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Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.

Publication ,  Journal Article
Stafford-Smith, M; Li, Y-J; Mathew, JP; Li, Y-W; Ji, Y; Phillips-Bute, BG; Milano, CA; Newman, MF; Kraus, WE; Kertai, MD; Shah, SH ...
Published in: Kidney Int
October 2015

Acute kidney injury (AKI) is a common, serious complication of cardiac surgery. Since prior studies have supported a genetic basis for postoperative AKI, we conducted a genome-wide association study (GWAS) for AKI following coronary bypass graft (CABG) surgery. The discovery data set consisted of 873 nonemergent CABG surgery patients with cardiopulmonary bypass (PEGASUS), while a replication data set had 380 cardiac surgical patients (CATHGEN). Single-nucleotide polymorphism (SNP) data were based on Illumina Human610-Quad (PEGASUS) and OMNI1-Quad (CATHGEN) BeadChips. We used linear regression with adjustment for a clinical AKI risk score to test SNP associations with the postoperative peak rise relative to preoperative serum creatinine concentration as a quantitative AKI trait. Nine SNPs meeting significance in the discovery set were detected. The rs13317787 in GRM7|LMCD1-AS1 intergenic region (3p21.6) and rs10262995 in BBS9 (7p14.3) were replicated with significance in the CATHGEN data set and exhibited significantly strong overall association following meta-analysis. Additional fine mapping using imputed SNPs across these two regions and meta-analysis found genome-wide significance at the GRM7|LMCD1-AS1 locus and a significantly strong association at BBS9. Thus, through an unbiased GWAS approach, we found two new loci associated with post-CABG AKI providing new insights into the pathogenesis of perioperative AKI.

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Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

October 2015

Volume

88

Issue

4

Start / End Page

823 / 832

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Middle Aged
  • Male
  • Linear Models
  • Humans
 

Citation

APA
Chicago
ICMJE
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Stafford-Smith, M., Li, Y.-J., Mathew, J. P., Li, Y.-W., Ji, Y., Phillips-Bute, B. G., … Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team, . (2015). Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci. Kidney Int, 88(4), 823–832. https://doi.org/10.1038/ki.2015.161
Stafford-Smith, Mark, Yi-Ju Li, Joseph P. Mathew, Yen-Wei Li, Yunqi Ji, Barbara G. Phillips-Bute, Carmelo A. Milano, et al. “Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.Kidney Int 88, no. 4 (October 2015): 823–32. https://doi.org/10.1038/ki.2015.161.
Stafford-Smith M, Li Y-J, Mathew JP, Li Y-W, Ji Y, Phillips-Bute BG, et al. Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci. Kidney Int. 2015 Oct;88(4):823–32.
Stafford-Smith, Mark, et al. “Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.Kidney Int, vol. 88, no. 4, Oct. 2015, pp. 823–32. Pubmed, doi:10.1038/ki.2015.161.
Stafford-Smith M, Li Y-J, Mathew JP, Li Y-W, Ji Y, Phillips-Bute BG, Milano CA, Newman MF, Kraus WE, Kertai MD, Shah SH, Podgoreanu MV, Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team. Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci. Kidney Int. 2015 Oct;88(4):823–832.
Journal cover image

Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

October 2015

Volume

88

Issue

4

Start / End Page

823 / 832

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Middle Aged
  • Male
  • Linear Models
  • Humans