Overview
Dr. Smith is the Principal Investigator for the Duke site in the Cardiothoracic Surgery Clinical Trials Network (CTSN) and in recent years has focused his research efforts in clinical research. The CTSN is an NHLBI sponsored network developed to promote clinical research in cardiac surgery, and is now entering its 7th year of funding with a commitment now for an additional 5 years. Dr. Smith is the national PI for a randomized clinical trial comparing CABG alone to CABG with mitral repair for moderate ischemic mitral regurgitation. This trial is nearing completion of enrollment, and he is now the PI of a clinical trial of FFR vs angiographically guided CABG expected to begin national enrollment in September of 2013. Duke has participated as a site in 3 additional CTSN trials, and is one of two sites awarded NHLBI funding as a Clinical Skills Education Core. This funding is designed to formally develop surgical clinical trialists and promote clinical research capacity within our specialty. The Duke site has thus far sponsored 6 CTSN scholars who have all received Masters degrees in clinical research, participated in CTSN protocols and other activities of the Network. Additionally, Dr. Smith has been awarded site funding from the Veteran’s Administration to begin VA cooperative clinical research trials at the Durham VA. Through all of these activities, an integration of clinical research, publications, and scholarship with the advancement of clinically effective Thoracic Surgery is the goal.
Current Appointments & Affiliations
Mary and Deryl Hart Distinguished Professor of Surgery, in the School of Medicine
·
2016 - Present
Surgery, Cardiovascular and Thoracic Surgery,
Surgery
Professor of Surgery
·
1994 - Present
Surgery, Cardiovascular and Thoracic Surgery,
Surgery
Recent Publications
Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Left Main Disease With and Without Diabetes: Findings From a Pooled Analysis of 4 Randomized Clinical Trials.
Journal Article Circulation · April 23, 2024 BACKGROUND: Diabetes may be associated with differential outcomes in patients undergoing left main coronary revascularization with percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). The aim of this study was to investigate ... Full text Link to item CiteThe impact of perioperative stroke and delirium on outcomes after surgical aortic valve replacement.
Journal Article J Thorac Cardiovasc Surg · February 2024 OBJECTIVE: The effects of stroke and delirium on postdischarge cognition and patient-centered health outcomes after surgical aortic valve replacement (SAVR) are not well characterized. Here, we assess the impact of postoperative stroke and delirium on thes ... Full text Link to item CiteSTS/AATS-Endorsed Rebuttal to 2023 ACC/AHA Chronic Coronary Disease Guideline: A Missed Opportunity to Present Accurate and Comprehensive Revascularization Recommendations.
Journal Article Ann Thorac Surg · October 2023 Full text Link to item CiteRecent Grants
Mid-Atlantic praGmatic NETwork for Inclusive Clinical trials in emergency care (MAGNETIC)
ResearchCollaborator · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2028Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine: ÂżAnticoagulation for New-Onset Post-Operative
Clinical TrialPrincipal Investigator · Awarded by Icahn School of Medicine at Mount Sinai · 2019 - 2026Postdoctoral Training in Cardiovascular Clinical Research
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2003 - 2025View All Grants
Education, Training & Certifications
Duke University ·
1977
M.D.