscle of overweight men and women with the metabolic syndrome.

Journal Article J Appl Physiol (1985) · January 2005 Featured Publication Aerobic conditioned muscle shows increased oxidative metabolism or glucose relative to untrained muscle at a given absolute exercise intensity. The studies of a targeted risk reduction intervention through defined exercise (STRRIDE) study is an aerobic exe ... Full text Link to item Cite

Gender and racial differences in lipoprotein subclass distributions: the STRRIDE study.

Journal Article Atherosclerosis · October 2004 Recent research has focused on the potential atherogenicity of various lipoprotein subclasses and their link to coronary heart disease (CHD) risk. This investigation seeks to identify differences in lipoprotein subclass distributions among a biracial, midd ... Full text Link to item Cite

Agreement between a brief mailed screener and an in-depth telephone survey: observations from the Fresh Start study.

Journal Article J Am Diet Assoc · October 2004 Brief screening instruments can roughly characterize individual behavior and target those most in need of change. However, the level of agreement between abbreviated and full-scale instruments is often unknown. We determined agreement between a brief scree ... Full text Link to item Cite

A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study.

Journal Article Am J Hum Genet · September 2004 Featured Publication A family history of coronary artery disease (CAD), especially when the disease occurs at a young age, is a potent risk factor for CAD. DNA collection in families in which two or more siblings are affected at an early age allows identification of genetic fa ... Full text Link to item Cite

Stretch-induced nitric oxide modulates mechanical properties of skeletal muscle cells.

Journal Article Am J Physiol Cell Physiol · August 2004 Featured Publication In this study, we examined the hypothesis that stretch-induced (nitric oxide) NO modulates the mechanical properties of skeletal muscles by increasing accumulation of protein levels of talin and vinculin and by inhibiting calpain-induced proteolysis, there ... Full text Link to item Cite

Effect of a 6-month endurance training program on fasting lactate.

Conference Medicine & Science in Sports & Exercise · May 2004 Full text Cite

The effect of the PREMIER interventions on insulin sensitivity.

Journal Article Diabetes Care · February 2004 OBJECTIVE: This ancillary study of PREMIER sought to determine the effects on insulin sensitivity of a comprehensive behavioral intervention for hypertension with and without the Dietary Approaches to Stop Hypertension (DASH) dietary pattern. RESEARCH DESI ... Full text Link to item Cite

Effects of the amount of exercise on body weight, body composition, and measures of central obesity: STRRIDE--a randomized controlled study.

Journal Article Arch Intern Med · January 12, 2004 BACKGROUND: Obesity is a major health problem due, in part, to physical inactivity. The amount of activity needed to prevent weight gain is unknown. OBJECTIVE: To determine the effects of different amounts and intensities of exercise training. DESIGN: Rand ... Full text Link to item Cite

Effect of the volume and intensity of exercise training on insulin sensitivity.

Journal Article J Appl Physiol (1985) · January 2004 Featured Publication Physical activity enhances insulin action in obese/overweight individuals. However, the exercise prescription required for the optimal enhancement is not known. The purpose of this study was to test the hypothesis that exercise training consisting of vigor ... Full text Link to item Cite

PGC-1alpha mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle.

Journal Article J Appl Physiol (1985) · January 2004 Endurance training leads to many adaptational changes in several tissues. In skeletal muscle, fatty acid usage is enhanced and mitochondrial content is increased. The exact molecular mechanisms regulating these functional and structural changes remain to b ... Full text Link to item Cite

Differential effects of exercise training in men and women with chronic heart failure.

Journal Article Am Heart J · May 2003 BACKGROUND: Abnormalities of myosin heavy chain (MHC) isoforms, enzyme activity, and capillarity contribute to the exercise intolerance that is characteristic of patients with heart failure. To what extent these changes can be reversed with exercise traini ... Full text Link to item Cite

The social context of gastrointestinal cancer pain: a preliminary study examining the relation of patient pain catastrophizing to patient perceptions of social support and caregiver stress and negative responses.

Journal Article Pain · May 2003 A number of studies have shown that catastrophizing is an important predictor of pain and disability in persons having persistent pain conditions. The newly developed communal model of catastrophizing maintains that catastrophizing is a part of broader, in ... Full text Link to item Cite

Skeletal muscle dictates the fibrinolytic state after exercise training in overweight men with characteristics of metabolic syndrome.

Journal Article J Physiol · April 15, 2003 While there is indisputable evidence supporting the beneficial role of aerobic exercise in reducing cardiovascular risk factors, there are few dose-response studies of this relationship. Increasingly, it is thought that the cardiovascular benefits of exerc ... Full text Link to item Cite

Effects of exercise on plasma lipoproteins.

Journal Article N Engl J Med · April 10, 2003 Full text Link to item Cite

Design of the Genetics of Early Onset Cardiovascular Disease (GENECARD) study.

Journal Article Am Heart J · April 2003 BACKGROUND: Coronary artery disease (CAD) is the leading cause of death and a leading cause of disability in the developed world. Early onset (premature) coronary artery disease (EOCAD) is known to have a particularly strong genetic component. However, the ... Full text Link to item Cite

Design of FRESH START: a randomized trial of exercise and diet among cancer survivors.

Journal Article Med Sci Sports Exerc · March 2003 PURPOSE: FRESH START is a randomized controlled trial that will test whether a personally tailored, distance-medicine-based program will increase exercise and fruit and vegetable consumption, and decrease fat intake of individuals recently diagnosed with b ... Full text Link to item Cite

The effects of the actin cytoskeleton on the transverse mechanical properties of skeletal muscle cells

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings · December 1, 2002 This study examined the contributions of actin filaments and actomyosin cytoskeleton to the transverse mechanical properties of skeletal muscle cells. The study is motivated by the goal of understanding the molecular mechanism behind skeletal myoblast tran ... Cite

Effects of the amount and intensity of exercise on plasma lipoproteins.

Journal Article N Engl J Med · November 7, 2002 Featured Publication BACKGROUND: Increased physical activity is related to reduced risk of cardiovascular disease, possibly because it leads to improvement in the lipoprotein profile. However, the amount of exercise training required for optimal benefit is unknown. In a prospe ... Full text Link to item Cite

Skeletal muscle abnormalities in chronic heart failure

Journal Article Cardiology Review · November 1, 2002 We compared 26 chronic heartfailure patients with 15 normal controls matchedfor age and aerobic capacity to determine whether the skeletal muscle abnormalities in patients with heartfailure are caused by deconditioning alone. Skeletal muscle characteristic ... Cite

Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation.

Journal Article Am J Physiol Cell Physiol · October 2002 The effect of differentiation on the transverse mechanical properties of mammalian myocytes was determined by using atomic force microscopy. The apparent elastic modulus increased from 11.5 +/- 1.3 kPa for undifferentiated myoblasts to 45.3 +/- 4.0 kPa aft ... Full text Link to item Cite

Adiponectin is not altered with exercise training despite enhanced insulin action.

Journal Article Am J Physiol Endocrinol Metab · October 2002 Adiponectin is an adipocytokine that is hypothesized to be involved in the regulation of insulin action. The purpose of the present investigation was to determine whether plasma adiponectin is altered in conjunction with enhanced insulin action with exerci ... Full text Link to item Cite

Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta.

Journal Article J Biol Chem · July 19, 2002 Featured Publication Ablation of peroxisome proliferator activated receptor (PPAR) alpha, a lipid-activated transcription factor that regulates expression of beta-oxidative genes, results in profound metabolic abnormalities in liver and heart. In the present study we used PPAR ... Full text Link to item Cite

Factors associated with patient-recalled smoking cessation advice in a low-income clinic.

Journal Article J Natl Med Assoc · May 2002 It is recommended that providers advise cessation to their patients who smoke. However, patients' reports of cessation advice indicate disparities based on patients' race, gender, age, and smoking level. Providers' reports do not corroborate these disparit ... Link to item Cite

Deconditioning fails to explain peripheral skeletal muscle alterations in men with chronic heart failure.

Journal Article J Am Coll Cardiol · April 3, 2002 Featured Publication It remains controversial whether the skeletal muscle alterations in chronic heart failure (CHF) are due to disease pathophysiology or result from chronic deconditioning. The purpose of this study was to compare the skeletal muscle of CHF patients to peak o ... Full text Link to item Cite

Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells.

Journal Article Diabetes · April 2002 Featured Publication In humans, skeletal muscle is a major site of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) expression, but its function in this tissue is unclear. We investigated the role of hPPAR-alpha in regulating muscle lipid utilization by studying t ... Full text Link to item Cite

Preventing sarcopenic obesity among breast cancer patients who receive adjuvant chemotherapy: results of a feasibility study.

Journal Article Clin Exerc Physiol · February 2002 PURPOSE: Weight gain is a common side effect of adjuvant chemotherapy for breast cancer - a side effect that decreases quality of life and also may decrease both disease-free and overall survival. This weight gain also is unique, since patients lose lean b ... Link to item Cite

Endothelial, cardiac muscle and skeletal muscle exhibit different viscous and elastic properties as determined by atomic force microscopy.

Journal Article J Biomech · December 2001 This study evaluated the hypothesis that, due to functional and structural differences, the apparent elastic modulus and viscous behavior of cardiac and skeletal muscle and vascular endothelium would differ. To accurately determine the elastic modulus, the ... Full text Link to item Cite

Studies of a targeted risk reduction intervention through defined exercise (STRRIDE).

Journal Article Med Sci Sports Exerc · October 2001 PURPOSE: The Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) trial is a randomized controlled clinical trial designed to study the effects of exercise training regimens differing in dose (kcal.wk-1) and/or intensity (re ... Full text Link to item Cite

Antihypertensive efficacy and safety of losartan alone and in combination with hydrochlorothiazide in adult African Americans with mild to moderate hypertension.

Journal Article Clin Ther · August 2001 BACKGROUND: African Americans with hypertension, particularly those with more severe blood pressure elevations, are generally less responsive to monotherapy from any antihypertensive class. These patients usually require treatment with drugs from > or = 2 ... Full text Link to item Cite

Cardiac rehabilitation and survival in patients with left ventricular systolic dysfunction.

Journal Article Am Heart J · July 2001 BACKGROUND: Exercise training, the major component of cardiac rehabilitation (CR), has been shown in previous trials to improve many pathophysiologic changes found in patients with left ventricular systolic dysfunction. It remains unproven whether exercise ... Full text Link to item Cite

Effects of chronic exposure to simulated microgravity on skeletal muscle cell proliferation and differentiation.

Journal Article In Vitro Cell Dev Biol Anim · March 2001 Cell culture models that mimic long-term exposure to microgravity provide important insights into the cellular biological adaptations of human skeletal muscle to long-term residence in space. We developed insert scaffolding for the NASA-designed rotating c ... Full text Link to item Cite

Enhancing Recovery in Coronary Heart Disease (ENRICHD) study intervention: rationale and design.

Journal Article Psychosom Med · 2001 OBJECTIVE: Depression and low social support are risk factors for medical morbidity and mortality after acute MI. The ENRICHD study is a multicenter, randomized, controlled clinical trial of a cognitive-behavioral treatment for depression and low social su ... Link to item Cite

Normal skeletal muscle Na(+)-K(+) pump concentration in patients with chronic heart failure.

Journal Article Muscle Nerve · January 2001 Intrinsic changes in skeletal muscle are being increasingly suspected as part of the underlying cause of exercise intolerance in patients with chronic heart failure (CHF). The objective of the present study was to determine whether differences existed betw ... Full text Link to item Cite

Exercise-induced angiogenesis-related growth and transcription factors in skeletal muscle, and their modification in muscle pathology.

Journal Article Front Biosci · January 1, 2001 Angiogenesis is the process of formation of new blood vessels; it is generally a rare occurrence in the adult, although it is a common adaptive response to exercise training in skeletal muscle. Current thinking is that angiogenesis is mediated by diffusibl ... Full text Link to item Cite

Differences in skeletal muscle between men and women with chronic heart failure.

Journal Article J Appl Physiol (1985) · January 2001 Men with chronic heart failure (CHF) have alterations in their skeletal muscle that are partially responsible for a decreased exercise tolerance. The purpose of this study was to investigate whether skeletal muscle alterations in women with CHF are similar ... Full text Link to item Cite

Orientation and length of mammalian skeletal myocytes in response to a unidirectional stretch.

Journal Article Cell Tissue Res · November 2000 Effects of mechanical forces exerted on mammalian skeletal muscle cells during development were studied using an in vitro model to unidirectionally stretch cultured C2C12 cells grown on silastic membrane. Previous models to date have not studied these resp ... Full text Link to item Cite

Differentiation of mammalian skeletal muscle cells cultured on microcarrier beads in a rotating cell culture system.

Journal Article Med Biol Eng Comput · September 2000 The growth and repair of adult skeletal muscle are due in part to activation of muscle precursor cells, commonly known as satellite cells or myoblasts. These cells are responsive to a variety of environmental cues, including mechanical stimuli. The overall ... Full text Link to item Cite

Autocrine phosphorylation of p70(S6k) in response to acute stretch in myotubes.

Journal Article Mol Cell Biol Res Commun · August 2000 Phosphorylation of 70-KDa S6 kinase (p70(S6k)) is correlated with in vivo skeletal muscle hypertrophy. Experiments tested whether mechanical stretch is sufficient to increase p70(S6k) phosphorylation in skeletal myotubes. Immediately following stretch, the ... Full text Link to item Cite

Capillary density of skeletal muscle: a contributing mechanism for exercise intolerance in class II-III chronic heart failure independent of other peripheral alterations.

Journal Article J Am Coll Cardiol · June 1999 OBJECTIVES: The study was conducted to determine if the capillary density of skeletal muscle is a potential contributor to exercise intolerance in class II-III chronic heart failure (CHF). BACKGROUND: Previous studies suggest that abnormalities in skeletal ... Full text Link to item Cite

Intracardiac transplantation of skeletal myoblasts yields two populations of striated cells in situ.

Journal Article Ann Thorac Surg · January 1999 BACKGROUND: Adult heart lacks stem cells and cannot effectively regenerate. In contrast, skeletal muscle is constantly undergoing repair. We proposed to transplant immature skeletal myoblasts into injured myocardium. METHODS: Approximately 7x10(6) soleus s ... Full text Link to item Cite

Regenerating functional myocardium: improved performance after skeletal myoblast transplantation.

Journal Article Nat Med · August 1998 The adult heart lacks reserve cardiocytes and cannot regenerate. Therefore, a large acute myocardial infarction often develops into congestive heart failure. To attempt to prevent this progression, we transplanted skeletal myoblasts into cryoinfarcted myoc ... Full text Link to item Cite

Induction and maintenance of increased VEGF protein by chronic motor nerve stimulation in skeletal muscle.

Journal Article Am J Physiol · March 1998 Vascular endothelial growth factor (VEGF) causes endothelial cell proliferation in vitro and angiogenesis in vivo. Glycolytic skeletal muscles have a lower capillary density than oxidative muscles but can increase their capillary density and convert to a m ... Full text Link to item Cite

Induction and maintenance of increased VEGF protein by chronic motor nerve stimulation in skeletal muscle

Journal Article American Journal of Physiology - Heart and Circulatory Physiology · March 1, 1998 Vascular endothelial growth factor (VEGF) causes endothelial cell proliferation in vitro and angiogenesis in vivo. Glycolytic skeletal muscles have a lower capillary density than oxidative muscles but can increase their capillary density and convert to a m ... Cite

The orientation of mammalian skeletal muscle followlng a unidirectional stretch

Journal Article American Society of Mechanical Engineers, Bioengineering Division (Publication) BED · December 1, 1997 Cite

Altered expression of myosin heavy chain in human skeletal muscle in chronic heart failure.

Journal Article Med Sci Sports Exerc · July 1997 To explore further alterations in skeletal muscle in chronic heart failure (CHF), we examined myosin heavy chain (MHC) isoforms from biopsies of the vastus lateralis in nine male patients with class II-III (CHF) (left ventricular ejection fraction (LVEF) 2 ... Full text Link to item Cite

Delivery of primary autologous skeletal myoblasts into rabbit heart by coronary infusion: a potential approach to myocardial repair.

Journal Article Proc Assoc Am Physicians · May 1997 Myocardial repair after injury is limited because the adult heart cannot regenerate. We propose using autologous skeletal muscle cells (myoblasts) as a source of reserve cells for repair of regions of damaged myocardium. This report examines two potential ... Link to item Cite

In vivo indices of myocardial performance in cardic gene therapy

Conference FASEB Journal · December 1, 1996 Demonstrating the efficacy of Cardiac Gene Therapy (CGT) remains hindered by the inability to measure changes in in vivo cardiac function in small animals. Post-implantation of transfected biopsy-derived skeletal muscle cells into the left ventricle (LV) o ... Cite

Isolation, growth and differentiation of adult rabbit skeletal myoblasts in vitro

Journal Article Methods in Cell Science · December 1, 1996 A simple and reliable method is described for the growth and differentiation of myoblasts isolated from adult New Zealand White rabbit fast-twitch (tibialis anterior) and slow-twitch (soleus) skeletal muscle. Cells were dissociated mechanically, and expand ... Full text Cite

Regulation of type II adenylyl cyclase mRNA in rabbit skeletal muscle by chronic motor nerve pacing.

Journal Article Am J Physiol · August 1996 Skeletal muscle exhibits a wide range in functional phenotype in response to changes in physiological demands. We have observed that, in response to changes in work patterns, alterations in gene expression of some proteins coincide with changes in adenylyl ... Full text Link to item Cite

The in vivo quantification of myocardial performance in rabbits: a model for evaluation of cardiac gene therapy.

Journal Article J Mol Cell Cardiol · May 1996 Evaluating cardiac gene therapy in the intact animal requires an index of cardiac function capable of detecting regional differences in contractility in a load-independent fashion. Potentially load-insensitive measures of ventricular performance were there ... Full text Link to item Cite

E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins.

Journal Article Mol Cell Biol · August 1993 The observation that adenovirus E1A gene products can inhibit differentiation of skeletal myocytes suggested that E1A may interfere with the activity of myogenic basic helix-loop-helix (bHLH) transcription factors. We have examined the ability of E1A to me ... Full text Link to item Cite

Electrical pacing induces adenylyl cyclase in skeletal muscle independent of the beta-adrenergic receptor.

Journal Article Am J Physiol · August 1992 Continuous electrical pacing (EP) at 10 Hz of the peroneal nerve innervating fast-twitch muscles of the hindlimb in adult rabbits increases skeletal muscle concentrations of adenosine 3',5'-cyclic monophosphate (cAMP) by 3.1-fold at 10 days and increases b ... Full text Link to item Cite

Acute response and chronic adaptation to exercise in women.

Journal Article Med Sci Sports Exerc · June 1992 Link to item Cite

ACUTE RESPONSE AND CHRONIC ADAPTATION TO EXERCISE IN WOMEN

Journal Article MEDICINE AND SCIENCE IN SPORTS AND EXERCISE · June 1, 1992 Link to item Cite

Acute response and chronic adaptation to exercise in women

Journal Article Medicine and Science in Sports and Exercise · 1992 Cite

Electrical pacing induces adenylyl cyclase in skeletal muscle independent of the β-adrenergic receptor

Journal Article American Journal of Physiology - Endocrinology and Metabolism · January 1, 1992 Continuous electrical pacing (EP) at 10 Hz of the peroneal nerve innervating fast-twitch muscles of the hindlimb in adult rabbits increases skeletal muscle concentrations of adenosine 3',5'-cyclic monophosphate (cAMP) by 3.1-fold at 10 days and increases β ... Cite

Mitochondrial biogenesis in striated muscles: rapid induction of citrate synthase mRNA by nerve stimulation.

Journal Article Am J Physiol · February 1991 Tonic contractile activity induces mitochondrial biogenesis in mammalian skeletal muscles, necessitating regulation of both nuclear and mitochondrial genes encoding mitochondrial proteins. In this study we compared the time course of induction of citrate s ... Full text Link to item Cite

Increased expression of fibroblast growth factors in a rabbit skeletal muscle model of exercise conditioning.

Journal Article J Clin Invest · June 1990 Increased tonic contractile activity from exercise or electrical stimulation induces a variety of changes in skeletal muscle, including vascular growth, myoblast proliferation, and fast to slow fiber type conversion. Little is known about the cellular cont ... Full text Link to item Cite

Identification of a muscle-specific enhancer within the 5'-flanking region of the human myoglobin gene.

Journal Article J Biol Chem · August 15, 1989 A 2-kilobase fragment from the 5'-flanking region of the human myoglobin gene extending from -2038 to +7 relative to the cap site regulates expression of a heterologous reporter gene in a cell-specific and developmentally regulated manner. Functional analy ... Link to item Cite

Interactions between sustained contractile activity and beta-adrenergic receptors in regulation of gene expression in skeletal muscles.

Journal Article Am J Physiol · March 1989 Continuous electrical stimulation for 10-21 days of the motor nerve innervating the anterior compartment muscles of adult rabbits increased both the density of beta-adrenergic receptors (beta-AR) and tissue concentrations of adenosine 3',5'-cyclic monophos ... Full text Link to item Cite

Interactions between sustained contractile activity and β-adrenergic receptors in regulation of gene expression in skeletal muscles

Journal Article American Journal of Physiology - Cell Physiology · January 1, 1989 Continuous electrical stimulation for 10-21 days of the motor nerve innervating the anterior compartment muscles of adult rabbits increased both the density of β-adrenergic receptors (β-AR) and tissue concentrations of adenosine 3',5'-cyclic monophosphate ... Cite

Purulent pericarditis caused by Candida: report of three cases and identification of high-risk populations as an aid to early diagnosis.

Journal Article Rev Infect Dis · 1988 Purulent pericarditis due to fungal organisms is rare and often unrecognized because of the subtle clinical clues and insidious onset. The records of 11 cases of purulent pericarditis were selected from records of 11,000 cases of pericarditis at Duke Unive ... Full text Link to item Cite

Effects of beta 1-selective and nonselective beta-adrenoceptor blockade during exercise conditioning in healthy adults.

Journal Article Am J Cardiol · June 1, 1984 The interaction of beta 1-selective (cardioselective) and nonselective beta-adrenoceptor blockade with exercise conditioning was investigated in 30 healthy adult persons. A double-blind protocol was used and the effects of atenolol (100 mg/day), propranolo ... Full text Link to item Cite